PAPERS PUBLISHED IN 1999

This list is arranged by the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (michal@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M., Leblova Z.: Dynamic database of references in molecular diversity. Internet http://www.5z.com.

Recently added entries are marked in bold

1. Anonymous. (1999) BASF plans to accelerate catalyst research. Performance Chemicals International, 14, 7-7. #14716

2. Anonymous. (1999) Combinatorial chemistry for molecular sieves. Advanced Materials, 11, 1330. #14905

3. Anonymous. (1999) Latest developments in combinatorial chemistry, discovery to process development. Chim. Oggi, 17, 30-31. #12912

4. Abate, P., Conroy, J.L., & Seto, C.T. (1999) Combinatorial library of serine and cysteine protease inhibitors that interact with both the S and S' binding sites. J. Med. Chem., 42, 4001-4009. #13895

5. Abato, P., Conroy, J.L., & Seto, C.T. (1999) Combinatorial library of serine and cysteine protease inhibitors that interact with both the S and S' binding sites. J. Med. Chem., 42, 4001-4009. #15612

6. Abele, R., & Tampe, R. (1999) Function of the transport complex TAP in cellular immune recognition. Biochimica et Biophysica Acta - Biomembranes, 1461, 405-419. #13896

7. Adams, J.H., Cook, R.M., Hudson, D., Jammalamadaka, V., Lyttle, M.H. & Songster, M.F. (1999) Improved supports and methods for solid phase mediated transformations. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 23-30). Mayflower Scientific Limited, Birmingham. #13454

8. Adang, A.E.P., Peters, C.A.M., Gerritsma, S., De Zwart, E., & Veeneman, G. (1999) Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety. Bioorg. Med. Chem. Lett., 9, 1227-1232. #12857

9. Adda, C.G., Tilley, L., Anders, R.F., & Foley, M. (1999) Isolation of peptides that mimic epitopes on a malarial antigen from random peptide libraries displayed on phage. Infec. Immunity, 67, 4679-4688. #13468

10. Adermann, K., Wattler, F., Wattler, S., Heine, G., Meyer, M., Forssmann, W.G., & Nehls, M. (1999) Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily. Protein Sci., 8, 810-819. #12704

11. Adesida, A.B., Aojula, R.R., Aojula, H.S., & Clarke, D.J. (1999) Nonepitopic antibody binding sequence: implications in screening and development of peptide vaccines. Vaccine, 18, 315-320. #13897

12. Adinolfi, M., Barone, G., De Napoli, L., Guariniello, L., Iadonisi, A., & Piccialli, G. (1999) Solid phase glycosidation of oligonucleotides. Tetrahedron Lett., 40, 2607-2610. #12621

13. Afshar, M., Prescott, C.D., & Varani, G. (1999) Structure-based and combinatorial search for new RNA-binding drugs. Curr. Opin. Biotechnol., 10, 59-63. #12705

14. Agrafiotis, D.K., & Lobanov, V.S. (1999) An efficient implementation of distance-based diversity measures based on k-d trees. Journal of Chemical Information and Computer Sciences, 39, 51-58. #12298

15. Agrafiotis, D.K., Myslik, J.C., & Salemme, F.R. (1999) Advances in diversity profiling and combinatorial series design. Mol. Diversity, 4, 1-22. #12921

16. Ahlberg, C. (1999) Realizing the potential of complex databases. Scientific Computing and Instrumentation, 16, 3. #15398

17. Ajay, Bemis, G.W., & Murcko, M.A. (1999) Designing libraries with CNS activity. J. Med. Chem., 42, 4942-4951. #13898

18. Akerblom, E.B. (1999) Six new photolabile linkers for solid phase synthesis. 2. Coupling of various building blocks and photolytic cleavage. Mol. Diversity, 4, 53-69. #12923

19. Al-Obeidi, F., & Ostrem, J.A. (1999) Factor Xa inhibitors. Exp. Opin. Ther. Patents, 9, 931-953. #13469

20. Albericio, F., Frieden, A., del Fresno, M., Royo, M., Alsina, J., Jensen, K.J., Kates, S.A. & Barany, G. (1999) Solid-phase synthesis of "head-to-tail" cyclic and C-terminal modified peptides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 7-10). Mayflower Scientific Limited, Birmingham. #13450

21. Albrecht, M., Blau, O., & Frohlich, R. (1999) An expansible metalla-cryptand as a component of a supramolecular combinatorial library formed from di(8-hydroxyquinoline) ligands and gallium(III) or zinc(II) ions. Chem. Eur. J., 5, 48-56. #12301

22. Alfaro-Lopez, J., Okayama, T., Hosohata, K., Davis, P., Porreca, F., Yamamura, H.I., & Hruby, V.J. (1999) Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand. J. Med. Chem., 42, 5359-5368. #13899

23. Ali, T., Chauhan, K.K., & Frost, C.G. (1999) Indium triflate: An efficient catalyst for hetero Diels-Alder reactions. Tetrahedron Lett., 40, 5621-5624. #13400

24. Alsina, J., Jensen, K.J., Albericio, F., & Barany, G. (1999) Solid-phase synthesis with tris(alkoxy)benzyl backbone amide linkage (BAL). Chem. Eur. J., 5, 2787-2795. #14915

25. Altman, R.K., Schwope, I., Sarracino, D.A., Tetzlaff, C.N., Bleczinski, C.F., & Richert, C. (1999) Selection of modified oligonucleotides with increased target affinity via MALDI-monitored nuclease survival assays. Journal of Combinatorial Chemistry, 1, 493-508. #13901

26. Altreuter, D.H., & Clark, D.S. (1999) Combinatorial biocatalysis: Taking the lead from Nature. Curr. Opin. Biotechnol., 10, 130-136. #12706

27. Ambler, J., Baker, E., Bentley, D., Brown, L., Butler, K., Butler, P., Farr, D., Dunnet, K., Le Grand, D., Hayler, J., Janus, D., Jones, D., Menear, K., Mercer, M., Smith, G., Talbot, M., & Tweed, M. (1999) Studies towards the identification of potent, selective and bioavailable thrombin inhibitors. Bioorg. Med. Chem. Lett., 9, 737-742. #15662

28. Anderson, R.C., Lin, M., & Shapiro, M.J. (1999) Affinity NMR: Decoding DNA binding. Journal of Combinatorial Chemistry, 1, 69-72. #12041 (Available on Internet)

29. Andersson, P.M., Linusson, A., Wold, S., Sjostrom, M., Lundstedt, T., & Norden, B. (1999) Design of small libraries for lead exploration. Molecular Diversity in Drug Design, 197-220. #14918

30. Andres, C.J., Swann, R.T., Grant-Young, K., D'Andrea, S.V., & Deshpande, M.S. (1999) A novel cleavage protocol for use with Rf-encoded split pool synthesis technology: Product cleavage and collection in standard 96 well format. Comb. Chem. High Throughput Screening, 2, 29-32. #12848

31. Andres, C.J., Denhart, D.J., Deshpande, M.S., & Gillman, K.W. (1999) Recent advances in the solid phase synthesis of drug-like heterocyclic small molecules. Comb. Chem. High Throughput Screening, 2, 191-210. #13903

32. Andrus, M.B., Turner, T.M., Asgari, D., & Li, W.K. (1999) The synthesis and evaluation of a solution-phase indexed combinatorial library of non-natural polyenes for multidrug resistance reversal. J. Org. Chem., 64, 2978-2979. #12925

33. Angell, Y.M., Jensen, K.J., Gross, C.M. & Barany, G. (1999) Solid-phase synthesis of peptide nucleic analogue (PNA) sequences taken to new lengths. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 59-62). Mayflower Scientific Limited, Birmingham. #13460

34. Angell, Y.M., Raman, P., Flentke, G.R. & Rich, D.H. (1999) Solid phase synthesis of cyclosporins involving on-resin and solution cyclizations. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 135-138). Mayflower Scientific Limited, Birmingham. #13664

35. Ankersen, M., Hansen, B.S., Hansen, T.K., Lau, J., Peschke, B., Madsen, K., & Johansen, N.L. (1999) Demonstration of the strength of focused combinatorial libraries in SAR optimisation of growth hormone secretagogues. Eur. J. Med. Chem., 34, 783-790. #13904

36. Antel, J. (1999) Integration of combinatorial chemistry and structure-based drug design. Curr. Opin. Drug. Disc. Develop., 2, 224-233. #13396

37. Antonenko, V.V. (1999) Automation in combinatorial chemistry. In Anonymous, Combinatorial Chemistry and Technology: Principles, Methods, and Applications. (pp. 205-232). #13471

38. Aoki, Y., & Kobayashi, S. (1999) Development of a reductive alkylation method using p-benzyloxybenzylamine (BOBA) resin for the synthesis of N-alkylated amides. Journal of Combinatorial Chemistry, 1, 371-372. #13650

39. Apostolakis, J., & Caflisch, A. (1999) Computational ligand design. Comb. Chem. High Throughput Screening, 2, 91-104. #12852

40. Appel, J.R., Johnson, J., Narayanan, V.L., & Houghten, R.A. (1999) Identification of novel antitumor agents from mixture-based synthetic combinatorial libraries using cell-based assays. Mol. Diversity, 4, 91-102. #12926

41. Appleton, T. (1999) Combinatorial chemistry and HTS: Feeding a voracious process. Drug Disc. Today, 4, 398-400. #13473

42. Aramburu, J., Yaffe, M.B., Lopez-Rodriguez, C., Cantley, L.C., Hogan, P.G., & Rao, A. (1999) Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science, 285, 2129-2133. #13907

43. Archer, R. (1999) The drug discovery factory: An inevitable evolutionary consequence of high-throughput parallel processing. Nat. Biotech., 17, 834-834. #14712

44. Argyris, E.G., Vanderkooi, J.M., Venkateswaran, P.S., Kay, B.K., & Paterson, Y. (1999) The connection domain is implicated in metalloporphyrin binding and inhibition of HIV reverse transcriptase. Journal of Biological Chemistry, 274, 1549-1556. #12927

45. Arsequell, G., Espuna, G., Valencia, G., Barluenga, J., Perez Carlon, R., & Gonzalez, J.M. (1999) Selective solid-phase iodination of phenolic groups with bis(pyridine)iodonium (I) tetrafluoroborate. Tetrahedron Lett., 40, 7279-7282. #13775

46. Atiq-ur-Rehman, Li, C., Budge, L.P., Street, S.E., & Savage, P. (1999) Preparation of amino acid-appended cholic acid derivatives as sensitizers of gram-negative bacteria. Tetrahedron Lett., 40, 1865-1868. #12606

47. Attanasi, O.A., Filippone, P., Guidi, B., Hippe, T., Mantellini, F., & Tietze, L.F. (1999) First preparation and reaction of polymer-bound 1,2-diaza-1,3-butadienes. A convenient entry to 4-triphenylphosphoranylidene-4,5-dihydropyrazol-5-ones. Tetrahedron Lett., 40, 9277-9280. #13879

48. Atwell, S., & Wells, J.A. (1999) Selection for improved subtiligases by phage display. Proc. Natl. Acad. Sci. USA, 96, 9497-9502. #13474

49. Aubagnac, J.L., Enjalbal, C., Drouot, C., Combarieu, R., & Martinez, J. (1999) Imaging time-of-flight secondary ion mass spectrometry of solid-phase peptide syntheses. J. Mass Spectrom., 34, 749-754. #13475

50. Aubagnac, J.L., Amblard, M., Enjalbal, C., Subra, G., Martinez, J., Durand, P., & Renaut, P. (1999) Identification of synthetic by-products in combinatorial libraries using high performance liquid chromatography-electrospray ionization mass spectrometry. Comb. Chem. High Throughput Screening, 2, 289-296. #13909

51. Augeri, D.J., Janowick, D., Kalvin, D., Sullivan, G., Larsen, J., Dickman, D., Ding, H., Cohen, J., Lee, J., Warner, R., Kovar, P., Cherian, S., Saeed, B., Zhang, H., Tahir, S., Ng, S.C., Sham, H., & Rosenberg, S.H. (1999) Potential and orally bioavailable noncysteine-containing inhibitors of protein farnesyltransferase. Bioorg. Med. Chem. Lett., 9, 1069-1074. #15613

52. Babaev, E.V. (1999) Organic synthesis and combinatorial chemistry [Russian]. Khimiya Geterotsiklicheskikh Soedinenii, 714-716. #13476

53. Bagno, A., Bicciato, S., Di Bello, C. & Bonora, G.M. (1999) Automated liquid-phase biopolymer synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 51-54). Mayflower Scientific Limited, Birmingham. #13458

54. Bailey, C., Baker, E., Hayler, J., & Kane, P. (1999) Amidine protection for solution phase library synthesis. Tetrahedron Lett., 40, 4847-4850. #13113

55. Bakhtiar, R., & Ochiai, E.I. (1999) Pharmacological applications of inorganic complexes. General Pharmacology, 32, 525-540. #12930

56. Baldwin, J. J., Burbaum, J., and Sigal, N. H. Combinatorial chemistry: Part of the evolution in drug discovery. In: Anonymous. (Eds.) Kluwer Academic/Plenum Publishers, New York p.71 Current Trends in Organic Synthesis. #15687OLD

57. Bankaitis-Davis, D., Beaton, G., Bjergarde, K., Callaway, W., Cook, A., Curtis, M., Herrera, C., Huang, L., Josey, J., Munson, M. & Tarlton, C. (1999) Flexible approaches for high-speed synthesis: A multiple platform strategy. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 257-258). Mayflower Scientific Limited, Birmingham. #13689

58. Barn, D.R., & Morphy, J.R. (1999) Solid-phase synthesis of cyclic imides. Journal of Combinatorial Chemistry, 1, 151-156. #12700

59. Barn, D.R., Bom, A., Cottney, J., Caulfield, W.L., & Morphy, J.R. (1999) Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis. Bioorg. Med. Chem. Lett., 9, 1329-1334. #15614

60. Barrett, A.G.M., Cramp, S.M., & Roberts, R.S. (1999) ROMP-spheres: A novel high-loading polymer support using cross metathesis between vinyl polystyrene and norbornene derivatives. Organic Letters, 1, 1083-1086. #14930

61. Barron, A.E., & Zuckermann, R.N. (1999) Bioinspired polymeric materials: In-between proteins and plastics. Curr. Opin. Chem. Biol., 3, 681-687. #15486

62. Barry, J.F., Davis, A.P., Perez-Payan, M.N., Elsegood, M.R.J., Jackson, R.F.W., Gennari, C., Piarulli, U., & Gude, M. (1999) A trifunctional steroid-based scaffold for combinatorial chemistry. Tetrahedron Lett., 40, 2849-2852. #12624

63. Bartlett, P.A., & Joyce, G.F. (1999) Combinatorial chemistry: The search continues - Editorial overview. Curr. Opin. Chem. Biol., 3, 253-255. #12932

64. Bayada, D.M., Hamersma, H., & van, G., V. (1999) Molecular diversity and representativity in chemical databases. Journal of Chemical Information and Computer Sciences, 39, 1-10. #12308

65. Becker, J.A.J., Wallace, A., Garzon, A., Ingallinella, P., Bianchi, E., Cortese, R., Simonin, F., Kieffer, B.L., & Pessi, A. (1999) Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library. Journal of Biological Chemistry, 274, 27513-27522. #13915

66. Becker, J.A.J., Wallace, A., Garzon, A., Ingallinella, P., Bianchi, E., Cortese, R., Simonin, F., Keiffer, B.L., & Pessi, A. (1999) Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library (vol 274, pg 27513, 1999). Journal of Biological Chemistry, 274, 33177-33177. #13914

67. Begent, R.H.J. (1999) Targeting cancer therapy. British Journal of Cancer, 80, -109. #13479

68. Bein, T. (1999) Efficient assays for combinatorial methods for the discovery of catalysts. Angew. Chem. Int. Ed., 38, 323-326. #12590

69. Bemis, G.W., & Murcko, M.A. (1999) Properties of known drugs. 2. Side chains. J. Med. Chem., 42, 5095-5099. #13918

70. Benigni, R., Gallo, G., Giorgi, F., & Giuliani, A. (1999) On the equivalence between different descriptions of molecules: Value for computational approaches. Journal of Chemical Information and Computer Sciences, 39, 575-578. #12935

71. Berg, T., Simeonov, A., & Janda, K.D. (1999) A combined parallel synthesis and screening of macrocyclic lanthanide complexes for the cleavage of phospho di- and triesters and double-stranded DNA. Journal of Combinatorial Chemistry, 1, 96-100. #12034 (Available on Internet)

72. Bergbreiter, D.E. (1999) Alternative polymer supports for organic chemistry. Med. Res. Rev., 19, 439-450. #13919

73. Berger, C., Martin, N., Collin, S., Gijs, L., Khan, J.A., Piraprez, G., Spinnler, H.E., & Vulfson, E.N. (1999) Combinatorial approach to flavor analysis. 2. Olfactory investigation of a library of S-methyl thioesters and sensory evaluation of selected components. J. Agric. Food Chem., 47, 3274-3279. #13481

74. Bergnes, G., Gilliam, C.L., Boisclair, M.D., Blanchard, J.L., Blake, K.V., Epstein, D.M., & Pal, K. (1999) Generation of an UGI library of phosphate mimic-containing compounds and identification of novel dual specific phosphatase inhibitors. Bioorg. Med. Chem. Lett., 9, 2849-2854. #13920

75. Berk, S.C., Rohrer, S.P., Degrado, S.J., Birzin, E.T., Mosley, R.T., Hutchins, S.M., Pasternak, A., Schaeffer, J.M., Underwood, D.J., & Chapman, K.T. (1999) A combinatorial approach toward the discovery of non-peptide, subtype-selective somatostatin receptor ligands. Journal of Combinatorial Chemistry, 1, 388-396. #13654

76. Berkessel, A., & Herault, D.A. (1999) Discovery of peptide-zirconium complexes that mediate phosphate hydrolysis by batch screening of a combinatorial undecapeptide library. Angew. Chem. Int. Ed., 38, 102-105. #12218

77. Berl, V., Huc, I., Lehn, J.M., DeCian, A., & Fischer, J. (1999) Induced fit selection of a barbiturate receptor from a dynamic structural and conformational/configurational library. Eur. J. Org. Chem., 3089-3094. #14942

78. Bernard, P., Berthon, J.Y., & Chretien, J.R. (1999) Computer-aided molecular selection and design of natural bioactive molecules. Curr. Opin. Drug. Disc. Develop., 2, 213-223. #13395

79. Berteina, S., De Mesmaeker, A., & Wendeborn, S. (1999) Functionalization via radical cyclization of cyclohexenediol derivatives bound to polystyrene. Synlett, 1121-1123. #13482

80. Bhagwat, S.S., Manning, A.M., Hoekstra, M.F., & Lewis, A. (1999) Gene-regulating protein kinases as importatnt anti-inflamatory targets. Drug Disc. Today, 4, 472-479. #15491

81. Bhat, A.S., Whetstone, J.L., & Brueggemeier, R.W. (1999) Novel synthetic routes suitable for constructing benzopyrone combinatorial libraries. Tetrahedron Lett., 40, 2469-2472. #12626

82. Bianchi, A.A., & Baneyx, F. (1999) Stress responses as a tool to detect and characterize the mode of action of antibacterial agents. Appl. Environ. Microbiol., 65, 5023-5027. #13921

83. Biederman, K.J., Lee, H., Haney, C.A., Kaczmarek, M., & Buettner, J.A. (1999) Combinatorial peptide on-resin analysis: Optimization of static nanoelectrospray ionization technique for sequence determination. J. Pept. Res., 53, 234-243. #12859

84. Birr, C. (1999) Organic synthetic methodology extensions forgotten in peptide science. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 75-84). Mayflower Scientific Limited, Birmingham. #13464

85. Bjorling, E., von Garrelts, E., Morner, A., Ehnlund, M., & Persson, M.A.A. (1999) Human neutralizing human immunodeficiency virus type 2-specific Fab molecules generated by phage display. J. Gen. Virol., 80, -1993. #13483

86. Blackburn, C., Barany, G., Albericio, F. & Kates, S.A. (1999) Handles for solid-phase chemistry: Progress from peptide to small molecule synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 31-38). Mayflower Scientific Limited, Birmingham. #13455

87. Blackburn, C. & Kates, S.A. (1999) Homodetic cyclic peptides via solid phase synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 129-134). Mayflower Scientific Limited, Birmingham. #13663

88. Blettner, C.G., Konig, W.A., Ruhter, G., Stenzel, W., & Schotten, T. (1999) Parallel synthesis of poly(ethylene)glycol supported biaryl benzimidazoles and imidazopyridines. Synlett, 307-310. #15615

89. Blettner, C.G., Schotten, T., Stenzel, W. & Konig, W.A. (1999) PEG polymer supported liquid phase parallel synthesis of Suzuki and Heck products. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 263-266). Mayflower Scientific Limited, Birmingham. #13690

90. Blitz, J., & Little, C.B. (1999) Fundamental and applied aspects of chemically modified surfaces. The Royal Society of Chemistry, Cambridge. ISBN 085404714X #14720

91. Blom, K.F., Larsen, B.S., & McEwen, C.N. (1999) Determining affinity-selected ligands and estimating binding affinities by online size exclusion chromatography/liquid chromatography-mass spectrometry. Journal of Combinatorial Chemistry, 1, 82-90. #12032 (Available on Internet)

92. Blondelle, S.E. & Houghten, R.A. (1999) Synthetic combinatorial libraries: A new tool for antimicrobial agent discovery. In S. Grabley & R. Thiericke (Eds.), Drug discovery from nature. (pp. 311-319). #12909

93. Blondelle, S.E., Takahashi, E., Robles, B.L., Houghten, R.A. & Perez-Paya, E. (1999) Design of catalytic mimics for the decarboxylation of oxaloacetate using synthetic combinatorial libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 163-166). Mayflower Scientific Limited, Birmingham. #13669

94. Blondelle, S.E., Crooks, E., Ostresh, J.M., & Houghten, R.A. (1999) Mixture-based heterocyclic combinatorial positional scanning libraries: Discovery of bicyclic guanidines having potent antifungal activities against Candida albicans and Cryptococcus neoformans. Antimicrob. Agents Chemother., 43, 106-114. #12711

95. Boeijen, A., & Liskamp, R.M.J. (1999) Solid-phase synthesis of oligourea peptidomimetics. Eur. J. Org. Chem., 2127-2135. #14947

96. Boger, D.L., Jiang, W.Q., & Goldberg, J. (1999) Convergent solution-phase combinatorial synthesis with multiplication of diversity through rigid biaryl and diarylacetylene couplings. J. Org. Chem., 64, 7094-7100. #13792

97. Boger, D.L., Goldberg, J., & Andersson, C.M. (1999) Solution phase combinatorial synthesis of biaryl libraries employing heterogeneous conditions for catalysis and isolation with size exclusion chromatography for purification. J. Org. Chem., 64, 2422-2427. #12860

98. Boguslavsky, J. (1999) Need protein? Organic chemistry holds the key. Drug. Dis. Develop., 30-33. #12914

99. Bohlmann, J., Phillips, M., Ramachandiran, V., Katoh, S., & Croteau, R. (1999) cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis). Arch. Biochem. Biophys., 368, 232-243. #13793

100. Bohm, H.J., Banner, D.W., & Weber, L. (1999) Combinatorial docking and combinatorial chemistry: Design of potent non-peptide thrombin inhibitors. J. Comput. Aid. Molec. Design, 13, 51-56. #12712

101. Boisnard, S., Chastanet, J., & Zhu, J. (1999) A high throughput synthesis of aryl triflate and aryl nonaflate promoted by a polymer supported base (PTBD). Tetrahedron Lett., 40, 7469-7472. #13767

102. Boivin, J., Pothier, J., & Zard, S.Z. (1999) A flexible, convergent approach to piperidines, pyridines, azepines, and related derivatives. Tetrahedron Lett., 40, 3701-3704. #14208

103. Boiziau, C., Dausse, E., Yurchenko, L., & Toulme, J.J. (1999) DNA aptamers selected against the HIV-1 trans-activation-responsive RNA element form RNA-DNA kissing complexes. Journal of Biological Chemistry, 274, 12730-12737. #12937

104. Boldi, A.M., Johnson, C.R., & Eissa, H.O. (1999) Solid-phase library synthesis of triazolopyridazines via [4+2] cycloadditions. Tetrahedron Lett., 40, 619-622. #12220

105. Bolton, G.L., & Hodges, J.C. (1999) Solid-phase synthesis of substituted benzazepines via intramolecular Heck cyclization. Journal of Combinatorial Chemistry, 1, 130-133. #12697

106. Bongardt, P., Gerster, M. & Bayer, E. (1999) Synthesis and characterization of very short peptide-oligonucleotide conjugates used for the transport of antisense oligonucleotides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 267-270). Mayflower Scientific Limited, Birmingham. #13691

107. Booth, R.J., & Hodges, J.C. (1999) Solid-supported reagent strategies for rapid purification of combinatorial synthesis products. Account. Chem. Res., 32, 18-26. #12284

108. Bordusa, F., Dahl, C., Jakubke, H.D., Burger, K., & Koksch, B. (1999) Synthesis of alpha-fluoroalkyl substituted peptides via enzymatic fragment condensation. Tetrahedron-Asymmetry, 10, 307-313. #12713

109. Borman, S. (1999) Modified T-cell receptors produced as a library. C&EN, 77, 34-34. #13097

110. Borman, S. (1999) Genomics rises to drug discovery challenge. C&EN, 77, 59-68. #13098

111. Borman, S. (1999) Reducing time to drug discovery. Recent advances in solid-phase synthesis, informatics, and high-throughput screening suggest combinatorial chemistry is coming of age. C&EN, 77, 33-48. #12854

112. Borman, S. (1999) New phage display format developed. C&EN, 77, 6-6. #13096

113. Bottoli, A.P.F., Kertesz-Chaloupkova, K., Boulianne, R.P., Granado, J.D., Aebi, M., & Kues, U. (1999) Rapid isolation of genes from an indexed genomic library of C-cinereus in a novel pab1+ cosmid. J. Microbiol. Methods, 35, 129-141. #12628

114. Bourne, G.T., Meutermans, W.D.F., & Smythe, M.L. (1999) The development of solid phase protocols for a backbone amide linker and its application to the Boc-based assembly of linear peptides. Tetrahedron Lett., 40, 7271-7274. #13774

115. Bourne, G.T., Meutermans, W.D.F., Alewood, P.F., McGeary, R.P., Scanlon, M., Watson, A.A., & Smythe, M.L. (1999) A backbone linker for BOC-based peptide synthesis and on-resin cyclization: Synthesis of stylostatin 1. J. Org. Chem., 64, 3095-3101. #12861

116. Boutin, J.A., Marande, W., Petit, L., Loynel, A., Desmet, C., Canet, E., & Fauchere, J.L. (1999) Investigation of S-farnesyl transferase substrate specificity with combinatorial tetrapeptide libraries. Cell. Signal., 11, 59-69. #12140

117. Boutin, J.A., Lambert, P.H., Bertin, S., Volland, J.P., & Fauchere, J.L. (1999) Physico-chemical and biological analysis of true combinatorial libraries. Journal of Chromatography B, 725, 17-37. #12714

118. Braban, M., Pop, I., Willard, X., & Horvath, D. (1999) Reactivity prediction models applied to the selection of novel candidate building blocks for high-throughput organic synthesis of combinatorial libraries. Journal of Chemical Information and Computer Sciences, 39, 1119-1127. #14960

119. Brain, C.T., Paul, J.M., Loong, Y., & Oakley, P.J. (1999) Novel procedure for the synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using polymer-supported Burgess reagent under microwave conditions. Tetrahedron Lett., 40, 3275-3278. #12695

120. Brase, S., Kobberling, J., Enders, D., Lazny, R., Wang, M., & Brandtner, S. (1999) Triazenes as robust and simple linkers for amines in solid-phase organic synthesis. Tetrahedron Lett., 40, 2105-2108. #12613

121. Brase, S., & Schroen, M. (1999) Efficient cleavage. Cross-coupling strategy for solid-phase synthesis: A modular building system for combinatorial chemistry. Angew. Chem. Int. Ed., 38, 1071-1073. #12938

122. Bridonneau, P., Chang, Y.F., Buvoli, V.B., O'Connell, D., & Parma, D. (1999) Site-directed selection of oligonucleotide antagonists by competitive elution. Antisense Nucl. Acid Drug Devel., 9, 1-11. #12715

123. Broadbridge, R.J., Sharma, R.P. & Akhtar, M. (1999) Design and synthesis of novel Src homology-2 domain inhibitors. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 211-216). Mayflower Scientific Limited, Birmingham. #13678

124. Bromidge, S.M., Brown, A.M., Clarke, S.E., Dodgson, K., Gager, T., Grassam, H.L., Jeffrey, P.M., Joiner, G.F., King, F.D., Middlemiss, D.N., Moss, S.F., Newman, H., Riley, G., Routledge, C., & Wyman, P. (1999) 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): A potent, selective, and orally bioavailable 5-HT6 receptor antagonist. J. Med. Chem., 42, 202-205. #13391

125. Brooking, P., Doran, A., Grimsey, P., Hird, N.W., MacLachlan, W.S., & Vimal, M. (1999) Split-split. A multiple synthesiser approach to efficient automated parallel synthesis. Tetrahedron Lett., 40, 1405-1408. #12319

126. Brown, A.R. (1999) Vapor-phase Hofmann elimination: A rapid one-pot method for the cleavage of tertiary amines from radio frequency encoded solid-phase synthesis. Journal of Combinatorial Chemistry, 1, 283-285. #13486

127. Brown, F., & Gund, P. (1999) The management of chemical and biological information. Editorial overview. Curr. Opin. Drug. Disc. Develop., 2, 184-185. #13392

128. Bryant, M.D., Flick, K.E., Koduri, R.S., Wilton, D.C., Stoddard, B.L., & Gelb, M.H. (1999) 1,3-Dioxane-4,6-dione-5-carboxamide-based inhibitors of human group IIA phospholipase A2: X-Ray structure of the complex and interfacial selection of inhibitors from a structural library. Bioorg. Med. Chem. Lett., 9, 1097-1102. #15616

129. Bui, C.T., Bray, A.M., Pham, Y., Campbell, R., Ercole, F., Rasoul, F.A., & Maeji, N.J. (1999) Comparative study of reductive amination on 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid and its monomethoxy analog using the MultipinTM approach. Mol. Diversity, 4, 155-163. #14388

130. Bui, C.T., Maeji, N.J., Rasoul, F., & Bray, A.M. (1999) A simple method for the generation of chloromethyl polystyrene on the MultipinTM solid support. Tetrahedron Lett., 40, 5383-5386. #13120

131. Bunin, B.A., Dener, J.M., & Livingston, D.A. (1999) Application of combinatorial and parallel synthesis to medicinal chemistry. Annu. Rep. Med. Chem., 34, 267-286. #14354

132. Burden, F.R., & Winkler, D.A. (1999) New QSAR methods applied to structure-activity mapping and combinatorial chemistry. Journal of Chemical Information and Computer Sciences, 39, 236-242. #12716

133. Burg, M.A., Pasqualini, R., Arap, W., Ruoslahti, E., & Stallcup, W.B. (1999) NG2 proteoglycan-binding peptides target tumor neovasculature. Cancer Res., 59, 2869-2874. #12939

134. Burgoon, M.P., Williamson, R.A., Owens, G.P., Ghausi, O., Bastidas, R.B., Burton, D.R., & Gilden, D.H. (1999) Cloning the antibody response in humans with inflammatory CNS disease: Isolation of measles virus-specific antibodies from phage display libraries of a subacute sclerosing panencephalitis brain. J. Neuroimmunol., 94, 204-211. #12717

135. Burkett, B.A., & Chai, C.L.L. (1999) The Diels-Alder reactions of polymer bound dehydroalanine derivatives. Tetrahedron Lett., 40, 7035-7038. #13763

136. Bussolari, J.C., Rehborn, D.C., & Combs, D.W. (1999) Parallel synthesis of 2-alkoxy and 2-acyloxyphenylpropyl amides and amines using dihydrocoumarins as versatile synthons. Application of a novel resin quench-capture method. Tetrahedron Lett., 40, 1241-1244. #12530

137. Buus, S. (1999) Immunological techniques: Examining specificities of the immune system using peptide libraries. Overview. Curr. Opin. Immunol., 11, 191-192. #12630

138. Cabrele, C., Langer, M., & Beck-Sickinger, A.G. (1999) Amino acid side chain attachment approach and its application to the synthesis of tyrosine-containing cyclic peptides. J. Org. Chem., 64, 4353-4361. #12940

139. Calvert, S., Stewart, F.P., Swarna, K., & Wiseman, J.S. (1999) The use of informatics and automation to remove bottlenecks in drug discovery. Curr. Opin. Drug. Disc. Develop., 2, 234-238. #13397

140. Carboni, B., Pourbaix, C., Carreaux, F., Deleuze, H., & Maillard, B. (1999) Boronic ester as a linker system for solid phase synthesis. Tetrahedron Lett., 40, 7979-7983. #13853

141. Carrithers, M.D., Marotti, L.A., Yoshimura, A., & Lerner, M.R. (1999) A melanophore-based screening assay for erythropoietin receptors. J. Biomol. Screen., 4, 9-14. #12719

142. Cavallaro, C.L., Herpin, T., McGuinness, B.F., Shimshock, Y.C., & Dolle, R.E. (1999) Allylindium and allylboronic acid pinacolate: Mild reagents for the allylation of resin-bound aldehydes. Application to the solid-phase synthesis of hydroxypropylamines. Tetrahedron Lett., 40, 2711-2714. #12631

143. Cesareni, G., Castagnoli, L., & Cestra, G. (1999) Phage displayed peptide libraries. Comb. Chem. High Throughput Screening, 2, 1-18. #12846

144. Cestra, G., Castagnoli, L., Dente, L., Minenkova, O., Petrelli, A., Migone, N., Hoffmuller, U., Schneider-Mergener, J., & Cesareni, G. (1999) The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. Journal of Biological Chemistry, 274, 32001-32007. #13927

145. Chai, W., & Murray, W.V. (1999) Solid phase synthesis of highly substituted 2,4-dioxopiperidines. Tetrahedron Lett., 40, 7185-7188. #13772

146. Challa, H., & Woski, S.A. (1999) Solution phase synthesis of potential DNA-binding molecules based on the PNA backbone. Tetrahedron Lett., 40, 419-422. #15617

147. Chandrasekhar, S., Padmaja, M.B., & Raza, A. (1999) Solid phase-solid-state synthesis of N-alkyl imides from anhydrides. Synlett, 1597-1599. #15618

148. Chandrasekhar, S., Raza, A., & Padmaja, M.B. (1999) Novel solid state reduction of organic functional groups on solid support (Merrifield's resin). Synlett, 1061-1062. #13493

149. Chang, C.Y., Norris, J.D., Gron, H., Paige, L.A., Hamilton, P.T., Kenan, D.J., Fowlkes, D., & McDonnell, D.P. (1999) Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: Discovery of peptide antagonists of estrogen receptors alpha and beta. Mol. Cell. Biol., 19, 8226-8239. #13929

150. Chang, H.H., Sheu, S.Y., & Lo, S.C.J. (1999) Expression of foreign antigens on the surface of Escherichia coli by fusion to the outer membrane protein TraT. Journal of Biomedical Science, 6, 64-70. #12721

151. Chang, J., Oyelaran, O., Esser, C.K., Kath, G.S., King, G.W., Uhrig, B.G., Konteatis, Z., Kim, R.M., & Chapman, K.T. (1999) Synthesis of di- and trisubstituted guanidines on multivalent soluble supports. Tetrahedron Lett., 40, 4477-4480. #12942

152. Chang, Y.T., Gray, N.S., Rosania, G.R., Sutherlin, D.P., Kwon, S., Norman, T.C., Sarohia, R., Leost, M., Meijer, L., & Schultz, P.G. (1999) Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem. Biol., 6, 361-375. #14228

153. Chaturvedi, S., Otteson, K., & Bergot, J. (1999) Carbon-carbon bond formation via the Mitsunobu reaction on solid supports. Tetrahedron Lett., 40, 8205-8209. #13840

154. Chen, A.D., & Shapiro, M.J. (1999) Affinity NMR. Anal. Chem., 71, 669A-675A. #13931

155. Chen, C., & Munoz, B. (1999) Solid phase synthesis of 2-acyl-3,7,8-substituted-5-oxo-2-azabicyclo[2.2.2]octane and triaza analogs: Resin activation/capture approach/REACAP technolgy. Tetrahedron Lett., 40, 3491-3494. #12686

156. Chen, J., Dixon, B.R., Dumas, J., & Brittelli, D. (1999) Protocols for amide high-speed analoging. Preparation of novel, small molecule cathepsin D inhibitors. Tetrahedron Lett., 40, 9195-9199. #13878

157. Chen, L.P. (1999) Mimotopes of cytolytic T lymphocytes in cancer immunotherapy. Curr. Opin. Immunol., 11, 219-222. #12723

158. Cheng, C.C., & Chu, Y.H. (1999) Characterization of spatially addressable libraries: Stereoisomer analysis of tetrahydro-beta-carbolines as an example. Journal of Combinatorial Chemistry, 1, 461-466. #13933

159. Cheng, S., Comer, D.D., Myers, P.L., & Saunders, J. (1999) Liquid phase parallel synthesis of iminodiacetic acid derivatives. Tetrahedron Lett., 40, 8975-8978. #13858

160. Cheng, W.C., Halm, C., Evarts, J.B., Olmstead, M.M., & Kurth, M.J. (1999) Allylic sulfones in solid-phase synthesis: Preparation of cyclobutylidenes. J. Org. Chem., 64, 8557-8562. #13934

161. Chiba, H., Sano, H., Saitoh, M., Sohma, H., Voelker, D.R., Akino, T., & Kuroki, Y. (1999) Introduction of mannose binding protein-type phosphatidylinositol recognition into pulmonary surfactant protein A. Biochemistry, 38, 7321-7331. #12944

162. Chirinos-Rojas, C.L., Steward, M.W., & Partidos, C.D. (1999) A phage-displayed mimotope inhibits tumour necrosis factor-alpha-induced cytotoxicity more effectively than the free mimotope. Immunology, 96, 109-113. #12330

163. Chiu, C., Tang, Z., & Ellingboe, J.W. (1999) Solid-phase synthesis of 2,4,6-trisubstituted pyridines. Journal of Combinatorial Chemistry, 1, 73-77. #12042 (Available on Internet)

164. Cho, C.Y., Liu, C.W., Wemmer, D.E., & Schultz, P.G. (1999) Cyclic and linear oligocarbamate ligands for human thrombin. Bioorg. Med. Chem., 7, 1171-1179. #13494

165. Choi, K., Gardner, D., Hilbrandt, N., & Bein, T. (1999) Combinatorial methods for the synthesis of aluminophosphate molecular sieves. Angew. Chem. Int. Ed., 38, 2891-2894. #13935

166. Chong, P.Y., & Petillo, P.A. (1999) Solid phase hydantoin synthesis: An efficient and direct conversion of Fmoc-protected dipeptides to hydantoins. Tetrahedron Lett., 40, 2493-2496. #12632

167. Christmann, A., Walter, K., Wentzel, A., Kratzner, R., & Kolmar, H. (1999) The cystine knot of a squash-type protease inhibitor as a structural scaffold for Escherichia coli cell surface display of conformationally constrained peptides. Protein Eng., 12, 797-806. #13936

168. Chukwuocha, R.U., Zhang, B.P., Lai, C.J., Scavulli, J.F., Albani, S., Carson, D.A., & Chen, P.P. (1999) Isolation of an IgG monoclonal anti-dnaJ antibody from an immunoglobulin combinatorial library from a patient with rheumatoid arthritis. Journal of Rheumatology, 26, 1439-1445. #13495

169. Clark, D.E. (1999) Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration. J. Pharm. Sci., 88, 815-821. #13496

170. Coe, D.M., & Storer, R. (1999) Solution-phase combinatorial chemistry. Mol. Diversity, 4, 31-38. #12946

171. Coffey, P., Ramieri, J., Garr, C., & Schultz, L. (1999) An open, multivendor specification for high-throughput organic chemistry (HTOC): A flexible production process for pure, characterized, quantified organic compounds. Amer. Lab., 31, 57-71. #12620

172. Coleman, K. (1999) High-throughput preparative separations from combinatorial libraries. Analusis, 27, 719-723. #14987

173. Combs, A.P., Saubern, S., Rafalski, M., & Lam, P.Y.S. (1999) Solid supported aryl/heteroaryl C-N cross-coupling reactions. Tetrahedron Lett., 40, 1623-1626. #12591

174. Cong, P.J., Doolen, R.D., Fan, Q., Giaquinta, D.M., Guan, S.H., McFarland, E.W., Poojary, D.M., Self, K., Turner, H.W., & Weinberg, W.H. (1999) High-throughput synthesis and screening of combinatorial heterogeneous catalyst libraries. Angew. Chem. Int. Ed., 38, 484-488. #12592

175. Copeland, G.T., & Miller, S.J. (1999) A chemosensor-based approach to catalyst discovery in solution and on solid support. J. Amer. Chem. Soc., 121, 4306-4307. #12947

176. Cormier, W.E., Marcus, B.K., & Maesen, T.L.M. (1999) Molecular design of zeolite catalysts and adsorbents. Chim. Oggi, 17, 26-28. #12911

177. Cornille, F., & Roques, B.P. (1999) Tetanus and botulinum toxins are zinc metallopeptidases: Molecular mechanisms and inhibition of their neurotoxicity. J. Soc. Biol., 193, 509-516. #14754

178. Cottney, J., Rankovic, Z., & Morphy, J.R. (1999) Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin. Bioorg. Med. Chem. Lett., 9, 1323-1328. #12863

179. Cousins, G.R.L., Poulsen, S.A., & Sanders, J.K.M. (1999) Dynamic combinatorial libraries of pseudo-peptide hydrazone macrocycles. Chem. Commun., 1575-1576. #13497

180. Crabtree, R.H. (1999) Speeding catalyst discovery and optimization. Chemtech, 29, 21-26. #12727

181. Crabtree, R.H. (1999) Combinatorial and rapid screening approaches to homogeneous catalyst discovery and optimization. Chem. Commun., 1611-1616. #14994

182. Cramer, R.D., Poss, M.A., Hermsmeier, M.A., Caulfield, T.J., Kowala, M.C., & Valentine, M.T. (1999) Prospective identification of biologicaly active structures by topomer shape similarity searching. J. Med. Chem., 42, 3919-3933. #15619

183. Crameri, R., & Walter, G. (1999) Selective enrichment and high-throughput screening of phage surface-displayed cDNA libraries from complex allergenic systems. Comb. Chem. High Throughput Screening, 2, 63-72. #12850

184. Curtet, S., & Langlois, M. (1999) Solid-phase synthesis of 2-methoxyaniline derivatives by the traceless silicon linker strategy. Tetrahedron Lett., 40, 8563-8566. #13846

185. Czarnik, A.W. (1999) Editorial. Journal of Combinatorial Chemistry, 1, 1-2. #13498

186. D'Mello, F., Kairo, S.K., Howard, C.R., & Partidos, C.D. (1999) Mapping the specificity of an anti-feline immunodeficiency virus monoclonal antibody using a filamentous phage displayed peptide library. Vaccine, 18, 371-375. #13940

187. Dagani, R. (1999) A faster route to new materials. Combinatorial synthesis and rapid screening methods promise to make materials discovery more efficient and less wasteful. C&EN, 77, 51-60. #12855

188. Daniels, D.L., & Richert, C. (1999) One-pot synthesis of L-felinine. Tetrahedron Lett., 40, 4463-4465. #12950

189. Darvas, F., & Dorman, G. (1999) Early integration of ADME/Tox parameters into the design process of combinatorial libraries. Chim. Oggi, 17, 10-13. #13370

190. Dass, C. (1999) Recent developments and applications of high-performance chromatography electrospray ionization mass spectrometry. Current Organic Chemistry, 3, 193-209. #12729

191. Daugherty, P.S., Olsen, M.J., Iverson, B.L., & Georgiou, G. (1999) Development of an optimized expression system for the screening of antibody libraries displayed on the Escherichia coli surface. Protein Eng., 12, 613-621. #13797

192. David, C., Bischoff, L., Meudal, H., Mothe, A., De Mota, N., DaNascimento, S., Llorens-Cortes, C., Fournie-Zaluski, M.C., & Roques, B.P. (1999) Investigation of substitute preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme. J. Med. Chem., 42, 5197-5211. #15620

193. Davies, J.M., Rowley, M.J., & Mackay, I.R. (1999) Phagotopes derived by antibody screening of phage-displayed random peptide libraries vary in immunoreactivity: Studies using an exemplary monoclonal antibody, CII-C1, to type II collagen. Immunol. Cell Biol., 77, 483-490. #13942

194. Davies, J.M., Mackay, I.R., & Rowley, M.J. (1999) Rheumatoid arthritis sera react with a phage-displayed peptide selected by a monoclonal antibody to type II collagen that has homology to EBNA-1. Autoimmunity, 30, 53-59. #12951

195. Davies, J.M., Scealy, M., Cai, Y.P., Whisstock, J., Mackay, I.R., & Rowley, M.J. (1999) Multiple alignment and sorting of peptides derived from phage-displayed random peptide libraries with polyclonal sera allows discrimination of relevant phagotopes. Mol. Immunol., 36, 659-667. #13798

196. Davies, K., & White, C. (1999) Managing combinatorial chemistry information. Molecular Diversity in Drug Design, 175-196. #15002

197. Davis, R.G., Anderegg, R.J., & Blanchard, S.G. (1999) Iterative size-exclusion chromatography coupled with liquid chromatographic mass spectrometry to enrich and identify tight-binding ligands from complex mixtures. Tetrahedron, 55, 11653-11667. #13799

198. Dax, S.L., McNally, J.J., & Youngman, M.A. (1999) Multi-component methodologies in solid-phase organic synthesis. Curr. Med. Chem., 6, 255-270. #12633

199. de Biasi, V., Haskins, N., Organ, A., Bateman, R., Giles, K., & Jarvis, S. (1999) High throughput liquid chromatography mass spectrometric analyses using a novel multiplexed electrospray interface. Rapid Commun. Mass Spectrom., 13, 1165-1168. #12954

200. de Bont, D.B.A., Sliedregt-Bol, K.M., Hofmeyer, L.J.F., & Liskamp, R.M.J. (1999) Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation. Bioorg. Med. Chem., 7, 1043-1047. #13499

201. de Julian-Ortiz, J.V., Galvez, J., Munoz-Collado, C., Garcia-Domenech, R., & Gimeno-Cardona, C. (1999) Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds. J. Med. Chem., 42, 3308-3314. #13946

202. de Koster, H.S., Vermeulen, C.J., Hiemstra, H.S., Amons, R., Drijfhout, J.W., & Koning, F. (1999) Definition of agonists and design of antagonists for alloreactive T cell clones using synthetic peptide libraries. Int. Immunol., 11, 585-591. #12865

203. de Lucena, S.L., Carbonell, R.G., & Santana, C.C. (1999) Peptide affinity chromatography process for adsorption of fibrinogen. Powder Technology, 101, -177. #12732

204. de Meijere, A., Nuske, H., Es-Sayed, M., Labahn, T., Schroen, M., & Brase, S. (1999) New efficient multicomponent reactions with C-C coupling for combinatorial application in liquid and on solid phase. Angew. Chem. Int. Ed., 38, 3669-3672. #13948

205. Deegan, T.L., Nitz, T.J., Cebzanov, D., Pufko, D.E., & Porco, J.A.Jr. (1999) Parallel synthesis of 1,2,4-oxadiazoles using CDI activation. Bioorg. Med. Chem., 9, 209-212. #15621

206. Deshpande, A.M., Argade, N.P., Natu, A.A., & Eckman, J. (1999) Synthesis and screening of a combinatorial library of naphthalene substituted chalcones: Inhibitors of leukotriene B-4. Bioorg. Med. Chem., 7, 1237-1240. #13502

207. DeWitt, S.H. (1999) Microreactors for chemical synthesis. Curr. Opin. Chem. Biol., 3, 350-356. #15500

208. Ding, K.L., Ishii, A., & Mikami, K. (1999) Super high throughput screening (SHTS) of chiral ligands and activators: Asymmetric activation of chiral diol-zinc catalysts by chiral nitrogen activators for the enantioselective addition of diethylzinc to aldehydes. Angew. Chem. Int. Ed., 38, 497-501. #12593

209. Dive, V., Cotton, J., Yiotakis, A., Michaud, A., Vassiliou, S., Jiracek, J., Vazeux, G., Chauvet, M.T., Cuniasse, P., & Corvol, P. (1999) RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites. Proc. Natl. Acad. Sci. USA, 96, 4330-4335. #12955

210. Doi, T., Sugiki, M., Yamada, H., & Takahashi, T. (1999) Glycosidation of solid-supported glycosyl donors tethered by a trialkylsilane linker. Tetrahedron Lett., 40, 2141-2144. #12614

211. Doleckova, L., Pavlik, M., Mares, M. & Kluh, I. (1999) Inhibitory specificity spectrum of peptide a-amylase inhibitors designed by limited combinatorial libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 277-278). Mayflower Scientific Limited, Birmingham. #13693

212. Dolle, R.E. (1999) Comprehensive survey of combinatorial libraries with undisclosed biological activity: 1992-1997. Mol. Diversity, 4, 233-256. #14538

213. Dolle, R.E., Barden, M.C., Brennan, P.E., Ahmed, G., Tran, V., & Ho, D.M. (1999) Application of the intramolecular azomethine imine cycloaddition to the construction of a novel, orthogonally protected spirodiamino acid scaffold. Tetrahedron Lett., 40, 2907-2908. #12634

214. Dolle, R.E., & Nelson, K.H.Jr. (1999) Comprehensive survey of combinatorial library synthesis: 1998. Journal of Combinatorial Chemistry, 1, 235-282. #13427

215. Domling, A., Chi, K.Z., & Barrere, M. (1999) A novel method to highly versatile monomeric PNA building blocks by multi component reactions. Bioorg. Med. Chem. Lett., 9, 2871-2874. #13952

216. Dong, D.L.Y., Liu, R., Sherlock, R., Wigler, M.H., & Nestler, H.P. (1999) Molecular forcepts from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyterminus. Chem. Biol., 6, 133-141. #12905

217. Dooley, C.T., & Houghten, R.A. (1999) New opioid peptides, peptidomimetics, and heterocyclic compounds from combinatorial libraries. Biopolymers (Pept. Sci. ), 51, 379-390. #14360

218. Dorey, E. (1999) ArQule-Pfizer deal breaks mould. Nat. Biotech., 17, 843-843. #14709

219. Dorner, B., Steinauer, R., & White, P. (1999) Solid-phase organic chemistry: Linkers and functionalized solid supports. Chimia, 53, 11-17. #12734

220. Dostmann, W.R.G., Nickl, C., Thiel, S., Tsigelny, I., Frank, R., & Tegge, W.J. (1999) Delineation of selective cyclic GMP-dependent protein kinase I alpha substrate and inhibitor peptides based on combinatorial peptide libraries on paper. Pharmacol. Ther., 82, 373-387. #12956

221. Dove, A. (1999) Drug screening-beyond the bottleneck. Nat. Biotech., 17, 859-865. #14713

222. Dragoli, D.R., Thompson, L.A., O'Brien, J., & Ellman, J.A. (1999) Parallel synthesis of prostaglandin E1 analogues. Journal of Combinatorial Chemistry, 1, 534-539. #14749

223. Drain, C.M., Gong, X., Ruta, V., Soll, C.E., & Chicoineau, P.F. (1999) Combinatorial synthesis and modification of functional porphyrin libraries: Identification of new, amphipathic motifs for biomolecule binding. Journal of Combinatorial Chemistry, 1, 286-290. #13633

224. Drewry, D.H., & Young, S.S. (1999) Approaches to the design of combinatorial libraries. Chemometr. Intell. Lab. Syst., 48, 1-20. #12958

225. Drewry, D.H., Coe, D.M., & Poon, S. (1999) Solid-supported reagents in organic synthesis. Med. Res. Rev., 19, 97-148. #12635

226. Drolet, D.W., Jenison, R.D., Smith, D.E., Pratt, D., & Hicke, B.J. (1999) A high throughput platform for systematic evolution of ligands by exponential enrichment (SELEX (TM)). Comb. Chem. High Throughput Screening, 2, 271-278. #13954

227. Dulery, B.D., Verne-Mismer, J., Wolf, E., Kugel, C., & Van Hijfte, L. (1999) Analyses of compound libraries obtained by high-throughput parallel synthesis: Strategy of quality control by high-performance liquid chromatography, mass spectrometry and nuclear magnetic resonance techniques. Journal of Chromatography B, 725, 39-47. #12735

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253. Ferrer, M., Kapoor, T.M., Strassmaier, T., Weissenhorn, W., Skehel, J.J., Oprian, D., Schreiber, S.L., Wiley, D.C., & Harrison, S.C. (1999) Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nat. Struc. Biol., 6, 953-960. #13965

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257. Fierabracci, A., Biro, P.A., Yiangou, Y., Mennuni, C., Luzzago, A., Ludvigsson, J., Cortese, R., & Bottazzo, G.F. (1999) Osteopontin is an autoantigen of the somatostatin cells in human islets: Identification by screening random peptide libraries with sera of patients with insulin-dependent diabetes mellitus. Vaccine, 18, 342-254. #13966

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264. Fleckenstein, B., Jung, G., & Wiesmuller, K.H. (1999) Quantitative analysis of peptide-MHC class II interaction. Seminars in Immunology, 11, 405-416. #13969

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267. Flynn, D.L. (1999) Phase-trafficking reagents and phase-switching strategies for parallel synthesis. Med. Res. Rev., 19, 408-431. #13970

268. Forrer, P., Jung, S., & Pluckthun, A. (1999) Beyond binding: Using phage display to select for structure, folding and enzymatic activity in proteins. Curr. Opin. Struct. Biol., 9, 514-520. #13513

269. Francis, M.B., & Jacobsen, E.N. (1999) New catalysts for epoxidizing alkenes by means of metal-bonding combinatorial libraries. Angew. Chem., 111, 987-991. #14719

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278. Gao, H., & Bajorath, J. (1999) Comparison of binary and 2D QSAR analyses using inhibitors of human carbonic anhydrase II as a test case. Mol. Diversity, 4, 115-130. #12965

279. Gao, X.S., Huang, Y.X., & Zhu, S.G. (1999) Construction of murine phage antibody library and selection of ricin-specific single-chain antibodies. Iubmb Life, 48, 513-517. #13974

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283. Gast, R., Glokler, J., Hoxter, M., Kiess, M., Frank, R., & Tegge, W. (1999) Method for determining protein kinase substrate specificities by the phosphorylation of peptide libraries on beads, phosphate-specific staining, automated sorting, and sequencing. Anal. Biochem., 276, 227-241. #13976

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350. Heinonen, P., Virta, P., & Lonnberg, H. (1999) Synthesis of achiral alpha,alpha-disubstituted beta-alanines, and their use in construction of libraries of beta-peptide conjugates of N-2-alkyl-1,2,3,4-tetrahydroisoquinolines on a solid support. Tetrahedron, 55, 7613-7624. #12979

351. Heiskanen, T., Lundkvist, A., Soliymani, R., Koivunen, E., Vaheri, A., & Lankinen, H. (1999) Phage-displayed peptides mimicking the discontinuous neutralization sites of Puumala hantavirus envelope glycoproteins. Virology, 262, 321-332. #14008

352. Heizmann, G., Hildebrand, P., Tanner, H., Ketterer, S., Pansky, A., Froidevaux, S., Beglinger, C., & Eberle, A.N. (1999) A combinatorial peptoid library for the identification of novel MSH and GRP/bombesin receptor ligands. Journal of Receptor and Signal Transduction Research, 19, 449-466. #12746

353. Helene, C. (1999) Scientific and technological innovations in the search for new drugs. C. R. Acad. Sci. Ser. III-Vie., 322, 529-536. #14009

354. Hemmer, B., Gran, B., Zhao, Y.D., Marques, A., Pascal, J., Tzou, A., Kondo, T., Cortese, I., Bielekova, B., Straus, S.E., McFarland, H.F., Houghten, R., Simon, R., Pinilla, C., & Martin, R. (1999) Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease. Nat. Med., 5, 1375-1382. #14010

355. Henry, C. (1999) Combinatorial chemistry gains a new dimension. C&EN, 77, 9-9. #13754

356. Henry, K.J.Jr., Wasicak, J., Tasker, A.S., Cohen, J., Ewing, P., Mitten, M., Larsen, J.J., Kalvin, D.M., Swenson, R., Ng, S.C., Saeed, B., Cherian, S., Sham, H., & Rosenberg, S.H. (1999) Discovery of a series of cyclohexylethylamine-containing protein farnesyltransferase inhibitors exhibiting potent cellular activity. J. Med. Chem., 42, 4844-4852. #15642

357. Hermkens, P.H.H., & Hamersma, H. (1999) Functional group transformation: An efficacy-enhancing approach in combinatorial chemistry. Journal of Combinatorial Chemistry, 1, 307-316. #13527

358. Herpin, T.F., Morton, G.C., Dunn, A.K., Fillon, C., Menard, P.R., Tang, S.Y., Salvino, J.M., & Labaudiniere, R.F. (1999) Synthesis and diversity analysis of lead discovery piperazine-2-carboxamide libraries. Mol. Diversity, 4, 221-232. #14537

359. Hiemstra, H.S., Van Veelen, P.A., Willemen, S.J.M., Benckhuijsen, W.E., Geluk, A., de Vries, R.R.P., Roep, B.O., & Drijfhout, J.W. (1999) Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases. Eur. J. Immunol., 29, 2385-2391. #13528

360. Hiemstra, H.S., Van Veelen, P.A., Geluk, A., Schloot, N.C., de Vries, R.R.P., Ottenhoff, T.H.M., Roep, B.O., & Drijfhout, J.W. (1999) Limitations of homology searching for identification of T-cell antigens with library derived mimicry epitopes. Vaccine, 18, 204-208. #14013

361. Higaki, J.N., Chakravarty, S., Bryant, C.M., Cowart, L.R., Harden, P., Scardina, J.M., Mavunkel, B., Luedtke, G.R., & Cordell, B. (1999) A combinatorial approach to the identification of dipeptide aldehyde inhibitors of b-amyloid production. J. Med. Chem., 42, 3889-3898. #14385

362. Hildmann, T., Kong, X.G., O'Brien, J., Riesselman, L., Christensen, H.M., Dagand, E., Lehrach, H., & Yaspo, M.L. (1999) A contiguous 3-Mb sequence-ready map in the S3-MX region on 21q22.2 based on high-throughput nonisotopic library screenings. Genome Res., 9, 360-372. #12871

363. Hinderling, C., & Chen, P. (1999) Rapid screening of olefin polymerization catalyst libraries by electrospray ionization tandem mass spectrometry. Angew. Chem., 38, 2253-2256. #13529

364. Hioki, H., Yamada, T., Fujioka, C., & Kodama, M. (1999) Peptide library based on calix[4]arene. Tetrahedron Lett., 40, 6821-6825. #13761

365. Hirao, I., Spingola, M., Peabody, D., & Ellington, A.D. (1999) The limits of specificity: An experimental analysis with RNA aptamers to MS2 coat protein variants. Mol. Diversity, 4, 75-89. #12980

366. Hird, N.W. (1999) Automated synthesis: New tools for the organic chemist. Drug Disc. Today, 4, 265-274. #14014

367. Ho, J.Z., Levy, O.E., Gibson, T.S., Nguyen, K., & Semple, J.E. (1999) Exploratory solid-phase synthesis of factor Xa inhibitors: Discovery and application of P-3-heterocyclic amides as novel types of non-basic arginine surrogates. Bioorg. Med. Chem. Lett., 9, 3459-3464. #14015

368. Ho, K.C., Pan, P.C., Shey, J.Y., & Sun, C.M. (1999) Applications of solid-phase combinatorial chemistry in the drug discovery [Chinese]. Huaxue, 57, 327-334. #15401

369. Ho, K.C., & Sun, C.M. (1999) Liquid phase parallel synthesis of guanidines. Bioorg. Med. Chem. Lett., 9, 1517-1520. #15643

370. Ho, M.F., Wilson, B.A., & Peterson, J.W. (1999) Bacterially expressed Raf-1 catalytic domain is highly associated with GroEL. J. Chin. Chem. Soc., 46, 735-742. #15089

371. Hochlowski, J.E., Whittern, D.N., & Sowin, T.J. (1999) Encoding of combinatorial chemistry libraries by fluorine-19 NMR. Journal of Combinatorial Chemistry, 1, 291-293. #13530

372. Hoekstra, W.J., Maryanoff, B.E., Damiano, B.P., Andrade-Gordon, P., Cohen, J.H., Costanzo, M.J., Haertlein, B.J., Hecker, L.R., Hulshizer, B.L., Kauffman, J.A., Keane, P., McComsey, D.F., Mitchell, J.A., Scott, L., Shah, R.D., & Yabut, S.C. (1999) Potent, orally active GPIIb/IIIa antagonists containing a nipecotic acid subunit. Structure-activity studies leading to the discovery of RWJ-53308. J. Med. Chem., 42, 5254-5265. #15644

373. Hoel, A.M.L., & Nielsen, J. (1999) Microwave-assisted solid-phase Ugi four-component condensations. Tetrahedron Lett., 40, 3941-3944. #12872

374. Hoffmann, C., Wolf, A., & Schuth, F. (1999) Parallel synthesis and testing of catalysts under nearly conventional testing conditions. Angew. Chem. Int. Ed., 38, 2800-2803. #14017

375. Hopfinger, A.J., Reaka, A., Venkatarangan, P., Duca, J.S., & Wang, S. (1999) Construction of a virtual nigh throughput screen by 4D-QSAR analysis: Application to a combinatorial library of glucose inhibitors of glycogen phosphorylase b. Journal of Chemical Information and Computer Sciences, 39, 1151-1160. #15093

376. Horlick, R.A., Ohlmeyer, M.H., Stroke, I.L., Strohl, B., Pan, G.H., Schilling, A.E., Paradkar, V., Quintero, J.G., You, M., Riviello, C., Thorn, M.B., Damaj, B., Fitzpatrick, V.D., Dolle, R.E., Webb, M.L., Baldwin, J.J., & Sigal, N.H. (1999) Small molecule antagonists of the bradykinin B1 receptor. Immunopharmacology, 43, 169-177. #14019

377. Hortnagel, K., Voloshin, O.N., Kinal, H.H., Ma, N., Schaffer-Judge, C., & Camerini-Otero, R.D. (1999) Saturation mutagenesis of the E-coli RecA loop L2 homologous DNA pairing region reveals residues essential for recombination and recombinational repair. J. Mol. Biol., 286, 1097-1106. #12748

378. Houghten, R.A., Dooley, C.T., Giulianotti, M.A., Hamashin, V.T., Schoner, C.C., Ostresh, J.M. & Nefzi, A. (1999) Solid phase synthesis of heterocyclic positional scanning combinatorial libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 11-14). Mayflower Scientific Limited, Birmingham. #13451

379. Houghten, R.A., Pinilla, C., Appel, J.R., Blondelle, S.E., Dooley, C.T., Eichler, J., Nefzi, A., & Ostresh, J.M. (1999) Mixture-based synthetic combinatorial libraries. J. Med. Chem., 42, 3743-3778. #13738

380. Houimel, M., Mach, J.P., Corthesy-Theulaz, I., Corthesy, B., & Fisch, I. (1999) New inhibitors of Helicobacter pylori urease holoenzyme selected from phage-displayed peptide libraries. Eur. J. Biochem., 262, 774-780. #13409

381. Houshmand, H., Froman, G., & Magnusson, G. (1999) Use of bacteriophage T7 displayed peptides for determination of monoclonal antibody specificity and biosensor analysis of the binding reaction. Anal. Biochem., 268, 363-370. #12642

382. Hu, Y., Baudart, S., & Porco, J.A.Jr. (1999) Parallel synthesis of 1,2,3-thiadiazoles employing a "Catch and Release" strategy. J. Org. Chem., 64, 1049-1051. #15645

383. Hu, Y.H., Baudart, S., & Porco, J.A. (1999) Parallel synthesis of 1,2,3-thiadiazoles employing a "catch and release" strategy. J. Org. Chem., 64, 1049-1051. #12749

384. Hu, Y.J., Wei, Y.M., Zhou, Y., Rajagopalan, P.T.R., & Pei, D.H. (1999) Determination of substrate specificity for peptide deformylase through the screening of a combinatorial peptide library. Biochemistry, 38, 643-650. #12643

385. Huang, P.Y., & Carbonell, R.G. (1999) Affinity chromatographic screening of soluble combinatorial peptide libraries. Biotechnol. Bioeng., 63, 633-641. #12982

386. Huang, W.L., & Scarborough, R.M. (1999) A new "traceless" solid-phase synthesis strategy: Synthesis of a benzimidazole library. Tetrahedron Lett., 40, 2665-2668. #12644

387. Hubbell, E., & Pevzner, P.A. (1999) Fidelity probes for DNA arrays. ISMB, 113-117. #14739

388. Huber, W., Bubendorf, A., Grieder, A., & Obrecht, D. (1999) Monitoring solid phase synthesis by infrared spectroscopic techniques. Anal. Chim. Acta, 393, 213-221. #13532

389. Hubner, B., Haensler, M., & Hahn, U. (1999) Modification of ribonuclease T1 specificity by random mutagenesis of the substrate binding segment. Biochemistry, 38, 1371-1376. #12750

390. Huc, I., Krische, M.J., Funeriu, D.P., & Lehn, J.M. (1999) Dynamic combinatorial chemistry: Substrate H-bonding directed assembly of receptors based on bipyridine-metal complexes. European Journal of Inorganic Chemistry, 1415-1420. #15102

391. Hudson, D. (1999) Matrix assisted synthetic transformations: A mosaic of diverse contributions. II. The pattern is completed. Journal of Combinatorial Chemistry, 1, 403-457. #13833

392. Hudson, D. (1999) Matrix assisted synthetic transformations: A mosaic of diverse contributions. I. The pattern emerges. Journal of Combinatorial Chemistry, 1, 333-360. #13444

393. Huffman, M.A., & Reider, P.J. (1999) Improved stereoselectivity in the heterogeneous catalytic synthesis of enalapril obtained through multidimensional screening. Tetrahedron Lett., 40, 831-834. #12244

394. Hufton, S.E., Moerkerk, P.T., Meulemans, E.V., de Bruine, A., Arends, J.W., & Hoogenboom, H.R. (1999) Phage display of cDNA repertoires: The pVI display system and its applications for the selection of immunogenic ligands. J. Immunol. Method, 231, 39-51. #15104

395. Hulme, C., & Cherrier, M.P. (1999) Novel applications of ethyl glyoxalate with the Ugi MCR. Tetrahedron Lett., 40, 5295-5299. #13119

396. Hulme, C., Ma, L., Romano, J., & Morrissette, M. (1999) Remarkable three-step-one-pot solution phase preparation of novel imidazolines utilizing a UDC (Ugi/de-Boc/cyclize) strategy. Tetrahedron Lett., 40, 7925-7928. #13849

397. Hulst, R., Seyger, R.M., van Duynhoven, J.P.M., van der Does, L., Noordermeer, J.W.M., & Bantjes, A. (1999) Vulcanization of butadiene rubber by means of cyclic disulfides. 3. A 2D solid state HRMAS NMR study on accelerated sulfur vulcanizates of BR rubber. Macromolecules, 32, 7521-7529. #15107

398. Hulst, R., Seyger, R.M., van Duynhoven, J.P.M., van der Does, L., Noordermeer, J.W.M., & Bantjes, A. (1999) Vulcanization of butadiene rubber by means of cyclic disulfides. 2. A 2D solid state HRMAS NMR study on cross-link structures in BR vulcanizates. Macromolecules, 32, 7509-7520. #15106

399. Husken, D., Deichert, A., Hall, J., & Haner, R. (1999) Combinatorial library of artificial ribonucleases. Nucleosides Nucleotides, 18, 1507-1511. #13533

400. Huuskonen, J.J., Villa, A.E.P., & Tetko, I.V. (1999) Prediction of partition coefficient based on atom-type electrotopological state indices. J. Pharm. Sci., 88, 229-233. #12751

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405. Ichiyama, K., Ishikawa, D., Tanaka, Y., Kashiwa, T., Koyanagi, Y., Handa, S., Yamashita, A., Fukushi, M., Yamamoto, N., & Taki, T. (1999) Epitope mapping of rat neutralizing monoclonal antibody against human immunodeficiency virus type-1 by a phage peptide library: Comparison with ELISA using synthetic peptides. Viral Immunol., 12, 57-66. #12984

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417. Jefferson, E.A., & Swayze, E.E. (1999) b-Amino acid facilitates macrocyclic ring closure in a combinatorial library. Tetrahedron Lett., 40, 7757-7760. #13778

418. Jennings, L.D., Wawrzak, Z., Amorose, D., Schwartz, R.S., & Jordan, D.B. (1999) A new potent inhibitor of fungal melanin biosynthesis identified through combinatorial chemistry. Bioorg. Med. Chem. Lett., 9, 2509-2514. #13803

419. Jensen-Jarolim, E., Wiedermann, U., Ganglberger, E., Zurcher, A., Stadler, B.M., Boltz-Nitulescu, G., Scheiner, O., & Breiteneder, H. (1999) Allergen mimotopes in food enhance type I allergic reactions in mice. FASEB J., 13, 1586-1592. #14027

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437. Kawasaki, A.M., Casper, M.D., Gaus, H.J., Herrmann, R., Griffey, R.H., & Cook, P.D. (1999) Solution phase combinatorial chemistry. Purine- and pyrimidine-based libraries with antibacterial activity via solution phase simultaneous addition of functionalities. Nucleosides Nucleotides, 18, 659-660. #13411

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443. Keough, T., Youngquist, R.S., & Lacey, M.P. (1999) A method for high-sensitivity peptide sequencing using postsource decay matrix-assisted laser desorption ionization mass spectrometry. Proc. Natl. Acad. Sci. USA, 96, 7131-7136. #12987

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449. Kinchington, D. (1999) Recent advances in antiviral therapy. J. Clin. Pathol., 52, 89-94. #12764

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453. Kirshenbaum, K., Zuckermann, R.N., & Dill, K.A. (1999) Designing polymers that mimic biomolecules. Curr. Opin. Struct. Biol., 9, 530-535. #15494

454. Kiselyov, A.S., Eisenberg, S., & Luo, Y. (1999) Solid support synthesis of 14-membered macrocycles via SNAr methodology on acrylate resin. Tetrahedron Lett., 40, 2465-2468. #12646

455. Kiselyov, A.S., Smith, L., & Tempest, P. (1999) Solid support synthesis of 14-and 17-membered macrocycles via the SNAr methodology. Tetrahedron, 55, 14813-14822. #14038

456. Kitching, M.S., Clegg, W., Elsegood, M.R.J., Griffin, R.J., & Golding, B.T. (1999) Synthesis of 3-alkoxy- and 3-alkylamino-2-alkyl-3-arylisoindolinones. Synlett, -999. #13541

457. Klebe, G., & Abraham, U. (1999) Comparative Molecular Similarity Index Analysis (CoMSIA) to study hydrogen-bonding properties and to score combinatorial libraries. J. Comput. Aid. Molec. Design, 13, 1-10. #12765

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820. Smith, J.M., Gard, J., Cummings, W., Kanizsai, A., & Krchnak, V. (1999) Necklace-coded polymer-supported combinatorial synthesis of 2-arylaminobenzimidazoles. Journal of Combinatorial Chemistry, 1, 368-370. #13649

821. Smith, J.M., & Krchnak, V. (1999) A solid phase traceless synthesis of benzimidazoles with three combinatorial steps. Tetrahedron Lett., 40, 7633-7636. #13770

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856. Sylvain, C., Wagner, A., & Mioskowski, C. (1999) An efficient procedure for the esterification of nitroacetic acid: Application to the preparation of Merrifield resin-bound nitroacetate. Tetrahedron Lett., 40, 875-878. #12231

857. Szardenings, A.K., Antonenko, V., Campbell, D.A., DeFrancisco, N., Ida, S., Shi, L.H., Sharkov, N., Tien, D., Wang, Y.W., & Navre, M. (1999) Identification of highly selective inhibitors of collagenase-1 from combinatorial libraries of diketopiperazines. J. Med. Chem., 42, 1348-1357. #13060

858. Tachibana, H., Cheng, X.J., Watanabe, K., Takekoshi, M., Maeda, F., Aotsuka, S., Kaneda, Y., Takeuchi, T., & Ihara, S. (1999) Preparation of recombinant human monoclonal antibody Fab fragments specific for Entamoeba histolytica. Clinical and Diagnostic Laboratory Immunology, 6, 383-387. #13061

859. Tadesse, S., Bhandari, A., & Gallop, M.A. (1999) Solid-phase synthesis of highly functionalized 2,2'-bipyridines. Journal of Combinatorial Chemistry, 1, 184-187. #13606

860. Takahashi, T., Inoue, H., Tomida, S., & Doi, T. (1999) Palladium(0)-catalyzed carbonylation on the MultipinTM system. Tetrahedron Lett., 40, 7843-7846. #13780

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866. Tanaka, F., Almer, H., Lerner, R.A., & Barbas, C.F.I. (1999) Catalytic single-chain antibodies possessing beta-lactamase activity selected from a phage displayed combinatorial library using a mechanism-based inhibitor. Tetrahedron Lett., 40, 8063-8066. #13842

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884. Thurnheer, M.C., Zuercher, A.W., Miescher, S.M., Rudolf, M.P., Vogel, M., & Stadler, B.M. (1999) Molecular mimicry of the unidentified antigen of myeloma antibody IgE-ND. Eur. J. Immunol., 29, 2676-2683. #14167

885. Tighe, P.J., Powell-Richards, A., Sewell, H.F., Fischer, D., Donoso, L., & Dua, H.S. (1999) Epitope discovery using bacteriophage display: The minimum epitope of an anti-IRBP antibody. Experimental Eye Research, 68, 679-684. #13611

886. Timmerman, P., & Reinhoudt, D.N. (1999) A combinatorial approach to synthetic receptors. Advanced Materials, 11, 71-74. #12455

887. Todd, M.D., Lin, X.D., Stankowski, L.F., Desai, M., & Wolfgang, G.H.I. (1999) Toxicity screening of a combinatorial library: Correlation of cytotoxicity and gene induction to compound structure. J. Biomol. Screen., 4, 259-268. #14169

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891. Tong, H., Bell, D., Tabei, K., & Siegel, M.M. (1999) Automated data massaging, interpretation, and E-mailing modules for high throughput open access mass spectrometry. J. Amer. Soc. Mass Spectrom., 10, 1174-1187. #15340

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893. Toy, P.H., & Janda, K.D. (1999) New supports for solid-phase organic synthesis: Development of polystyrene resins containing tetrahydrofuran derived cross-linkers. Tetrahedron Lett., 40, 6329-6332. #13757

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940. Watson, C. (1999) Polymer-supported synthesis of non-oligomeric natural products. Angew. Chem. Int. Ed., 38, 1903-1908. #13424

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