[ CSPS Pharmaceuticals, Inc. ] [ SPYDER ]

5Z.COM HOME
MOLECULAR DIVERSITY
DIVERSITY INFORMATION PAGES

Articles thru 2003
Articles 2004
Reviews
SPOS Papers
SPPS Papers
Robotics/Automation
Classics
Patents
Books
Procedures
Symposia
Companies
Suppliers
Scientists
Graffiti Wall
Links
Jobs
Hot News
Site News
Fun

PAPERS PUBLISHED IN 2004

This list is arranged by the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (m@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M.: Dynamic database of references in molecular diversity. Internet http://www.5z.com/divinfo.


Recently added entries are marked in bold

  1. Adams,N., Arts,H.J., Bolton,P.D., Cowell,D., Dubberley,S.R., Friederichs,N., Grant,C.M., Kranenburg,M., Sealey,A.J., Wang,B., Wilson,P.J., Cowley,A.R., Mountford,P., & Schroeder,M. (2004) Discovery and evaluation of highly active imidotitanium ethylene polymerisation catalysts using high throughput catalyst screening. Chemical Communications (Cambridge, United Kingdom), 434-435. #20163

  2. Akavia,A., Senderowitz,H., Lerner,A., & Shamir,R. (2004) Designing a Multiroute Synthesis Scheme in Combinatorial Chemistry. Journal of Combinatorial Chemistry, 6, 540-548. #20097

  3. Amaya,T., Tanaka,H., & Takahashi,T. (2004) Combinatorial synthesis of carbohydrate cluster on tree-type linker with orthogonally cleavable parts. Synlett, 497-502. #20145

  4. Anon. (2004) Combinatorial chemistry-product focus. Nature (London, United Kingdom), 430, No. #20037

  5. Anon. (2004) Analytical currents: combinatorial chemistry for biological targets. Anal. Chem., 76, 221A. #20059

  6. Ansede,J.H., & Thakker,D.R. (2004) High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism. J. Pharm. Sci., 93, 239-255. #20149

  7. Apostolidis,A., Klimant,I., Andrzejewski,D., & Wolfbeis,O.S. (2004) A Combinatorial Approach for Development of Materials for Optical Sensing of Gases. Journal of Combinatorial Chemistry, 6, 325-331. #20160

  8. Arakawa,M., & Funatsu,K. (2004) Development of multi-dimensional data-modeling software. Journal of Computer Chemistry, Japan, 3, 77-84. #20046

  9. Arseniyadis,S., Wagner,A., & Mioskowski,C. (2004) Resin-bound 4-phenyl-1,2-dihydroquinoline (DHQ): a new safety-catch linker for solid-phase organic synthesis (SPOS). Tetrahedron Lett., 45, 2251-2253. #20155

  10. Arya,P., Wei,C.Q., Barnes,M.L., & Daroszewska,M. (2004) A Solid Phase Library Synthesis of Hydroxyindoline-Derived Tricyclic Derivatives by Mitsunobu Approach. Journal of Combinatorial Chemistry, 6, 65-72. #20180

  11. Ayesa,S., Argyropoulos,D., Maltseva,T., Sund,C., & Samuelsson,B. (2004) An expeditious library synthesis of N-monoalkylated aminopiperidines and -pyrrolidines. Eur. J. Org. Chem., 2723-2737. #20056

  12. Babine,R.E., Rynkiewicz,M.J., Jin,L., & Abdel-Meguid,S.S. (2004) Towards an experimental de Novo design protocol. The use of protein crystallography to deconvolute dynamic combinatorial processes. Letters in Drug Design & Discovery, 1, 173-177. #20102

  13. Bao,Y., Li,C., Shen,H., & Nan,F. (2004) Determination of Saikosaponin Derivatives in Radix bupleuri and in Pharmaceuticals of the Chinese Multiherb Remedy Xiaochaihu-tang Using Liquid Chromatographic Tandem Mass Spectrometry. Anal. Chem., 76, 4208-4216. #20088

  14. Battersby, Bronwyn J., Grondahl, Lisbeth, Lawrie, Gwendolyn A., and Trau, Matt Colloids for encoding chemical libraries: applications in biological screening. In: Anonymous. (Eds.) Colloids and Colloid Assemblies. #20448NEW

  15. Baurin,N., Baker,R., Richardson,C., Chen,I., Foloppe,N., Potter,A., Jordan,A., Roughley,S., Parratt,M., Greaney,P., Morley,D., & Hubbard,R.E. (2004) Drug-like Annotation and Duplicate Analysis of a 23-Supplier Chemical Database Totaling 2.7 Million Compounds. Journal of Chemical Information and Computer Sciences, 44, 643-651. #20162

  16. Baytas,S.N., & Linhardt,R.J. (2004) Combinatorial carbohydrate synthesis. Mini-Reviews in Organic Chemistry, 1, 27-39. #20157

  17. Berezin,V., & Bock,E. (2004) NCAM mimetic peptides: Pharmacological and therapeutic potential. Journal of Molecular Neuroscience, 22, 33-39. #20154

  18. Bianchi,I., La Porta,E., Barlocco,D., & Raveglia,L.F. (2004) Solid-Phase Convergent Synthesis of a Benzimidazolone Library via the Combination of Two Smaller Arrays of Carboxylic Acids and Secondary Amines. Journal of Combinatorial Chemistry, 6, 835-845. #20040

  19. Blake,J.F. (2004) Integrating cheminformatic analysis in combinatorial chemistry. Curr. Opin. Chem. Biol., 8, 407-411. #20045

  20. Boas,U., Gertz,H., Christensen,J.B., & Heegaard,P.M.H. (2004) Facile synthesis of aliphatic isothiocyanates and thioureas on solid phase using peptide coupling reagents. Tetrahedron Lett., 45, 269-272. #20182

  21. Bonaccurso,E., Butt,H.J., & Graf,K. (2004) Microarrays by structured substrate swelling. Eur. Polym. J., 40, 975-980. #20115

  22. Bork,J.T., Lee,J.W., & Chang,Y.T. (2004) The combinatorial synthesis of purine, pyrimidine and triazine-based libraries. QSAR & Combinatorial Science, 23, 245-260. #20064

  23. Brown,J.X., Buckett,P.D., & Wessling-Resnick,M. (2004) Identification of Small Molecule Inhibitors that Distinguish between Non-Transferrin Bound Iron Uptake and Transferrin-Mediated Iron Transport. Chemistry & Biology, 11, 407-416. #20124

  24. Buelow,A., Sinning,S., Wiborg,O., & Bols,M. (2004) Two- and Three Dimensional Combinatorial Chemistry from Multicomponent Grignard Reagents. Journal of Combinatorial Chemistry, 6, 509-519. #20108

  25. Bugaut,A., Toulime,J.J., & Rayner,B. (2004) Use of dynamic combinatorial chemistry for the identification of covalently appended residues that stabilize oligonucleotide complexes. Angewandte Chemie, International Edition, 43, 3144-3147. #20061

  26. Burke,M.D., & Schreiber,S.L. (2004) A planning strategy for diversity-oriented synthesis. Angewandte Chemie, International Edition, 43, 46-58. #20175

  27. Byeon,W.H., & Weisblum,B. (2004) Affinity adsorbent based on combinatorial phage display peptides that bind a-cobratoxin. Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences, 805, 361-363. #20104

  28. Caturla,F., Enjo,J., Bernabeu,M.C., & Le Serre,S. (2004) New fluorescent probes for testing combinatorial catalysts with phosphodiesterase and esterase activities. Tetrahedron, 60, 1903-1911. #20455

  29. Cavazzini,A., Massi,A., Bergamaschi,G., Braga,S., Dondi,F., & Dondoni,A. (2004) Combining Synthetic and Analytical Strategies for Preparative HPLC Enantioseparation of Monastrol Racemic Mixture. Biotechnol. Progr., 20, 603-612. #20401

  30. Cawse,J.N., Baerns,M., & Holena,M. (2004) Efficient Discovery of Nonlinear Dependencies in a Combinatorial Catalyst Data Set. Journal of Chemical Information and Computer Sciences, 44, 143-146. #20186

  31. Chakraborty,T.K., Srinivasu,P., Tapadar,S., & Mohan,B.K. (2004) Sugar amino acids and related molecules: Some recent developments. Journal of Chemical Sciences (Bangalore, India), 116, 187-207. #20039

  32. Chen,D., Hackbarth,C., Ni,Z.J., Wu,C., Wang,W., Jain,R., He,Y., Bracken,K., Weidmann,B., Patel,D.V., Trias,J., White,R.J., & Yuan,Z. (2004) Peptide deformylase inhibitors as antibacterial agents: Identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach. Antimicrob. Agents Chemother., 48, 250-261. #20168

  33. Chen,H., Li,Q., Yao,X., Fan,B., Yuan,S., Panaye,A., & Doucet,J.P. (2004) CoMFA/CoMSIA/HQSAR and docking study of the binding mode of selective cyclooxygenase (COX-2) inhibitors. QSAR & Combinatorial Science, 23, 36-55. #20132

  34. Chen,L., Bao,J., Gao,C., Huang,S., Liu,C., & Liu,W. (2004) Combinatorial Synthesis of Insoluble Oxide Library from Ultrafine/Nano Particle Suspension Using a Drop-on-Demand Inkjet Delivery System. Journal of Combinatorial Chemistry, 6, 699-702. #20063

  35. Chen,Y.T., & Seto,C.T. (2004) Parallel synthesis of a library of bidentate protein tyrosine phosphatase inhibitors based on the a-ketoacid motif. Bioorganic & Medicinal Chemistry, 12, 3289-3298. #20093

  36. Cheng,C.W., Lin,K.C., Pan,F.M., Sinchaikul,S., Wong,C.H., Su,W.C., Hsu,C.H., & Chen,S.t. (2004) Facile synthesis of metal-chelating peptides on chip for protein array. Bioorganic & Medicinal Chemistry Letters, 14, 1987-1990. #20120

  37. Christensen,C., Tornoe,C.W., & Meldal,M. (2004) Pyrazines on solid support from peptides by periodinane oxidation of threonine side-chains. A quantitative chemical transformation (QCT) for combinatorial chemistry. QSAR & Combinatorial Science, 23, 109-116. #20081

  38. Cipolla,L. (2004) Combinatorial libraries of biocatalysts: application and screening. Comb. Chem. High Throughput Screening, 7, 101-114. #20110

  39. Corbett,A.D., Cheeseman,J.D., Kazlauskas,R.J., & Gleason,J.L. (2004) Pseudodynamic combinatorial libraries: A receptor-assisted approach for drug discovery. Angew. Chem. Int. Ed., 43, 2432-2436. #20028

  40. Cozzi,P., Mongelli,N., & Suarato,A. (2004) Recent anticancer cytotoxic agents. Current Medicinal Chemistry: Anti-Cancer Agents, 4, 93-121. #20118

  41. Cui,Z., Sun,L., & Zhang,B. (2004) A peptidyl transferase ribozyme capable of combinatorial peptide synthesis. Bioorganic & Medicinal Chemistry, 12, 927-933. #20150

  42. de Graaf,K.L., Barth,S., Herrmann,M.M., Storch,M.K., Otto,C., Olsson,T., Melms,A., Jung,G., Wiesmueller,K.H., & Weissert,R. (2004) MHC Class II Isotype- and Allele-Specific Attenuation of Experimental Autoimmune Encephalomyelitis. Journal of Immunology, 173, 2792-2802. #20043

  43. de la Hoz,A., Diaz-Ortiz,A., & Moreno,A. (2004) Selectivity in organic synthesis under microwave irradiation. Current Organic Chemistry, 8, 903-918. #20067

  44. Delpiccolo,C.M.L., & Mata,E.G. (2004) Efficient and selective solid-phase synthesis of trans 3-alkyl b-lactams from nonactivated acid chlorides. Tetrahedron Lett., 45, 4085-4088. #20106

  45. Dikmans,A.J., Morr,M.Z.N., Adler,F., Turk,G., & Frank,R. (2004) A new compact disc format of high density array synthesis applied to peptide nucleic acids and in situ MALDI analysis. Mol. Diversity, 8, 197-207. #20025

  46. Diness,F., Beyer,J., & Meldal,M. (2004) Synthesis of 3-Boc-(1,3)-oxazinane-protected amino aldehydes from amino acids and their conversion into urea precursors. Novel building blocks for combinatorial synthesis. QSAR & Combinatorial Science, 23, 130-144. #20080

  47. Ding,K., Du,H., Yuan,Y., & Long,J. (2004) Combinatorial chemistry approach to chiral catalyst engineering and screening: Rational design and serendipity. Chemistry--A European Journal, 10, 2872-2884. #20057

  48. Dong,Y., Roberge,J.Y., Wang,Z., Wang,X., Tamasi,J., Dell,V., Golla,R., Corte,J.R., Liu,Y., Fang,T., Anthony,M.N., Schnur,D.M., Agler,M.L., Dickson,J.K., Lawrence,R.M., Prack,M.M., Seethala,R., & Feyen,J.H.M. (2004) Characterization of a new class of selective nonsteroidal progesterone receptor agonists. Steroids, 69, 201-217. #20114

  49. Edwards,A.A., Ichihara,O., Murfin,S., Wilkes,R., Whittaker,M., Watkin,D.J., & Fleet,G.W.J. (2004) Tetrahydrofuran-Based Amino Acids as Library Scaffolds. Journal of Combinatorial Chemistry, 6, 230-238. #20165

  50. El Araby,M., Guo,H., Pottorf,R.S., & Player,M.R. (2004) Solid-Phase Synthesis of an Alkylaminobenzanilide Library. Journal of Combinatorial Chemistry, 6, 789-795. #20065

  51. Erlanson,D.A., McDowell,R.S., & O'Brien,T. (2004) Fragment-Based Drug Discovery. J. Med. Chem., 47, 3463-3482. #20082

  52. Fechner,U., & Schneider,G. (2004) Optimization of a pharmacophore-based correlation vector descriptor for similarity searching. QSAR & Combinatorial Science, 23, 19-22. #20134

  53. Fernandez,D., Ahaidar,A., Danelon,G., Cironi,P., Marfil,M., Perez,O., Cuevas,C., Albericio,F., Joule,J.A., & Alvarez,M. (2004) Synthesis of Polyheterocyclic Nitrogen-Containing Marine Natural Products. Monatshefte fuer Chemie, 135, 615-627. #20098

  54. Fischer,P.M. (2004) The design of drug candidate molecules as selective inhibitors of therapeutically relevant protein kinases. Curr. Med. Chem., 11, 1563-1583. #20089

  55. Floriano,W.B., Vaidehi,N., Zamanakos,G., & Goddard,W.A., III. (2004) HierVLS Hierarchical Docking Protocol for Virtual Ligand Screening of Large-Molecule Databases. J. Med. Chem., 47, 56-71. #20185

  56. Fonseca,M.H., & List,B. (2004) Combinatorial chemistry and high-throughput screening for the discovery of organocatalysts. Curr. Opin. Chem. Biol., 8, 319-326. #20071

  57. Frantzen,A., Scheidtmann,J., Frenzer,G., Maier,W.F., Jockel,J., Brinz,T., Sanders,D., & Simon,U. (2004) High-throughput method for the impedance spectroscopic characterization of resistive gas sensors. Angewandte Chemie, International Edition, 43, 752-754. #20152

  58. Fricker,P.C., Gastreich,M., & Rarey,M. (2004) Automated Drawing of Structural Molecular Formulas under Constraints. Journal of Chemical Information and Computer Sciences, 44, 1065-1078. #20113

  59. Ganesan,A. (2004) Combinatorial chemistry. Curr. Opin. Chem. Biol., 8, 209-210. #20077

  60. Garbacia,S., Touzani,R., & Lavastre,O. (2004) Image Analysis as a Quantitative Screening Test in Combinatorial Catalysis: Discovery of an Unexpected Ruthenium-Based Catalyst for the Sonogashira Reaction. Journal of Combinatorial Chemistry, 6, 297-300. #20164

  61. Garcia-Junceda,E., Garcia-Garcia,J.F., Bastida,A., & Fernandez-Mayoralas,A. (2004) Enzymes in the synthesis of bioactive compounds: the prodigious decades. Bioorganic & Medicinal Chemistry, 12, 1817-1834. #20125

  62. Giacomelli,G., Porcheddu,A., & De Luca,L. (2004) [1,3,5]-triazine: A versatile heterocycle in current applications of organic chemistry. Current Organic Chemistry, 8, 1497-1519. #20031

  63. Gil,C., Schwoegler,A., & Braese,S. (2004) The Synthesis of 3-Substituted 6-Aryl-3 H-benzo[a][1,2,3]triazinones Using Polymer-Bound Triazenes. Journal of Combinatorial Chemistry, 6, 38-42. #20183

  64. Gilabert,M. (2004) Combinatorial chemical paper in the drug discovery process. Tecnicas de Laboratorio, 26, 140-143. #20398

  65. Girard,C., Tranchant,I., Gorteau,V., Potey,L., & Herscovici,J. (2004) Development of a DNA interaction test with small molecules still grafted on solid phase. Journal of Combinatorial Chemistry, 6, 275-278. #20454

  66. Gooding,O.W. (2004) Process optimization using combinatorial design principles: parallel synthesis and design of experiment methods. Curr. Opin. Chem. Biol., 8, 297-304. #20399

  67. Graham,D.J., Malarkey,C., & Schulmerich,M.V. (2004) Information Content in Organic Molecules: Quantification and Statistical Structure via Brownian Processing. Journal of Chemical Information and Computer Sciences, 44, 1601-1611. #20050

  68. Graham,D.J., & Schulmerich,M.V. (2004) Information Content in Organic Molecules: Reaction Pathway Analysis via Brownian Processing. Journal of Chemical Information and Computer Sciences, 44, 1612-1622. #20049

  69. Gros,P., Doudouh,A., & Fort,Y. (2004) New polystyrene-supported stable source of 2-pyridylboron reagent for Suzuki couplings in combinatorial chemistry. Tetrahedron Lett., 45, 6239-6241. #20048

  70. Hahn,H.G., Oh,H.S., Cheon,S.H., Oak,M.H., Kim,Y.R., & Kim,K.M. (2004) Excavation of lead compounds that inhibit mast cell degranulation by combinatorial chemistry and activity-guided. Archives of Pharmacal Research, 27, 518-523. #20066

  71. Han,Y., Giroux,A., Grimm,E.L., Aspiotis,R., Francoeur,S., Bayly,C.I., McKay,D.J., Roy,S., Xanthoudakis,S., Vaillancourt,J.P., Rasper,D.M., Tam,J., Tawa,P., Thornberry,N.A., Paterson,E.P., Garcia-Calvo,M., Becker,J.W., Rotonda,J., Nicholson,D.W., & Zamboni,R.J. (2004) Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors. Bioorganic & Medicinal Chemistry Letters, 14, 805-808. #20169

  72. Harper,G., Pickett,S.D., & Green,D.V.S. (2004) Design of a compound screening collection for use in high throughput screening. Comb. Chem. High Throughput Screening, 7, 63-71. #20126

  73. Hattori,K., Kido,Y., Yamamoto,H., Ishida,J., Kamijo,K., Murano,K., Ohkubo,M., Kinoshita,T., Iwashita,A., Mihara,K., Yamazaki,S., Matsuoka,N., Teramura,Y., & Miyake,H. (2004) Rational Approaches to Discovery of Orally Active and Brain-Penetrable Quinazolinone Inhibitors of Poly(ADP-ribose)polymerase. J. Med. Chem., 47, 4151-4154. #20053

  74. Heeren,R.M.A., Kleinnijenhuis,A.J., McDonnell,L.A., & Mize,T.H. (2004) A mini-review of mass spectrometry using high-performance FTICR-MS methods. Analytical and Bioanalytical Chemistry, 378, 1048-1058. #20151

  75. Hobbs,J.S., Simonian,M.H., Betgovargez,E., Ioffe,V., Movsisyan,A., Yu,J., James,C., & Bogler,O. (2004) The fast and the curious: fragment-based lead discovery and optimization via high-throughput X-ray crystallography. Mod. Drug Dis., 7, 53-54, 56. #20069

  76. Hou,T.J., Zhang,W., Xia,K., Qiao,X.B., & Xu,X.J. (2004) ADME Evaluation in Drug Discovery. 5. Correlation of Caco-2 Permeation with Simple Molecular Properties. Journal of Chemical Information and Computer Sciences, 44, 1585-1600. #20060

  77. Houghten,R.A. Anonymous. (2004) Silicagel-HF. This Book.#20024

  78. Houghten,R.A., Dooley,C.T., & Appel,J.R. (2004) De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library. Bioorganic & Medicinal Chemistry Letters, 14, 1947-1951. #20121

  79. Hu,Y., Nawoschik,K.J., Liao,Y., Ma,J., Fathi,R., & Yang,Z. (2004) Synthesis of Conformationally Restricted 2,3-Diarylbenzo[b]furan by the Pd-Catalyzed Annulation of o-Alkynylphenols: Exploring a Combinatorial Approach. J. Org. Chem., 69, 2235-2239. #20139

  80. Huenger,U., Ohnsmann,J., & Kunz,H. (2004) Carbohydrate scaffolds for combinatorial syntheses that allow selective deprotection of all four positions independent of the sequence. Angewandte Chemie, International Edition, 43, 1104-1107. #20137

  81. Jensen,A.A., & Spalding,T.A. (2004) Allosteric modulation of G-protein coupled receptors. European Journal of Pharmaceutical Sciences, 21, 407-420. #20147

  82. Ji,Y.F., Pan,X.D., & Wei,X.Y. (2004) A solid-phase approach to fluorobenzimidazoles and fluoro-2-hydroxyquinoxalines using 'one-bead-two-compound' method. Synlett, 1607-1609. #20437

  83. Joensson,D., Warrington,B.H., & Ladlow,M. (2004) Automated Flow-Through Synthesis of Heterocyclic Thioethers. Journal of Combinatorial Chemistry, 6, 584-595. #20100

  84. Juskowiak,G.L., Stachel,S.J., Tivitmahaisoon,P., & Van Vranken,D.L. (2004) Fluorogenic Peptide Sequences - Transformation of Short Peptides into Fluorophores under Ambient Photooxidative Conditions. J. Amer. Chem. Soc., 126, 550-556. #20179

  85. Kaempke,T. (2004) Scalable distance similarity of chemical structures. Comb. Chem. High Throughput Screening, 7, 11-21. #20127

  86. Kam,Y.L., Rhee,S.J., & Choo,H.Y. (2004) Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists. Bioorganic & Medicinal Chemistry, 12, 3543-3552. #20079

  87. Kenseth,J.R., He,Y., Tallman,D., Pang,H.m., & Coldiron,S.J. (2004) Techniques for high-throughput characterization of peptides, oligonucleotides and catalysis efficiency. Curr. Opin. Chem. Biol., 8, 327-333. #20070

  88. Knepper,K., Lormann,M.E.P., & Braese,S. (2004) Efficient Synthesis of Highly Substituted Diaryl Ethers on Solid Supports Using the Ullmann Reaction. Journal of Combinatorial Chemistry, 6, 460-463. #20109

  89. Kohler,J.M., Henkel,T., Grodrian,A., Kirner,T., Roth,M., Martin,K., & Metze,J. (2004) Digital reaction technology by micro segmented flow - components, concepts and applications. Chemical Engineering Journal (Amsterdam, Netherlands), 101, 201-216. #20087

  90. Koinuma,H., & Takeuchi,I. (2004) Combinatorial solid-state chemistry of inorganic materials. Nature Materials, 3, 429-438. #20396

  91. Lai,G. (2004) A convenient preparation of tetrahydrofuran-based diamines. Syn. Commun., 34, 1981-1987. #20062

  92. Larsson,R., Pei,Z., & Ramstroem,O. (2004) Catalytic self-screening of cholinesterase substrates from a dynamic combinatorial thioester library. Angewandte Chemie, International Edition, 43, 3716-3718. #20047

  93. Lavastre,O., Bonnette,F., & Gallard,L. (2004) Parallel and combinatorial approaches for synthesis of ligands. Curr. Opin. Chem. Biol., 8, 311-318. #20072

  94. Lee,H.K., & Rana,T.M. (2004) Microwave-Assisted Parallel Synthesis of a 4,6-Diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine Library. Journal of Combinatorial Chemistry, 6, 504-508. #20084

  95. Lee,M.J., & Sun,C.M. (2004) Traceless synthesis of hydantoin by focused microwave irradiation. Tetrahedron Lett., 45, 437-440. #20181

  96. Lemmo,A.V., Hobbs,S., & Patel,P. (2004) Micro Parallel Liquid Chromatography: Enabling Technology for Discovery Analytical Chemistry. Assay and Drug Development Technologies, 2, 389-395. #20034

  97. Leonard,J.T., & Roy,K. (2004) Classical QSAR modeling of HIV-1 reverse transcriptase inhibitor 2-amino-6-arylsulfonylbenzonitriles and congeners. QSAR & Combinatorial Science, 23, 23-35. #20133

  98. Li,W., Chen,Y., & Lam,Y. (2004) A facile solid-phase synthesis of 3,4,6-trisubstituted-2-pyridones using sodium benzenesulfinate as a traceless linker. Tetrahedron Lett., 45, 6545-6547. #20042

  99. Lin,M.J., & Sun,C.M. (2004) Focused microwave-assisted parallel synthesis of bis-benzimidazoles. Synlett, 663-666. #20130

  100. Lindsay,J.P., Clark,D.S., & Dordick,J.S. (2004) Combinatorial formulation of biocatalyst preparations for increased activity in organic solvents: Salt activation of penicillin amidase. Biotechnol. Bioeng., 85, 553-560. #20143

  101. Liu,R., Hsieh,C.Y., & Lam,K.S. (2004) New approaches in identifying drugs to inactivate oncogene products. Seminars in Cancer Biology, 14, 13-21. #20457

  102. Ma,Y., Margarida,L., Brookes,J., Makara,G.M., & Berk,S.C. (2004) Combinatorial Synthesis of Substituted Biaryls and Heterocyclic Arylamines. Journal of Combinatorial Chemistry, 6, 426-430. #20123

  103. Maclean,D., Holden,F., Davis,A.M., Scheuerman,R.A., Yanofsky,S., Holmes,C.P., Fitch,W.L., Tsutsui,K., Barrett,R.W., & Gallop,M.A. (2004) Agonists of the Follicle Stimulating Hormone Receptor from an Encoded Thiazolidinone Library. Journal of Combinatorial Chemistry, 6, 196-206. #20177

  104. Maclean,D., & Martin,E.J. (2004) On the representation of combinatorial libraries. Journal of Combinatorial Chemistry, 6, 1-11. #20184

  105. Maison,W., Grohs,D.C., & Prenzel,A.H.G.P. (2004) Efficient synthesis of structurally diverse diazabicycloalkanes: scaffolds for modular dipeptide mimetics with tunable backbone conformations. Eur. J. Org. Chem., 1527-1543. #20116

  106. Maltais,R., Tremblay,M.R., Ciobanu,L.C., & Poirier,D. (2004) Steroids and Combinatorial Chemistry. Journal of Combinatorial Chemistry, 6, 443-456. #20101

  107. Matikainen,J.K.T., & Elo,H.O. (2004) A Novel Intramolecular Cyclization Reaction: Facile Solvent-Free Microscale Synthesis Suitable for Rapid Production of Libraries of 3-Amino-1,2,4-Triazines and for Combinatorial Chemistry. Microchimica Acta, 146, 49-53. #20103

  108. Matsuura,T., Ernst,A., Zechel,D.L., & Plueckthun,A. (2004) Combinatorial approaches to novel proteins. Chembiochem, 5, 177-182. #20148

  109. McCarthy,J.F., Marx,K.A., Hoffman,P.E., Gee,A.G., O'Neil,P., Ujwal,M.L., & Hotchkiss,J. (2004) Applications of machine learning and high-dimensional visualization in cancer detection, diagnosis, and management. Annals of the New York Academy of Sciences, 1020, 239-262. #20054

  110. Meier,M.A.R., Gohy,J.F., Fustin,C.A., & Schubert,U.S. (2004) Combinatorial Synthesis of Star-Shaped Block Copolymers: Host-Guest Chemistry of Unimolecular Reversed Micelles. J. Amer. Chem. Soc., 126, 11517-11521. #20038

  111. Mekenyan,O., Nikolova,N., Schmieder,P., & Veith,G. (2004) COREPA-M: a multi-dimensional formulation of COREPA. QSAR & Combinatorial Science, 23, 5-18. #20135

  112. Meldal,M. (2004) One bead two compound libraries' for detecting chemical and biochemical conversions. Curr. Opin. Chem. Biol., 8, 238-244. #20076

  113. Miller,S.J. (2004) In Search of Peptide-Based Catalysts for Asymmetric Organic Synthesis. Account. Chem. Res., 37, 601-610. #20141

  114. Mitscher,L.A. (2004) Analysis and Purification Methods in Combinatorial Chemistry, Edited by Bing Yang. Journal of Natural Products, 67, 1076-1077. #20096

  115. Musonda,C.C., & Chibale,K. (2004) Application of combinatorial and parallel synthesis chemistry methodologies to antiparasitic drug discovery. Curr. Med. Chem., 11, 2519-2533. #20030

  116. Nad,S., & Breinbauer,R. (2004) Electroorganic synthesis on the solid phase using polymer beads as supports. Angewandte Chemie, International Edition, 43, 2297-2299. #20105

  117. Nefzi,A., Ostresh,J.M., Yu,Y., & Houghten,R.A. (2004) Combinatorial Chemistry: Libraries from Libraries, the Art of the Diversity-Oriented Transformation of Resin-Bound Peptides and Chiral Polyamides to Low Molecular Weight Acyclic and Heterocyclic Compounds. [Vol. 69, 2004]. J. Org. Chem., 69, 5516. #20055

  118. Nolte,M., & Fery,A. (2004) Coupling of individual polyelectrolyte capsules onto patterned substrates. Langmuir, 20, 2995-2998. #20131

  119. Oerfi,L., Waczek,F., Pato,J., Varga,I., Hegymegi-Barakonyi,B., Houghten,R.A., & Keri,G. (2004) Improved, high yield synthesis of 3H-quinazolin-4-ones, the key intermediates of recently developed drugs. Curr. Med. Chem., 11, 2549-2553. #20029

  120. Ohno,H., Tanaka,H., & Takahashi,T. (2004) Solid-phase synthesis of N-alkylated naltrindoles using a 3-nitrobenzyl safety-catch linker. Synlett, 508-511. #20144

  121. Omata,K., Hashimoto,M., Watanabe,Y., Sutarto, Umegaki,T., & Yamada,M. (2004) Design of low cost pipe fitting device for high-throughput screening reactor for screening of methanol synthesis catalyst. Journal of the Japan Petroleum Institute, 47, 218-221. #20099

  122. Ortholand,J.Y., & Ganesan,A. (2004) Natural products and combinatorial chemistry: back to the future. Curr. Opin. Chem. Biol., 8, 271-280. #20074

  123. Ott,T., Kern,A., Schuffenhauer,A., Popov,M., Acklin,P., Jacoby,E., & Stoop,R. (2004) Sequential Superparamagnetic Clustering for Unbiased Classification of High-Dimensional Chemical Data. Journal of Chemical Information and Computer Sciences, 44, 1358-1364. #20083

  124. Park,J.G., Langenwalter,K.J., Weinbaum,C.A., Casey,P.J., & Pang,Y.P. (2004) Improved Loading and Cleavage Methods for Solid-Phase Synthesis Using Chlorotrityl Resins: Synthesis and Testing of a Library of 144 Discrete Chemicals as Potential Farnesyltransferase Inhibitors. Journal of Combinatorial Chemistry, 6, 407-413. #20119

  125. Parr,N.J., McKeown,S.C., Lindvall,M.K., Lorthioir,O.E., Congreve,M.S., & Watson,S.P. (2004) The application of quantitative analytical constructs for chemistry optimization, monomer rehearsal and reactivity prediction in solid phase library synthesis. Letters in Organic Chemistry, 1, 87-92. #20453

  126. Patek,M., Safar,P., Smrcina,M., Wegrzyniak,E., Bjergarde,K., Weichsel,A., & Strop,P. (2004) 2D and 3D Spatially Addressed Arrays for High-Throughput Automated Synthesis of Combinatorial Libraries. Journal of Combinatorial Chemistry, 6, 43-49. #20189

  127. Petrenko,V.A., & Sorokulova,I.B. (2004) Detection of biological threats. A challenge for directed molecular evolution. J. Microbiol. Methods, 58, 147-168. #20058

  128. Pirrung,M.C., & Das Sarma,K. (2004) Multicomponent Reactions Are Accelerated in Water. J. Amer. Chem. Soc., 126, 444-445. #20178

  129. Piscopio,A.D., & Robinson,J.E. (2004) Recent applications of olefin metathesis to combinatorial chemistry. Curr. Opin. Chem. Biol., 8, 245-254. #20075

  130. Porcheddu,A., Giacomelli,G., De Luca,L., & Ruda,A.M. (2004) A \"Catch and Release\" Strategy for the Parallel Synthesis of 2,4,5-Trisubstituted Pyrimidines. Journal of Combinatorial Chemistry, 6, 105-111. #20190

  131. Prakash,G.K.S., & Etzkorn,M. (2004) Direct oxidation of azides to nitro compounds. Angewandte Chemie, International Edition, 43, 26-28. #20176

  132. Rachakonda,S., & Cartee,L. (2004) Challenges in antimicrobial drug discovery and the potential of nucleoside antibiotics. Curr. Med. Chem., 11, 775-793. #20128

  133. Raghavendra,M.S., & Lam,Y. (2004) Regiospecific solid-phase synthesis of substituted 1,2,3-triazoles. Tetrahedron Lett., 45, 6129-6132. #20051

  134. Ralets,I., Ostergaard,S., Holm,A., Kohler,L., Bock,E., & Berezin,V. (2004) Identification of neurite extension inducing peptides by means of soluble combinatorial peptide libraries. J. Neurosci. Meth., 137, 61-69. #20443

  135. Ramstroem,O., Lohmann,S., Bunyapaiboonsri,T., & Lehn,J.M. (2004) Dynamic combinatorial carbohydrate libraries: probing the binding site of the Concanavalin A lectin. Chemistry--A European Journal, 10, 1711-1715. #20111

  136. Richards,W.G., Grant,G.H., & Harrison,K.N. (2004) Combating bioterrorism with personal computers. Journal of Molecular Graphics & Modelling, 22, 473-478. #20078

  137. Roque,A.C., Taipa,M.A., & Lowe,C.R. (2004) A new method for the screening of solid-phase combinatorial libraries for affinity chromatography. J. Mol. Recog., 17, 262-267. #20086

  138. Sanchez-Martin,R.M., Mittoo,S., & Bradley,M. (2004) The impact of combinatorial methodologies on medicinal chemistry. Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates), 4, 653-669. #20447

  139. Savchuk,N.P., Balakin,K.V., & Tkachenko,S.E. (2004) Exploring the chemogenomic knowledge space with annotated chemical libraries. Curr. Opin. Chem. Biol., 8, 412-417. #20044

  140. Schimmer,A.D., Welsh,K., Pinilla,C., Wang,Z., Krajewska,M., Bonneau,M.J., Pedersen,I.M., Kitada,S., Scott,F.L., Bailly-Maitre,B., Glinsky,G., Scudiero,D., Sausville,E., Salvesen,G., Nefzi,A., Ostresh,J.M., Houghten,R.A., & Reed,J.C. (2004) Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell, 5, 25-35. #20158

  141. Schmidt,F.R. (2004) The challenge of multidrug resistance: actual strategies in the development of novel antibacterials. Applied Microbiology and Biotechnology, 63, 335-343. #20174

  142. Schwabacher,A.W., Johnson,C.W., & Geissinger,P. (2004) Linear combinatorial synthesis with Fourier transform library analysis. Macromolecular Rapid Communications, 25, 108-118. #20456

  143. Sebestik,J., Matejka,P., Hlavacek,J., & Stibor,I. (2004) Solid-phase synthesis of head and tail bis-acridinylated peptides. Tetrahedron Lett., 45, 1203-1205. #20170

  144. Shannon,S.K., & Barany,G. (2004) Colorimetric monitoring of solid-phase aldehydes using 2,4-dinitrophenylhydrazine. Journal of Combinatorial Chemistry, 6, 165-170. #20161

  145. Song,A., Zhang,J., & Lam,K.S. (2004) Synthesis and Reactions of 7-Fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic Acid: A Novel Scaffold for Combinatorial Synthesis of Coumarins. Journal of Combinatorial Chemistry, 6, 112-120. #20188

  146. Song,A., Zhang,J., Lebrilla,C.B., & Lam,K.S. (2004) Solid-Phase Synthesis and Spectral Properties of 2-Alkylthio-6H-pyrano[2,3-f]benzimidazole-6-ones: A Combinatorial Approach for 2-Alkylthioimidazocoumarins. Journal of Combinatorial Chemistry, 6, 604-610. #20444

  147. Song,A., Wang,X., Zhang,J., Marik,J., Lebrilla,C.B., & Lam,K.S. (2004) Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase. Bioorganic & Medicinal Chemistry Letters, 14, 161-165. #20461

  148. Song,A., Marik,J., & Lam,K.S. (2004) Solid-phase synthesis of 3-alkyl-2-arylamino-3,4-dihydroquinazolines. Tetrahedron Lett., 45, 2727-2730. #20138

  149. Song,Y., Yu,J., Li,Y., Li,G., & Xu,R. (2004) Hydrogen-bonded helices in the layered aluminophosphate (C2H8N)2[Al2(HPO4)(PO4)2]. Angewandte Chemie, International Edition, 43, 399-2402. #20094

  150. Spivey,A.C., Turner,D.J., Turner,M.L., & Yeates,S. (2004) A tuneable Ge-based linker that enables application-led solid phase synthesis optimization - towards a robust iterative synthesis of oligothiophenes. Synlett, 111-115. #20167

  151. Srinivasan,N., & Kilburn,J.D. (2004) Combinatorial approaches to synthetic receptors. Curr. Opin. Chem. Biol., 8, 305-310. #20073

  152. Stock,N., & Bein,T. (2004) High-throughput synthesis of phosphonate-based inorganic-organic hybrid compounds under hydrothermal conditions. Angewandte Chemie, International Edition, 43, 749-752. #20153

  153. Ternon,M., Diaz-Mochon,J.J., Belsom,A., & Bradley,M. (2004) Dendrimers and combinatorial chemistry-tools for fluorescent enhancement in protease assays. Tetrahedron, 60, 8721-8728. #20036

  154. Tornoe,C.W., Sanderson,S.J., Mottram,J.C., Coombs,G.H., & Meldal,M. (2004) Combinatorial Library of Peptidotriazoles: Identification of [1,2,3]-Triazole Inhibitors against a Recombinant Leishmania mexicana Cysteine Protease. Journal of Combinatorial Chemistry, 6, 312-324. #20122

  155. Tounge,B.A., & Reynolds,C.H. (2004) Defining Privileged Reagents Using Subsimilarity Comparison. Journal of Chemical Information and Computer Sciences, 44, 1810-1815. #20052

  156. Troitskaya,L.A., & Kodadek,T. (2004) Peptides as modulators of enzymes and regulatory proteins. Methods (San Diego, CA, United States), 32, 406-415. #20146

  157. Tung,C.L., & Sun,C.M. (2004) Liquid phase synthesis of chiral quinoxalinones by microwave irradiation. Tetrahedron Lett., 45, 1159-1162. #20171

  158. Uttamchandani,M., Chen,G.Y.J., Lesaicherre,M.L., & Yao,S.Q. (2004) Site-specific peptide immobilization strategies for the rapid detection of kinase activity on microarrays. Methods in Molecular Biology (Totowa, NJ, United States), 264, 191-204. #20445

  159. Vasilyev,V., & Bliznyuk,A. (2004) Application of semiempirical quantum chemical methods as a scoring function in docking. Theoretical Chemistry Accounts, 112, 313-317. #20033

  160. Ventura,M., Farrell,W., Aurigemma,C., Tivel,K., Greig,M., Wheatley,J., Yanovsky,A., Milgram,K.E., Dalesandro,D., DeGuzman,R., Tran,P., Nguyen,L., Chung,L., Gron,O., & Koch,C.A. (2004) High-throughput preparative process utilizing three complementary chromatographic purification technologies. Journal of Chromatography, A, 1036, 7-13. #20112

  161. Vess,C.J., Gilmore,J., Kohrt,N., & McGinn,P.J. (2004) Combinatorial Synthesis of Oxide Powders with an Autopipetting System. Journal of Combinatorial Chemistry, 6, 86-90. #20191

  162. Vickerstaffe,E., Warrington,B.H., Ladlow,M., & Ley,S.V. (2004) Fully Automated Polymer-Assisted Synthesis of 1,5-Biaryl Pyrazoles. Journal of Combinatorial Chemistry, 6, 332-339. #20129

  163. Viljanen,J., Tegler,L., & Broo,K.S. (2004) Combinatorial Chemical Reengineering of the Alpha Class Glutathione Transferases. Bioconjug. Chem., 15, 718-727. #20091

  164. Villard,A.L., Warrington,B.H., & Ladlow,M. (2004) A Fluorous-Tagged, Acid-Labile Protecting Group for the Synthesis of Carboxamides and Sulfonamides. Journal of Combinatorial Chemistry, 6, 611-622. #20085

  165. Virta,P., Leppaenen,M., & Loennberg,H. (2004) Pentaerythrityltetramine scaffolds for solid-phase combinatorial chemistry. J. Org. Chem., 69, 2008-2016. #20156

  166. Wang,G., De,J., Schoeniger,J.S., Roe,D.C., & Carbonell,R.G. (2004) A hexamer peptide ligand that binds selectively to staphylococcal enterotoxin B: Isolation from a solid phase combinatorial library. J. Pept. Res., 64, 51-64. #20436

  167. Wang,X., Zhang,J., Song,A., Lebrilla,C.B., & Lam,K.S. (2004) Encoding method for OBOC small molecule libraries using a biphasic approach for ladder-synthesis of coding tags. J. Amer. Chem. Soc., 126, 5740-5749. #20446

  168. Watts,J., Benn,A., Flinn,N., Monk,T., Ramjee,M., Ray,P., Wang,Y., & Quibell,M. (2004) Functionalised 2,3-dimethyl-3-aminotetrahydrofuran-4-one and N-(3-oxo-hexahydrocyclopenta[b]furan-3a-yl)acylamide based scaffolds: synthesis and cysteinyl proteinase inhibition. Bioorganic & Medicinal Chemistry, 12, 2903-2925. #20095

  169. Watts,P., & Haswell,S.J. (2004) Combinatorial synthesis in micro reactors. Comb. Chem. High Throughput Screening, 7, 397-405. #20035

  170. Wermuth,C.G. (2004) Selective Optimization of Side Activities: Another Way for Drug Discovery. J. Med. Chem., 47, 1303-1314. #20159

  171. Whitney,A.M., Ladame,S., & Balasubramanian,S. (2004) Templated ligand assembly by using G-quadruplex DNA and dynamic covalent chemistry. Angewandte Chemie, International Edition, 43, 1143-1146. #20136

  172. Wiczling,P., Markuszewski,M.J., & Kaliszan,R. (2004) Determination of pKa by pH Gradient Reversed-Phase HPLC. Anal. Chem., 76, 3069-3077. #20107

  173. Willand,N., Beghyn,T., Nowogrocki,G., Gesquiere,J.C., & Deprez,B. (2004) Synthesis and structural studies of a novel scaffold for drug discovery: a 4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]. Tetrahedron Lett., 45, 1051-1054. #20173

  174. Wittmann,V., & Seeberger,S. (2004) Spatial screening of cyclic neoglycopeptides: Identification of polyvalent wheat-germ agglutinin ligands. Angewandte Chemie, International Edition, 43, 900-903. #20452

  175. Wu,X., Ding,S., Ding,Q., Gray,N.S., & Schultz,P.G. (2004) Small molecules that induce cardiomyogenesis in embryonic stem cells. J. Amer. Chem. Soc., 126, 1590-1591. #20166

  176. Xie,W., & Firestine,S.M. (2004) A Simple, Inexpensive Reactor with Condenser for Use in Combinatorial Chemistry. Journal of Combinatorial Chemistry, 6, 24-26. #20187

  177. Xu,J., Szakal,C.W., Martin,S.E., Peterson,B.R., Wucher,A., & Winograd,N. (2004) Molecule-Specific Imaging with Mass Spectrometry and a Buckminsterfullerene Probe: Application to Characterizing Solid-Phase Synthesized Combinatorial Libraries. J. Amer. Chem. Soc., 126, 3902-3909. #20140

  178. Yan,B. (2004) New combichem QC standards guard the supply of compounds and ensure HTS results. Mod. Drug Dis., 7, 30-32, 34. #20142

  179. Yao,H., Costache,A.D., & Sem,D.S. (2004) Chemical proteomic tool for ligand mapping of CYP antitargets: An NMR-compatible 3D QSAR descriptor in the heme-based coordinate system. Journal of Chemical Information and Computer Sciences, 44, 1456-1465. #20090

  180. Yao,N.H., He,W.Y., Lam,K.S., & Liu,G. (2004) Solid-Phase Synthesis of O-Glycosylated Na-Fmoc Amino Acids and Analysis by High-Resolution Magic Angle Spinning NMR. Journal of Combinatorial Chemistry, 6, 214-219. #20459

  181. Yeh,W.B., & Sun,C.M. (2004) Soluble polymer-supported synthesis of thioxotetrapyrimidinone by focused microwave irradiation. Journal of Combinatorial Chemistry, 6, 279-282. #20172

  182. Yeo,D.S.Y., Panicker,R.C., Tan,L.P., & Yao,S.Q. (2004) Strategies for immobilization of biomolecules in a microarray. Comb. Chem. High Throughput Screening, 7, 213-221. #20442

  183. Yingyongnarongkul,B.E., Howarth,M., Elliott,T., & Bradley,M. (2004) DNA transfection screening from single beads. Journal of Combinatorial Chemistry, 6, 753-760. #20438

  184. Young,S.S., & Ge,N. (2004) Design of diversity and focused combinatorial libraries in drug discovery. Current Opinion in Drug Discovery & Development, 7, 318-324. #20041

  185. Zablotna,E., Dysasz,H., Lesner,A., Jaskiewicz,A., Kazmierczak,K., Miecznikowska,H., & Rolka,K. (2004) A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach. Biochem. Biophys. Res. Commun., 319, 185-188. #20092

  186. Zajdel,P., Subra,G., Bojarski,A.J., Duszynska,B., Pawlowski,M., & Martinez,J. (2004) A New Class of Arylpiperazine Derivatives: the Library Synthesis on SynPhase Lanterns and Biological Evaluation on Serotonin 5-HT1A and 5-HT2A Receptors. Journal of Combinatorial Chemistry, 6, 761-767. #20068

  187. Zaks-Makhina,E., Kim,Y., Aizenman,E., & Levitan,E.S. (2004) Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast. Mol. Pharmacol., 65, 214-219. #20117

  188. Zhou,F.X., Bonin,J., & Predki,P.F. (2004) Development of functional protein microarrays for drug discovery: Progress and challenges. Comb. Chem. High Throughput Screening, 7, 539-546. #20032


Wednesday, September 29, 2004