Selection of papers on solid phase peptide synthesis published after 1996

Solid phase peptide synthesis was invented by Bruce Merrifield in 1963 and became very quickly the routine tool for preparation of peptides and later small proteins. Surprisingly, solid phase synthesis of small organic molecules was accepted only after another 30 years. The compilation of papers dealing with solid phase peptide synthesis would be extremely long. Luckily, Gregg Fields edited the book Solid Phase Peptide Synthesis in the series Methods in Enzymology (Fields, G.B. (1997) Solid-Phase Peptide Synthesis. Academic Press, San Diego. #9830), which covers all aspects of this methodology. We decided to cover here only papers published after publication of Fields' book. This compilation will probably never be complete, but we will try to cover the most important methodological papers. This list is arranged by the year and the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (michal@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M., Leblova Z.: Dynamic database of references in solid phase synthesis. Internet http://www.5z.com.

Recently added entries are marked in bold

1. Balaspiri, L., & Langel, U. (2001) Synthesis of b-amyloid precursor peptide and presenilin segments. J. Peptide Sci., 7, 58-60. #16430

2. Bullesbach, E.E., & Schwabe, C. (2001) Synthesis and conformational analysis of the insulin-like 4 gene product. J. Pept. Res., 57, 77-83. #16258

3. Burgess, K., Han, I., Zhang, A., Zheng, W.H., Shanmugam, K., Featherstone, M.S., & Saragovi, H.U. (2001) DiSSiMiL: Diverse Small Size Mini-Libraries applied to simple and rapid epitope mapping of a monoclonal antibody. J. Pept. Res., 57, 68-76. #16259

4. Dekker, N., Cox, R.C., Kramer, R.A., & Egmond, M.R. (2001) Substrate specificity of the integral membrane protease OmpT determined by spatially addressed peptide libraries. Biochemistry, 40, 1694-1701. #16271

5. Demarcus, M., Ganadu, M.L., Mura, G.M., Porcheddu, A., Quaranta, L., Reginato, G., & Taddei, M. (2001) Small ring constrained peptidomimetics. Synthesis of epoxy peptidomimetics, inhibitors of cysteine proteases. J. Org. Chem., 66, 697-706. #16273

6. Dolence, E.K., Dolence, J.M., & Poulter, C.D. (2001) Solid-phase synthesis of a radiolabeled, biotinylated, and farnesylated Ca(1)a(2)X peptide substrate for Ras- and a-mating factor converting enzyme. Bioconjug. Chem., 12, 35-43. #16275

7. Futaki, S., Youjun, Z., & Sugiura, Y. (2001) Detecting a tag on a channel opening: Blockage of the biotinylated channels by strepravidin. Tetrahedron Lett., 42, 1563-1565. #16423

8. Gatos, D., & Tzavara, C. (2001) Comparison of the solid-phase fragment condensation and phase-change approaches in the synthesis of salmon I calcitonin. J. Pept. Res., 57, 168-174. #16427

9. Geginat, G., Schenk, S., Skoberne, M., Goebel, W., & Hof, H. (2001) A novel approach of direct ex vivo epitope mapping identifies dominant and subdominant CD4 and CD8 T cell epitopes from Listeria monocytogenes. Journal of Immunology, 166, 1877-1884. #16288

10. Henlin, J.M., Boutin, J.A., Kucharczyk, N., Desmet-Beaufort, C., Loynel, A., Bertrand, M., Genton, A., Tucker, G.C., Atassi, G., & Fauchere, J.L. (2001) From peptide libraries to optimized nonpeptide ligands in the search for S-farnesyltransferase inhibitors. J. Pept. Res., 57, 85-96. #16425

11. Kitagawa, K., Aida, C., Fujiwara, H., Yagami, T., Futaki, S., Kogire, M., Ida, J., & Inoue, K. (2001) Facile solid-phase synthesis of sulfated tyrosine-containing peptides: Total synthesis of human big gastrin-II and cholecystokinin (CCK)-39(1,2). J. Org. Chem., 66, 1-10. #16313

12. Kumar, K.S., Roice, M., Sasikumar, P.G., Poduri, C.D., Sugunan, V.S., Pillai, V.N.R., & Das, M.R. (2001) Syntheses of immunodominant peptide regions of hepatitis C viral pathogens using PS-BDODMA resin: A single peptide derived from the conserved domain (E2/NS1) was highly effective in detecting anti-HCV antibodies. J. Pept. Res., 57, 140-150. #16426

13. Lelievre, D., Bure, C., Laot, F., & Delmas, A. (2001) Synthesis of peptide di-aldehyde precursor for stepwise chemoselective ligations via oxime bonds. Tetrahedron Lett., 42, 235-238. #16326

14. Licha, K., Hessenius, C., Becker, A., Henklein, P., Bauer, M., Wisniewski, S., Wiedenmann, B., & Semmler, W. (2001) Synthesis, characterization, and biological properties of cyanine-labeled somatostatin analogues as receptor-targeted fluorescent probes. Bioconjug. Chem., 12, 44-50. #16329

15. Marchetto, R., Nicolas, E., Castillo, N., Bacardit, J., Navia, M., Vila, J., & Giralt, E. (2001) Two short peptides including segments of subunit A of Escherichia coli DNA gyrase as potential probes to evaluate the antibacterial activity of quinolones. J. Peptide Sci., 7, 27-40. #16441

16. McNamara, L.M.A., Andrews, M.J.I., Mitzel, F., Siligardi, G., & Tabor, A.B. (2001) Unexpected conformational properties of a peptide constrained by an aliphatic link between the i and i+4 positions. Tetrahedron Lett., 42, 1591-1593. #16424

17. Nilsson, M.R., Nguyen, L.L., & Raleigh, D.P. (2001) Synthesis and purification of amyloidogenic peptides. Anal. Biochem., 288, 76-82. #16355

18. Qiu, W., Gu, X., Soloshonok, V.A., Carducci, M.D., & Hruby, V.J. (2001) Stereoselective synthesis of conformationally constrained reverse turn dipeptide mimetics. Tetrahedron Lett., 42, 145-148. #16181

19. Royo, M., Jimenez, J.C., Lopez-Macia, A., Giralt, E., & Albericio, F. (2001) Solid-phase synthesis of peptides containing alpha,beta-didehydroamino acids. Eur. J. Org. Chem., 45-48. #16373

20. Shuker, S.B., Esterbrook, J., & Gonzalez, J. (2001) Solid-phase synthesis of a novel peptide substituted calix[4]arene. Synlett, 210-213. #16382

21. Aimoto, S., Hasegawa, K., Li, X. & Kawakami, T. (2000) Synthesis of phosphorylated CRE BP1(19-106) amide using a phosphopeptide thioester prepared directly by an Fmoc solid-phase method. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 82-83). Kluwer Academic Publisher, Dordrecht. #15701

22. Ajikumar, P.K., & Devaky, K.S. (2000) EGDMA-cross-linked polystyrene resin: An efficient support for gel phase peptide synthesis. Proc. Indian Acad. Sci. -Chem. Sci., 112, 465-474. #15819

23. Alam, M.R., Maeda, M., & Sasaki, S. (2000) DNA-binding peptides searched from the solid-phase combinatorial library with the use of the magnetic beads attaching the target duplex DNA. Bioorg. Med. Chem., 8, 465-473. #14913

24. Albericio, F. (2000) Orthogonal protecting groups for Na-amino and C-terminal carboxyl functions in solid-phase peptide synthesis. Biopolymers (Pept. Sci. ), 55, 123-139. #16434

25. Albericio, F. (2000) Orthogonal protecting groups for N alpha-amino and C-terminal carboxyl functions in solid-phase peptide synthesis. Biopolymers, 55, 123-139. #16237

26. Alsina, J., Yokum, T.S., Albericio, F., & Barany, G. (2000) A modified Backbone Amide Linker (BAL) solid-phase peptide synthesis strategy accommodating prolyl, N-alkylamino acyl, or histidyl derivatives at the C-terminus. Tetrahedron Lett., 41, 7277-7280. #15629

27. Alsina, J., Yokum, T.S., Albericio, F. & Barany, G. (2000) Backbone Amide Linker (BAL) methodology to accommodate C-terminal hindered, unreactive, and/or sensitive modification. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 102-103). Kluwer Academic Publisher, Dordrecht. #15707

28. Andersson, L., Blomberg, L., Flegel, M., Lepsa, L., Nilsson, B., & Verlander, M. (2000) Large-scale synthesis of peptides. Biopolymers (Pept. Sci. ), 55, 227-250. #16440

29. Andersson, L., Blomberg, L., Flegel, M., Lepsa, L., Nilsson, B., & Verlander, M. (2000) Large-scale synthesis of peptides. Biopolymers, 55, 227-250. #16238

30. Ando, S., Nakahara, Y., Ito, Y., & Ogawa, T. (2000) Solid-phase synthesis of the glycopeptide of human glycophorin AM bearing the consecutive sialyl-T antigen. Carbohyd. Res., 329, 773-780. #16239

31. Anichini, B., Ricci, R., Fabbri, G., Balacco, G., Mauro, S., Triolo, A., Altamura, M., Maggi, C.A., & Quartara, L. (2000) Solid-phase synthesis of MEN 11270, a new cyclic peptide kinin B2 receptor antagonist. J. Peptide Sci., 6, 612-620. #16152

32. Annis, I. & Barany, G. (2000) Alternative solid-phase reagents for formation of intramolecular sulfur-sulfur bridges in peptides under mild conditions. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 96-97). Kluwer Academic Publisher, Dordrecht. #15704

33. Antopolsky, M., & Azhayev, A. (2000) Stepwise solid-phase synthesis of peptide-oligonucleotide phosphorothioate conjugates employing Fmoc peptide chemistry. Tetrahedron Lett., 41, 9113-9117. #15823

34. Arnon, R., Tarrab-Hazdai, R., & Steward, M. (2000) A mimotope peptide-based vaccine against Schistosoma mansoni: Synthesis and characterization. Immunology, 101, 555-562. #16245

35. Arunan, C., & Pillai, V.N.R. (2000) Synthesis of acyl carrier protein fragment 65-74 on a flexible cross-linked polystyrene support: Comparison with Merrifield resin. Tetrahedron, 56, 3005-3011. #14623

36. Arunan, C., Naaraj, R., & Pillai, V.N.R. (2000) Solid-phase synthesis of a modified 13-residue seminalplasmin fragment on 1,6-hexanediol diacrylate-crosslinked polystyrene support. Peptides, 21, 773-777. #15758

37. Balaspiri, L., Tegyei, Z., Dux, M., Jancso, G., Jozsa, R., Csernus, V., & Mess, B. (2000) Synthesis of chicken galanin and its N- and C-terminal segments, and preparation of their antisera. Lett. Peptide Sci., 7, 23-26. #15431

38. Balse, P., Han, G., Hruby, V.J. & Sun, L. (2000) Diisopropylethylamine salts for protected amino acids: Direct synthesis of peptides on solid-phase. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 80-81). Kluwer Academic Publisher, Dordrecht. #15700

39. Balse, P.M., Kim, H.J., Han, G., & Hruby, V.J. (2000) Evaluation of new base-labile 2-(4-nitrophenylsulfonyl)ethoxycarbonyl (Nsc)-amino acids for solid-phase peptide synthesis. J. Pept. Res., 56, 70-79. #15444

40. Baumann, M., Dietrich, U., Koenigs, C. & Griesinger, C. (2000) Combinatorial peptide synthesis, NMR-aided screening and testing of low molecular weight RNA-ligands. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 170-171). Kluwer Academic Publisher, Dordrecht. #15717

41. Bechinger, B. (2000) Biophysical investigations of membrane perturbations by polypeptides using solid-state NMR spectroscopy. Molecular Membrane Biology, 17, 135-142. #15832

42. Beebe, K.D., Wang, P., Arabaci, G., & Pei, D.H. (2000) Determination of the binding specificity of the SH2 domains of protein tyrosine phosphatase SHP-1 through the screening of a combinatorial phosphotyrosyl peptide library. Biochemistry, 39, 13251-13260. #15833

43. Beligere, G.S., & Dawson, P.E. (2000) Design, synthesis, and characterization of 4-ester CI2, a model for backbone hydrogen bonding in protein alpha-helices. J. Amer. Chem. Soc., 122, 12079-12082. #16250

44. Besser, D., Muller, B., Agricola, I., & Reissmann, S. (2000) Synthesis of differentially protected N-acylated reduced pseudodipeptides as building units for backbone cyclic peptides. J. Peptide Sci., 6, 130-138. #14943

45. Besser, D., Muller, B., Kleinwachter, P., Greiner, G., Seyfarth, L., Steinmetzer, T., Arad, O., & Reissmann, S. (2000) Synthesis and characterization of octapeptide somatostatin analogues with backbone cyclization: Comparison of different strategies, biological activities and enzymatic stabilities. Journal fur Praktische Chemie-Practical Applications and Applied Chemistry, 342, 537-545. #15837

46. Bibbs, L., Ambulos, N.P., Kates, S.A., Khatri, A., Medzihradszky, K.F., Osapay, G. & Weintraub, S.T. (2000) Strategies for the synthesis of labeled peptides. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 113-114). Kluwer Academic Publisher, Dordrecht. #15710

47. Bishop, B.M., McCafferty, D.G., & Erickson, B.W. (2000) 4'-Aminomethyl-2,2'-bipyridyl-4-carboxylic acid (Abc) and related derivatives: Novel bipyridine amino acids for the solid-phase incorporation of a metal coordination site within a peptide backbone. Tetrahedron, 56, 4629-4638. #14946

48. Blaskovich, M.A., Boatman, P.D., Cao, B., Eguchi, M., Kim, H.O., Lee, M., Little, T., Mathew, F., McCann, I., Mehlin, C., Nakanishi, H., Nelson, S., Nguyen, M., Ogbu, C., Qabar, M.N., Ruan, F., Shea, J.P., Stasiak, M., Urban, J. & Kahn, M. (2000) Highly efficient and versatile construction of secondary structure peptide mimetic libraries: Application to biology and drug development. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 191-193). Kluwer Academic Publisher, Dordrecht. #15726

49. Blondelle, S.E., Crooks, E., Aligue, R., Agell, N., Bachs, O., Esteve, V., Tejero, R., Celda, B., Pastor, M.T., & Perez-Paya, E. (2000) Novel, potent calmodulin antagonists derived from an all-D hexapeptide combinatorial library that inhibit in vivo cell proliferation: Activity and structural characterization. J. Pept. Res., 55, 148-162. #14266

50. Blondelle, S.E., Esteve, V., Celda, B., Pastor, M.T., & Perez-Paya, E. (2000) Influence of the hydrophylic face on the folding ability and stability of a-helix bundles: Relevance to the peptide catalytic activity. J. Pept. Res., 56, 121-131. #15789

51. Bonner, G.G., Davis, P., Stropova, D., Edsall, S., Yamamura, H.I., Porreca, F., & Hruby, V.J. (2000) Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays. J. Med. Chem., 43, 569-580. #14952

52. Bordusa, F. (2000) Nonconventional amide bond formation catalysis: Programming enzyme specificity with substrate mimetics. Braz. J. Med. Biol. Res., 33, 469-485. #14953

53. Borgia, J.A., Oegema, T.R.Jr. & Fields, G.B. (2000) Synthesis and application of a glycoprotein derived from the proteoglycan linkage structure. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 773-774). Kluwer Academic Publisher, Dordrecht. #15751

54. Bourel, L., Carion, O., Gras-Masse, H., & Melnyk, O. (2000) The deprotection of Lys(Mtt) revisited. J. Peptide Sci., 6, 264-270. #14956

55. Bourne, G.T., McGeary, R.P., Golding, S.W., Meutermans, W.D.F., Alewood, P.F. & Smythe, M.L. (2000) An evaluation of a novel safety catch linker for development of cyclic peptide libraries. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 98-99). Kluwer Academic Publisher, Dordrecht. #15705

56. Boykins, R.A., Joshi, M., Syin, C., Dhawan, S., & Nakhasi, H. (2000) Synthesis and construction of a novel multiple peptide conjugate system: strategy for a subunit vaccine design. Peptides, 21, 9-17. #14958

57. Boysen, R.I., & Hearn, M.T.W. (2000) Direct characterisation by electrospray ionisation mass spectroscopy of mercuro-polypeptide complexes after deprotection of acetamidomethyl groups from protected cysteine residues of synthetic polypeptides. J. Biochem. Biophys. Meth., 45, 157-168. #15846

58. Bozo, B., Farkas, J., Toth, G., Wollemann, M., Szucs, M., & Benyhe, S. (2000) Receptor binding and G-protein activation by new Met(5)-enkephalin-Arg(6)-Phe(7) derived peptides. Life Sci., 66, 1241-1251. #14959

59. Brask, J., & Jensen, K.J. (2000) Carbopeptides: Chemoselective ligation of peptide aldehydes to an aminooxy-functionalized D-galactose template. J. Peptide Sci., 6, 290-299. #15448

60. Braslau, R., Axon, J.R., & Lee, B. (2000) Synthesis of N-hydroxy peptides: Chemical ligation of O-acyl hydroxamic acids. Organic Letters, 2, 1399-1401. #14964

61. Buchardt, J., & Meldal, M. (2000) Novel methodology for the solid-phase synthesis of phosphinic peptides. Journal of the Chemical Society-Perkin Transaction 1, 3306-3310. #15852

62. Bui, C.T., Ercole, F., Pham, Y., Campbell, R., Rasoul, F.A., Maeji, N.J., & Ede, N.J. (2000) Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMO) linker on resin and SynPhaseTM grafted solid-supports. J. Peptide Sci., 6, 534-538. #15756

63. Bui, C.T., Bray, A.M., Nguyen, T., Ercole, F., Rasoul, F., Sampson, W., & Maeji, N.J. (2000) Acetophenone-based linker for solid-phase peptide synthesis. J. Peptide Sci., 6, 49-56. #14310

64. Bui, C.T., Bray, A.M., Nguyen, T., Ercole, F., & Maeji, N.J. (2000) Solid phase synthesis of C-terminal peptide amides: Development of a new aminoethyl-polystyrene linker on the MultipinTM solid support. J. Peptide Sci., 6, 243-250. #14408

65. Burgess, K. (2000) Solid-phase organic synthesis. John Wiley & Sons, New York. ISBN 0471318256 #14304

66. Calcagni, A., Gavuzzo, E., Lucente, G., Mazza, F., Morera, E., Paradisi, M.P., & Rossi, D. (2000) Peptides containing the sulfonamide junction. 2. Structure and conformation of Z-Tau-Pro-D-Phe-NHiPr. Biopolymers, 54, 379-387. #15855

67. Camarero, J.A., Adeva, A., & Muir, T.W. (2000) 3-Thiopropionic acid as a highly versatile multidetachable thioester resin linker. Lett. Peptide Sci., 7, 17-21. #15430

68. Cammish, L.E., & Kates, S.A. (2000) Instrumentation for automated solid phase peptide synthesis. Fmoc Solid Phase Peptide Synthesis: A Practical ApproachÉ, 222, 277-302. #15857

69. Carlson, C.B., & Beal, P.A. (2000) Solid-phase synthesis of acridine-based threading intercalator peptides. Bioorg. Med. Chem. Lett., 10, 1979-1982. #15764

70. Carreno, C., Mendez, M.E., Kim, Y.D., Kim, H.J., Kates, S.A., Andreu, D., & Albericio, F. (2000) Nsc and Fmoc Na-amino protection for solid-phase peptide synthesis: A parallel study. J. Pept. Res., 56, 63-69. #15443

71. Cavero, M., Hobbs, A., Madge, D., Motherwell, W.B., Selwood, D., & Potier, P. (2000) Synthesis and biological evaluation of enantiopure thionitrites: The solid-phase synthesis and nitrosation of D-glutathione as a molecular probe. Bioorg. Med. Chem. Lett., 10, 641-644. #14632

72. Cerovsky, V., & Bordusa, F. (2000) Protease-catalyzed fragment condensation via substrate mimetic strategy: A useful combination of solid-phase peptide synthesis with enzymatic methods. J. Pept. Res., 55, 325-329. #14363

73. Chetyrkina, S., Estieu-Gionnet, K., Lain, G., Bayle, M., & Deleris, G. (2000) Synthesis of N-Fmoc-4-[(diethylphosphono)-2',2'-difluoro-1'-hydroxyethyl]phenylalanine, a novel phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. Tetrahedron Lett., 41, 1923-1926. #14347

74. Cho, J.K., Park, B.D., & Lee, Y.S. (2000) A novel core-shell type polymer support for solid-phase peptide synthesis. Tetrahedron Lett., 41, 7481-7485. #15861

75. Cilli, E.M., Jubilut, G.N., Ribeiro, S.C.F., Oliveira, E., & Nakaie, C.R. (2000) Importance of the solvation degree of peptide-resin beads for amine groups determination by the picric acid method. J. Braz. Chem. Soc., 11, 474-478. #15862

76. Clippingdale, A.B., Barrow, C.J., & Wade, J.D. (2000) Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation. J. Peptide Sci., 6, 225-234. #14405

77. Conde-Frieboes, K., Andersen, S., & Breinholt, J. (2000) Synthesis of symmetrical dimeric N,N'-linked peptides on solid support by olefin metathesis. Tetrahedron Lett., 41, 9153-9156. #16159

78. Cotton, G.J., & Muir, T.W. (2000) Generation of a dual-labeled fluorescence biosensor for Crk-II phosphorylation using solid-phase expressed protein ligation. Chem. Biol., 7, 253-261. #15864

79. Cruz, L.J., Quintana, D., Iglesias, E., Garcia, Y., Huerta, V., Garay, H.E., Duarte, C., & Reyes, O. (2000) Immunogenicity comparison of a multi-antigenic peptide bearing V3 sequences of the human immunodeficiency virus type 1 with TAB9 protein in mice. J. Peptide Sci., 6, 217-224. #14402

80. Cudic, M., Wade, J.D., & Otvos, L.Jr. (2000) Convenient synthesis of a head-to-tail cyclic peptide containing an expanded ring. Tetrahedron Lett., 41, 4527-4531. #14594

81. Dai, X., Su, Z., & Liu, J.O. (2000) An improved synthesis of a selective aVb3-integrin antagonist cyclo(-RGDfK-). Tetrahedron Lett., 41, 6295-6298. #15531

82. Dal, X.D., Su, Z., & Liu, J.O. (2000) An improved synthesis of a selective alpha(v)beta(3)-integrin antagonist cyclo(-RGDfK-). Tetrahedron Lett., 41, 6295-6298. #15868

83. Dankwardt, S.M., Billedeau, R.J., Lawley, L.K., Abbot, S.C., Martin, R.L., Chan, C.S., Van Wart, H.E., & Walker, K.A.M. (2000) Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase. Bioorg. Med. Chem. Lett., 10, 2513-2516. #15870

84. Denis, B., & Trifilieff, E. (2000) Synthesis of palmitoyl-thioester T-cell epitopes of myelin proteolipid protein (PLP). Comparison of two thiol protecting groups (StBu and Mmt) for on-resin-acylation. J. Peptide Sci., 6, 372-377. #15450

85. Dionyssopoulou, H., Mouzaki, A., Slootstra, J., Puijk, W., Meloen, R., Cordopatis, P., & Sotiropoulou, G. (2000) Synthetic peptides as putative therapeutic agents in transplantation medicine: Application of PEPSCAN to the identification of functional sequences in the extracellular domain of the interleukin-2 receptor beta chain (IL-2R beta). J. Immunol. Method, 241, 83-95. #15882

86. Dolence, E.K., Dolence, J.M., & Poulter, C.D. (2000) Solid-phase synthesis of a farnesylated CaaX peptide library: Inhibitors of the Ras CaaX endoprotease. Journal of Combinatorial Chemistry, 2, 522-536. #15605

87. Drakopoulou, E., Uray, K., Mezo, G., Price, M.R., Vita, C., & Hudecz, F. (2000) Synthesis and antibody recognition of mucin 1 (MUC1)-a-conotoxin chimera. J. Peptide Sci., 6, 175-185. #14361

88. Dufau, I., & Mazarguil, H. (2000) Design of a fluorescent amino acid derivative usable in peptide synthesis. Tetrahedron Lett., 41, 6063-6066. #15517

89. Dutta, A.S., Gormley, J.J., Coath, M., Hassall, L., Hayward, C.F., Gellert, P.R., Kittlety, R.S., Alcock, P.J., Ferguson, R., Halterman, T., Jamieson, A., Moors, J.A., Moores, J.M., Rees, A., Wood, L.J., Reilly, C.F., & Haworth, D. (2000) Potent cyclic peptide inhibitors of VLA-4 (a4b1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation. J. Peptide Sci., 6, 398-412. #15453

90. Dutta, A.S., Crowther, M., Gormley, J.J., Hassall, L., Hayward, C.F., Gellert, P.R., Kittlety, R.S., Alcock, P.J., Jamieson, A., Moores, J.M., Rees, A., Wood, L.J., Reilly, C.F., & Haworth, D. (2000) Potent cyclic monomeric and dimeric peptide inhibitors of VLA-4 (alpha(4)beta(1) integrin)-mediated cell adhesion based on the Ile-Leu-Asp-Val tetrapeptide. J. Peptide Sci., 6, 321-341. #15892

91. Ede, N.J., Eagle, S.N., Wickham, G., Bray, A.M., Warne, B., Shoemaker, K., & Rosenberg, S. (2000) Solid phase synthesis of peptide aldehyde protease inhibitors. Probing the proteolytic sites of hepatitis C virus polyprotein. J. Peptide Sci., 6, 11-18. #13956

92. Egleton, R.D., Mitchell, S.A., Huber, J.D., Janders, J., Stropova, D., Polt, R., Yamamura, H.I., Hruby, V.J., & Davis, T.P. (2000) Improved bioavailability to the brain of glycosylated Met-enkephalin analogs. Brain Res., 881, 37-46. #15894

93. El-Agnaf, O.M.A., Mahil, D.S., Patel, B.P., & Austen, B.M. (2000) Oligomerization and toxicity of beta-amyloid-42 implicated in Alzheimer's disease. Biochem. Biophys. Res. Commun., 273, 1003-1007. #15895

94. Falb, E., Yechezkel, T., Salitra, Y., Gellerman, G., Muller, D. & Gilon, C. (2000) In situ generation of Fmoc amino acid chlorides for extremely difficult couplings to sterically hindered secondary amines in solid-phase peptide synthesis. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 55-57). Kluwer Academic Publisher, Dordrecht. #15694

95. Falchi, A., Giacomelli, G., Porcheddu, A., & Taddei, M. (2000) 4-(4,6-Dimethoxy[1,3,5]triazin-2-yl)-4-methyl-morpholinium chloride (DMTMM): A valuable alternative to PyBOP for solid phase peptide synthesis. Synlett, 275-277. #15026

96. Fields, G.B., Tam, J.P., & Barany, G. (2000) Peptides for the New Millennium. Kluwer Academic Publisher, Dordrecht. ISBN 0792364457 #15688

97. Fiertek, D., Gromowska, M., Andersen, A.R., Hansen, P.H., Majewski, T., & Izdebski, J. (2000) Primary structure of fox (Vulpes vulpes) proinsulin based on sequence studies of pancreatic peptides and cDNA. J. Peptide Sci., 6, 413-419. #15454

98. Freund, E., Vitali, F., Linden, A., & Robinson, J.A. (2000) Solid-phase synthesis using (allyloxy)carbonyl(Alloc) chemistry of a putative heptapeptide intermediate in vancomycin biosynthesis containing m-chloro-3-hydroxytyrosine. Helv. Chim. Acta, 83, 2572-2579. #15902

99. Fruchart, J.S., Grandjean, C., Bonnet, D., Rommens, C., Gras-Masse, H. & Melnyk, O. (2000) A new tartaric acid-based linker for the synthesis of C-terminal peptide a-oxo-aldehydes. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 104-106). Kluwer Academic Publisher, Dordrecht. #15708

100. Fruchart, J.S., Lippens, G., Warrass, R., Seetharaman, C., Dhalluin, C., & Boutillon, C. (2000) The Chemical Shift Index method applied to resin-bound peptides. J. Pept. Res., 56, 346-351. #16286

101. Ghosh, A.K., & Fan, E. (2000) A novel method for sequence independent incorporation of activated/protected cysteine in Fmoc solid phase peptide synthesis. Tetrahedron Lett., 41, 165-168. #13884

102. Goetz, M., Rusconi, F., Belghazi, M., Schmitter, J.M., & Dufourc, E.J. (2000) Purification of the c-erbB2/neu membrane-spanning segment: A hydrophobic challenge. Journal of Chromatography B, 737, 55-61. #13985

103. Goldstein, A.S., & Gelb, M.H. (2000) An alternate preparation of thioester resin linkers for solid-phase synthesis of peptide C-terminal thioacids. Tetrahedron Lett., 41, 2797-2800. #14539

104. Gordon, L.M., Lee, K.Y.C., Lipp, M.M., Zasadzinski, J.A., Walther, F.J., Sherman, M.A., & Waring, A.J. (2000) Conformational mapping of the N-terminal segment of surfactant protein B in lipid using 13C-enhanced Fourier transform infrared spectroscopy. J. Pept. Res., 55, 330-347. #14364

105. Gottschling, D., Seliger, H., Tarrason, G., Piulats, J., Wiersma, M., & Eritja, R. (2000) Synthesis of peptide nucleic acid-peptide chimeras carrying the c-myc tag-sequence. Lett. Peptide Sci., 7, 35-39. #15433

106. Groth, T., Meldal, M. & Bock, K. (2000) Backbone amide protection in solid-phase synthesis of peptide isosters derived from N-terminal g-aldehydes. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 146-147). Kluwer Academic Publisher, Dordrecht. #15712

107. Gu, C.G., Tsaprailis, G., Breci, L., & Wysocki, V.H. (2000) Selective gas-phase cleavage at the peptide bond terminal to aspartic acid in fixed-charge derivatives of asp-containing peptides. Anal. Chem., 72, 5804-5813. #16294

108. Guichard, G., Semetey, V., Didierjean, C., Aubry, A., Rodriguez, M. & Briand, J.P. (2000) An efficient preparation of O-succinimidyl carbamate derivatives from N-protected b-amino acids: Application to the synthesis of urea containing pseudopeptides and oligoureas. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 148-149). Kluwer Academic Publisher, Dordrecht. #15713

109. Guillaumie, F., Kelly, N.M., Kappel, J.C., Barany, G. & Jensen, K.J. (2000) Solid-phase synthesis of peptide aldehydes by a Backbone Amide Linker (BAL) strategy. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 100-101). Kluwer Academic Publisher, Dordrecht. #15706

110. Guillaumie, F., Kappel, J.C., Kelly, N.M., Barany, G., & Jensen, K.J. (2000) Solid-phase synthesis of C-terminal peptide aldehydes from amino acetals anchored to a backbone amide linker (BAL) handle. Tetrahedron Lett., 41, 6131-6135. #15518

111. Gururaja, T.L., Narasimhamurthy, S., Payan, D.G., & Anderson, D.C. (2000) A novel artificial loop scaffold for the noncovalent constraint of peptides. Chem. Biol., 7, 515-527. #15921

112. Hargittai, B., Annis, I., & Barany, G. (2000) Application of solid-phase Ellman's reagent for preparation of disulfide-paired isomers of a-conotoxin SI. Lett. Peptide Sci., 7, 47-52. #15434

113. Hargittai, B., Annis, I. & Barany, G. (2000) Application of solid-phase Ellman's reagent for preparation of disulfide-paired isomers of a-conotoxin SI. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 94-95). Kluwer Academic Publisher, Dordrecht. #15703

114. Harris, J.L., Backes, B.J., Leonetti, F., Mahrus, S., Ellman, J.A., & Craik, C.S. (2000) Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries. Proc. Natl. Acad. Sci. USA, 97, 7754-7759. #15073

115. Heinonen, P., Rosenberg, J., & Lonnberg, H. (2000) Synthesis of achiral alpha,alpha-bis(aminomethyl)-beta-alanines and their use in the preparation of branched beta-peptide conjugates of N-2-alkyl-1,2,3,4-tetrahydroisoquinolines on solid support. Eur. J. Org. Chem., 3647-3652. #15926

116. Hernandez, J.F., Gagnon, J., Chiche, L., Nguyen, T.M., Andrieu, J.P., Heitz, A., Hong, T.T., Pham, T.T.C., & Nguyen, D.L. (2000) Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structure. Biochemistry, 39, 5722-5730. #15083

117. Hernandez, M., Pozo, L., Gomez, I., & Melchor, A. (2000) Chimeric synthetic peptide as antigen for immunodiagnosis of HIV-1 infection. Biochem. Biophys. Res. Commun., 272, 259-262. #15084

118. Hilpert, K., Hansen, G., Wessner, H., Schneider-Mergener, J., & Hohne, W. (2000) Characterizing and optimizing protease/peptide inhibitor interactions, a new application for spot synthesis. J. Biochem. Tokyo, 128, 1051-1057. #16299

119. Hlavacek, J., Marcova, R., Budesinsky, M., & Slaninova, J. (2000) 1-Deamino-1(15)-carba and -dicarba analogues of endothelin-1. Collect. Czech. Chem. Commun., 65, 407-424. #15088

120. Holm, A., Jorgensen, R.M., Ostergaard, S., & Theisen, M. (2000) Ligand-presenting assembly: A method for C- and N-terminal antigen presentation. J. Pept. Res., 56, 105-113. #15447

121. Howe, J., Quibell, M., & Johnson, T. (2000) A new generation of reversible backbone-amide protection for the solid phase synthesis of difficult sequences. Tetrahedron Lett., 41, 3997-4001. #14563

122. Hu, B.H., & Messersmith, P.B. (2000) Protection of 3,4-dihydroxyphenylalanine (DOPA) for Fmoc solid-phase peptide synthesis. Tetrahedron Lett., 41, 5795-5798. #15423

123. Ishii, A., Hojo, H., Kobayashi, A., Nakamura, K., Nakahara, Y., & Ito, Y. (2000) A facile silyl linker strategy for the solid-phase synthesis of protected glycopeptide: Synthesis of an N-terminal fragment of IL-2 (1-10). Tetrahedron, 56, 6235-6243. #15773

124. Ius, A., Bacigalupo, M.A., Longhi, R., & Meroni, G. (2000) Selectively conjugated melittins for liposome time-resolved fluoroimmunoassay of theophylline in serum. Fresenius J. Anal. Chem., 366, 869-872. #15112

125. Jensen, K.J., & Barany, G. (2000) Carbopeptides: Carbohydrates as potential templates for de novo design of protein models. J. Pept. Res., 56, 3-11. #15119

126. Jiaang, W.T., Tseng, P.H., & Chen, S.T. (2000) Facile solid phase synthesis of YEE(ah-GalNAc)(3), a ligand with known high affinity for the asialoglycoprotein receptor. Synlett, 797-800. #15123

127. Jiaang, W.T., Chang, M.Y., Tseng, P.H., & Chen, S.T. (2000) A concise synthesis of the O-glycosylated amino acid building block; using phenyl selenoglycoside as a glycosyl donor. Tetrahedron Lett., 41, 3127-3130. #15122

128. Johansson, A., Akerblom, E., Ersmark, K., Lindeberg, G., & Hallberg, A. (2000) An improved procedure for N- to C-directed (inverse) solid-phase peptide synthesis. Journal of Combinatorial Chemistry, 2, 496-507. #15602

129. Jones, R.C.F., & Dickson, J. (2000) An amidazoline pseudodipeptide suitable for solid phase peptide synthesis. J. Peptide Sci., 6, 621-624. #16153

130. Karlstrom, A., Rosenthal, K., & Unden, A. (2000) Study of the alkylation propensity of cations generated by acidolytic cleavage of protecting groups in Boc chemistry. J. Pept. Res., 55, 36-40. #14033

131. Kempe, M. (2000) Oxytocin receptor mimetics prepared by molecular imprinting. Lett. Peptide Sci., 7, 27-33. #15432

132. Kennedy, K.J., Lundquist, J.T.IV., Simandan, T.L., Kokko, K.P., Beeson, C.C., & Dix, T.A. (2000) Design rationale, synthesis, and chararacterization of non-natural analogs of the cationic amino acids arginine and lysine. J. Pept. Res., 55, 348-358. #14365

133. Kim, H.J. & Samukov, V.V. (2000) Na-2-(4-Nitrophenylsulfonyl)ethoxycarbonyl (Nsc) as an amino-protecting group and its application for peptide synthesis. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 50-52). Kluwer Academic Publisher, Dordrecht. #15692

134. Klugmann, K., Karawajczyk, B., Kunikowska, D., Glosnicka, R., & Mackiewicz, Z. (2000) Synthesis of hepatitis C virus protein fragments and evaluation of their immunogenicity. Part II. Polish J. Chem., 74, 1085-1090. #15955

135. Koeller, K.M., Smith, M.E.B., & Wong, C.H. (2000) Tyrosine sulfation on a PSGL-1 glycopeptide influences the reactivity of glycosyltransferases responsible for synthesis of the attached O-glycan. J. Amer. Chem. Soc., 122, 742-743. #15146

136. Koeller, K.M., Smith, M.E.B., & Wong, C.H. (2000) Chemoenzymatic synthesis of PSGL-1 glycopeptides: Sulfation on tyrosine affects glycosyltransferase-catalyzed synthesis of the O-glycan. Bioorg. Med. Chem., 8, 1017-1025. #15145

137. Komba, S., Werdelin, O., Jensen, T., & Meldal, M. (2000) Synthesis of tumor associated sialyl-T-glycopeptides and their immunogenicity. J. Peptide Sci., 6, 585-593. #16150

138. Korol'kov, V.I., Platonova, G.A., Azanova, V.V., Tennikova, T.B., & Vlasov, G.P. (2000) In situ preparation of peptidylated polymers as ready-to-use adsorbents for rapid immunoaffinity chromatography. Lett. Peptide Sci., 7, 53-61. #15435

139. Kudryavtseva, E.V., Sidorova, M.V., Ovchinnikov, M.V., & Bespalova, Z.D. (2000) Hydrogen peroxide for disulfide bridge formation in methionine-containing peptides. J. Peptide Sci., 6, 208-216. #14403

140. Kumar, K.S., Pillai, V.N.R., & Das, M.R. (2000) Syntheses of four peptides from the immunodominant region of hepatitis C viral pathogens using PS-TTEGDA support for the investigation of HCV infection in human blood. J. Pept. Res., 56, 88-96. #15446

141. Laczko, I., Vas, E., Toth, G.K., Marczinovits, I., Kiss, M., Husz, S., & Molnar, J. (2000) Conformational consequences of coupling bullous pemphigoid antigenic peptides to glutathione-S-transferase and their diagnostic significance. J. Peptide Sci., 6, 378-386. #15451

142. Lauer-Fields, J.L., Tuzinski, K.A., Shimokawa, K., Nagase, H., & Fields, G.B. (2000) Hydrolysis of triple-helical collagen peptide models by matrix metalloproteinases. Journal of Biological Chemistry, 275, 13282-13290. #15157

143. Lawrence, S.A. (2000) Hydrazine carboxylate t-butylester (BOC-hydrazide): Its properties and applications. Chim. Oggi, 18, 20-24. #14573

144. Lebl, M., Ma, J., Pires, J., Dooley, C. & Houghten, R.A. (2000) Rapid parallel synthesis of 584 betides, peptides composed largely of beta-amino acids with side-chains not found in natural peptides. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 174-175). Kluwer Academic Publisher, Dordrecht. #15719

145. Lebl, M. (2000) New technique for high-throughput synthesis of peptides, peptidomimetics and nonpeptide small organic molecule arrrays. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 164-166). Kluwer Academic Publisher, Dordrecht. #15715

146. Lee, Y.S., Lee, H.J., Lee, D. & Kim, H.J. (2000) Nsc- and Fmoc-amino acids for automated solid-phase peptide synthesis: Comparative study of the stability in various conditions. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 53-54). Kluwer Academic Publisher, Dordrecht. #15693

147. Leelasvatanakij, L., & Aldrich, J.V. (2000) A solid-phase synthetic strategy for the preparation of peptide-based affinity labels: Synthesis of dynorphin A analogs. J. Pept. Res., 56, 80-87. #15445

148. Li, P., & Xu, J.C. (2000) HOBt and HOAt-derived immonium salts: New and highly efficient coupling reagents for peptide synthesis. Tetrahedron Lett., 41, 721-724. #14229

149. Li, P., & Xu, J.C. (2000) (1H-Benzotriazol-1-yloxy)-N,N-dimethylmethaniminium hexachloroantimonate (BOMI), a novel coupling reagent for solution and solid-phase peptide synthesis. J. Pept. Res., 55, 110-119. #14265

150. Li, P., & Xu, J.C. (2000) Total synthesis of cyclosporin O both in solution and in the solid phase using novel thiazolium-, immonium-, and pyridinium-type coupling reagents: BEMT, BDMP, and BEP. J. Org. Chem., 65, 2951-2958. #15777

151. Li, Q., Moutiez, M., Charbonnier, J.B., Vaudry, K., Menez, A., Quemeneur, E., & Dugave, C. (2000) Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: New insights for the development of novel anti-HIV-1 drugs. J. Med. Chem., 43, 1770-1779. #15171

152. Li, W.R., Lin, S.T., & Yang, J.H. (2000) An expedient N-termimal attachment methodology for the solid phase peptide synthesis. Synlett, 1608-1612. #15972

153. Li, X., Zhang, L., Hall, S.E., & Tam, J.P. (2000) A new ligation method for N-terminal tryptophan-containing peptides using the Pictet-Spengler reaction. Tetrahedron Lett., 41, 4069-4073. #14591

154. Licha, K., Bhargava, S., Rheinlander, C., Becker, A., Schneider-Mergener, J., & Volkmer-Engert, R. (2000) Highly parallel nano-synthesis of cleavable peptide-dye conjugates on cellulose membranes. Tetrahedron Lett., 41, 1711-1715. #14337

155. Liu, C.F., Rao, C. & Tam, J.P. (2000) Use of orthogonal ligation methods for the synthesis of a hetero peptide dendrimer. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 118-119). Kluwer Academic Publisher, Dordrecht. #15711

156. Liu, G., Fan, Y., Zhao, D., Zhao, Z.G. & Lam, K.S. (2000) Development of novel peptide antibiotics for vancomycin resistant infection using the "one-bead, one-compound" combinatorial library method. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 736-737). Kluwer Academic Publisher, Dordrecht. #15748

157. Loidl, G., Musiol, H.J., Groll, M., Huber, R., & Moroder, L. (2000) Synthesis of bivalent inhibitors of eucaryotic proteasomes. J. Peptide Sci., 6, 36-46. #14062

158. Malkar, N.B., Lauer-Fields, J.L., & Fields, G.B. (2000) Convenient synthesis of glycosylated hydroxylysine derivatives for use in solid-phase peptide synthesis. Tetrahedron Lett., 41, 1137-1140. #14267

159. Malkinson, J.P., Falconer, R.A., & Toth, I. (2000) Synthesis of C-terminal glycopeptides from resin-bound glycosyl azides via a modified Staudinger reaction. J. Org. Chem., 65, 5249-5252. #15779

160. Marastoni, M., Bazzaro, M., Gavioli, R., Micheletti, F., Traniello, S., & Tomatis, R. (2000) Design of dimeric peptides obtained from a subdominant Epstein-Barr virus LMP2-derived epitope. Eur. J. Med. Chem., 35, 593-598. #15780

161. Mathieu, M.N., Wade, J.D., Tan, Y.Y., Summers, R.J., & Tregear, G.W. (2000) Novel strategy for the synthesis of template-assembled analogues of rat relaxin. J. Peptide Sci., 6, 235-242. #14407

162. Matsumura, S., Sakamoto, S., Ueno, A., & Mihara, H. (2000) Construction of alpha-helix peptides with beta-cyclodextrin and dansyl units and their conformational and molecular sensing properties. Chem. Eur. J., 6, 1781-1788. #15200

163. Mayo, K.H. (2000) Recent advances in the design and construction of synthetic peptides: For the love of basics or just for the technology of it. Trends Biotech., 18, 212-217. #15203

164. McBride, J.D., Freeman, H.N., & Leatherbarrow, R.J. (2000) Identification of chymotrypsin inhibitors from a second-generation template assisted combinatorial peptide library. J. Peptide Sci., 6, 446-452. #15611

165. McMurray, J.S., Khabashesku, O., Birtwistle, J.S., & Wang, W. (2000) Convenient preparartion of 4-(tetrazol-5-yl)-phenylalanine for use in Fmoc-based solid-phase peptide synthesis. Tetrahedron Lett., 41, 6555-6558. #15524

166. McNamara, J.F., Lombardo, H., Pillai, S.K., Jensen, I., Albericio, F., & Kates, S.A. (2000) An efficient solid-phase strategy for the construction of chemokines. J. Peptide Sci., 6, 512-518. #15755

167. Melnyk, O., Fehrentz, J.A., Martinez, J., & Gras-Masse, H. (2000) Functionalization of peptides and proteins by aldehyde or keto groups. Biopolymers (Pept. Sci. ), 55, 165-186. #16436

168. Mergler, M., Dick, F., Gosteli, J., & Nyfeler, R. (2000) Protected peptide p-nitroanilides by solid-phase synthesis. Lett. Peptide Sci., 7, 1-7. #15429

169. Merrifield, B., Barany, G., Deber, C.M., Goodman, M., Hodges, R.S., Hruby, V.J., Muir, T.W., Offord, R., Spatola, A.F., Veber, D.F. & Fields, G.B. (2000) Perspectives for the new peptide millennium. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 797-804). Kluwer Academic Publisher, Dordrecht. #15754

170. Meutermans, W.D.F., Golding, S.W., Bourne, G.T., Miranda, L.P., Dooley, M.J., Alewood, P.F. & Smythe, M.L. (2000) Synthesis of small cyclic peptides: An auxiliary approach to address the "difficult cyclization" problem. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 183-185). Kluwer Academic Publisher, Dordrecht. #15723

171. Miao, Z.W., & Tam, J.P. (2000) Dehydropeptides from orthogonal ligation of unprotected peptides. Organic Letters, 2, 3711-3713. #16003

172. Micklatcher, C.L., Lutgring, R.A. & Chmielewski, J. (2000) Synthetic steps toward de novo designed catalytic five helix bundle proteins. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 496-497). Kluwer Academic Publisher, Dordrecht. #15742

173. Miranda, L.P., & Alewood, P.F. (2000) Challenges for protein chemical synthesis in the 21st century: Bringing genomics and proteomics. Biopolymers (Pept. Sci. ), 55, 217-226. #16439

174. Miranda, L.P., Meutermans, W.D.F., Smythe, M.L., & Alewood, P.F. (2000) Activated O -> N acyl transfer auxiliary: Efficient amide-backbone substitution of hindered "difficult" peptides. J. Org. Chem., 65, 5460-5468. #16006

175. Monnee, M.C.F., Marijne, M.F., Brouwer, A.J., & Liskamp, R.M.J. (2000) A practical solid phase synthesis of oligopeptidosulfonamide foldamers. Tetrahedron Lett., 41, 7991-7995. #15640

176. Moraes, C.M., Bemquerer, M.P., & Miranda, M.T.M. (2000) Solvolysis and aminolysis on peptidyl-Kaiser oxime resin assisted by Ca2+ and Eu3+: A mild procedure to prepare a-methyl and -ethyl esters of protected peptides. J. Pept. Res., 55, 279-288. #14648

177. Nishiuchi, Y., Nishio, H., Inui, T., Bodi, J., & Kimura, T. (2000) Combined solid-phase and solution approach for the synthesis of large peptides or proteins. J. Peptide Sci., 6, 84-93. #14311

178. Nishiyama, Y., Shikama, S., Morita, K., & Kurita, K. (2000) Cyclohexyl ether as a new hydroxy-protecting group for serine and threonine in peptide synthesis. Journal of the Chemical Society-Perkin Transaction 1, 1949-1954. #779

179. Noda, M. (2000) 2-Methoxy-10,11-dihydro-5H-dibenzo[a,d]cycloheplen-5-one: Application for the peptide amide linkers and guanidino protection of arginine during Fmoc solid-phase peptide synthesis. Amer. Lab., 32, 44. #15222

180. Nowick, J.S., Chung, D.M., Maitra, K., Maitra, S., Stigers, K.D., & Sun, Y. (2000) An unnatural amino acid that mimics a tripeptide beta-strand and forms beta-sheetlike hydrogen-bonded dimers. J. Amer. Chem. Soc., 122, 7654-7661. #16028

181. O'Donnell, M.J., Drew, M.D., Pottorf, R.S., & Scott, W.L. (2000) UPS on Weinreb resin: A facile solid-phase route to aldehyde and ketone derivatives of "unnatural" amino acids and peptides. Journal of Combinatorial Chemistry, 2, 172-181. #14381

182. Okayama, T., Burritt, A., & Hruby, V.J. (2000) 4-Alkoxy-2-hydroxybenzaldehyde (AHB): A versatile aldehyde linker for solid-phase synthesis of C-terminal modified peptides and peptidomimetics. Organic Letters, 2, 1787-1790. #15228

183. Osapay, K., Tran, D., Ladokhin, A.S., White, S.H., Henschen, A.H., & Selsted, M.E. (2000) Formation and characterization of a single Trp-Trp cross-link in indolicidin that confers protease stability without altering antimicrobial activity. Journal of Biological Chemistry, 275, 12017-12022. #15232

184. Otaka, A. (2000) Development of new deprotecting methodologies for peptides and application to studies on signaling mechanism. Yakugaku Zasshi - Journal of the Pharmaceutical Society of Japan, 120, 54-67. #14096

185. Otaka, A., Mitsuyama, E., Kinoshita, T., Tamamura, H., & Fujii, N. (2000) Stereoselective synthesis of CF2-substituted phosphothreonine mimetics and their incorporation into peptides using newly developed deprotection procedures. J. Org. Chem., 65, 4888-4899. #16032

186. Otvos, L.Jr., Bokonyi, K., Pease, A.M., Giles-Davis, W., Rogers, M.E., Hintz, P.A., Hoffmann, R. & Ertl, H.C.J. (2000) In situ identification of T helper cell epitopes from a cellulose-bound peptide array. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 685-686). Kluwer Academic Publisher, Dordrecht. #15746

187. Pellois, J.P., Wang, W., & Gao, X. (2000) Peptide synthesis based on t-Boc chemistry and solution photogenerated acids. Journal of Combinatorial Chemistry, 2, 355-360. #14688

188. Percot, A., Zhu, X.X., & Lafleur, M. (2000) Immobilization of lipid vesicles on polymer support via an amphiphilic peptidic anchor: Application to a membrane enzyme. Bioconjug. Chem., 11, 674-678. #16043

189. Perodin, J., Bouley, R., Escher, E., Assimomytis, N., Magafa, V., Manessi-Zoupa, E., Theodoropoulos, D., & Cordopatis, P. (2000) Angiotensin II analogues with sulphur-containing side-chains in position 5. A structure-activity relationship study. Arzneim. -Forsch., 50, 526-529. #15247

190. Pfeifer, M.E., Moehle, K., Linden, A., & Robinson, J.A. (2000) Synthesis and solution conformation of beta-hairpin mimetics utilizing a template derived from (2S,3R,4R)-diaminoproline. Helv. Chim. Acta, 83, 444-464. #15251

191. Planas, M., Bardaji, E., & Barany, G. (2000) Synthesis of cyclic peptide hybrids with amino acid and nucleobase side-chains. Tetrahedron Lett., 41, 4097-4100. #14592

192. Planas, M., Bardaji, E. & Barany, G. (2000) Chemical synthesis of cyclic peptide nucleic acid-peptide hybrids. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 786-787). Kluwer Academic Publisher, Dordrecht. #15753

193. Pons, M., Albericio, F., Royo, M., & Giralt, E. (2000) Disulfide bonded cyclic peptide dimers and trimers: An easy entry to high symmetry peptide frameworks. Synlett, 172-181. #15255

194. Priem, G., Rocheblave, L., De Michelis, C., Courcambeck, J., & Kraus, J.L. (2000) Synthesis and chemical reactivity of thiophenoxyphenylalanine bioisosteres, suitable synthons for the design of HIV protease inhibitors. J. Chem. Soc. Perkin Trans. 1, 819-824. #15258

195. Rabanal, F., Pastor, J.J., Nicolas, E., Albericio, F., & Giralt, E. (2000) Synthesis of aspartimide-free protected peptides on base-labile functionalized resins. Tetrahedron Lett., 41, 8093-8096. #15625

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300. Canne, L.E., Botti, P., Simon, R.J., Chen, Y.J., Dennis, E.A., & Kent, S.B.H. (1999) Chemical protein synthesis by solid phase ligation of unprotected peptide segments. J. Amer. Chem. Soc., 121, 8720-8727. #14232

301. Ceruso, M.A., McComsey, D.F., Leo, G.C., Andrade-Gordon, P., Addo, M.F., Scarborough, R.M., Oksenberg, D., & Maryanoff, B.E. (1999) Thrombin receptor-activating peptides (TRAPs): Investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies. Bioorg. Med. Chem., 7, 2353-2371. #13926

302. Cervini, L., Theobald, P., Corrigan, A., Craig, A.G., Rivier, C., Vale, W., & Rivier, J. (1999) Corticotropin releasing factor (CRF) agonists with reduced amide bonds and Ser(7) substitutions. J. Med. Chem., 42, 761-768. #12720

303. Chaloin, L., Mery, J., Van Mau, N., Divita, G., & Heitz, F. (1999) Synthesis of a template-associated peptide designed as a transmembrane ion channel former. J. Peptide Sci., 5, 381-391. #13928

304. Chen, H., Cong, L.N., Li, Y.H., Yao, Z.J., Wu, L., Zhang, Z.Y., Burke, T.R., & Quon, M.J. (1999) Phosphotyrosyl mimetic peptide reverses impairment of insulin-stimulated translocation of GLUT4 caused by overexpression of PTP1B in rat adipose cells. Biochemistry, 38, 384-389. #12722

305. Chen, L., Golser, R., Machova, A., Slaninova, J., & Barany, G. (1999) Chemical syntheses and biological studies on dimeric chimeras of oxytocin and the V-2-antagonist, d(CH2)(5)[D-Ile(2),Ile(4)]arginine vasopressin. J. Med. Chem., 42, 5002-5009. #13932

306. Chitnumsub, P., Fiori, W.R., Lashuel, H.A., Diaz, H., & Kelly, J.W. (1999) The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution. Bioorg. Med. Chem., 7, 39-59. #12724

307. Chiva, C., Vilaseca, M., Giralt, E., & Albericio, F. (1999) An HPLC-ESMS study on the solid-phase assembly of C-terminal proline peptides. J. Peptide Sci., 5, 131-140. #12725

308. Cilli, E.M., Marchetto, R., Schreier, S., & Nakaie, C.R. (1999) Correlation between the mobility of spin-labeled peptide chains and resin solvation: An approach to optimize the synthesis of aggregating sequences. J. Org. Chem., 64, 9118-9123. #13937

309. Clippingdale, A.B., Macris, M., Wade, J.D., & Barrow, C.J. (1999) Synthesis and secondary structural studies of penta(acetyl-Hmb)A beta(1-40). J. Pept. Res., 53, 665-672. #12945

310. Cornille, F., Wecker, K., Loffet, A., Genet, R., & Roques, B. (1999) Efficient solid-phase synthesis of Vpr from HIV-1 using low quantities of uniformly 13C-, 15N-labeled amino acids for NMR structural studies. J. Pept. Res., 54, 427-435. #13787

311. Cotton, G.J., & Muir, T.W. (1999) Peptide ligation and its application to protein engineering. Chem. Biol., 6, R247-R256. #13939

312. Coupal, M., De Lean, A., McNicoll, N., & Fournier, A. (1999) Development of p-benzoylbenzoylated [N,C,rANP(1-28)]pBNP32 (pBNP1) derivatives and affinity photolabeling of the bovine NPR-A receptor. Biochem. Biophys. Res. Commun., 258, 81-86. #12948

313. Cudic, M., Bulet, P., Hoffmann, R., Craik, D.J., & Otvos, L.Jr. (1999) Chemical synthesis, antibacterial activity and conformation of diptericin, an 82-mer peptide originally isolated from insects. Eur. J. Biochem., 266, 549-558. #14234

314. Daquinag, A.C., Sato, T., Koda, H., Takao, T., Fukuda, M., Shimonishi, Y., & Tsukamoto, T. (1999) A novel endogenous inhibitor of phenoloxidase from Musca domestica has a cystine motif commonly found in snail and spider toxins. Biochemistry, 38, 2179-2188. #12728

315. Davies, M., & Bradley, M. (1999) Internal resin capture: A self purification method for the synthesis of C-terminally modified peptides. Tetrahedron, 55, 4733-4746. #12730

316. Davis, B.G. (1999) Recent developments in glycoconjugates. J. Chem. Soc. Perkin Trans. 1, 3215-3237. #13943

317. Dawson, N.F., Tan, Y.Y., Macris, M., Otvos, L., Summers, R.J., Tregear, G.W., & Wade, J.D. (1999) Solid-phase synthesis of ovine Leydig cell insulin-like peptide: A putative ovine relaxin? J. Pept. Res., 53, 542-547. #12953

318. Dawson, N.F., Craik, D.J., McManus, A.M., Dashper, S.G., Reynolds, E.C., Tregear, G.W., Otvos, L., & Wade, J.D. (1999) Chemical synthesis, characterization and activity of RK-1, a novel alpha-defensin-related peptide. J. Peptide Sci., 6, 19-25. #13945

319. de Bont, D.B.A., Sliedregt-Bol, K.M., Hofmeyer, L.J.F., & Liskamp, R.M.J. (1999) Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation. Bioorg. Med. Chem., 7, 1043-1047. #13499

320. Debenham, S.D., Cossrow, J., & Toone, E.J. (1999) Synthesis of alpha- and beta-carbon-linked serine analogues of the P-k trisaccharide. J. Org. Chem., 64, 9153-9163. #13950

321. DeGrado, W.F., Schneider, J.P., & Hamuro, Y. (1999) The twists and turns of beta-peptides. J. Pept. Res., 54, 206-217. #13951

322. Delarue, S., & Sergheraert, C. (1999) PyBroP: A convenient activator for the synthesis of formamidines. Tetrahedron Lett., 40, 5487-5490. #13122

323. Doleckova, L., Pavlik, M., Mares, M. & Kluh, I. (1999) Inhibitory specificity spectrum of peptide a-amylase inhibitors designed by limited combinatorial libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 277-278). Mayflower Scientific Limited, Birmingham. #13693

324. Dong, S.L., Wang, T., Chen, Q., & Wang, R. (1999) Synthesis, structure-activity relationship of nociceptin and its fragments. Chin. Sci. Bull., 44, 1655-1659. #15014

325. Dragovich, P.S., Zhou, R., Skalitzky, D.J., Fuhrman, S.A., Patick, A.K., Ford, C.E., Meador, J.W., & Worland, S.T. (1999) Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides. Bioorg. Med. Chem., 7, 589-598. #12957

326. Drozdz, R., Hintermann, E., Tanner, H., Zumsteg, U., & Eberle, A.N. (1999) (D-(p-Benzoylphenylalanine)13,tyrosine19)-melanin-concentrating hormone, a potent analogue for MCH receptor crosslinking. J. Peptide Sci., 5, 234-242. #14430

327. Echner, H. & Voelter, W. (1999) The 5-phenyl-5H-dibenzo[a,d]cyclohepten-5-yl (Pdbs) and the 5-anisyl-5H-dibenzo[a,d]cyclohepten-5-yl (Adbs) residues: Two new protecting groups for the Nim-function of histidine. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 279-282). Mayflower Scientific Limited, Birmingham. #13694

328. Eggenweiler, H.M., Clausen, N. & Bayer, E. (1999) a-Hydroxymethylacrylic acid in solid phase synthesis: An extremely nucleophile sensitive linker. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 283-286). Mayflower Scientific Limited, Birmingham. #13695

329. Eggleston, I.M., Peggion, C., Svendsen, J.S. & Mutter, M. (1999) Practical synthesis and application of a b-turn mimetic for SPPS. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 287-290). Mayflower Scientific Limited, Birmingham. #13696

330. Eichler, J. & Houghten, R.A. (1999) Scaffolded peptide combinatorial libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 155-158). Mayflower Scientific Limited, Birmingham. #13667

331. Eisele, F., Owen, D.J., & Waldmann, H. (1999) Peptide conjugates as tools for the study of biological signal transduction. Bioorg. Med. Chem., 7, 193-224. #12736

332. Elbayed, K., Bourdonneau, M., Furrer, J., Richert, T., Raya, J., Hirschinger, J., & Piotto, M. (1999) Origin of the residual NMR linewidth of a peptide bound to a resin under magic angle spinning. J. Magn. Resonance, 136, 127-129. #12531

333. Eleftheriou, S., Gatos, D., Panagopoulos, A., Stathopoulos, S., & Barlos, K. (1999) Attachment of histidine, histamine and urocanic acid to resins of the trityl-type. Tetrahedron Lett., 40, 2825-2828. #12636

334. Englebretsen, D.R., & Robillard, G.T. (1999) An N-terminal method for peptide solubilisation. Tetrahedron, 55, 6623-6634. #12959

335. Epton, R. (1999) Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. Mayflower Scientific Limited, Birmingham. ISBN 0952701138 #13448

336. Evstigneeva, R.P., Zheltukhina, G.A., Khalil', V., & Efimova, E.I. (1999) The synthesis of Arg-containing peptides and their conjugates with protohemin IX and tetraphenylporphyrin. Bioorganicheskaia Khimiia, 25, 572-580. #13960

337. Falb, E., Yechezkel, T., Salitra, Y., & Gilon, C. (1999) In situ generation of Fmoc-amino acid chlorides using bis(trichloromethyl) carbonate and its utilization for difficult couplings in solid-phase peptide synthesis. J. Pept. Res., 53, 507-517. #12960

338. Fischer, M., & Tran, C.D. (1999) Investigation of solid phase peptide synthesis by the near-infrared multispectral imaging technique: A detection method for combinatorial chemistry. Anal. Chem., 71, 2255-2261. #13402

339. Fotsch, C., Kumaravel, G., Sharma, S.K., Wu, A.D., Gounarides, J.S., Nirmala, N.R., & Petter, R.C. (1999) On-resin macrocyclization of peptides via intramolecular SnAr reactions. Bioorg. Med. Chem. Lett., 9, 2125-2130. #13514

340. Francke, C., Loyal, R., Ohad, I., & Haehnel, W. (1999) In vitro assembly of a beta(2) cytochrome b(559)-like complex from the chemically synthesised beta-subunit encoded by the Synechocystis sp 6803 psbF gene. FEBS Lett., 442, 75-78. #12354

341. Freund, E., & Robinson, J.A. (1999) Solid-phase synthesis of a putative heptapeptide intermediate in vancomycin biosynthesis. Chem. Commun., 2509-2510. #14236

342. Fruchart, J.S., Gras-Masse, H., & Melnyk, O. (1999) A new linker for the synthesis of C-terminal peptide alpha-oxo-aldehydes. Tetrahedron Lett., 40, 6225-6228. #13517

343. Fukuda, H., Shimizu, T., Nakajima, M., Mori, H., & Shirasawa, T. (1999) Synthesis, aggregation, and neurotoxicity of the Alzheimer's Ab1-42 amyloid peptide and its isoaspartyl isomers. Bioorg. Med. Chem. Lett., 9, 953-956. #12867

344. Fukuda, H., Irie, K., Nakahara, A., Ohigashi, H., & Wender, P.A. (1999) Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma. Bioorg. Med. Chem., 7, 1213-1221. #13519

345. Gademann, K., Hintermann, T., & Schreiber, J.V. (1999) b-Peptides: Twisting and turning. Curr. Med. Chem., 6, 905-925. #13973

346. Ganguly, D., & Rodriguez, M.J. (1999) Cyclopeptamine lipopeptide antifungal agents. Exp. Opin. Ther. Patents, 9, 67-71. #12358

347. Gennari, C., Mielgo, A., Potenza, D., Scolastico, C., Piarulli, U., & Manzoni, L. (1999) Solid-phase synthesis of peptides containing reverse-turn mimetic bicyclic lactams. Eur. J. Org. Chem., 379-388. #12742

348. Gibson, C., Goodman, S.L., Hahn, D., Holzemann, G., & Kessler, H. (1999) Novel solid-phase synthesis of azapeptides and azapeptoides via Fmoc-strategy and its application in the synthesis of RGD-mimetics. J. Org. Chem., 64, 7388-7394. #13981

349. Giraud, M., Cavelier, F., & Martinez, J. (1999) A side-reaction in the SPPS of Trp-containing peptides. J. Peptide Sci., 5, 457-461. #13983

350. Goetz, M., Schmitter, J.M., Geoffre, S., & Dufourc, E.J. (1999) Chemical synthesis of yeast mitochondrial ATP synthase membranous subunit 8. J. Peptide Sci., 5, 245-250. #13106

351. Gomez-Martinez, P., Dessolin, M., Guibe, F., & Albericio, F. (1999) N-a-Alloc temporary protection in solid-phase peptide synthesis. The use of amine-borane complexes as allyl group scavengers. J. Chem. Soc. Perkin Trans. 1, 2871-2874. #13987

352. Gomme, P.T., Stanton, P.G., & Hearn, M.T.W. (1999) Evaluation of a pepscan approach to identify epitopes recognised by anti-hTSH monoclonal antibodies. J. Biochem. Biophys. Meth., 38, 53-70. #12594

353. Grahn, S., Kurth, T., Ullmann, D., & Jakubke, H.D. (1999) S' subsite mapping of serine proteases based on fluorescence resonance energy transfer. Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology, 1431, 329-337. #12969

354. Gras-Masse, H., Georges, B., Estaquier, J., Tranchand-Bunel, D., Tartar, A., Druilhe, P., & Auriault, C. (1999) Convergent peptide libraries, or mixotopes, to elicit or to identify specific immune responses. Curr. Opin. Immunol., 11, 223-228. #12639

355. Guarna, A., Guidi, A., Machetti, F., Menchi, G., Occhiato, E.G., Scarpi, D., Sisi, S., & Trabocchi, A. (1999) Synthesis and reactivity of bicycles derived from tartaric acid and alpha-amino acids: A novel class of conformationally constrained dipeptide isosteres based upon enantiopure 3-aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic acid. J. Org. Chem., 64, 7347-7364. #13995

356. Gung, B.W., Zou, D., Stalcup, A.M., & Cottrell, C.E. (1999) Characterization of a water-soluble, helical beta-peptide. J. Org. Chem., 64, 2176-2177. #12973

357. Habermann, J. & Kunz, H. (1999) Pentafluorophenyluronium reagents and allylic anchoring groups in solid phase glycopeptide synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 217-220). Mayflower Scientific Limited, Birmingham. #13679

358. Hamuro, Y., Scialdone, M.A., & DeGrado, W.F. (1999) Resin-to-resin acyl- and aminoacyl-transfer reactions using oxime supports. J. Amer. Chem. Soc., 121, 1636-1644. #12641

359. Hanessian, S., Luo, X.H., & Schaum, R. (1999) Synthesis and folding preferences of gamma-amino acid oligopeptides: Stereochemical control in the formation of a reverse turn and a helix. Tetrahedron Lett., 40, 4925-4929. #13524

360. Haramura, M., Tsuzuki, K., Okamachi, A., Yogo, K., Ikuta, M., Kozono, T., Takanashi, H., & Murayama, E. (1999) Structure-activity study of intact porcine motilin. Chem. Pharm. Bull. Tokyo, 47, 1555-1559. #14003

361. Hargittai, B., & Barany, G. (1999) Controlled syntheses of natural and disulfide-mispaired regioisomers of alpha-conotoxin SI. J. Pept. Res., 54, 468-479. #14004

362. Heizmann, G., Hildebrand, P., Tanner, H., Ketterer, S., Pansky, A., Froidevaux, S., Beglinger, C., & Eberle, A.N. (1999) A combinatorial peptoid library for the identification of novel MSH and GRP/bombesin receptor ligands. Journal of Receptor and Signal Transduction Research, 19, 449-466. #12746

363. Henkel, W., Vogl, T., Echner, H., Voelter, W., Urbanke, C., Schleuder, D., & Rauterberg, J. (1999) Synthesis and folding of native collagen III model peptides. Biochemistry, 38, 13610-13622. #14012

364. Henklein, P., Ionescu, D., El-Faham, A., Wenschuh, H., Bienert, M., Carpino, L.A. & Beyermann, M. (1999) Coupling of highly hindered systems using protected amino acid chlorides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 221-224). Mayflower Scientific Limited, Birmingham. #13680

365. Henklein, P., Mugge, C., Costisella, B., Wray, V., Domke, T., El-Faham, A., Lee, Y., Kates, S.A. & Carpino, L.A. (1999) Solution structure of uronium and phosphonium salts. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 309-310). Mayflower Scientific Limited, Birmingham. #13700

366. Higashimoto, Y., Kodama, H., Jelokhani-Niaraki, M., Kato, F., & Kondo, M. (1999) Structure-function relationship of model Aib-containing peptides as ion transfer intermembrane templates. J. Biochem. Tokyo, 125, 705-712. #12747

367. Hintermann, E., Drozdz, R., Tanner, H. & Eberle, A.N. (1999) Synthesis and receptor binding activity of analogues and fragment of human melanin-concentrating hormone (MCH). In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 193-196). Mayflower Scientific Limited, Birmingham. #13673

368. Hioki, H., Yamada, T., Fujioka, C., & Kodama, M. (1999) Peptide library based on calix[4]arene. Tetrahedron Lett., 40, 6821-6825. #13761

369. Hoffmann, R., Craik, D.J., Bokonyi, K., Varga, I., & Otvos, L. (1999) High level of aspartic acid-bond isomerization during the synthesis of an N-linked tau glycopeptide. J. Peptide Sci., 5, 442-456. #14018

370. Hoffmann, R., Ertl, H.C.J., Pease, A.M., Rovera, G. & Otvos, L.Jr. (1999) Optimization of synthesis and DNA hybridization of peptide nucleic acids. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 311-314). Mayflower Scientific Limited, Birmingham. #13701

371. Hoogerhout, P., Stittelaar, K.J., Brugghe, H.F., Timmermans, J.A.M., ten Hove, G.J., Jiskoot, W., Hoekman, J.H.G., & Roholl, P.J.M. (1999) Solid-phase synthesis and application of double-fluorescent-labeled lipopeptides, containing a CTL-epitope from the measles fusion protein. J. Pept. Res., 54, 436-443. #13788

372. Hsieh, H.P., Wu, Y.T., Chen, S.T., & Wang, K.T. (1999) Direct solid-phase synthesis of octreotide conjugates: Precursors for use as tumor-targeted radiopharmaceuticals. Bioorg. Med. Chem., 7, 1797-1803. #14020

373. Huang, H., & Rabenstein, D.L. (1999) A cleavage cocktail for methionine-containing peptides. J. Pept. Res., 53, 548-553. #12981

374. Huang, Y.D., Chen, H., Feng, Y.M., & Zhang, J.P. (1999) Preliminary crystallographic studies on two insulin analogues which retain high biological activities after alterations in A chain. Chin. Sci. Bull., 44, 1480-1483. #15101

375. Huang, Y.D., Yang, S.Z., Feng, Y.M., & Niu, C.I. (1999) An insulin analog with g-amino butyric acid substitution for A13Leu-A14Tyr. J. Pept. Res., 54, 18-22. #13100

376. Husbyn, M., Orning, L., Cuthbertson, A., & Fischer, P.M. (1999) Linear analogues derived from the first EGF-like domain of human blood coagulation factor VII: Enhanced inhibition of FVIIa/TF complex activity by backbone modification through aspartimide formation. J. Peptide Sci., 5, 323-329. #14023

377. Ingenito, R., Bianchi, E., Fattori, D., & Pessi, A. (1999) Solid phase synthesis of peptide C-terminal thioesters by Fmoc/t-Bu chemistry. J. Amer. Chem. Soc., 121, 11369-11374. #14025

378. Ishida, H., & Inoue, Y. (1999) Peptides that contain unnatural amino acids: Toward artificial proteins. Reviews on Heteroatom Chemistry, 19, 79-142. #12754

379. Jang, T.S., Shin, S.Y., Ha, J.M., & Kang, S.W. (1999) Structure-contractile activity relationships of neurokinin A on guinea pig tracheal smooth muscle. Bull. Kor. Chem. Soc., 20, 199-202. #12757

380. Jenkins, K.E., Higson, A.P., Seeberger, P.H. & Caruthers, M.H. (1999) Solid phase synthesis of O-boranophosphopeptides and O-dithiophosphopeptides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 225-228). Mayflower Scientific Limited, Birmingham. #13681

381. Jezek, J., Velek, J., Veprek, P., Velkova, V., Trnka, T., Pecka, J., Ledvina, M., Vondrasek, J., & Pisacka, M. (1999) Solid phase synthesis of glycopeptide dendrimers with Tn antigenic structure and their biological activities. Part I. J. Peptide Sci., 5, 46-55. #12759

382. Jubilut, G.N., Miranda, M.T., Tominaga, M., Okada, Y., Miranda, A., & Nakaie, C.R. (1999) Resin selection based on the lability of peptidyl-resin linkage towards HF and TFA steps: Dependence on the C-terminal amino acid and peptide length. Chem. Pharm. Bull. Tokyo, 47, 1560-1563. #14239

383. Juvvadi, P., Vunnam, S., Yoo, B., & Merrifield, R.B. (1999) Structure-activity studies of normal and retro pig cecropin-melittin hybrids. J. Pept. Res., 53, 244-251. #12874

384. Kaiser, T., Luppa, P., & Voelter, W. (1999) Solid-phase synthesis, isolation and analysis of a mouse protein, the macrophage migration inhibitory factor. J. Chromatogr., 852, 189-195. #13536

385. Kates, S.A., Cammish, L.E., & Albericio, F. (1999) Continuous-flow solid-phase peptide synthesis using polystyrene resins. J. Pept. Res., 53, 682-683. #12986

386. Kim, Y., Zeng, F.W., & Zimmerman, S.C. (1999) Peptide dendrimers from natural amino acids. Chem. Eur. J., 5, 2133-2138. #13539

387. Kim, Y.D., Cho, B.K., Park, J.I., Lee, S.H. & Kim, H.J. (1999) Solid phase peptide synthesis using 2-(4-nitrophenyl)sulfonylethoxycarbonyl (Nsc) amino acids for salmon calcitonin. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 315-318). Mayflower Scientific Limited, Birmingham. #13702

388. Kiso, Y., Matsumoto, H., Mizumoto, S., Kimura, T., Fujiwara, Y., & Akaji, K. (1999) Small dipeptide-based HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic. Biopolymers (Pept. Sci. ), 51, 59-68. #13095

389. Koeller, K.M., & Wong, C.H. (1999) Synthesis of biologically active glycopeptides. J. Chin. Chem. Soc., 46, 659-685. #15144

390. Kohlbau, H.J., Meisenbach, M., Echner, H. & Voelter, W. (1999) Introduction of different methoxy-substituted 9-phenyl-9-fluoenylamine linkers: Mildly cleavable anchoring groups for the synthesis of peptide amides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 319-322). Mayflower Scientific Limited, Birmingham. #13703

391. Kolodziejczyk, A.S., Sugajska, E., Falkiewicz, B., & Wisniewski, K. (1999) The application of the Pmc-protecting group to reduced peptide bond synthesis. Synlett, 1606-1608. #15150

392. Komba, S., Meldal, M., Werdelin, O., Jensen, T., & Bock, K. (1999) Convenient synthesis of Thr and Ser carrying the tumor associated sialyl-(2-->3)-T antigen as building blocks for solid-phase glycopeptide synthesis. J. Chem. Soc. Perkin Trans. 1, 415-419. #12647

393. Koppitz, M., Matha, B., & Kessler, H. (1999) Structure investigation of amphiphilic cyclopeptides in isotropic and anisotropic environments: A model study simulating peptide-membrane interactions. J. Peptide Sci., 5, 507-518. #14439

394. Kramer, A., Reineke, U., Dong, L., Hoffmann, B., Hoffmuller, U., Winkler, D., Volkmer-Engert, R., & Schneider-Mergener, J. (1999) Spot synthesis: Observations and optimizations. J. Pept. Res., 54, 319-327. #13753

395. Kudryavtseva, E.V., Sidorova, M.V., Molokoedov, A.S., Ovchinnikov, M.V., & Bespalova, Z.D. (1999) Directed and spontaneous disulfide bond closure by hydrogen peroxide during the synthesis of endothelin 1 and endothelin 3 [Russian]. Bioorganicheskaia Khimiia, 25, 107-116. #12991

396. Kuisle, O., Lolo, M., Quinoa, E., & Riguera, R. (1999) Monitoring the solid-phase synthesis of depsides and depsipeptides. A color test for hydroxyl groups linked to a resin. Tetrahedron, 55, 14807-14812. #14044

397. Kuisle, O., Quinoa, E., & Riguera, R. (1999) A general methodology for automated solid-phase synthesis of depsides and depsipeptides. Preparation of a valinomycin analogue. J. Org. Chem., 64, 8063-8075. #14045

398. Kutterer, K.M.K., Barnes, M.L., & Arya, P. (1999) Automated, solid-phase synthesis of C-neoglycopeptides: Coupling of glycosyl derivatives to resin-bound peptides. Journal of Combinatorial Chemistry, 1, 28-31. #12039 (Available on Internet)

399. Kuttner, G., Kramer, A., Schmidtke, G., Giessmann, E., Dong, L., Roggenbuck, D., Scholz, C., Seifert, M., Stigler, R.D., Schneider-Mergener, J., Porstmann, T., & Hohne, W. (1999) Characterization of neutralizing anti-pre-S1 and anti-pre-S2 (HBV) monoclonal antibodies and their fragments. Mol. Immunol., 36, 669-683. #13808

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401. Lanter, C.L., Guiles, J.W., & Rivero, R.A. (1999) The solid-phase synthesis of novel 14-membered macrocycles for high throughput screening. Mol. Diversity, 4, 149-153. #12996

402. Lauer, J.L. & Fields, G.B. (1999) Protein-like molecular structure: Synthesis and application for inducing cellular receptor binding and signal transduction. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 185-188). Mayflower Scientific Limited, Birmingham. #13671

403. Lebl, M., Pires, J., Poncar, P., & Pokorny, V. (1999) Evaluation of gaseous hydrogen fluoride as a convenient reagent for parallel cleavage from the solid support. Journal of Combinatorial Chemistry, 1, 474-479. #13836

404. Lebl, M. (1999) Parallel personal comments on "classical" papers in combinatorial chemistry. Journal of Combinatorial Chemistry, 1, 3-24. #12028 (Available on Internet)

405. Lee, H.B., & Balasubramanian, S. (1999) Studies on a dithiane-protected benzoin photolabile safety catch linker for solid-phase synthesis. J. Org. Chem., 64, 3454-3460. #12877

406. Lee, K., Hwang, S.Y., & Park, C.W. (1999) Thrombin inhibitors based on a propargylglycine template. Bioorg. Med. Chem. Lett., 9, 1013-1018. #12998

407. Lew, B.M., Mills, K.V., & Paulus, H. (1999) Characteristics of protein splicing in trans mediated by a semisynthetic split intein. Biopolymers (Pept. Sci. ), 51, 355-362. #14271

408. Li, P., & Xu, J.C. (1999) BOMI: A novel peptide coupling reagent. Tetrahedron Lett., 40, 3605-3608. #12690

409. Li, S.H., & Dass, C. (1999) Iron(lll)-immobilized metal ion affinity chromatography and mass spectrometry for the purification and characterization of synthetic phosphopeptides. Anal. Biochem., 270, 9-14. #13001

410. Li, X.X., Cheng, Y.Z., Zhang, L.G., & Zhang, L.H. (1999) Synthesis of spin labeled conjugate of peptide and peptide nucleic acid. Syn. Commun., 29, 1519-1525. #13002

411. Liehr, S., & Chenault, H.K. (1999) A comparison of the alpha-helix forming propensities and hydrogen bonding properties of serine phosphate and alpha-amino-gamma-phosphonobutyric acid. Bioorg. Med. Chem. Lett., 9, 2759-2762. #15174

412. Limal, D., Semetey, V., Dalbon, P., Jolivet, M., & Briand, J.P. (1999) Solid-phase synthesis of N,N'-unsymmetrically substituted ureas: Application to the synthesis of carbaza peptides. Tetrahedron Lett., 40, 2749-2752. #12650

413. Lippens, G., Bourdonneau, M., Dhalluin, C., Warrass, R., Richert, T., Seetharaman, C., Boutillon, C., & Piotto, M. (1999) Study of compounds attached to solid supports using high resolution magic angle spinning NMR. Current Organic Chemistry, 3, 147-169. #12774

414. Lisowski, M., Stasiak, M., & Leplawy, M.T. (1999) The study on helix-inducing propensity of alpha-hydroxymethylserine based on the host-guest approach. Polish J. Chem., 73, 313-319. #12775

415. Litowski, J.R., Semchuk, P.D., Mant, C.T., & Hodges, R.S. (1999) Hydrophilic interaction/cation-exchange chromatography for the purification of synthetic peptides from closely related impurities: Serine side-chain acetylated peptides. J. Pept. Res., 54, 1-11. #13550

416. Lohse, A., Jensen, K.B., & Bols, M. (1999) The first combinatorial library of azasugar glycosidase inhibitors. Tetrahedron Lett., 40, 3033-3036. #12679

417. Lu, W.Y., Randal, M., Kossiakoff, A., & Kent, S.B.H. (1999) Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes. Chem. Biol., 6, 419-427. #13554

418. Luke, R.W.A. & Boyce, P.G.T. (1999) Design, synthesis and characterization of a beta-turn mimic library. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 335-338). Mayflower Scientific Limited, Birmingham. #13706

419. Lundquist, J.T., & Dix, T.A. (1999) Synthesis and human neurotensin receptor binding activities of neurotensin(8-13) analogues containing position 8 alpha-azido-N-alkylated derivatives of ornithine, lysine, and homolysine. J. Med. Chem., 42, 4914-4918. #14066

420. Madder, A., Farcy, N., Hosten, N.G.C., De Muynck, H., De Clercq, P.J., Barry, J., & Davis, A.P. (1999) A novel sensitive colorimetric assay for visual detection of solid-phase bound amines. Eur. J. Org. Chem., 2787-2791. #15987

421. Malik, Z., Amir, S., Pal, G., Buzas, Z., Varallyay, E., Antal, J., Szilagyi, Z., Vekey, K., Asboth, B., Patthy, A., & Graf, L. (1999) Proteinase inhibitors from desert locust, Schistocerca gregaria: Engineering of both P-1 and P-1' residues converts a potent chymotrypsin inhibitor to a potent trypsin. Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology, 1434, 143-150. #14069

422. Manning, M., Stoev, S., Cheng, L.L., Wo, N.C., & Chan, W.Y. (1999) Synthesis and structure-activity investigation of novel vasopressin hypotensive peptide agonists. J. Peptide Sci., 5, 472-490. #14070

423. Marastoni, M., Guerrini, R., Balboni, G., Salvadori, S., Fantin, G., Fogagnolo, M., Lazarus, L.H., & Tomatis, R. (1999) Opioid deltorphin C analogues containing cis- or trans-2- or 3- or 4-aminocyclohexanecarboxylic acid residues. Arzneim. -Forsch., 49, 6-12. #12779

424. Marcaurelle, L.A., & Bertozzi, C.R. (1999) New directions in the synthesis of glycopeptide mimetics. Chem. Eur. J., 5, 1384-1390. #13010

425. Martin, F., Steinkuhler, C., Brunetti, M., Pessi, A., Cortese, R., De Francesco, R., & Sollazzo, M. (1999) A loop-mimetic inhibitor of the HCV-NS3 protease derived from a minibody. Protein Eng., 12, 1005-1011. #14074

426. Maruyama, T., Ikeo, T., & Ueki, M. (1999) A rapid and facile method for the preparation of peptide disulfides. Tetrahedron Lett., 40, 5031-5034. #13111

427. Matusina, Z., Olbrimkova, R., Votavova, H., Neumann, J., Hradilek, M., Soucek, M., Malon, P., Kodicek, M., & Stibor, I. (1999) Linear heptapeptides containing DNA-intercalators. Synthesis and interaction with DNA. Collect. Czech. Chem. Commun., 64, 1419-1432. #15202

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429. Mayfield, L.D., & Corey, D.R. (1999) Enhancing solid phase synthesis by a noncovalent protection strategy-efficient coupling of rhodamine to resin-bound peptide nucleic acids. Bioorg. Med. Chem. Lett., 9, 1419-1422. #12881

430. McBride, J.D., Freeman, N. & Leatherbarrow, R.J. (1999) Selection of human elastase inhibitors from a conformationally-constrained combinatorial peptide library. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 167-172). Mayflower Scientific Limited, Birmingham. #13670

431. Meisenbach, M., Echner, H., Kohlbau, H.J. & Voelter, W. (1999) Methoxy substituted 9-phenylxanthenylamine linkers: Useful tools for the solid phase synthesis of protected peptide peptide amides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 345-348). Mayflower Scientific Limited, Birmingham. #13708

432. Meldal, M., Tornoe, C., Tedebark, U., Jansson, A.M., Juliano, M.A., Panza, L. & Lay, L. (1999) Azido acids in a novel method of solid phase synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 19-22). Mayflower Scientific Limited, Birmingham. #13453

433. Melnyk, O., Rommens, C., & Gras-Masse, H. (1999) Chemistry of hydrazinopeptides: A new hydroperoxydeamination process. Tetrahedron Lett., 40, 1491-1494. #12601

434. Merette, S.A.M., Green, D., Patel, G., Scully, M.F., Kakkar, V.V. & Deadman, J.J. (1999) A general method for N to C terminal solid phase peptide synthesis applied to bioactive peptidic boronates. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 349-350). Mayflower Scientific Limited, Birmingham. #13709

435. Mergler, M., Dick, F., Gosteli, J., & Nyfeler, R. (1999) Solid phase synthesis of fully protected peptide alcohols. Tetrahedron Lett., 40, 4663-4664. #13015

436. Mergler, M. & Nyfeler, R. (1999) Polymeric diphenyldiazomethane: A useful resin for SPPS and solid phase organic chemistry. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 351-35). Mayflower Scientific Limited, Birmingham. #13710

437. Mergler, M., Gosteli, J., Grogg, P., Nyfeler, P., & Tanner, R. (1999) SASRIN(TM), a versatile tool in peptide synthesis and solid-phase organic chemistry. Chimia, 53, 29-34. #12782

438. Mezo, G., Majer, Z., Valero, M.L., Andreu, D., & Hudecz, F. (1999) Synthesis of cyclic Herpes simplex virus peptides containing 281-284 epitope of glycoprotein D-1 in endo- or exo-position. J. Peptide Sci., 5, 272-282. #13108

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440. Miranda, L.P., & Alewood, P.F. (1999) Accelerated chemical synthesis of peptides and small proteins. Proc. Natl. Acad. Sci. USA, 96, 1181-1186. #12785

441. Mizuno, M., Haneda, K., Iguchi, R., Muramoto, I., Kawakami, T., Aimoto, S., Yamamoto, K., & Inazu, T. (1999) Synthesis of a glycopeptide containing oligosaccharides: Chemoenzymatic synthesis of eel calcitonin analogues having natural N-linked oligosaccharides. J. Amer. Chem. Soc., 121, 284-290. #12786

442. Morris, M.C., Mery, J., Heitz, A., Heitz, F., & Divita, G. (1999) Design and synthesis of a peptide derived from positions 195-244 of human cdc25C phosphatase. J. Peptide Sci., 5, 263-271. #13107

443. Muller, B., Besser, D., Kleinwachter, P., Arad, O., & Reissmann, S. (1999) Synthesis of N-carboxyalkyl and N-aminoalkyl functionalized dipeptide building units for the assembly of backbone cyclic peptides. J. Pept. Res., 54, 383-393. #14086

444. Nagase, T. (1999) Development of peptidic endothelin receptor antagonists: Elucidating physiological roles of endothelin and medicinal chemistry efforts toward its receptor antagonists [Japanese]. J. Syn. Org. Chem. Jpn., 57, 888-897. #15213

445. Nagy, I.B., Mak, M., Varga, I., Kovacs, J., Fellinger, E. & Hudecz, F. (1999) Solid phase synthesis of KDEL peptides labelled with fluorophore and/or bifunctional chelating agent for receptor localisation. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 229-230). Mayflower Scientific Limited, Birmingham. #13682

446. Niidome, T., Anzai, S., Sonoda, J., Tokunaga, Y., Nakahara, M., Hatakeyama, T., & Aoyagi, H. (1999) Effect of amino acid substitution in amphiphilic a-helical peptides on peptide-phospholipid membrane interaction. J. Peptide Sci., 5, 298-305. #14432

447. Nishiyama, Y., & Kurita, K. (1999) Cyclohexyl ether as a new hydroxy-protecting group for serine in solid-phase peptide synthesis. Tetrahedron Lett., 40, 927-930. #12248

448. Nokihara, K. & Yasuhara, T. (1999) Highly efficient preparation of 7KDa peptides by single coupling assembly without capping followed by a single step of purification using reverse-phase HPLC. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 105-110). Mayflower Scientific Limited, Birmingham. #13658

449. Offer, J., Quibell, M. & Johnson, T. (1999) A new generation of reversible backbone amide protection. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 357-360). Mayflower Scientific Limited, Birmingham. #13712

450. Oh, J.E., Hong, S.Y., & Lee, K.H. (1999) Design, synthesis and characterization of antimicrobial pseudopeptides corresponding to membrane-active peptide. J. Pept. Res., 54, 129-136. #13576

451. Ota, M., Sawa, A., Nio, N., & Ariyoshi, Y. (1999) Enzymatic ligation for synthesis of single-chain analogue of monellin by transglutaminase. Biopolymers, 50, 193-200. #13023

452. Ottl, J., Musiol, H.J., & Moroder, L. (1999) Heterotrimeric collagen peptides containing functional epitopes, synthesis of single-stranded collagen type I peptides related to the collagenase cleavage site. J. Peptide Sci., 5, 103-110. #12793

453. Ottl, J., & Moroder, L. (1999) Disulfide-bridged heterotrimeric collagen peptides containing the collagenase cleavage site of collagen type I. Synthesis and conformational properties. J. Amer. Chem. Soc., 121, 653-661. #12794

454. Overkleeft, H.S., Verhelst, S.H.L., Pieterman, E., Meeuwenoord, N.J., Overhand, M., Cohen, L.H., van der Marel, G.A., & van Boom, J.H. (1999) Design and synthesis of a protein: Farnesyltransferase inhibitor based on sugar amino acids. Tetrahedron Lett., 40, 4103-4106. #12898

455. Panek, Z., Pavlik, M. & Flegel, M. (1999) Asparagine as racemization sensitive site in analogs of neurohypophyseal hormones. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 365-366). Mayflower Scientific Limited, Birmingham. #13714

456. Papageorgopoulos, C., Caldwell, K., Shackleton, C., Schweingrubber, H., & Hellerstein, M.K. (1999) Measuring protein synthesis by mass isotopomer distribution analysis (MIDA). Anal. Biochem., 267, 1-16. #12799

457. Paris, M., Pothion, C., Heitz, A., Rocheblave, L., Rouch, F., Fehrentz, J.A. & Martinez, J. (1999) Solid phase synthesis of peptide aldehydes. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 15-18). Mayflower Scientific Limited, Birmingham. #13452

458. Paris, M., Douat, C., Heitz, A., Gibbons, W., Martinez, J., & Fehrentz, J.A. (1999) Post-synthesis modification of aspartyl or glutamyl residue side-chains on solid support. Tetrahedron Lett., 40, 5179-5182. #13118

459. Patel, G., Husman, W., Jehanli, A.M., Deadman, J.J., Green, D., Kakkar, V.V., & Brennand, D.M. (1999) A cyclic peptide analogue of the loop III region of platelet-derived growth factor-BB is a synthetic antigen for the native protein. J. Pept. Res., 53, 68-74. #12654

460. Patterson, J.A., & Ramage, R. (1999) Solid phase synthesis of peptide C-terminal semicarbazones and aldehydes. Tetrahedron Lett., 40, 6121-6124. #13579

461. Pearce, A.J., Ramaya, S., Thorn, S.N., Bloomberg, G.B., Walter, D.S., & Gallagher, T. (1999) C-glycosyl tyrosines. Synthesis and incorporation into C-glycopeptides. J. Org. Chem., 64, 5453-5462. #13580

462. Pedersen, W.B., Almdal, K., Winther, L., & Berg, R.H. (1999) R.D. Forskniingscenter Riso. Grafted cross-linked polyolefin substrates for peptide synthesis and assays. US Patent. 5,886,104. 569,255, #13154

463. Pegoraro, S., Besse, D., Fiori, S., Rudolph-Bohner, S., Watanabe, T.X., Kimura, T. & Moroder, L. (1999) Synthesis and folding properties of selenocystine-containing peptides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 89-92). Mayflower Scientific Limited, Birmingham. #13466

464. Peluso, S., Dumy, P., Nkubana, C., Yokokawa, Y., & Mutter, M. (1999) Solid-phase strategies for the assembly of template-based protein mimetics. J. Org. Chem., 64, 7114-7120. #13816

465. Peng, Z.H. (1999) Solid phase synthesis and NMR conformational studies on cyclic decapeptide template molecule. Biopolymers, 49, 565-574. #12884

466. Peng, Z.H. (1999) NMR conformational analysis on cyclic decapeptide template molecule. Can. J. Chem., 77, 1394-1404. #13817

467. Pennington, M.W., Baur, P., Westling, J. & Dunn, B.M. (1999) Using 2-chlorotrityl resin tactics for the preparation of DABCYL-EDANS derivatized peptides: Application to a fluorogenic substrate for an aspartyl proteinase from human malaria parasite. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 367-370). Mayflower Scientific Limited, Birmingham. #13715

468. Peri, F., Grell, D., Dumy, P., Yokokawa, Y., Welzenbach, K., Weitz-Schmidt, G., & Mutter, M. (1999) Assembly of binding loops on aromatic templates as VCAM-1 mimetics. J. Peptide Sci., 5, 313-322. #14433

469. Perich, J.W., Black, C.L., Huq, N.L., & Reynolds, E.C. (1999) Epitope analysis of the multiphosphorylated peptide aS1-casein(59-79). J. Peptide Sci., 5, 221-233. #14429

470. Peterson, J.J., Pak, R.H., & Meares, C.F. (1999) Total solid-phase synthesis of 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-functionalized peptides for radioimmunotherapy. Bioconjug. Chem., 10, 316-320. #12656

471. Pinilla, C., Martin, R., Gran, B., Appel, J.R., Boggiano, C., Wilson, D.B., & Houghten, R.A. (1999) Exploring immunological specificity using synthetic peptide combinatorial libraries. Curr. Opin. Immunol., 11, 193-202. #12800

472. Poupart, M.A., Fazal, G., Goulet, S., & Mar, L.T. (1999) Solid-phase synthesis of peptidyl trifluoromethyl ketones. J. Org. Chem., 64, 1356-1361. #12658

473. Ramage, R., Jiang, L., Kim, Y.D., Shaw, K., Park, J.L., & Kim, H.J. (1999) Comparative studies of Nsc and Fmoc as Na-protecting groups for SPPS. J. Peptide Sci., 5, 195-200. #12903

474. Reineke, U., Kramer, A., & Schneider-Mergener, J. (1999) Antigen sequence- and library-based mapping of linear and discontinuous protein-protein-interation sites by spot synthesis. Curr. Topics Microbiol. Immun., 243, 23-36. #13750

475. Renil, M., & Pillai, V.N.R. (1999) Solid-phase peptide synthesis using a new PS-TTEGDA resin: Synthesis of pardaxin (1-26). Ind. J. Chem. B-Org. Chem. Med. Chem., 38, 1030-1035. #15267

476. Rinnova, M., Lebl, M., & Soucek, M. (1999) Solid-phase peptide synthesis by fragment condensation: Coupling in swelling volume. Lett. Peptide Sci., 6, 15-22. #13834

477. Rinnova, M., Soucek, M., Voburka, Z., Lebl, M. & Fusek, M. (1999) Sanger's reagent: An excellent end-capping and/or labeling agent for SPPS. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 385-386). Mayflower Scientific Limited, Birmingham. #13719

478. Rivier, J.E., Kirby, D.A., Lahrichi, S.L., Corrigan, A., Vale, W.W., & Rivier, C.L. (1999) Constrained corticotropin releasing factor antagonists (astressin analogues) with long duration of action in the rat. J. Med. Chem., 42, 3175-3182. #13591

479. Robertson, N., & Ramage, R. (1999) Total chemical synthesis of deglycosylated human erythropoietin. J. Chem. Soc., 1015-1021. #13038

480. Robertson, N., Jiang, L., & Ramage, R. (1999) Racemisation studies of a novel coupling reagent for solid phase peptide synthesis. Tetrahedron, 55, 2713-2720. #12660

481. Robinson, B.M., Tellam, D.J., Smart, D., Mohammad, Y.N., Brennand, J., Rivier, J.E., & Lovejoy, D.A. (1999) Cloning and characterization of corticotropin-releasing factor and urocortin in Syrian hamster (Mesocricetus auratus). Peptides, 20, 1177-1185. #14118

482. Roggero, M.A., Servis, C. & Corradin, G. (1999) Purification of synthetic polypeptides by immobilized metal affinity chromatography and methionine chemistry. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 111-114). Mayflower Scientific Limited, Birmingham. #13659

483. Roice, M., Kumar, K.S., & Pillai, V.N.R. (1999) Synthesis, characterization, and application of butanediol dimethacrylate cross-linked polystyrene: A flexible support for gel phase peptide synthesis. Macromolecules, 32, 8807-8815. #15276

484. Rose, K., & Vizzavona, J. (1999) Stepwise solid-phase synthesis of polyamides as linkers. J. Amer. Chem. Soc., 121, 7034-7038. #13592

485. Rosenthal, K., Erlandsson, M., & Und n, A. (1999) 4-(3-Hydroxy-4-methylpentyl)phenylacetic acid as a new linker for the solid phase synthesis of peptides with Boc chemistry. Tetrahedron Lett., 40, 377-380. #12106

486. Sampson, W.R., Patsiouras, H., & Ede, N.J. (1999) The synthesis of 'difficult' peptides using 2-hydroxy-4-methoxybenzyl or pseudoproline amino acid building blocks: A comparative study. J. Peptide Sci., 5, 403-409. #14125

487. Samson, F., Bonnet, D., Rommens, C., Gras-Masse, H., & Melnyk, O. (1999) Reactivity of Lys(NH2)-containing peptides toward endopeptidases. J. Peptide Sci., 5, 352-359. #14422

488. Sanz-Nebot, V., Garces, A., & Barbosa, J. (1999) Investigation of crudes of synthesis of carbetocin by liquid chromatography coupled to electrospray ionization mass spectrometry. J. Chromatogr., 833, 267-275. #13041

489. Sanz-Nebot, V., Toro, I., & Barbosa, J. (1999) Fractionation and characterization of a crude peptide mixture from the synthesis of eledoisin by liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. A, 846, 25-38. #13418

490. Sanz-Nebot, V., Toro, I., Garces, A., & Barbosa, J. (1999) Separation and identification of peptide mixtures in a synthesis crude of carbetocin by liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom., 13, 2341-2347. #15292

491. Sasaki, Y., Suto, T., Ambo, A., Ouchi, H., & Yamamoto, Y. (1999) Biological properties of opioid peptides replacing Tyr at position 1 by 2,6-dimethyl-Tyr. Chem. Pharm. Bull. Tokyo, 47, 1506-1509. #14128

492. Scheller, A., Oehlke, J., Wiesner, B., Dathe, M., Krause, E., Beyermann, M., Melzig, M., & Bienert, M. (1999) Structural requirements for cellular uptake of a-helical amphipathic peptides. J. Peptide Sci., 5, 185-194. #12902

493. Scott, R.H., Barnes, C., Gerhard, U., & Balasubramanian, S. (1999) Exploring a chemical encoding strategy for combinatorial synthesis using Friedel-Crafts alkylation. Chem. Commun., 1331-1332. #13821

494. Seebach, D., Abele, S., Gademann, K., & Jaun, B. (1999) Pleated sheets and turns of beta-peptides with proteinogenic side chains. Angew. Chem., 1595-1597. #13047

495. Seitz, O. (1999) Solid phase synthesis of protected peptide nucleic acids. Tetrahedron Lett., 40, 4161-4164. #12889

496. Sheridan, J.M., Hayes, G. & Austen, B.M. (1999) Convergent solid phase synthesis of immunoglobulin-like domains of macrophage specific Fc receptor (FcgRI). In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 391-394). Mayflower Scientific Limited, Birmingham. #13721

497. Sheridan, J.M., Hayes, G.M., & Austen, B.M. (1999) Solid-phase synthesis and cyclization of a large branched peptide from IgG Fc with affinity for Fc gamma RI. J. Peptide Sci., 5, 555-562. #14138

498. Shin, Y., Winans, K.A., Backes, B.J., Kent, S.B.H., Ellman, J.A., & Bertozzi, C.R. (1999) Fmoc-based synthesis of peptide-(alpha)thioesters: Application to the total chemical synthesis of a glycoprotein by native chemical ligation. J. Amer. Chem. Soc., 121, 11684-11689. #14141

499. Sidorova, M.V., Molokoedov, A.S., Azmuko, A.A., Stambolskii, D.V., Kashirina, N.M., Bochkov, V.N., Tkachuk, V.A., & Bespalova, Z.D. (1999) Antibodies to synthetic peptide fragments of T-cadherin as inhibitors of T-cadherin binding to low density lipoproteins [Russian]. Bioorganicheskaia Khimiia, 25, 171-178. #13051

500. Siev, D.V., Gaudette, J.A., & Semple, J.E. (1999) Novel protocol for the solid-phase synthesis of peptidyl and peptidomimetic P1-argininal derivatives. Tetrahedron Lett., 40, 5123-5127. #13117

501. Sithigorngul, P., Panchan, N., Vilaivan, T., Sithigorngul, W., & Petsom, A. (1999) Immunochemical analysis and immunocytochemical localization of crustacean hyperglycemic hormone from the eyestalk of Macrobrachium rosenbergii. Comparative Biochemistry and Physiology B-Biochemistry and Molecular Biology, 124, 73-80. #14146

502. Sjolin, P., George, S.K., Bergquist, K.E., Roy, S., Svensson, A., & Kihlberg, J. (1999) Synthesis of deoxy and alanine-substituted derivatives of a T cell stimulating glycopeptide: An investigation of conditions for cleavage from the solid phase and deprotection. J. Chem. Soc. Perkin Trans. 1, 1731-1742. #13421

503. Slootstra, J.W., Schaaper, W.M.M., Puijk, W.C., Ligtvoet, G.J., Kuperus, D. & Meloen, R.H. (1999) Contribution of solid-phase in antibody binding activity of sythetic peptides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 300-400). Mayflower Scientific Limited, Birmingham. #13722

504. Smith, A.B., Benowitz, A.B., Sprengeler, P.A., Barbosa, J., Guzman, M.C., Hirschmann, R., Schweiger, E.J., Bolin, D.R., Nagy, Z., Campbell, R.M., Cox, D.C., & Olson, G.L. (1999) Design and synthesis of a competent pyrrolinone-peptide hybrid ligand for the class II major histocompatibility complex protein HLA-DR1. J. Amer. Chem. Soc., 121, 9286-9298. #14147

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