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Selection of papers on solid phase peptide synthesis published after 1996

Solid phase peptide synthesis was invented by Bruce Merrifield in 1963 and became very quickly the routine tool for preparation of peptides and later small proteins. Surprisingly, solid phase synthesis of small organic molecules was accepted only after another 30 years. The compilation of papers dealing with solid phase peptide synthesis would be extremely long. Luckily, Gregg Fields edited the book Solid Phase Peptide Synthesis in the series Methods in Enzymology (Fields, G.B. (1997) Solid-Phase Peptide Synthesis. Academic Press, San Diego. #9830), which covers all aspects of this methodology. We decided to cover here only papers published after publication of Fields' book. This compilation will probably never be complete, but we will try to cover the most important methodological papers. This list is arranged by the year and the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (michal@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M., Leblova Z.: Dynamic database of references in solid phase synthesis. Internet http://www.5z.com.


Recently added entries are marked in bold

  1. Balaspiri, L., & Langel, U. (2001) Synthesis of b-amyloid precursor peptide and presenilin segments. J. Peptide Sci., 7, 58-60. #16430

  2. Bullesbach, E.E., & Schwabe, C. (2001) Synthesis and conformational analysis of the insulin-like 4 gene product. J. Pept. Res., 57, 77-83. #16258

  3. Burgess, K., Han, I., Zhang, A., Zheng, W.H., Shanmugam, K., Featherstone, M.S., & Saragovi, H.U. (2001) DiSSiMiL: Diverse Small Size Mini-Libraries applied to simple and rapid epitope mapping of a monoclonal antibody. J. Pept. Res., 57, 68-76. #16259

  4. Dekker, N., Cox, R.C., Kramer, R.A., & Egmond, M.R. (2001) Substrate specificity of the integral membrane protease OmpT determined by spatially addressed peptide libraries. Biochemistry, 40, 1694-1701. #16271

  5. Demarcus, M., Ganadu, M.L., Mura, G.M., Porcheddu, A., Quaranta, L., Reginato, G., & Taddei, M. (2001) Small ring constrained peptidomimetics. Synthesis of epoxy peptidomimetics, inhibitors of cysteine proteases. J. Org. Chem., 66, 697-706. #16273

  6. Dolence, E.K., Dolence, J.M., & Poulter, C.D. (2001) Solid-phase synthesis of a radiolabeled, biotinylated, and farnesylated Ca(1)a(2)X peptide substrate for Ras- and a-mating factor converting enzyme. Bioconjug. Chem., 12, 35-43. #16275

  7. Futaki, S., Youjun, Z., & Sugiura, Y. (2001) Detecting a tag on a channel opening: Blockage of the biotinylated channels by strepravidin. Tetrahedron Lett., 42, 1563-1565. #16423

  8. Gatos, D., & Tzavara, C. (2001) Comparison of the solid-phase fragment condensation and phase-change approaches in the synthesis of salmon I calcitonin. J. Pept. Res., 57, 168-174. #16427

  9. Geginat, G., Schenk, S., Skoberne, M., Goebel, W., & Hof, H. (2001) A novel approach of direct ex vivo epitope mapping identifies dominant and subdominant CD4 and CD8 T cell epitopes from Listeria monocytogenes. Journal of Immunology, 166, 1877-1884. #16288

  10. Henlin, J.M., Boutin, J.A., Kucharczyk, N., Desmet-Beaufort, C., Loynel, A., Bertrand, M., Genton, A., Tucker, G.C., Atassi, G., & Fauchere, J.L. (2001) From peptide libraries to optimized nonpeptide ligands in the search for S-farnesyltransferase inhibitors. J. Pept. Res., 57, 85-96. #16425

  11. Kitagawa, K., Aida, C., Fujiwara, H., Yagami, T., Futaki, S., Kogire, M., Ida, J., & Inoue, K. (2001) Facile solid-phase synthesis of sulfated tyrosine-containing peptides: Total synthesis of human big gastrin-II and cholecystokinin (CCK)-39(1,2). J. Org. Chem., 66, 1-10. #16313

  12. Kumar, K.S., Roice, M., Sasikumar, P.G., Poduri, C.D., Sugunan, V.S., Pillai, V.N.R., & Das, M.R. (2001) Syntheses of immunodominant peptide regions of hepatitis C viral pathogens using PS-BDODMA resin: A single peptide derived from the conserved domain (E2/NS1) was highly effective in detecting anti-HCV antibodies. J. Pept. Res., 57, 140-150. #16426

  13. Lelievre, D., Bure, C., Laot, F., & Delmas, A. (2001) Synthesis of peptide di-aldehyde precursor for stepwise chemoselective ligations via oxime bonds. Tetrahedron Lett., 42, 235-238. #16326

  14. Licha, K., Hessenius, C., Becker, A., Henklein, P., Bauer, M., Wisniewski, S., Wiedenmann, B., & Semmler, W. (2001) Synthesis, characterization, and biological properties of cyanine-labeled somatostatin analogues as receptor-targeted fluorescent probes. Bioconjug. Chem., 12, 44-50. #16329

  15. Marchetto, R., Nicolas, E., Castillo, N., Bacardit, J., Navia, M., Vila, J., & Giralt, E. (2001) Two short peptides including segments of subunit A of Escherichia coli DNA gyrase as potential probes to evaluate the antibacterial activity of quinolones. J. Peptide Sci., 7, 27-40. #16441

  16. McNamara, L.M.A., Andrews, M.J.I., Mitzel, F., Siligardi, G., & Tabor, A.B. (2001) Unexpected conformational properties of a peptide constrained by an aliphatic link between the i and i+4 positions. Tetrahedron Lett., 42, 1591-1593. #16424

  17. Nilsson, M.R., Nguyen, L.L., & Raleigh, D.P. (2001) Synthesis and purification of amyloidogenic peptides. Anal. Biochem., 288, 76-82. #16355

  18. Qiu, W., Gu, X., Soloshonok, V.A., Carducci, M.D., & Hruby, V.J. (2001) Stereoselective synthesis of conformationally constrained reverse turn dipeptide mimetics. Tetrahedron Lett., 42, 145-148. #16181

  19. Royo, M., Jimenez, J.C., Lopez-Macia, A., Giralt, E., & Albericio, F. (2001) Solid-phase synthesis of peptides containing alpha,beta-didehydroamino acids. Eur. J. Org. Chem., 45-48. #16373

  20. Shuker, S.B., Esterbrook, J., & Gonzalez, J. (2001) Solid-phase synthesis of a novel peptide substituted calix[4]arene. Synlett, 210-213. #16382

  21. Aimoto, S., Hasegawa, K., Li, X. & Kawakami, T. (2000) Synthesis of phosphorylated CRE BP1(19-106) amide using a phosphopeptide thioester prepared directly by an Fmoc solid-phase method. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 82-83). Kluwer Academic Publisher, Dordrecht. #15701

  22. Ajikumar, P.K., & Devaky, K.S. (2000) EGDMA-cross-linked polystyrene resin: An efficient support for gel phase peptide synthesis. Proc. Indian Acad. Sci. -Chem. Sci., 112, 465-474. #15819

  23. Alam, M.R., Maeda, M., & Sasaki, S. (2000) DNA-binding peptides searched from the solid-phase combinatorial library with the use of the magnetic beads attaching the target duplex DNA. Bioorg. Med. Chem., 8, 465-473. #14913

  24. Albericio, F. (2000) Orthogonal protecting groups for Na-amino and C-terminal carboxyl functions in solid-phase peptide synthesis. Biopolymers (Pept. Sci. ), 55, 123-139. #16434

  25. Albericio, F. (2000) Orthogonal protecting groups for N alpha-amino and C-terminal carboxyl functions in solid-phase peptide synthesis. Biopolymers, 55, 123-139. #16237

  26. Alsina, J., Yokum, T.S., Albericio, F., & Barany, G. (2000) A modified Backbone Amide Linker (BAL) solid-phase peptide synthesis strategy accommodating prolyl, N-alkylamino acyl, or histidyl derivatives at the C-terminus. Tetrahedron Lett., 41, 7277-7280. #15629

  27. Alsina, J., Yokum, T.S., Albericio, F. & Barany, G. (2000) Backbone Amide Linker (BAL) methodology to accommodate C-terminal hindered, unreactive, and/or sensitive modification. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 102-103). Kluwer Academic Publisher, Dordrecht. #15707

  28. Andersson, L., Blomberg, L., Flegel, M., Lepsa, L., Nilsson, B., & Verlander, M. (2000) Large-scale synthesis of peptides. Biopolymers (Pept. Sci. ), 55, 227-250. #16440

  29. Andersson, L., Blomberg, L., Flegel, M., Lepsa, L., Nilsson, B., & Verlander, M. (2000) Large-scale synthesis of peptides. Biopolymers, 55, 227-250. #16238

  30. Ando, S., Nakahara, Y., Ito, Y., & Ogawa, T. (2000) Solid-phase synthesis of the glycopeptide of human glycophorin AM bearing the consecutive sialyl-T antigen. Carbohyd. Res., 329, 773-780. #16239

  31. Anichini, B., Ricci, R., Fabbri, G., Balacco, G., Mauro, S., Triolo, A., Altamura, M., Maggi, C.A., & Quartara, L. (2000) Solid-phase synthesis of MEN 11270, a new cyclic peptide kinin B2 receptor antagonist. J. Peptide Sci., 6, 612-620. #16152

  32. Annis, I. & Barany, G. (2000) Alternative solid-phase reagents for formation of intramolecular sulfur-sulfur bridges in peptides under mild conditions. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 96-97). Kluwer Academic Publisher, Dordrecht. #15704

  33. Antopolsky, M., & Azhayev, A. (2000) Stepwise solid-phase synthesis of peptide-oligonucleotide phosphorothioate conjugates employing Fmoc peptide chemistry. Tetrahedron Lett., 41, 9113-9117. #15823

  34. Arnon, R., Tarrab-Hazdai, R., & Steward, M. (2000) A mimotope peptide-based vaccine against Schistosoma mansoni: Synthesis and characterization. Immunology, 101, 555-562. #16245

  35. Arunan, C., & Pillai, V.N.R. (2000) Synthesis of acyl carrier protein fragment 65-74 on a flexible cross-linked polystyrene support: Comparison with Merrifield resin. Tetrahedron, 56, 3005-3011. #14623

  36. Arunan, C., Naaraj, R., & Pillai, V.N.R. (2000) Solid-phase synthesis of a modified 13-residue seminalplasmin fragment on 1,6-hexanediol diacrylate-crosslinked polystyrene support. Peptides, 21, 773-777. #15758

  37. Balaspiri, L., Tegyei, Z., Dux, M., Jancso, G., Jozsa, R., Csernus, V., & Mess, B. (2000) Synthesis of chicken galanin and its N- and C-terminal segments, and preparation of their antisera. Lett. Peptide Sci., 7, 23-26. #15431

  38. Balse, P., Han, G., Hruby, V.J. & Sun, L. (2000) Diisopropylethylamine salts for protected amino acids: Direct synthesis of peptides on solid-phase. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 80-81). Kluwer Academic Publisher, Dordrecht. #15700

  39. Balse, P.M., Kim, H.J., Han, G., & Hruby, V.J. (2000) Evaluation of new base-labile 2-(4-nitrophenylsulfonyl)ethoxycarbonyl (Nsc)-amino acids for solid-phase peptide synthesis. J. Pept. Res., 56, 70-79. #15444

  40. Baumann, M., Dietrich, U., Koenigs, C. & Griesinger, C. (2000) Combinatorial peptide synthesis, NMR-aided screening and testing of low molecular weight RNA-ligands. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 170-171). Kluwer Academic Publisher, Dordrecht. #15717

  41. Bechinger, B. (2000) Biophysical investigations of membrane perturbations by polypeptides using solid-state NMR spectroscopy. Molecular Membrane Biology, 17, 135-142. #15832

  42. Beebe, K.D., Wang, P., Arabaci, G., & Pei, D.H. (2000) Determination of the binding specificity of the SH2 domains of protein tyrosine phosphatase SHP-1 through the screening of a combinatorial phosphotyrosyl peptide library. Biochemistry, 39, 13251-13260. #15833

  43. Beligere, G.S., & Dawson, P.E. (2000) Design, synthesis, and characterization of 4-ester CI2, a model for backbone hydrogen bonding in protein alpha-helices. J. Amer. Chem. Soc., 122, 12079-12082. #16250

  44. Besser, D., Muller, B., Agricola, I., & Reissmann, S. (2000) Synthesis of differentially protected N-acylated reduced pseudodipeptides as building units for backbone cyclic peptides. J. Peptide Sci., 6, 130-138. #14943

  45. Besser, D., Muller, B., Kleinwachter, P., Greiner, G., Seyfarth, L., Steinmetzer, T., Arad, O., & Reissmann, S. (2000) Synthesis and characterization of octapeptide somatostatin analogues with backbone cyclization: Comparison of different strategies, biological activities and enzymatic stabilities. Journal fur Praktische Chemie-Practical Applications and Applied Chemistry, 342, 537-545. #15837

  46. Bibbs, L., Ambulos, N.P., Kates, S.A., Khatri, A., Medzihradszky, K.F., Osapay, G. & Weintraub, S.T. (2000) Strategies for the synthesis of labeled peptides. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 113-114). Kluwer Academic Publisher, Dordrecht. #15710

  47. Bishop, B.M., McCafferty, D.G., & Erickson, B.W. (2000) 4'-Aminomethyl-2,2'-bipyridyl-4-carboxylic acid (Abc) and related derivatives: Novel bipyridine amino acids for the solid-phase incorporation of a metal coordination site within a peptide backbone. Tetrahedron, 56, 4629-4638. #14946

  48. Blaskovich, M.A., Boatman, P.D., Cao, B., Eguchi, M., Kim, H.O., Lee, M., Little, T., Mathew, F., McCann, I., Mehlin, C., Nakanishi, H., Nelson, S., Nguyen, M., Ogbu, C., Qabar, M.N., Ruan, F., Shea, J.P., Stasiak, M., Urban, J. & Kahn, M. (2000) Highly efficient and versatile construction of secondary structure peptide mimetic libraries: Application to biology and drug development. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 191-193). Kluwer Academic Publisher, Dordrecht. #15726

  49. Blondelle, S.E., Crooks, E., Aligue, R., Agell, N., Bachs, O., Esteve, V., Tejero, R., Celda, B., Pastor, M.T., & Perez-Paya, E. (2000) Novel, potent calmodulin antagonists derived from an all-D hexapeptide combinatorial library that inhibit in vivo cell proliferation: Activity and structural characterization. J. Pept. Res., 55, 148-162. #14266

  50. Blondelle, S.E., Esteve, V., Celda, B., Pastor, M.T., & Perez-Paya, E. (2000) Influence of the hydrophylic face on the folding ability and stability of a-helix bundles: Relevance to the peptide catalytic activity. J. Pept. Res., 56, 121-131. #15789

  51. Bonner, G.G., Davis, P., Stropova, D., Edsall, S., Yamamura, H.I., Porreca, F., & Hruby, V.J. (2000) Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays. J. Med. Chem., 43, 569-580. #14952

  52. Bordusa, F. (2000) Nonconventional amide bond formation catalysis: Programming enzyme specificity with substrate mimetics. Braz. J. Med. Biol. Res., 33, 469-485. #14953

  53. Borgia, J.A., Oegema, T.R.Jr. & Fields, G.B. (2000) Synthesis and application of a glycoprotein derived from the proteoglycan linkage structure. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 773-774). Kluwer Academic Publisher, Dordrecht. #15751

  54. Bourel, L., Carion, O., Gras-Masse, H., & Melnyk, O. (2000) The deprotection of Lys(Mtt) revisited. J. Peptide Sci., 6, 264-270. #14956

  55. Bourne, G.T., McGeary, R.P., Golding, S.W., Meutermans, W.D.F., Alewood, P.F. & Smythe, M.L. (2000) An evaluation of a novel safety catch linker for development of cyclic peptide libraries. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 98-99). Kluwer Academic Publisher, Dordrecht. #15705

  56. Boykins, R.A., Joshi, M., Syin, C., Dhawan, S., & Nakhasi, H. (2000) Synthesis and construction of a novel multiple peptide conjugate system: strategy for a subunit vaccine design. Peptides, 21, 9-17. #14958

  57. Boysen, R.I., & Hearn, M.T.W. (2000) Direct characterisation by electrospray ionisation mass spectroscopy of mercuro-polypeptide complexes after deprotection of acetamidomethyl groups from protected cysteine residues of synthetic polypeptides. J. Biochem. Biophys. Meth., 45, 157-168. #15846

  58. Bozo, B., Farkas, J., Toth, G., Wollemann, M., Szucs, M., & Benyhe, S. (2000) Receptor binding and G-protein activation by new Met(5)-enkephalin-Arg(6)-Phe(7) derived peptides. Life Sci., 66, 1241-1251. #14959

  59. Brask, J., & Jensen, K.J. (2000) Carbopeptides: Chemoselective ligation of peptide aldehydes to an aminooxy-functionalized D-galactose template. J. Peptide Sci., 6, 290-299. #15448

  60. Braslau, R., Axon, J.R., & Lee, B. (2000) Synthesis of N-hydroxy peptides: Chemical ligation of O-acyl hydroxamic acids. Organic Letters, 2, 1399-1401. #14964

  61. Buchardt, J., & Meldal, M. (2000) Novel methodology for the solid-phase synthesis of phosphinic peptides. Journal of the Chemical Society-Perkin Transaction 1, 3306-3310. #15852

  62. Bui, C.T., Ercole, F., Pham, Y., Campbell, R., Rasoul, F.A., Maeji, N.J., & Ede, N.J. (2000) Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMO) linker on resin and SynPhaseTM grafted solid-supports. J. Peptide Sci., 6, 534-538. #15756

  63. Bui, C.T., Bray, A.M., Nguyen, T., Ercole, F., Rasoul, F., Sampson, W., & Maeji, N.J. (2000) Acetophenone-based linker for solid-phase peptide synthesis. J. Peptide Sci., 6, 49-56. #14310

  64. Bui, C.T., Bray, A.M., Nguyen, T., Ercole, F., & Maeji, N.J. (2000) Solid phase synthesis of C-terminal peptide amides: Development of a new aminoethyl-polystyrene linker on the MultipinTM solid support. J. Peptide Sci., 6, 243-250. #14408

  65. Burgess, K. (2000) Solid-phase organic synthesis. John Wiley & Sons, New York. ISBN 0471318256 #14304

  66. Calcagni, A., Gavuzzo, E., Lucente, G., Mazza, F., Morera, E., Paradisi, M.P., & Rossi, D. (2000) Peptides containing the sulfonamide junction. 2. Structure and conformation of Z-Tau-Pro-D-Phe-NHiPr. Biopolymers, 54, 379-387. #15855

  67. Camarero, J.A., Adeva, A., & Muir, T.W. (2000) 3-Thiopropionic acid as a highly versatile multidetachable thioester resin linker. Lett. Peptide Sci., 7, 17-21. #15430

  68. Cammish, L.E., & Kates, S.A. (2000) Instrumentation for automated solid phase peptide synthesis. Fmoc Solid Phase Peptide Synthesis: A Practical ApproachÉ, 222, 277-302. #15857

  69. Carlson, C.B., & Beal, P.A. (2000) Solid-phase synthesis of acridine-based threading intercalator peptides. Bioorg. Med. Chem. Lett., 10, 1979-1982. #15764

  70. Carreno, C., Mendez, M.E., Kim, Y.D., Kim, H.J., Kates, S.A., Andreu, D., & Albericio, F. (2000) Nsc and Fmoc Na-amino protection for solid-phase peptide synthesis: A parallel study. J. Pept. Res., 56, 63-69. #15443

  71. Cavero, M., Hobbs, A., Madge, D., Motherwell, W.B., Selwood, D., & Potier, P. (2000) Synthesis and biological evaluation of enantiopure thionitrites: The solid-phase synthesis and nitrosation of D-glutathione as a molecular probe. Bioorg. Med. Chem. Lett., 10, 641-644. #14632

  72. Cerovsky, V., & Bordusa, F. (2000) Protease-catalyzed fragment condensation via substrate mimetic strategy: A useful combination of solid-phase peptide synthesis with enzymatic methods. J. Pept. Res., 55, 325-329. #14363

  73. Chetyrkina, S., Estieu-Gionnet, K., Lain, G., Bayle, M., & Deleris, G. (2000) Synthesis of N-Fmoc-4-[(diethylphosphono)-2',2'-difluoro-1'-hydroxyethyl]phenylalanine, a novel phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. Tetrahedron Lett., 41, 1923-1926. #14347

  74. Cho, J.K., Park, B.D., & Lee, Y.S. (2000) A novel core-shell type polymer support for solid-phase peptide synthesis. Tetrahedron Lett., 41, 7481-7485. #15861

  75. Cilli, E.M., Jubilut, G.N., Ribeiro, S.C.F., Oliveira, E., & Nakaie, C.R. (2000) Importance of the solvation degree of peptide-resin beads for amine groups determination by the picric acid method. J. Braz. Chem. Soc., 11, 474-478. #15862

  76. Clippingdale, A.B., Barrow, C.J., & Wade, J.D. (2000) Peptide thioester preparation by Fmoc solid phase peptide synthesis for use in native chemical ligation. J. Peptide Sci., 6, 225-234. #14405

  77. Conde-Frieboes, K., Andersen, S., & Breinholt, J. (2000) Synthesis of symmetrical dimeric N,N'-linked peptides on solid support by olefin metathesis. Tetrahedron Lett., 41, 9153-9156. #16159

  78. Cotton, G.J., & Muir, T.W. (2000) Generation of a dual-labeled fluorescence biosensor for Crk-II phosphorylation using solid-phase expressed protein ligation. Chem. Biol., 7, 253-261. #15864

  79. Cruz, L.J., Quintana, D., Iglesias, E., Garcia, Y., Huerta, V., Garay, H.E., Duarte, C., & Reyes, O. (2000) Immunogenicity comparison of a multi-antigenic peptide bearing V3 sequences of the human immunodeficiency virus type 1 with TAB9 protein in mice. J. Peptide Sci., 6, 217-224. #14402

  80. Cudic, M., Wade, J.D., & Otvos, L.Jr. (2000) Convenient synthesis of a head-to-tail cyclic peptide containing an expanded ring. Tetrahedron Lett., 41, 4527-4531. #14594

  81. Dai, X., Su, Z., & Liu, J.O. (2000) An improved synthesis of a selective aVb3-integrin antagonist cyclo(-RGDfK-). Tetrahedron Lett., 41, 6295-6298. #15531

  82. Dal, X.D., Su, Z., & Liu, J.O. (2000) An improved synthesis of a selective alpha(v)beta(3)-integrin antagonist cyclo(-RGDfK-). Tetrahedron Lett., 41, 6295-6298. #15868

  83. Dankwardt, S.M., Billedeau, R.J., Lawley, L.K., Abbot, S.C., Martin, R.L., Chan, C.S., Van Wart, H.E., & Walker, K.A.M. (2000) Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase. Bioorg. Med. Chem. Lett., 10, 2513-2516. #15870

  84. Denis, B., & Trifilieff, E. (2000) Synthesis of palmitoyl-thioester T-cell epitopes of myelin proteolipid protein (PLP). Comparison of two thiol protecting groups (StBu and Mmt) for on-resin-acylation. J. Peptide Sci., 6, 372-377. #15450

  85. Dionyssopoulou, H., Mouzaki, A., Slootstra, J., Puijk, W., Meloen, R., Cordopatis, P., & Sotiropoulou, G. (2000) Synthetic peptides as putative therapeutic agents in transplantation medicine: Application of PEPSCAN to the identification of functional sequences in the extracellular domain of the interleukin-2 receptor beta chain (IL-2R beta). J. Immunol. Method, 241, 83-95. #15882

  86. Dolence, E.K., Dolence, J.M., & Poulter, C.D. (2000) Solid-phase synthesis of a farnesylated CaaX peptide library: Inhibitors of the Ras CaaX endoprotease. Journal of Combinatorial Chemistry, 2, 522-536. #15605

  87. Drakopoulou, E., Uray, K., Mezo, G., Price, M.R., Vita, C., & Hudecz, F. (2000) Synthesis and antibody recognition of mucin 1 (MUC1)-a-conotoxin chimera. J. Peptide Sci., 6, 175-185. #14361

  88. Dufau, I., & Mazarguil, H. (2000) Design of a fluorescent amino acid derivative usable in peptide synthesis. Tetrahedron Lett., 41, 6063-6066. #15517

  89. Dutta, A.S., Gormley, J.J., Coath, M., Hassall, L., Hayward, C.F., Gellert, P.R., Kittlety, R.S., Alcock, P.J., Ferguson, R., Halterman, T., Jamieson, A., Moors, J.A., Moores, J.M., Rees, A., Wood, L.J., Reilly, C.F., & Haworth, D. (2000) Potent cyclic peptide inhibitors of VLA-4 (a4b1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation. J. Peptide Sci., 6, 398-412. #15453

  90. Dutta, A.S., Crowther, M., Gormley, J.J., Hassall, L., Hayward, C.F., Gellert, P.R., Kittlety, R.S., Alcock, P.J., Jamieson, A., Moores, J.M., Rees, A., Wood, L.J., Reilly, C.F., & Haworth, D. (2000) Potent cyclic monomeric and dimeric peptide inhibitors of VLA-4 (alpha(4)beta(1) integrin)-mediated cell adhesion based on the Ile-Leu-Asp-Val tetrapeptide. J. Peptide Sci., 6, 321-341. #15892

  91. Ede, N.J., Eagle, S.N., Wickham, G., Bray, A.M., Warne, B., Shoemaker, K., & Rosenberg, S. (2000) Solid phase synthesis of peptide aldehyde protease inhibitors. Probing the proteolytic sites of hepatitis C virus polyprotein. J. Peptide Sci., 6, 11-18. #13956

  92. Egleton, R.D., Mitchell, S.A., Huber, J.D., Janders, J., Stropova, D., Polt, R., Yamamura, H.I., Hruby, V.J., & Davis, T.P. (2000) Improved bioavailability to the brain of glycosylated Met-enkephalin analogs. Brain Res., 881, 37-46. #15894

  93. El-Agnaf, O.M.A., Mahil, D.S., Patel, B.P., & Austen, B.M. (2000) Oligomerization and toxicity of beta-amyloid-42 implicated in Alzheimer's disease. Biochem. Biophys. Res. Commun., 273, 1003-1007. #15895

  94. Falb, E., Yechezkel, T., Salitra, Y., Gellerman, G., Muller, D. & Gilon, C. (2000) In situ generation of Fmoc amino acid chlorides for extremely difficult couplings to sterically hindered secondary amines in solid-phase peptide synthesis. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 55-57). Kluwer Academic Publisher, Dordrecht. #15694

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  297. Buku, A. (1999) Mast cell degranulating (MCD) peptide: A prototypic peptide in allergy and inflammation. Peptides, 20, 415-420. #13489

  298. Cabezas, E., & Satterthwait, A.C. (1999) The hydrogen bond mimic approach: Solid-phase synthesis of a peptide stabilized as an a-helix with a hydrazone link. J. Amer. Chem. Soc., 121, 3862-3875. #12862

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  302. Cervini, L., Theobald, P., Corrigan, A., Craig, A.G., Rivier, C., Vale, W., & Rivier, J. (1999) Corticotropin releasing factor (CRF) agonists with reduced amide bonds and Ser(7) substitutions. J. Med. Chem., 42, 761-768. #12720

  303. Chaloin, L., Mery, J., Van Mau, N., Divita, G., & Heitz, F. (1999) Synthesis of a template-associated peptide designed as a transmembrane ion channel former. J. Peptide Sci., 5, 381-391. #13928

  304. Chen, H., Cong, L.N., Li, Y.H., Yao, Z.J., Wu, L., Zhang, Z.Y., Burke, T.R., & Quon, M.J. (1999) Phosphotyrosyl mimetic peptide reverses impairment of insulin-stimulated translocation of GLUT4 caused by overexpression of PTP1B in rat adipose cells. Biochemistry, 38, 384-389. #12722

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  306. Chitnumsub, P., Fiori, W.R., Lashuel, H.A., Diaz, H., & Kelly, J.W. (1999) The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution. Bioorg. Med. Chem., 7, 39-59. #12724

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  310. Cornille, F., Wecker, K., Loffet, A., Genet, R., & Roques, B. (1999) Efficient solid-phase synthesis of Vpr from HIV-1 using low quantities of uniformly 13C-, 15N-labeled amino acids for NMR structural studies. J. Pept. Res., 54, 427-435. #13787

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  312. Coupal, M., De Lean, A., McNicoll, N., & Fournier, A. (1999) Development of p-benzoylbenzoylated [N,C,rANP(1-28)]pBNP32 (pBNP1) derivatives and affinity photolabeling of the bovine NPR-A receptor. Biochem. Biophys. Res. Commun., 258, 81-86. #12948

  313. Cudic, M., Bulet, P., Hoffmann, R., Craik, D.J., & Otvos, L.Jr. (1999) Chemical synthesis, antibacterial activity and conformation of diptericin, an 82-mer peptide originally isolated from insects. Eur. J. Biochem., 266, 549-558. #14234

  314. Daquinag, A.C., Sato, T., Koda, H., Takao, T., Fukuda, M., Shimonishi, Y., & Tsukamoto, T. (1999) A novel endogenous inhibitor of phenoloxidase from Musca domestica has a cystine motif commonly found in snail and spider toxins. Biochemistry, 38, 2179-2188. #12728

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  317. Dawson, N.F., Tan, Y.Y., Macris, M., Otvos, L., Summers, R.J., Tregear, G.W., & Wade, J.D. (1999) Solid-phase synthesis of ovine Leydig cell insulin-like peptide: A putative ovine relaxin? J. Pept. Res., 53, 542-547. #12953

  318. Dawson, N.F., Craik, D.J., McManus, A.M., Dashper, S.G., Reynolds, E.C., Tregear, G.W., Otvos, L., & Wade, J.D. (1999) Chemical synthesis, characterization and activity of RK-1, a novel alpha-defensin-related peptide. J. Peptide Sci., 6, 19-25. #13945

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  320. Debenham, S.D., Cossrow, J., & Toone, E.J. (1999) Synthesis of alpha- and beta-carbon-linked serine analogues of the P-k trisaccharide. J. Org. Chem., 64, 9153-9163. #13950

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  324. Dong, S.L., Wang, T., Chen, Q., & Wang, R. (1999) Synthesis, structure-activity relationship of nociceptin and its fragments. Chin. Sci. Bull., 44, 1655-1659. #15014

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  328. Eggenweiler, H.M., Clausen, N. & Bayer, E. (1999) a-Hydroxymethylacrylic acid in solid phase synthesis: An extremely nucleophile sensitive linker. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 283-286). Mayflower Scientific Limited, Birmingham. #13695

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  330. Eichler, J. & Houghten, R.A. (1999) Scaffolded peptide combinatorial libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 155-158). Mayflower Scientific Limited, Birmingham. #13667

  331. Eisele, F., Owen, D.J., & Waldmann, H. (1999) Peptide conjugates as tools for the study of biological signal transduction. Bioorg. Med. Chem., 7, 193-224. #12736

  332. Elbayed, K., Bourdonneau, M., Furrer, J., Richert, T., Raya, J., Hirschinger, J., & Piotto, M. (1999) Origin of the residual NMR linewidth of a peptide bound to a resin under magic angle spinning. J. Magn. Resonance, 136, 127-129. #12531

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  336. Evstigneeva, R.P., Zheltukhina, G.A., Khalil', V., & Efimova, E.I. (1999) The synthesis of Arg-containing peptides and their conjugates with protohemin IX and tetraphenylporphyrin. Bioorganicheskaia Khimiia, 25, 572-580. #13960

  337. Falb, E., Yechezkel, T., Salitra, Y., & Gilon, C. (1999) In situ generation of Fmoc-amino acid chlorides using bis(trichloromethyl) carbonate and its utilization for difficult couplings in solid-phase peptide synthesis. J. Pept. Res., 53, 507-517. #12960

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  340. Francke, C., Loyal, R., Ohad, I., & Haehnel, W. (1999) In vitro assembly of a beta(2) cytochrome b(559)-like complex from the chemically synthesised beta-subunit encoded by the Synechocystis sp 6803 psbF gene. FEBS Lett., 442, 75-78. #12354

  341. Freund, E., & Robinson, J.A. (1999) Solid-phase synthesis of a putative heptapeptide intermediate in vancomycin biosynthesis. Chem. Commun., 2509-2510. #14236

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  344. Fukuda, H., Irie, K., Nakahara, A., Ohigashi, H., & Wender, P.A. (1999) Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma. Bioorg. Med. Chem., 7, 1213-1221. #13519

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  348. Gibson, C., Goodman, S.L., Hahn, D., Holzemann, G., & Kessler, H. (1999) Novel solid-phase synthesis of azapeptides and azapeptoides via Fmoc-strategy and its application in the synthesis of RGD-mimetics. J. Org. Chem., 64, 7388-7394. #13981

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  1033. Pascal, R., & Sola, R. (1997) Calcium-promoted hydrolysis of N-acylureas allows mild release of peptides anchored with the Dpr(Phoc) linker to hydrophilic resins. Tetrahedron Lett., 38, 4549-4552. #8873

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  1047. Rano, T.A., Timkey, T., Peterson, E.P., Rotonda, J., Nicholson, D.W., Becker, J.W., Chapman, K.T., & Thornberry, N.A. (1997) A combinatorial approach for determining protease specificities: Application to interleukin-1beta converting enzyme (ICE). Chem. Biol., 4, 149-155. #9284

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  1049. Rodionova, L.N., Zagranichny, V.E., Rodionov, I.L., Lipkin, V.M., & Ivanov, V.T. (1997) The total solid phase synthesis of the gamma subunit of cGMP phosphodiesterase from bovine retina and some physicochemical properties of the synthetic protein [russian]. Bioorganicheskaia Khimiia, 23, 933-948. #10498

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  1055. Sabirov, A.N., Kim, Y.D., Kim, H.J., & Samukov, V.V. (1997) FMOC- and NSC-groups as a base labile N(alpha)-amino protection: A comparative study in the automated SPPS. Protein Peptide Lett., 4, 307-312. #9742

  1056. Safavy, A., Buchsbaum, D.J., Qin, H., & Khazaeli, M.B. (1997) Synthesis of bombesin analogues for radiolabeling with rhenium-188. Cancer, 80, 2354-2359. #9926

  1057. Samson, I., Rozenski, J., Samyn, B., van Aerschot, A., van Beeumen, J., & Herdewijn, P. (1997) Screening a random pentapeptide library, composed of 14 D-amino acids, against the COOH-terminal sequence of fructose-1,6-bisphosphate aldolase from Trypanosoma brucei. Journal of Biological Chemistry, 272, 11378-11383. #9247

  1058. Sanchez, A., & Smith, A.J. (1997) Capillary electrophoresis. Methods Enzymol., 289, 469-478. #10002

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  1061. Satoh, T., Aramini, J.M., Li, S., Friedman, T.M., Gao, J., Edling, A.E., Townsend, R., Koch, U., Choksi, S., Germann, M.W., Korngold, R., & Huang, Z. (1997) Bioactive peptide design based on protein surface epitopes. A cyclic heptapeptide mimics CD4 domain 1 CC' loop and inhibits CD4 biological function. Journal of Biological Chemistry, 272, 12175-12180. #11665

  1062. Scarfi, S., Gasparini, A., Damonte, G., & Benatti, U. (1997) Synthesis, uptake, and intracellular metabolism of a hydrophobic tetrapeptide-peptide nucleic acid (PNA)-biotin molecule. Biochem. Biophys. Res. Commun., 236, 323-326. #9366

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  1068. Seitz, O., & Wong, C.H. (1997) Chemoenzymatic solution- and solid-phase synthesis of O-glycopeptides of the mucin domain of madcam-1: A general route to O-lacnac, O-sialyl-lacnac, and O-sialyl-lewis-x peptides [review]. J. Amer. Chem. Soc., 119, 8766-8776. #10357

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  1088. Tholey, A., & Hoffmann, B. (1997) Solid-phase synthesis of tyrosyl H-phosphonopeptides and methylphosphonopeptides. J. Peptide Sci., 3, 186-192. #9890

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  1091. Uray, K. (1997) Analysis of the epitope structure of mucin glycoproteins with synthetic peptides and mucin specific monoclonal antibodies [hungarian]. Magyar Kemiai Folyoirat, 103, 237-240. #9076

  1092. Valentijn, A.R.P.M., van der Marel, G.A., Sliedregt, L.A.J.M., van Berkel, T.J.C., Biessen, E.A.L., & van Boom, J.H. (1997) Solid-phase synthesis of lysine-based cluster galactosides with high affinity for the asialoglycoprotein receptor. Tetrahedron, 53, 759-770. #8267

  1093. Vandijk, A.A., Vanwijk, L.L., van Vliet, A., Haris, P., Vanswieten, E., Tesser, G.I., & Robillard, G.T. (1997) Structure characterization of the central repetitive domain of high molecular weight gluten proteins. 1. Model studies using cyclic and linear peptides. Protein Sci., 6, 637-648. #9289

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