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PAPERS PUBLISHED IN 1998

This list is arranged by the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (michal@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M., Leblova Z.: Dynamic database of references in molecular diversity. Internet http://www.5z.com.


Recently added entries are marked in bold

  1. Anonymous. (1998) Combinatorial chemistry promises better catalysts and materials. Chemical Engineering Progress, 94, 11. #11816

  2. Anonymous. (1998) Combinatorial chemistry. Chemical Engineering, 105, 31. #11817

  3. Anonymous. (1998) Simplified characterization of combinatorial libraries. Drug Disc. Today, 3, 483-484. #11815

  4. Abedi, M.R., Caponigro, G., & Kamb, A. (1998) Green fluorescent protein as a scaffold for intracellular presentation of peptides. Nucl. Acid. Res., 26, 623-630. #10582

  5. Ajay, A., Walters, W.P., & Murcko, M.A. (1998) Can we learn to distinguish between "drug-like" and "nondrug-like" molecules? J. Med. Chem., 41, 3314-3324. #11189

  6. Akerblom, E.B., Nygren, A.S., & Agback, K.H. (1998) Six new photolabile linkers for solid-phase synthesis. 1. Methods of preparation. Mol. Diversity, 3, 137-148. #10881

  7. Akporiaye, D.E., Dahl, I.M., Karlsson, A., & Wendelbo, R. (1998) Combinatorial approach to the hydrothermal synthesis of zeolites. Angew. Chem. Int. Ed., 37, 609-611. #11044

  8. Al-Obeidi, F., & Ostrem, J.A. (1998) Factor Xa inhibitors by classical and combinatorial chemistry. Drug Disc. Today, 3, 223-231. #267

  9. Al-Obeidi, F.A., Wu, J.J., & Lam, K.S. (1998) Protein tyrosine kinases: Structure, substrate specificity, and drug discovery. Biopolymers, 47, 197-223. #12299

  10. Albert, R., Knecht, H., Andersen, E., Hungerford, V., Schreier, M.H., & Papageorgiou, C. (1998) Isoxazolylthioamides as potential immunosuppressants a combinatorial chemistry approach. Bioorg. Med. Chem. Lett., 8, 2203-2208. #11187

  11. Alewood, P. (1998) Conotoxins as molecular templates for drug design. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 183-186). Mayflower Scientific Ltd., Kingswinford. #11500

  12. Amzel, L.M. (1998) Structure-based drug design. Curr. Opin. Biotechnol., 9, 366-369. #11249

  13. An, H., Haly, B.D., & Cook, P.D. (1998) New piperazinyl polyazacyclophane scaffolds, libraries and biological activities. Bioorg. Med. Chem. Lett., 8, 2345-2350. #11205

  14. An, H., & Cook, P.D. (1998) A solution-phase combinatorial chemistry methodology for drug discovery. Recent Research Developments in Organic Chemistry, 2, 473-488. #13431

  15. An, H.Y., & Cook, P.D. (1998) A solution-phase combinatorial chemistry methodology for drug discovery. Recent Research Developments in Organic Chemistry, 2, 488. #12924

  16. An, H.Y., Wang, T., Mohan, V., Griffey, R.H., & Cook, P.D. (1998) Solution phase combinatorial chemistry. Discovery of 13- and 15-membered polyazapyridinocyclophane libraries with antibacterial activity. Tetrahedron, 54, 3999-4012. #10632

  17. An, H.Y., Haly, B.D., & Cook, P.D. (1998) Discovery of novel pyridinopolyamines with potent antimicrobial activity: Deconvolution of mixtures synthesized by solution-phase combinatorial chemistry. J. Med. Chem., 41, 706-716. #10590

  18. Anderson, E.M., Karin, M., & Kirk, O. (1998) One biocatalyst - many applications: The use of Candida antarctica B-lipase in organic synthesis. Biocatalysis and Biotransformation, 16, 181-204. #12302

  19. Andersson, P.M., Sjostrom, M., & Lundstedt, T. (1998) Preprocessing peptide sequences for multivariate sequence-property analysis. Chemometr. Intell. Lab. Syst., 42, 50. #11818

  20. Andres, C.J., Swann, R.T., Severino, J., Grant-Young, K., Edinger, K., Mongillo, J., & Deshpande, M.S. (1998) A novel parallel distributor for dispensing of Irori(TM) Rf-encoded tags to microkans in 96-well format. Biotech. Bioeng. (Comb. Chem. ), 61, 93-94. #11250

  21. Andres, C.J., Whitehouse, D.L., & Deshpande, M.S. (1998) Transition-metal-mediated reactions in combinatorial synthesis. Curr. Opin. Chem. Biol., 2, 353-362. #12073

  22. Annis, D.A., Helluin, O., & Jacobsen, E.N. (1998) Stereochemistry as a diversity element: Solid-phase synthesis of cyclic RGD peptide derivatives by asymmetric catalysis. Angew. Chem. Int. Ed., 37, 1907-1909. #11251

  23. Apletalina, E., Appel, J., Lamango, N.S., Houghten, R.A., & Lindberg, I. (1998) Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library. Journal of Biological Chemistry, 273, 26589-26595. #11819

  24. Appel, J.R., Campbell, G.D., Buencamino, J., Houghten, R.A., & Pinilla, C. (1998) Characterization of antigen-antibody interactions using single substitution analogs and mixture-based synthetic combinatorial libraries. J. Pept. Res., 52, 346-355. #12303

  25. Appell, K.C., Chung, T.D.Y., Solly, K.J., & Chelsky, D. (1998) Biological characterization of neurokinin antagonists discovered through screening of a combinatorial library. J. Biomol. Screen., 3, 19-27. #11158

  26. Arap, W., Pasqualini, R., & Ruoslahti, E. (1998) Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science, 279, 377-380. #10643

  27. Arsequell, G., Espuna, G., Valencia, G., Barluenga, J., Perez Carlon, R., & Gonzalez, J.M. (1998) First aromatic electrophilic iodination reaction on the solid-phase: Iodination of bioactive peptides. Tetrahedron Lett., 39, 7393-7396. #11574

  28. Arza, B., & Felez, J. (1998) The emerging impact of phage display technology in thrombosis and haemostasis [Review]. Thromb. Haemost., 80, 354-365. #11820

  29. Aubagnac, J.L., Enjalbal, C., Subra, G., Bray, A.M., Combarieu, R., & Martinez, J. (1998) Application of time-of-flight secondary ion mass spectrometry to in situ monitoring of solid-phase peptide synthesis on the Multipin(TM) system. J. Mass Spectrom., 33, 1094-1103. #12136

  30. Aubagnac, J.L., Drouot, C., Enjalbal, C., Fulcrand, P., & Martinez, J. (1998) Monitoring of peptides libraries by Fast Atom Bombardment and Electrospray Ionization mass spectrometry. An. Quim., 94, 262-267. #12929

  31. Audet, J., Zandstra, P.W., Eaves, C.J., & Piret, J.M. (1998) Advances in hematopoietic stem cell culture. Curr. Opin. Biotechnol., 9, 146-151. #11111

  32. Ault-Justus, S.E., Hodges, J.C., & Wilson, M.W. (1998) Generation of a library of 4-thiazolidinones utilizing polymer supported quench (PSQ) reagent methodology. Biotech. Bioeng. (Comb. Chem. ), 61, 17-22. #11128

  33. Avdagic, A., & Sunjic, V. (1998) Biocatalytic deracemization of 1,4-benzodiazepines in the synthesis of enantiomerically pure serine. Helv. Chim. Acta, 81, 85-92. #10684

  34. Bailey, D.S., Bondar, A., & Furness, L.M. (1998) Pharmacogenomics: It's not just pharmacogenetics. Curr. Opin. Biotechnol., 9, 595-601. #12304

  35. Baldwin, J.J. (1998) Small molecule libraries: Overview of issues and strategies in library design. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 181-188). John Wiley & Sons, New York. #11711

  36. Ball, C.P., Barrett, A.G.M., Commercon, A., Compere, D., Kuhn, C., Roberts, R.S., Smith, M.L., & Venier, O. (1998) Chameleon catches in combinatorial chemistry: Tebbe olefination of polymer supported esters and the synthesis of amines, cyclohexanones, enones, methyl ketones and thiazoles. Chem. Commun., 2019-2020. #11821

  37. Banerjee, A., Lee, K., Yu, Q., Fang, A.G., & Falvey, D.E. (1998) Protecting group release through photoinduced electron transfer: Wavelength control through sensitized irradiation. Tetrahedron Lett., 39, 4635-4638. #10916

  38. Barbaste, M., Rolland-Fulcrand, V., Roumestant, M.L., Viallefont, P., & Martinez, J. (1998) Rapid solid phase synthesis of alpha-amino acids. Tetrahedron Lett., 39, 6287-6290. #11026

  39. Barco, A., Benetti, S., De Risi, C., Marchetti, P., Pollini, G.P., & Zanirato, V. (1998) Polymer-bound 4-benzyl-sulfonyl-1-triphenylphosphoranylidene-2-butanone as a tool for the solid-phase synthesis of substituted piperidin-4-one derivatives. Tetrahedron Lett., 39, 7591-7594. #11565

  40. Barrett, A.G.M., Smith, M.L., & Zecri, F.J. (1998) Impurity annihilation: A strategy for solution phase combinatorial chemistry with minimal purification. Chem. Commun., 2317-2318. #12138

  41. Bartoli, F., Nuzzo, M., Urbanelli, L., Bellintani, F., Prezzi, C., Cortese, R., & Monaci, P. (1998) DNA-based selection and screening of peptide ligands. Nat. Biotech., 16, 1068-1073. #12306

  42. Baudelle, R., Melnyk, P., Deprez, B., & Tartar, A. (1998) Parallel synthesis of polysubstituted tetrahydroquinolines. Tetrahedron, 54, 4125-4140. #10641

  43. Baumbach, W.R., Carrick, T.A., Pausch, M.H., Bingham, B., Carmignac, D., Robinson, I.C.A.F., Houghten, R., Eppler, C.M., Price, L.A., & Zysk, J.R. (1998) A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats. Mol. Pharmacol., 54, 864-873. #12307

  44. Bauser, M., Winter, M., Valenti, C.A., Wiesmuller, K.H., & Jung, G. (1998) Synthesis of hydantoins via N,N'-ureas derived from polymer-bound amino acids. Mol. Diversity, 3, 257-260. #12101

  45. Baxter, E.W., Rueter, J.K., Nortey, S.O., & Reitz, A.B. (1998) Arylsulfonate esters in solid phase organic synthesis. II.Compatibility with commonly-used reaction conditions. Tetrahedron Lett., 39, 979-982. #10491

  46. Bayle, D., Wangler, S., Weitzenegger, T., Steinhilber, W., Volz, J., Przybylski, M., Schafer, K.P., Sachs, G., & Melchers, K. (1998) Properties of the P-type ATPases encoded by the copAP operons of Helicobacter pyroli and Helicobacter felis. J. Bacteriol., 180, 317-329. #10812

  47. Behrens, C., & Nielsen, P.E. (1998) A combinatorial approach to new DNA minor groove bonders. Comb. Chem. High Throughput Screening, 1, 127-134. #11758

  48. Bender, L.H. (1998) The oral delivery of macromolecules: 75 Years of need. Innovations in Pharmaceutical Technology, 1, 30-33. #12126

  49. Benedetti, F., Berti, F., Flego, M., Resmini, M., & Bastiani, E. (1998) A competitive immunoassay for the detection of esterolytic activity of antibodies and enzymes. Anal. Biochem., 256, 67-73. #10722

  50. Benson, D.E., Wisz, M.S., & Hellinga, H.W. (1998) The development of new biotechnologies using metalloprotein design. Curr. Opin. Biotechnol., 9, 370-376. #11253

  51. Berg, T., Vandersteen, A.M., & Janda, K.D. (1998) High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes. Bioorg. Med. Chem. Lett., 8, 1221-1224. #10832

  52. Bergbreiter, D.E., Liu, Y.S., Furyk, S., & Case, B.L. (1998) Pd-Catalyzed synthesis of a tethered soluble polymeric phosphine ligand. Tetrahedron Lett., 39, 8799-8802. #11969

  53. Berglund, J., Lindbladh, C., Nicholls, I.A., & Mosbach, K. (1998) Selection of phage display combinatorial library peptides with affinity for a yohimbine imprinted methacrylate polymer. Anal. Commun., 35, 3-7. #10689

  54. Berlin, K., Jain, R.K., & Richert, C. (1998) Are porphyrin mixtures favorable photodynamic anticancer drugs? A model study with combinatorial libraries of tetraphenylporphyrins. Biotech. Bioeng. (Comb. Chem. ), 61, 107-118. #11254

  55. Berlin, K., Jain, R.K., Tetzlaff, C., Steinbeck, C., & Richert, C. (1998) Spectrometrically monitored selection experiments: Quantitative laser desorption mass spectrometry of small chemical libraries [erratum]. Chem. Biol., 4, 237-238. #9957

  56. Berman, J. & Howard, R.J. (1998) Combinatorial drug discovery: Concepts. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 447-452). John Wiley & Sons, New York. #11729

  57. Berteina, S., & De Mesmaeker, A. (1998) Application of radical chemistry to solid support synthesis. Tetrahedron Lett., 39, 5759-5762. #10965

  58. Bertini, V., Lucchesini, F., Pocci, M., & De Munno, A. (1998) 1,3-Dithiane polymers for the supported synthesis of ketones. Tetrahedron Lett., 39, 9263-9266. #12019

  59. Beutel, B.A. (1998) Strategies for screening combinatorial libraries. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 421-432). John Wiley & Sons, New York. #11727

  60. Bevilacqua, J.M., & Bevilacqua, P.C. (1998) Thermodynamic analysis of an RNA combinatorial library contained in a short hairpin. Biochemistry, 37, 15877-15884. #12311

  61. Bhalay, G., & Dunstan, A.R. (1998) Facile solid phase synthesis of an activated diazo linker. Tetrahedron Lett., 39, 7803-7806. #11577

  62. Bhalay, G., Cowell, D., Hone, N.D., Scobie, M., & Baxter, A.D. (1998) Multiple solid-phase synthesis of hydantoins and thiohydantoins. Mol. Diversity, 3, 195-198. #11255

  63. Bhandari, A., Jones, D.G., Schullek, J.R., Vo, K., Schunk, C.A., Tamanaha, L.L., Chen, D., Yuan, Z., Needels, M.C., & Gallop, M.A. (1998) Exploring structure-activity relationship around the phosphomannose isomerase inhibitor AF14049 via combinatorial synthesis. Bioorg. Med. Chem. Lett., 8, 2303-2308. #11198

  64. Bhat, L., Liu, Y.B., Victory, S.F., Himes, R.H., & Georg, G.I. (1998) Synthesis and evaluation of paclitaxel C7 derivatives: Solution phase synthesis of combinatorial libraries. Bioorg. Med. Chem. Lett., 8, 3181-3186. #12312

  65. Bianco, A., Brock, C., Zabel, C., Walk, T., Walden, P., & Jung, G. (1998) New synthetic non-peptide ligands for classical major histocompatibility complex class I molecules. Journal of Biological Chemistry, 273, 28759-28765. #12314

  66. Bicknell, A.J., Hird, N.W., & Readshaw, S.A. (1998) Efficient robotic synthesis. Multi-component preparation of a tricyclic template by solid phase Tsuge reaction. Tetrahedron Lett., 39, 5869-5872. #10968

  67. Bienayme, H., & Bouzid, K. (1998) Synthesis of rigid hydrophobic tetrazoles using an Ugi multi-component heterocyclic condensation. Tetrahedron Lett., 39, 2735-2738. #10748

  68. Bienayme, H. (1998) "Reagent explosion": An efficient method to increase library size and diversity. Tetrahedron Lett., 39, 4255-4258. #10858

  69. Bienayme, H., & Bouzid, K. (1998) A new heterocyclic multicomponent reaction for the combinatorial synthesis of fused 3-aminoimidazoles. Angew. Chem. Int. Ed., 37, 2234-2237. #11823

  70. Bilodeau, M.T., & Cunningham, A.M. (1998) Solid-supported synthesis of imidazoles: A strategy for direct resin-attachment to the imidazole core. J. Org. Chem., 63, 2800-2801. #10754

  71. Bing, Y. (1998) Monitoring the progress and the yield of solid-phase organic reactions directly on resin supports. Account. Chem. Res., 31, 621-630. #12219

  72. Blackburn, C. (1998) A three-component solid-phase synthesis of 3-aminoimidazol[1,2-a]azines. Tetrahedron Lett., 39, 5469-5472. #10954

  73. Blackburn, C., Guan, B., Fleming, P., Shiosaki, K., & Tsai, S. (1998) Parallel synthesis of 3-aminoimidazol[1,2-a]pyridines and pyrazines by a new three-component condensation. Tetrahedron Lett., 39, 3635-3638. #10845

  74. Blaskovich, M.A., & Kahn, M. (1998) Solid-phase preparation of dienes. J. Org. Chem., 63, 1119-1125. #11798

  75. Blaskovich, M.A., & Kahn, M. (1998) Polymer-supported acetylide addition to hexa-2,4-dienal. Synthesis-Stuttgart, 965-966. #12236

  76. Bleczinski, C.F., & Richert, C. (1998) Monitoring the hybridization of the components of oligonucleotide mixtures to immobilized DNA via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom., 12, 1737-1743. #12315

  77. Bleicher, K., Lin, M.F., Shapiro, M.J., & Wareing, J.R. (1998) Diffusion edited NMR: Screening compound mixtures by affinity NMR to detect binding ligands to vancomycin. J. Org. Chem., 63, 8486-8490. #12316

  78. Blettner, C.G., Konig, W.A., Stenzel, W., & Schotten, T. (1998) Poly(ethylene glycol) supported liquid phase synthesis of biaryls. Synlett, 295-297. #12125

  79. Blondelle, S.E., Nefzi, A., Ostresh, J.M., & Houghten, R.A. (1998) Novel antifungal compounds derived from heterocyclic positional scanning. Combinatorial libraries. Pure Appl. Chem., 70, 2107-2145. #12907

  80. Boder, E.T., & Wittrup, K.D. (1998) Optimal screening of surface-displayed polypeptide libraries. Biotechnol. Progr., 14, 55-62. #12203

  81. Boeijen, A., & Liskamp, R.M.J. (1998) Sequencing of peptoid peptidomimetics by Edman degradation. Tetrahedron Lett., 39, 3589-3592. #10810

  82. Boeijen, A., Kruijtzer, J.A.W., & Liskamp, R.M.J. (1998) Combinatorial chemistry of hydantoins. Bioorg. Med. Chem. Lett., 8, 2375-2380. #11210

  83. Boesteanu, A., Brehm, M., Mylin, L.M., Christianson, G.J., Tevethia, S.S., Roopenian, D.C., & Joyce, S. (1998) A molecular basis for how a single TCR interfaces multiple ligands. Journal of Immunology, 161, 4719-4727. #12317

  84. Boger, D.L. (1998) Combinatorial chemistry. Bioorg. Med. Chem. Lett., 8, VII-VII. #11824

  85. Boger, D.L., Goldberg, J., Jiang, W.Q., Chai, W.Y., Ducray, P., Lee, J.K., Ozer, R.S., & Andersson, C.M. (1998) Higher order iminodiacetic acid libraries for probing protein-protein interactions. Bioorg. Med. Chem., 6, 1347-1378. #11825

  86. Boger, D.L., Ducray, P., Chai, W., Jiang, W., & Goldberg, J. (1998) Higher order iminodiacetic acid libraries for probing protein-protein interactions. Bioorg. Med. Chem. Lett., 8, 2339-2344. #11204

  87. Boger, D.L., Chai, W., & Jin, Q. (1998) Multistep convergent solution-phase combinatorial synthesis and deletion synthesis deconvolution. J. Amer. Chem. Soc., 120, 7220-7225. #11014

  88. Boger, D.L., & Chai, W. (1998) Solution-phase combinatorial synthesis: Convergent multiplication of diversity via the olefin metathesis reaction. Tetrahedron, 54, 3955-3970. #10629

  89. Bohm, H.J. (1998) Combinatorial docking. In H. van de Waterbeemd, B. Testa & G. Folkers (Eds.), Computer-Assisted Lead Finding and Optimization. (pp. 123-133). Verlag Helvetica Chimica Acta and VCH, Basel and Weinheim. #11379

  90. Bolli, M.H., & Ley, S.V. (1998) Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to b-hydroxyamines. J. Chem. Soc. Perkin Trans. 1, 1, 2243-2246. #13438

  91. Bols, M. (1998) 1-Aza sugars, apparent transition state analogues of equatorial glycoside formation/cleavage [review]. Account. Chem. Res., 31, 1-8. #10685

  92. Bondy, S.S. (1998) The role of automation in drug discovery. Curr. Opin. Drug. Disc. Develop., 1, 116-119. #11395

  93. Borman, S. (1998) Beetles do it combinatorially. Bugs combine simple precursors to make library of novel defensive compounds. C&EN, 76, 11-11. #10876

  94. Borman, S. (1998) Combinatorial carbohydrates. Prospects are looking sweet for use of sugar-based combinatorial libraries to find novel bioactive substances. C&EN, 76, 49-52. #10877

  95. Borman, S. (1998) Biosynthesis, combinatorially. A variety of techniques nudge microbes to produce 'unnatural' natural products. C&EN, 76, 29-30. #11583

  96. Boudjennah, L., Daletfumeron, V., & Pagano, M. (1998) Expression of collagenase/gelatinase activity from basement-membrane fibronectin: Isolation after limited proteolysis of a bovine lens capsule and molecular definition of this thiol-dependent zinc metalloproteinase. Eur. J. Biochem., 255, 246-254. #11256

  97. Boussie, T.R., Coutard, C., Turner, H., Murphy, V., & Powers, T.S. (1998) Solid-phase synthesis and encoding strategies for olefin polymerization catalyst libraries. Angew. Chem. Int. Ed., 37, 3272-3275. #12139

  98. Boyd, D.B. (1998) Innovation and the rational design of drugs. Chemtech, 28, 19-23. #11584

  99. Boyd, D.B. (1998) Rational drug design: Controlling the size of the haystack. Mod. Drug Dis., 1, 41-48. #12277

  100. Brandli, C., & Ward, T.R. (1998) Libraries via metathesis of internal olefins. Helv. Chim. Acta, 81, 1616-1621. #13439

  101. Bray, A.M., Maeji, N.J., Lagniton, L.M., Chiefari, D., James, I.W., Ang, K., Ede, N., Valerio, R.M. & Mason, T.J. (1998) Simultaneous multiple synthesis by the Multipin(TM) method: Techniques for multiple handling,high throughput characterization and reaction optimization on solid phase. In X. Xu, Y. Ye & J.P. Tam (Eds.), Peptides. Biology and Chemistry. Proceedings of the 1996 Chinese Peptide Symposium. (pp. 67. Kluwer/ESCOM, Dordrecht. #14303

  102. Breitenbucher, J.G., Johnson, C.R., Haight, M., & Phelan, J.C. (1998) Generation of a piperazine-2-carboxamide library: A practical application of the phenol-sulfide react and release linker. Tetrahedron Lett., 39, 1295-1298. #10510

  103. Breitenbucher, J.G., & Hui, H.C. (1998) Titanium mediated reductive amination on solid support: Extending the utility of the 4-hydroxy-thiophenol linker. Tetrahedron Lett., 39, 8207-8210. #12009

  104. Brennan, T., Biddison, G., Frauendorf, A., Schwarcz, L., Keen, B., Ecker, D.J., Davis, P.W., Tinder, R., & Swayze, E.E. (1998) Two-dimensional parallel array technology as a new approach to automated combinatorial solid-phase organic synthesis. Biotech. Bioeng. (Comb. Chem. ), 61, 33-45. #10759

  105. Bridonneau, P., Chang, Y.F., O'Connell, D., Gill, S.C., Snyder, D.W., Johnson, L., Goodson, T.Jr., Herron, D.K., & Parma, D.H. (1998) High-affinity aptamers selectively inhibit human nonpancreatic secretory phospholipase A2 (hnps-PLA2). J. Med. Chem., 41, 778-786. #11173

  106. Brill, W.K.D., De Mesmaeker, A., & Wendeborn, S. (1998) Solid phase synthesis of levoglucosan derivatives. Synlett, 1085-1090. #12318

  107. Brill, W.K.D., Schmidt, E., & Tommasi, R.A. (1998) Immobilizations of nucleophiles on polystyrene supports. Synlett, 906. #11258

  108. Brocchini, S., James, K., Tangpasuthadol, V., & Kohn, J. (1998) Structure-property correlations in a combinatorial library of degradable biomaterials. J. Biomed. Material. Res., 42, 66-75. #11827

  109. Broderick, S., Davis, A.P., & Williams, R.P. (1998) The "triamino-analogue" of methyl cholate: A facial amphiphile and scaffold with potential for combinatorial and molecular recognition chemistry. Tetrahedron Lett., 39, 6083-6086. #10992

  110. Bromidge, S., Wilson, P.C., & Whiting, A. (1998) A parallel combinatorial approach to locating homochiral Lewis acid catalysts for the asymmetric aza-Diels-Alder reaction of an imino dienophile. Tetrahedron Lett., 39, 8905-8908. #11970

  111. Brown, A.R., Hermkens, P.H.H., Ottenheijm, H.C.J., & Rees, D.C. (1998) Solid phase synthesis. Synlett, 817-827. #11260

  112. Brown, D.S., Revill, J.M., & Shute, R.E. (1998) Merrifield, alpha-methoxyphenyl (MAMP) resin: A new versatile solid support for the synthesis of secondary amides. Tetrahedron Lett., 39, 8533-8536. #11946

  113. Brown, R.C.D. (1998) Recent developments in solid-phase organic synthesis. J. Chem. Soc. Perkin Trans. 1, 3293-3320. #11829

  114. Brown, R.D., & Clark, D.E. (1998) Genetic diversity: applications of evolutionary algorithms to combinatorial library design. Exp. Opin. Ther. Patents, 8, 1447-1459. #12320

  115. Buchholz, C.J., Peng, K.W., Morling, F.J., Zhang, J., Cosset, F.L., & Russell, S.J. (1998) In vivo selection of protease cleavage sites from retrovirus display libraries. Nat. Biotech., 16, 951-954. #11830

  116. Buckman, B.O., Morrissey, M.M., & Mohan, R. (1998) Solution-phase parallel synthesis of benzoxazines using a polymer-supported carbodiimide. Tetrahedron Lett., 39, 1487-1488. #10518

  117. Bunin, B.A. (1998) The Combinatorial Index. Academic Press, San Diego. ISBN 0121413403 #10496

  118. Bures, M.G., & Martin, Y.C. (1998) Computational methods in molecular diversity and combinatorial chemistry. Curr. Opin. Chem. Biol., 2, 376-380. #12076

  119. Burioni, R., Plaisant, P., Bugli, F., Solforosi, L., Carri, V.D., Varaldo, P.E., & Fadda, G. (1998) A new subtraction technique for molecular cloning of rare antiviral antibody specificities from phage display libraries. Res. Virol., 149, 327-330. #12322

  120. Burioni, R., Plaisant, P., Bugli, F., Dellicarri, V., Clementi, M., & Fadda, G. (1998) A vector for the expression of recombinant monoclonal Fab fragments in bacteria. J. Immunol. Method, 217, 195-199. #11831

  121. Burioni, R., Plaisant, P., Bugli, F., Carri, V.D., Candela, M., Gabrielli, A., & Fadda, G. (1998) Probing the natural antibody repertoire by combinatorial cloning of IgM and IgD isotypes in phage display vectors. Res. Virol., 149, 321-325. #12321

  122. Burns, C.J., Groneberg, R.D., Salvino, J.M., McGeehan, G., Condon, S.M., Morris, R., Morrissette, M., Mathew, R., Darnbrough, S., Neuenschwander, K., Scotese, A., Djuric, S.W., Ullrich, J., & Labaudiniere, R. (1998) Nanomolar inhibitors for two distinct biological target families from a single synthetic sequence: A next step in combinatorial library design? Angew. Chem. Int. Ed., 37, 2848-2850. #12143

  123. Byk, G., Dubertret, C., Escriou, V., Frederic, M., Jaslin, G., Rangara, R., Pitard, B., Crouzet, J., Wils, P., Schwartz, B., & Scherman, D. (1998) Synthesis, activity, and structure-activity relationship studies of novel cationic lipids for DNA transfer. J. Med. Chem., 41, 224-235. #10751

  124. Byk, G., Soto, J., Mattler, C., Frederic, M., & Scherman, D. (1998) Novel non-viral vectors for gene delivery: Synthesis of a second-generation library of mono-functionalized poly-(guanidinium)amines and their introduction into cationic lipids. Biotechnol. Bioeng., 61, 81-87. #12221

  125. Cabilly, S., Heldman, J., & Katchalski-Katzir, E. (1998) Screening phage display peptide libraries on nitrocellulose membranes. Methods Mol. Biol., 87, 185-194. #11536

  126. Cabilly, S., Heldman, J., Heldman, E., & Katchalski-Katzir, E. (1998) The use of combinatorial libraries to identify ligands that interact with surface receptors in living cells. Methods Mol. Biol., 87, 175-183. #11537

  127. Cabilly, S. (1998) The basic structure of filamentous phage and its use in the display of combinatorial peptide libraries. Methods Mol. Biol., 87, 129-136. #11538

  128. Camarero, J.A., Ayers, B., & Muir, T.W. (1998) Studying receptor-ligand interactions using encoded amino acid scanning. Biochemistry, 37, 7487-7495. #11094

  129. Campian, E., Peterson, M.L., Saneii, H.H., & Furka, A. (1998) Deconvolution by omission libraries. Bioorg. Med. Chem. Lett., 8, 2357-2362. #11207

  130. Campian, E., Peterson, M.L., Saneii, H.H. & Furka, A. (1998) Automated synthesis in a single process of nine first order sub-libraries of an amino acid occurrence library. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 285-286). Mayflower Scientific Ltd., Kingswinford. #11503

  131. Campian, E., Chou, J., Peterson, M.L., Saneii, H.H. & Furka, A. (1998) Synthesis and aplicability of monomer tester mixtures. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 131-134). Mayflower Scientific Ltd., Kingswinford. #11494

  132. Cano, M., Camps, F., & Joglar, J. (1998) Solid phase synthesis of cyclopropenes. Tetrahedron Lett., 39, 9819-9822. #12044

  133. Cao, J., Cuny, G.D., & Hauske, J.R. (1998) Ring opening cross-metathesis on solid support: A combinatorial library synthesis of highly functionalized cyclopentanes. Mol. Diversity, 3, 173-179. #10884

  134. Carbonell, X., Feliu, J.X., Benito, A., & Villaverde, A. (1998) Display-induced antigenic variation in recombinant peptides. Biochem. Biophys. Res. Commun., 248, 773-777. #11263

  135. Carcamo, J., Ravera, M.W., Brissette, R., Dedova, O., Beasley, J.R., Alam-Moghe, A., Wan, C., Blume, A., & Mandecki, W. (1998) Unexpected frameshifts from gene to expressed protein in a phage-displayed peptide library. Proc. Natl. Acad. Sci. USA, 95, 11146-11151. #11832

  136. Carroll, C.D., Johnson, T.O., Tao, S., Lauri, G., Orlowski, M., Gluzman, I.Y., Goldberg, D.E., & Dolle, R.E. (1998) Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D. Bioorg. Med. Chem. Lett., 8, 3203-3206. #12326

  137. Carroll, C.D., Patel, H., Johnson, T.O., Guo, T., Orlowski, M., He, Z.M., Cavallaro, C.L., Guo, J., Oksman, A., Gluzman, I.Y., Connelly, J., Chelsky, D., Goldberg, D.E., & Dolle, R.E. (1998) Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg. Med. Chem. Lett., 8, 2315-2320. #11200

  138. Carroll, C.D., & Orlowski, M. (1998) Screening aspartyl proteases with combinatorial libraries. Adv. Exp. Med. Biol., 436, 375-380. #11540

  139. Case-Green, S.C., Mir, K.U., Pritchard, C.E., & Southern, E.M. (1998) Analysing genetic information with DNA arrays. Curr. Opin. Chem. Biol., 2, 404-410. #12080

  140. Casebier, D., & Baldino, C. (1998) Advances in combinatorial chemistry. Innovations in Pharmaceutical Technology, 1, 63-67. #12089

  141. Cashman, J.R. (1998) Combinatorial chemistry in the development of drugs of abuse therapeutics. Med. Chem. Res., 8, 100-113. #11091

  142. Chabala, J.C. (1998) Historical overview of the developing field of molecular diversity. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 3-15). John Wiley & Sons, New York. #11707

  143. Chamoin, S., Houldsworth, S., Kruse, C.G., Bakker, I., & Snieckus, V. (1998) The Suzuki-Miyaura cross coupling reactions on solid support. Link to solution phase directed ortho metalation. The Leznoff acetal linker approach to biaryl and heterobiaryl aldehydes. Tetrahedron Lett., 39, 4179-4182. #10855

  144. Chamoin, S., Houldsworth, S., & Snieckus, V. (1998) The Stille cross coupling reactions on solid support. Link to solution phase directed ortho metalation. An ester linker approach to styryl, biaryl and heterobiaryl carboxylic acids. Tetrahedron Lett., 39, 4175-4178. #10854

  145. Chan, D.C., Chutkowski, C.T., & Kim, P.S. (1998) Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target. Proc. Natl. Acad. Sci. USA, 95, 15613-15617. #12328

  146. Chandrasekhar, S., & Padmaja, M.B. (1998) Practical preparation of first carbon linked polymer bound 1,3-diol. Syn. Commun., 28, 3715-3720. #11834

  147. Chargelegue, D., Obeid, O.E., Hsu, S.C., Shaw, M.D., Denbury, A.N., Taylor, G., & Steward, M.W. (1998) A peptide mimic of a protective epitope of respiratory syncytial virus selected from a combinatorial library induces virus-neutralizing antibodies and reduces viral load in vivo. J. Virol., 72, 2040-2046. #10580

  148. Chen, B. & Turner, A.P.F. (1998) Generation of a peptide library in searching for a specific binding ligand for glycosylated haemoglobin HbA(1C). In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 305-306). Mayflower Scientific Ltd., Kingswinford. #11505

  149. Chen, C., McDonald, I.A., & Munoz, B. (1998) Synthesis of dihydropyridone scaffolds on solid support: Resin Activation/Capture Approach/REACAP Technology. Tetrahedron Lett., 39, 217-220. #9869

  150. Chen, C., & Munoz, B. (1998) Solid phase synthesis of 2,4-disubstituted pyridine and tetrahydropyridine derivatives: Resin activation/capture approach/REACAP technology. Tetrahedron Lett., 39, 3401-3404. #10805

  151. Chen, C., & Munoz, B. (1998) Solid phase synthesis of N-acyl-2-substituted-dihydro-4-pyridone: Resin activation/capture approach/REACAP technology. Tetrahedron Lett., 39, 6781-6784. #11224

  152. Chen, C.T., Wagner, H., & Still, W.C. (1998) Fluorescent, sequence-selective peptide detection by synthetic small molecules. Science, 279, 851-853. #10739

  153. Chen, L.P. (1998) Immunological ignorance of silent antigens as an explanation of tumor evasion. Immunol. Today, 19, 27-30. #10138

  154. Chen, S., & Janda, K.D. (1998) Total synthesis of naturally occuring prostaglandin F(2alpha) on a non-cross-linked polystyrene support. Tetrahedron Lett., 39, 3943-3946. #10840

  155. Cheng, C.C., & Chu, Y.H. (1998) Affinity capillary electrophoresis mass spectrometry in combinatorial library screening. Amer. Lab., 30, 79. #10997

  156. Cheng, J.F., & Mjalli, A.M.M. (1998) Solid-phase synthesis of D2-isoxazolines. Tetrahedron Lett., 39, 939-942. #10488

  157. Chhabra, S.R., Khan, A.N., & Bycroft, B.W. (1998) Versatile Dde-based primary amine linkers for solid phase synthesis. Tetrahedron Lett., 39, 3585-3588. #10809

  158. Chhabra, S.R., Hothi, B., Evans, D.J., White, P.D., Bycroft, B.W., & Chan, W.C. (1998) An appraisal of new variants of the Dde amine protecting group for solid phase peptide synthesis. Tetrahedron Lett., 39, 1603-1606. #10494

  159. Chiari, M., Desperati, V., Manera, E., & Longhi, R. (1998) Combinatorial synthesis of highly selective cyclohexapeptides for separation of amino acid enantiomers by capillary electrophoresis. Anal. Chem., 70, 4967-4973. #12144

  160. Chin, J., Fell, J.B., Jarosinski, M., Shapiro, M.J., & Wareing, J.R. (1998) HPLC/NMR in combinatorial chemistry. J. Org. Chem., 63, 386-390. #10682

  161. Chin, J., Fell, B., Pochapsky, S., Shapiro, M.J., & Wareing, J.R. (1998) 2D SECSY NMR for combinatorial chemistry: High-resolution MAS spectra for resin-bound molecules. J. Org. Chem., 63, 1309-1311. #10664

  162. Chirinos-Rojas, C.L., Steward, M.W., & Partidos, C.D. (1998) A peptidomimetic antagonist of TNF-a-mediated cytotoxicity identified from a phage-displayed random peptide library. Journal of Immunology, 161, 5621-5626. #12145

  163. Cho, C.Y., Youngquist, R.S., Paikoff, S.J., Beresini, M.H., Hebert, A.R., Berleau, L.T., Liu, C.W., Wemmer, D.E., Keough, T., & Schultz, P.G. (1998) Synthesis and screening of linear and cyclic oligocarbamate libraries: Discovery of high affinity ligands for GPIIb/IIIa. J. Amer. Chem. Soc., 120, 7706-7718. #11266

  164. Cho, S.J., Zheng, W., & Tropsha, A. (1998) Rational combinatorial library design. 2. Rational design of targeted combinatorial peptide libraries using chemical similarity probe and the inverse QSAR approaches. Journal of Chemical Information and Computer Sciences, 38, 259-268. #11041

  165. Cho, S.J., Zheng, W.F., & Tropsha, A. (1998) Focus-2D: A new approach to the design of targeted combinatorial chemical libraries. Pac. Symp. Biocomput., 305-316. #14395

  166. Choi, I.H., Park, S.G., Chung, J.H., Kim, I.J., & Hong, H.J. (1998) Generation of human Fab monoclonal antibodies against preS1 of hepatitis B virus using repertoire cloning. Hybridoma, 17, 535-540. #12331

  167. Chou, Y.L., Morrissey, M.M., & Mohan, R. (1998) Novel serine-based linker for the solid-phase synthesis of organic compounds. Tetrahedron Lett., 39, 757-760. #10050

  168. Christensen, L., Hansen, H.F., Koch, T., & Nielsen, P.E. (1998) Inhibition of PNA triplex formation by N-4-benzoylated cytosine. Nucl. Acid. Res., 26, 2735-2739. #11078

  169. Christopher, J., & Lea, L. (1998) Perkin 1 abstracts: Solid phase organic synthesis. J. Chem. Soc. Perkin Trans. 1, vii-x. #11016

  170. Chu, Y.H., Zang, X., & Tu, J. (1998) Affinity capillary electrophoresis: From binding measurement to combinatorial library screening. J. Chin. Chem. Soc., 45, 713-720. #12332

  171. Chu, Y.H., & Cheng, C.C. (1998) Affinity capillary electrophoresis in biomolecular recognition. Cell. Mol. Life Sci., 54, 663-683. #11267

  172. Chung, T.D.Y. (1998) Point-Counterpoint. Counterpoint. Screen compounds singly: Why muck it up? J. Biomol. Screen., 3, 171-173. #12088

  173. Clark, D.S. (1998) A new addition to the combinatorial library. Biotech. Bioeng. (Comb. Chem. ), 61, 3-3. #11126

  174. Coffen, D.L., Baldino, C.M., Lange, M., Tilton, R.F., & Tu, C. (1998) Molecular diversity, biological activity and common ground shared by both. Med. Chem. Res., 8, 206-218. #12333

  175. Coffen, D.L. (1998) Solution phase combinatorial chemistry. Preface. Tetrahedron, 54, XIII-XIII. #11022

  176. Cohen, B.A., Colas, P., & Brent, R. (1998) An artificial cell-cycle inhibitor isolated from a combinatorial library. Proc. Natl. Acad. Sci. USA, 95, 14272-14277. #12334

  177. Colas, P., & Brent, R. (1998) The impact of two-hybrid and related methods on biotechnology. Trends Biotech., 16, 355-363. #11268

  178. Collins, J.L., Blanchard, S.G., Boswell, G.E., Charifson, P.S., Cobb, J.E., Henke, B.R., Hull-Ryde, E.A., Kazmierski, W.M., Lake, D.H., Leesnitzer, L.M., Lehmann, J., Lenhard, J.M., Orband-Miller, L.A., Gray-Nunez, Y., Parks, D.J., Plunkett, K.D., & Tong, W.Q. (1998) N-(2-benzoylphenyl)-L-tyrosine PPAR gamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety. J. Med. Chem., 41, 5037-5054. #12335

  179. Conroy, J.L., Abato, P., Ghosh, M., Austermuhle, M.I., Kiefer, M.R., & Seto, C.T. (1998) Synthesis of cyclohexanone-based cathepsin B inhibitors that interact with both the S and S' binding sites. Tetrahedron Lett., 39, 8253-8256. #12013

  180. Cook, A.D., Davies, J.M., Myers, M.A., Mackay, I.R., & Rowley, M.J. (1998) Mimotopes identified by phage display for the monoclonal antibody cII-c1 to type II collagen. J. Autoimmun., 11, 205-211. #11269

  181. Coppola, G.M. (1998) A new scavenger resin for amines. Tetrahedron Lett., 39, 8233-8236. #12011

  182. Cortese, I., Capone, S., Luchetti, S., Grimaldi, L.M.E., Nicosia, A., & Cortese, R. (1998) CSF-enriched antibodies do not share specificities among MS patients. Mult. Scler., 4, 118-123. #11270

  183. Cortese, I., Capone, S., Tafi, R., Grimaldi, L.M.E., Nicosia, A., & Cortese, R. (1998) Identification of peptides binding to IgG in the CSF of multiple sclerosis patients. Mult. Scler., 4, 31-36. #10713

  184. Cotterill, I.C., Usyatinsky, A.Y., Arnold, J.M., Clark, D.S., Dordick, J.S., Michels, P.C., & Khmelnitsky, Y.L. (1998) Microwave assisted combinatorial chemistry synthesis of substituted pyridines. Tetrahedron Lett., 39, 1117-1120. #10501

  185. Craig, L., Sanschagrin, P.C., Rozek, A., Lackie, S., Kuhn, L.A., & Scott, J.K. (1998) The role of structure in antibody cross-reactivity between peptides and folded proteins. J. Mol. Biol., 281, 183-201. #11271

  186. Cramer, R.D., Patterson, D.E., Clark, R.D., Soltanshahi, F., & Lawless, M.S. (1998) Virtual compound libraries: A new approach to decision making in molecular discovery research. Journal of Chemical Information and Computer Sciences, 38, 1010-1023. #12337

  187. Crego Calama, M., Hulst, R., Fokkens, R., Nibbering, N.M.M., Timmerman, P., & Reinhoudt, D.N. (1998) Libraries of non-covalent hydrogen-bonded assemblies: Combinatorial synthesis of supramolecular systems. Chem. Commun., 1021-1022. #11631

  188. Creswell, M.W., Bolton, G.L., Hodges, J.C., & Meppen, M. (1998) Combinatorial synthesis of dihydropyridone libraries and their derivatives. Tetrahedron, 54, 3983-3998. #10631

  189. Crowe, J.E., Gilmour, P.S., Murphy, B.R., Chanock, R.M., Duan, L.X., Pomerantz, R.J., & Pilkington, G.R. (1998) Isolation of a second recombinant human respiratory syncytial virus monoclonal antibody fragment (Fab RSVF2-5) that exhibits therapeutic efficacy in vivo. J. Infect. Dis., 177, 1073-1076. #10900

  190. Crozet, Y., Wen, J.J., Loo, R.O., Andrews, P.C., & Spatola, A.F. (1998) Synthesis and characterization of cyclic pseudopeptide libraries containing thiomethylene and thiomethylene-sulfoxide amide bond surrogates. Mol. Diversity, 3, 261-276. #12102

  191. Cuny, G.D., & Hauske, J.R. (1998) Use ring-opening cross-metathesis to constract molecular motifs. Chemtech, 28, 25-31. #11053

  192. Curran, D.P., Luo, Z., & Degenkolb, P. (1998) "Propylene spaced" allyl tin reagents: A new class of fluorous tin reagents for allylations under radical and metal-catalyzed conditions. Bioorg. Med. Chem. Lett., 8, 2403-2408. #11216

  193. Curran, D.P. (1998) Strategy-level separations in organic synthesis: From planning to practice. Angew. Chem. Int. Ed., 37, 1175-1196. #10914

  194. Curran, D.P. (1998) Fluorous synthesis: An alternative to organic synthesis and solid phase synthesis for the preparation of small organic molecules. Canc. J. Sci. Amer., 4, S73-S76. #10898

  195. Czarnik, A.W., & Keene, J.D. (1998) Combinatorial chemistry. Curr. Biol., 8, R705-R707. #11836

  196. Czarnik, A.W. (1998) Combinatorial chemistry. Anal. Chem., 70, 378A-386A. #13786

  197. Czarnik, A.W. (1998) Combinatorial: What's in it for analytical chemists? Anal. Chem., 70, 378A-386A. #10945

  198. Czarnik, A.W. (1998) Solid-phase synthesis supports are like solvents. Biotech. Bioeng. (Comb. Chem. ), 61, 77-79. #11133

  199. Czarnik, A.W. (1998) Illuminating the SNP genomic code. Mod. Drug Dis., 1, 49-55. #12278

  200. Dalton, C., & Seligmann, B. (1998) Combinatorial chemistry consortia for cost-effective drug discovery. Drug Disc. Today, 3, 1-2. #10058

  201. Dalvit, C., & Bohlen, J.M. (1998) Evaluation of the performance of 2D H-1 PFG absorption mode DQ spectroscopy in the analysis of chemical and biological molecules. Magn. Reson. Chem., 36, 670-680. #11837

  202. Daniel, C., Horvath, S., & Allen, P.M. (1998) A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR. Immunity, 8, 543-552. #11092

  203. Danielson, E., Devenney, M., Giaquinta, D.M., Golden, J.H., Haushalter, R.C., McFarland, E.W., Poojary, D.M., Reaves, C.M., Weinberg, W.H., & Wu, X.D. (1998) A rare-earth phosphor containing one-dimensional chains identified through combinatorial methods. Science, 279, 837-839. #10681

  204. Danielson, E., Devenney, M., Giaquinta, D.M., Golden, J.H., Haushalter, R.G., McFarland, E.W., Poojary, D.M., Reaves, C.M., & Weinberg, W.H. (1998) X-ray powder structure of Sr2CeO4: A new luminescent material discovered by combinatorial chemistry. Journal of Molecular Structure, 470, 229-235. #12338

  205. Daugherty, P.S., Chen, G., Olsen, M.J., Iverson, B.L., & Georgiou, G. (1998) Antibody affinity maturation using bacterial surface display. Protein Eng., 11, 825-832. #12146

  206. Davies, M., Bonnat, M., Guillier, F., Kilburn, J.D., & Bradley, M. (1998) Screening an inverted peptide library in water with a guanidinium-based tweezer receptor. J. Org. Chem., 63, 8696-8703. #12147

  207. Davis, P.W., Osgood, S.A., Hebert, N., Sprankle, K.G., & Swayze, E.E. (1998) Solid-phase synthesis of a library of functionalized aminodiol scaffolds. Biotechnol. Bioeng., 61, 143-154. #12952

  208. de Haard, J.J.W., Kazemier, B., Oudshoorn, P., Boender, P., van Gemen, B., Koolen, M.J.M., van der Groen, G., Hoogenboom, H.R., & Arends, J.W. (1998) Selection of human anti-human immunodeficiency virus type 1 envelope single-chain antibodies from a peripheral blood cell-based phage repertoire. J. Gen. Virol., 79, 2894. #12339

  209. de Haard, J.J.W., Kazemier, B., Koolen, M.J.M., Nijholt, L.J., Meloen, R.H., Vangemen, B., Hoogenboom, H.R., & Arends, J.W. (1998) Selection of recombinant, library-derived antibody fragments against p24 for human immunodeficiency virus type 1 diagnostics. Clinical and Diagnostic Laboratory Immunology, 5, 636-644. #11839

  210. De Logu, A., Williamson, R.A., Rozenshteyn, R., Ramiro-Ibanez, F., Simpson, C.D., Burton, D.R., & Sanna, P.P. (1998) Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. J. Clin. Microbiol., 36, 3198-3204. #12340

  211. de Miguel, Y.R. (1998) A diversity of approaches to combinatorial chemistry and biology. Trends Biotech., 16, 49-50. #10720

  212. de Miguel, Y.R., & Sanders, J.K.M. (1998) Generation and screening of synthetic receptor libraries. Curr. Opin. Chem. Biol., 2, 417-421. #11273

  213. Deben, I., Goorden, J., van Doornum, E., Ovaa, H., & Kellenbach, E. (1998) MicroDRIFT: Rapid and efficient IR analysis of solid phase organic chemistry reactions. Eur. J. Org. Chem., 697-700. #10765

  214. Dechantsreiter, M.A., Burkhart, F., & Kessler, H. (1998) A stereoselective synthesis of a C-glycosylated peptoid building block. Tetrahedron Lett., 39, 253-254. #9871

  215. del Fresno, M., Alsina, J., Royo, M., Barany, G., & Albericio, F. (1998) Solid-phase synthesis of diketopiperazines, useful scaffolds for combinatorial chemistry. Tetrahedron Lett., 39, 2639-2642. #10619

  216. Delogu, A., Williamson, R.A., Rozenshteyn, R., Ramiro-Ibanez, F., Simpson, C.D., Burton, D.R., & Sanna, P.P. (1998) Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential. J. Clin. Microbiol., 36, 3198-3204. #11840

  217. Devulapalle, K.S., & Mooser, G. (1998) Preliminary screening of a hexapeptide combinatorial library for glucosyltransferase (GTF-I) inhibitor. Protein Peptide Lett., 5, 159-162. #13432

  218. Dhanoa, D.S., & et al. (1998) Serine proteases-directed small molecule probe libraries. Med. Chem. Res., 8, 187-205. #12123

  219. Dittrich, F., Tegge, W. & Frank, R. (1998) "Cut and combine": An easy membrane-supported combinatorial synthesis technique. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 341-342). Mayflower Scientific Ltd., Kingswinford. #11507

  220. Dittrich, F., Tegge, W., & Frank, R. (1998) "Cut and combine": An easy membrane-supported combinatorial synthesis technique. Bioorg. Med. Chem. Lett., 8, 2351-2356. #11206

  221. Doan, B.T., Fraternali, F., Do, Q.T., Atkinson, R.A., Palmas, P., Sklenar, V., Wildgoose, P., Strop, P., & Saudek, V. (1998) A NMR and MD study of the active site of factor Xa by selective inhibitors. J. Chim. Phys. Phys. -Chim. Biol., 95, 443-446. #10656

  222. Dodd, D.S., & Wallace, O.B. (1998) Solid-phase synthesis of N,N' substituted guanidines. Tetrahedron Lett., 39, 5701-5704. #10957

  223. Doi, N., & Yanagawa, H. (1998) Screening of conformationally constrained random polypeptide libraries displayed on a protein scaffold. Cell. Mol. Life Sci., 54, 394-404. #11074

  224. Dolle, R.E. (1998) Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997. Mol. Diversity, 3, 199-233. #12092

  225. Dominguez, E., O'Donnell, M.J., & Scott, W.L. (1998) Solid-phase synthesis of substituted glutamic acid derivatives via Michael addition reactions. Tetrahedron Lett., 39, 2167-2170. #10601

  226. Domling, A. (1998) Isocyanide based multi component reactions in combinatorial chemistry. Comb. Chem. High Throughput Screening, 1, 1-22. #11579

  227. Domling, A. (1998) A novel concept for the combinatorial synthesis of peptide nucleic acids. Nucleosides Nucleotides, 17, 1667-1670. #12148

  228. Dooley, C.T., Ny, P., Bidlack, J.M., & Houghten, R.A. (1998) Selective ligands for the mu, delta, and kappa opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library. Journal of Biological Chemistry, 273, 18848-18856. #11274

  229. Dooley, C.T., Spaeth, C.G., Toll, L., Berzetei-Gurske, I.P. & Houghten, R.A. (1998) Potent orphanin FQ receptor ligands identified using combinatorial libraries. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 343-344). Mayflower Scientific Ltd., Kingswinford. #11509

  230. Dooley, C.T., & Houghten, R.A. (1998) Synthesis and screening of positional scanning combinatorial libraries. Methods Mol. Biol., 87, 13-24. #10564

  231. Dore, J.M., Morard, F., Vita, N., & Wijdenes, J. (1998) Identification and location on syndecan-1 core protein of the epitopes of B-B2 and B-B4 monoclonal antibodies. FEBS Lett., 426, 67-70. #11134

  232. Dower, W.J. (1998) Targeting growth factor and cytokine receptors with recombinant peptide libraries. Curr. Opin. Chem. Biol., 2, 328-334. #12069

  233. Doyle, P.M., Barker, E., Harris, C.J., & Slater, M.J. (1998) Combinatorial technologies: A revolution in pharmaceutical research and development. Pharmaceutical Technology Europe, 26. #11471

  234. Dressman, B.A., Singh, U., & Kaldor, S.W. (1998) Solid phase synthesis of urea libraries using a diversifiable thiophenoxy carbonyl linker. Tetrahedron Lett., 39, 3631-3634. #10844

  235. Du, C.G., Yao, S.Y., Rojas, M., & Lin, Y.Z. (1998) Conformational and topological requirements of cell-permeable peptide function. Int. J. Peptide Prot. Res., 51, 235-243. #10711

  236. Du, Q.S., & Mezey, P.G. (1998) Heuristic lipophilicity potential for computer-aided rational drug design: Optimizations of screening functions and parameters. J. Comput. Aid. Molec. Design, 12, 451-470. #12344

  237. Du, X., & Armstrong, R.W. (1998) SmI2-Mediated sequential radical cyclization/anionic capture of aryl iodides on solid support. Tetrahedron Lett., 39, 2281-2284. #10593

  238. Dyatkin, A.B., & Rivero, R.A. (1998) The solid phase synthesis of complex propargylamines using the combination of Sonogashira and Mannich reaction. Tetrahedron Lett., 39, 3647-3650. #10846

  239. Ecker, D.J. (1998) Combinatorial chemistry: A scholarly journal serving a new community. Biotech. Bioeng. (Comb. Chem. ), 61, 1-1. #11125

  240. Ede, N.J., James, I.W., Wickham, G., Wu, Z., Maeji, N.J., Rasoul, F., & Bray, A.M. (1998) Combinatorial chemistry and pharmaceutical research. Chemistry in Australia, 13-15. #12134

  241. Edwards, M. (1998) Combinatorial chemistry: Everybody in the pool. Signals, online, #10011

  242. Eggenweiler, H.M. (1998) Linkers for solid-phase synthesis of small molecules: Coupling and cleavage techniques. Drug Disc. Today, 3, 552-560. #12348

  243. Ehrfeld, W. (1998) Microreaction Technologies: Proceedings of the First International Conference. Springer Verlag, Berlin. ISBN 3540638830 #10543

  244. Eichler, J., Blondelle, S.E., Dooley, C.T. & Houghten, R.A. (1998) Scaffolded peptide combinatorial libraries for the design of proteinmimetics. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 361-362). Mayflower Scientific Ltd., Kingswinford. #11511

  245. Eisenthal, R., & Cornish-Bowden, A. (1998) Prospects for antiparasitic drugs: The case of Trypanosoma brucei, the causative agent of african sleeping sickness. Journal of Biological Chemistry, 273, 5500-5505. #10697

  246. Eliseev, A.V. (1998) Emerging approaches to target-assisted screening of combinatorial mixtures. Curr. Opin. Drug. Disc. Develop., 1, 106-115. #11394

  247. Eliseev, A.V., & Nelen, M.I. (1998) Use of molecular recognition to drive chemical evolution. Part 2. Mechanisms of an automated genetic algorithm implementation. Chem. Eur. J., 4, 825-834. #10950

  248. Ellingboe, J.W. (1998) Combinatorial chemistry methodology and combinatorial library design. Med. Chem. Res., 8, 181-186. #12149

  249. Ellman, J.A., & Gallop, M.A. (1998) Combinatorial chemistry. Editorial overview. Curr. Opin. Chem. Biol., 2, 317-319. #12067

  250. Elston, R.C., Napthine, S., & Doorbar, J. (1998) The identification of a conserved binding motif within human papillomavirus type 16 E6 binding peptides, E6AP and E6BP. J. Gen. Virol., 79, 371-374. #10734

  251. Enhsen, A., Kramer, W., & Wess, G. (1998) Bile acids in drug discovery. Drug Disc. Today, 3, 409-418. #11278

  252. Estaquier, J., Ameisen, J.C., Auriault, C., Boutillon, C., Gras-Masse, H., & Tartar, A. (1998) Combinatorial peptide library as an immunogen. Methods Mol. Biol., 87, 281-296. #11533

  253. Estep, K.G., Neipp, C.E., Stramiello, L.M.S., Adam, M.D., Allen, M.P., Robinson, S., & Roskamp, E.J. (1998) Indole resin: A versatile new support for the solid-phase synthesis of organic molecules. J. Org. Chem., 63, 5300-5301. #11004

  254. Estienne, V., McIntosh, R.S., Ruf, J., Asghar, M.S., Watson, P.F., Carayon, P., & Weetman, A.P. (1998) Comparative mapping of cloned human and murine antithyroglobulin antibodies: Recognition by human antibodies of an immunodominant region. Thyroid, 8, 643-646. #11279

  255. Fairley, P. (1998) Pigments: Symyx inks combinatorial chemistry deal with Ciba. Chemical Week, 160, 15. #10902

  256. Fairley, P. (1998) Combinatorial chemistry: Imaging better catalysts. Chemical Week, 160, 36. #10903

  257. Fairley, P. (1998) Combinatorial chemistry: R-and-D power for a price. Chemical Week, 160, 18-20. #11280

  258. Fairley, P. (1998) Combinatorial chemistry: Irori receives radio tagging patent. Chemical Week, 160, 12. #11281

  259. Fairley, P. (1998) Combinatorial chemistry: Bayer, Symyx forge r-and-d collaboration. Chemical Week, 160, 16. #10904

  260. Fairley, P. (1998) Combinatorial chemistry: Hoechst restructuring Symyx deal. Chemical Week, 160, 80. #11843

  261. Fairley, P. (1998) Combinatorial chemistry: Symyx lands BF Goodrich in first US alliance. Chemical Week, 160, 10. #11842

  262. Falorni, M., Giacomelli, G., Mameli, L., & Porcheddu, A. (1998) New 1,3,5-triazine derivatives as templates for the homogeneous phase synthesis of chemical libraries. Tetrahedron Lett., 39, 7607-7610. #11566

  263. Famulok, M., & Jenne, A. (1998) Oligonucleotide libraries. Variatio delectat. Curr. Opin. Chem. Biol., 2, 320-327. #12068

  264. Fang, A.S., Vouros, P., Stacey, C.C., Kruppa, G.H., Laukien, F.H., Wintner, F.A., Carell, T., & Rebek, J.Jr. (1998) Rapid characterization of combinatorial libraries using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Comb. Chem. High Throughput Screening, 1, 23-34. #11580

  265. Fang, J., Xie, W., Li, J., & Wang, P.G. (1998) Chemical and enzymatic synthesis of glycoconjugates 3: Synthesis of lactosamine by thermophilic galactosidase catalysed galactosylation on a multigram scale. Tetrahedron Lett., 39, 919-922. #10485

  266. Fantauzzi, P.P., & Yager, K.M. (1998) Synthesis of diverse tetrahydro-beta-carboline-3-carboxamides and -2,3-bis-lactams on a versatile 4-hydroxythiophenol-linked solid support. Tetrahedron Lett., 39, 1291-1294. #10509

  267. Far, A.R., & Tidwell, T.T. (1998) Ketenes in soluble polymer bound synthesis: Preparation of succinamides and 4-pyridones. J. Org. Chem., 63, 8636-8637. #12350

  268. Fauchere, J.L., Boutin, J.A., Henlin, J.M., Kucharczyk, N., & Ortuno, J.C. (1998) Combinatorial chemistry for the generation of molecular diversity and the discovery of bioactive leads. Chemometr. Intell. Lab. Syst., 43, 43-68. #12351

  269. Fecik, R.A., Frank, K.E., Gentry, E.J., Menon, S.R., Mitscher, L.A., & Telikepalli, H. (1998) The search for orally active medications through combinatorial chemistry. Med. Res. Rev., 18, 149-185. #11136

  270. Feiertag, S., Wiesmuller, K.H. & Jung, G. (1998) Combinatorial head-to-tail cyclized peptide libraries: Evolution of synthestic and analytical methods based on 517 cyclohexapeptides. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 157-160). Mayflower Scientific Ltd., Kingswinford. #11497

  271. Feng, Y., Chung, D., Garrard, L., McEnroe, G., Lim, D., Scardina, J., McFadden, K., Guzzetta, A., Lam, A., Abraham, J., Liu, D., & Endemann, G. (1998) Peptides derived from the complementarity-determining regions of anti-Mac-1 antibodies block intercellular adhesion molecule-1 interaction with Mac-1. Journal of Biological Chemistry, 273, 5625-5630. #10698

  272. Fenniri, H. (1998) Synthetic methods for implementation of encoded reaction cassettes for rapid evaluation of combinatorial libraries of catalysts and substrates. Canc. J. Sci. Amer., 4, S67-S72. #10897

  273. Ferber, M.J., & Maher, L.J.I. (1998) Combinatorial selection of a small RNA that induces amplification of INCFII plasmids in Escherichia coli. J. Mol. Biol., 279, 565-576. #11066

  274. Ferrer-Montiel, A.V., Merino, J.M., Blondelle, S.E., Perez-Paya, E., Houghten, R.A., & Montal, M. (1998) Selected peptides targeted to the NMDA receptor channel protect neurons from excitotoxic death. Nat. Biotech., 16, 286-291. #10696

  275. Filigheddu, S.N., & Taddei, M. (1998) Small ring constrained peptidomimetics. Synthesis of aziridine parallel beta-sheet mimetics. Tetrahedron Lett., 39, 3857-3860. #10850

  276. Finney, N.S. (1998) Fluorescence assays for screening combinatorial libraries of drug candidates. Curr. Opin. Drug. Disc. Develop., 1, 98-105. #11393

  277. Fiorini, M.T., & Abell, C. (1998) Solution-phase synthesis of 2,6,9-trisubstituted purines. Tetrahedron Lett., 39, 1827-1830. #10610

  278. Fitch, W.L., Look, G.C. & Detre, G. (1998) Analytical chemistry issues in combinatorial organic synthesis. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 349-368). John Wiley & Sons, New York. #8754

  279. Floyd, C.D., Harnett, L.A., Miller, A., Patel, S., Saroglou, L., & Whittaker, M. (1998) Rapid synthesis of matrix metalloproteinase inhibitors via Ugi four-component condensation. Synlett, 637-639. #10911

  280. Flynn, D.L., Devraj, R.V., Naing, W., Parlow, J.J., Weidner, J.J., & Yang, S. (1998) Polymer-assisted solution phase (PASP) chemical library synthesis. Med. Chem. Res., 8, 219-243. #12127

  281. Flynn, D.L., Devraj, R.V., & Parlow, J.J. (1998) Recent advances in polymer-assisted solution-phase chemical library synthesis and purification. Curr. Opin. Drug. Disc. Develop., 1, 41-50. #11385

  282. Fokas, D., Ryan, W.J., Casebier, D.S., & Coffen, D.L. (1998) Solution phase synthesis of a spiro[pyrrolidine-2,3'-oxindole] library via a three component 1,3-dipolar cycloaddition reaction. Tetrahedron Lett., 39, 2235-2238. #10592

  283. Foti, M., Granucci, F., Ricciardicastagnoli, P., Spreafico, A., Ackermann, M., & Suter, M. (1998) Rabbit monoclonal Fab derived from a phage display library. J. Immunol. Method, 213, 201-212. #11283

  284. Fox, S., Yund, M.A., & Farr-Jones, S. (1998) Seeking innovation in high-throughput screening. R&D Mag., 40, 32-36. #12061

  285. Francis, M.B., Jamison, T.F., & Jacobsen, E.N. (1998) Combinatorial libraries of transition-metal complexes, catalysts and materials. Curr. Opin. Chem. Biol., 2, 422-428. #12083

  286. Frank, K.E., Devasthale, P.V., Gentry, E.J., Ravikumar, V.T., Keschavarz-Shokri, A., Mitscher, L.A., Nilius, A., Shen, L.L., Shawar, R., & Baker, W.R. (1998) A simple, inexpensive apparatus for performance of preparative scale solution phase multiple parallel synthesis of drug analogs. II.Biological evaluation of a retrospective library of quinolone antiinfective agents. Comb. Chem. High Throughput Screening, 1, 89-100. #11747

  287. Frank, K.E., Jung, M., & Mitscher, L.A. (1998) A simple, inexpensive apparatus for performance of preparative scale solution phase multiple parallel synthesis of drug analogs. I.Preparation of a retrospective library of quinolone antiinfective agents. Comb. Chem. High Throughput Screening, 1, 73-88. #11746

  288. Fraternali, F., Do, Q.T., Doan, B.T., Atkinson, R.A., Palmas, P., Sklenar, V., Safar, P., Wildgoose, P., Strop, P., & Saudek, V. (1998) Mapping the active site of factor Xa by selective inhibitors: An NMR and MD study. Proteins, 30, 264-274. #10700

  289. Friedler, A., Zakai, N., Karni, O., Broder, Y.C., Baraz, L., Kotler, M., Loyter, A., & Gilon, C. (1998) Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in nondividing cells. Biochemistry, 37, 5616-5622. #11102

  290. Friedman, S.H., Ganapathi, P.S., Rubin, Y., & Kenyon, G.L. (1998) Optimizing the binding of fullerene inhibitors of the HIV-1 protease through predicted increases in hydrophobic desolvation. J. Med. Chem., 41, 2424-2429. #11065

  291. Fujii, I., Fukuyama, S., Iwabuchi, Y., & Tanimura, R. (1998) Evolving catalytic antibodies in a phage-displayed combinatorial library. Nat. Biotech., 16, 463-467. #11108

  292. Fukase, K., Fukase, Y., Oikawa, M., Liu, W.C., Suda, Y., & Kusumoto, S. (1998) Divergent synthesis and biological activities of lipid A analogues of shorter acyl chains. Tetrahedron, 54, 4033-4050. #10634

  293. Furlan, R.L.E., & Mata, E.G. (1998) Transprotection in solid phase peptide synthesis: Easy conversion of Fmoc carbamates into Boc carbamates. Tetrahedron Lett., 39, 6421-6422. #11230

  294. Ganesan, A. (1998) Strategies for the dynamic integration of combinatorial synthesis and screening. Angew. Chem. Int. Ed., 37, 2828-2831. #12150

  295. Ganesan, A. (1998) Combinatorial chemistry in the hunt for medicines. Nature, 393, 727-727. #10924

  296. Gao, C.S., Lavey, B.J., Lo, C.H.L., Datta, A., Wentworth, P.Jr., & Janda, K.D. (1998) Direct selection for catalysis from combinatorial antibody libraries using a boronic acid probe: Primary amide bond hydrolysis. J. Amer. Chem. Soc., 120, 2211-2217. #11045

  297. Gao, X., & Kagan, H.B. (1998) One-pot multi-substrate screening in asymmetric catalysis. Chirality, 10, 120-124. #10735

  298. Gardiner, E.J., Holliday, J.D., Willett, P., Wilton, D.J., & Artymiuk, P.J. (1998) Selection of reagents for combinatorial synthesis using clique detection. Quant. Struct. -Act. Relat., 17, 232-236. #12151

  299. Gardsvoll, H., van Zonneveld, A.J., Holm, A., Eldering, E., van Meijer, M., Dano, K., & Pannekoek, H. (1998) Selection of peptides that bind to plasminogen activator inhibitor 1 (PAI-1) using random peptide phage-display libraries. FEBS Lett., 431, 170-174. #11285

  300. Gaus, H.J., Kung, P.P., Brooks, D., Cook, P.D., & Cummins, L.L. (1998) Monitoring solution-phase combinatorial library synthesis by capillary electrophoresis. Biotechnol. Bioeng., 61, 169-177. #12966

  301. Gayo, L.M. (1998) Solution-phase library generation: Methods and applications in drug discovery. Biotech. Bioeng. (Comb. Chem. ), 61, 95-106. #11286

  302. Gee, S.H., Sekely, S.A., Lombardo, C., Kurakin, A., Froehner, S.C., & Kay, B.K. (1998) Cyclic peptides as non-carboxyl-terminal ligands of syntrophin PDZ domains. Journal of Biological Chemistry, 273, 21980-21987. #11534

  303. Gennari, C., Longari, C., Ressel, S., Salom, B., Piarulli, U., Ceccarelli, S., & Mielgo, A. (1998) Synthesis of combinatorial libraries of vinylogous sulfonamidopeptides (vs-peptides). Eur. J. Org. Chem., 2437-2449. #12359

  304. Gennari, C., Ceccarelli, S., Piarulli, U., Aboutayab, K., Donghi, M., & Paterson, I. (1998) Stereocontrolled synthesis of polyketide libraries: Boron-mediated aldol reactions with aldehydes on solid support. Tetrahedron, 54, 14999-15016. #12223

  305. Gennari, C., Ceccarelli, S., Piarulli, U., Montalbetti, C.A.G.N., & Jackson, R.F.W. (1998) Investigation of a new family of chiral ligands for enantioselective catalysis via parallel synthesis and high-throughput screening. J. Org. Chem., 63, 5312-5313. #11287

  306. Georgopapadakou, N.H. (1998) Antifungals: Mechanism of action and resistance, established and novel drugs. Current Opinion in Microbiology, 1, 547-557. #12360

  307. Gerhardt, J. & Rapp, W. (1998) A new automatic system for synthesis in combinatorial chemistry. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 417-418). Mayflower Scientific Ltd., Kingswinford. #11512

  308. Gevorkian, G., Manoutcharian, K., Almagro, J.C., Govezensky, T., & Dominguez, V. (1998) Identification of autoimmune thrombocytopenic purpura-related epitopes using phage-display peptide library. Clin. Immunol. Immunopathol., 86, 305-309. #10899

  309. Gibbons, J.A., Taylor, E.W. & Braeckman, R.A. (1998) ADME/PK assays in screening for orally active drug candidates. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 453-474). John Wiley & Sons, New York. #11730

  310. Giger, T., Wigger, M., Audetat, S., & Benner, S.A. (1998) Libraries for receptor-assisted combinatorial synthesis (RACS): The olefin metathesis reaction. Synlett, 688-691. #10913

  311. Gilchrist, A., Mazzoni, M.R., Dineen, B., Dice, A., Linden, J., Proctor, W.R., Lupica, C.R., Dunwiddie, T.V., & Hamm, H.E. (1998) Antagonists of the receptor-G protein interface block G(1): Coupled signal transduction. Journal of Biological Chemistry, 273, 14912-14919. #11076

  312. Gillet, V.J., Wild, D.J., Willett, P., & Bradshaw, J. (1998) Similarity and dissimilarity methods for processing chemical structure databases. Computer Journal, 41, 547-558. #13522

  313. Gilon, C., Muller, D., Bitan, G., Salitra, Y., Goldwasser, I. & Hornik, V. (1998) Cycloscan: Backbone cyclic conformationally constraint libraries of peptides. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 423-424). Mayflower Scientific Ltd., Kingswinford. #11513

  314. Giver, L., & Arnold, F.H. (1998) Combinatorial protein design by in vitro recombination. Curr. Opin. Chem. Biol., 2, 335-338. #12070

  315. Gobbi, A., & Poppinger, D. (1998) Genetic optimization of combinatorial libraries. Biotech. Bioeng. (Comb. Chem. ), 61, 47-54. #11130

  316. Godolphin, W., Estey, C., Hoffmann, G., & Felder, R. (1998) Review of the LabAutomation'98 Conference and Exhibition. J. Assoc. Lab. Autom., 3, 18-34. #11028

  317. Goetzinger, W.K., & Kyranos, J.N. (1998) Fast gradient RP-HPLC for high-throughput quality control analysis of spatially addressable combinatorial libraries. Amer. Lab., 30, 27. #10996

  318. Goff, D.A. (1998) The synthesis of 2-imidazolidones on solid support by tandem aminoacylation/Michael addition. Tetrahedron Lett., 39, 1477-1480. #10517

  319. Goff, D.A. (1998) A peptoid based synthesis of di- and tri-substituted 2-oxopiperazines on solid support. Tetrahedron Lett., 39, 1473-1476. #10516

  320. Golebiowski, A., & Klopfenstein, S. (1998) Solid supported synthesis of hydroxamic acids. Tetrahedron Lett., 39, 3397-3400. #10804

  321. Gong, Y.D., Najdi, S., Olmstead, M.M., & Kurth, M.J. (1998) Solid-phase synthesis: Intramolecular azomethine ylide cycloaddition (-]proline) and carbanilide cyclization (-]hydantoin) reactions. J. Org. Chem., 63, 3081-3086. #10976

  322. Gonnella, N., Lin, M., Shapiro, M.J., Wareing, J.R., & Zhang, X. (1998) Isotope-filtered affinity NMR. J. Magn. Resonance, 131, 336-338. #10983

  323. Gordeev, M.F., Luehr, G.W., Hui, H.C., Gordon, E.M., & Patel, D.V. (1998) Combinatorial chemistry of natural products: Solid phase synthesis of D- and L-cycloserine derivatives. Tetrahedron, 54, 15879-15890. #12046

  324. Gordeev, M.F. & Patel, D.V. (1998) Heterocyclic combinatorial chemistry: Azine and diazepine pharmacophores. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 201-212). John Wiley & Sons, New York. #11716

  325. Gordeev, M.F., Patel, D.V., England, B.P., Jonnalagadda, S., Combs, J.D., & Gordon, E.M. (1998) Combinatorial synthesis and screening of a chemical library of 1,4-dihydropyridine calcium channel blockers. Bioorg. Med. Chem., 6, 883-889. #11176

  326. Gordeev, M.F. (1998) Combinatorial approaches to pharmacophoric heterocycles: A solid-phase synthesis of 3,1-benzoxazine-4-ones. Biotech. Bioeng. (Comb. Chem. ), 61, 13-16. #10760

  327. Gordon, E.M. (1998) Strategies in the design and synthesis of chemical libraries. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 17-38). John Wiley & Sons, New York. #11708

  328. Gordon, E.M., & Kerwin, J.F.J. (1998) Combinatorial Chemistry and Molecular Diversity in Drug Discovery. John Wiley & Sons, New York. ISBN 0471155187 #9827

  329. Gorlach, E., Richmond, R., & Lewis, I. (1998) High-throughput flow injection analysis mass spectroscopy with networked delivery of color-rendered results. 2. Three-dimensional spectral mapping of 96-well combinatorial chemistry racks. Anal. Chem., 70, 3227-3234. #11289

  330. Graf von Roedern, E. (1998) A new method for the characterization of chemical libraries: Solely by HPLC retention times. Mol. Diversity, 3, 253-256. #12100

  331. Graus, Y.F., Verschuuren, J.J., Degenhardt, A., Vriesman, P.J.V., Debaets, M.H., Posner, J.B., Burton, D.R., & Dalmau, J. (1998) Selection of recombinant anti-HuD Fab fragments from a phage display antibody library of a lung cancer patient with paraneoplastic encephalomyelitis. J. Neuroimmunol., 82, 200-209. #11150

  332. Gravert, D.J., & Janda, K.D. (1998) Bifunctional initiators for free radical polymerization of non-crosslinked block copolymers. Tetrahedron Lett., 39, 1513-1516. #10519

  333. Gray, N.S., Wodicka, L., Thunnissen, A.M.W.H., Norman, T.C., Kwon, S., Espinoza, F.H., Morgan, D.O., Barnes, G., LeClerc, S., Meijer, L., Kim, S.H., Lockhart, D.J., & Schultz, P.G. (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science, 281, 533-538. #11177

  334. Greenlee, W.J., & Desai, M. (1998) The chemistry of drug discovery and lead optimization. Editorial overview. Curr. Opin. Drug. Disc. Develop., 1, 3-3. #11233

  335. Grehn, L., & Ragnarsson, U. (1998) Multisubstituted urea derivatives of hydrazines by a flexible approach with potential application in combinatorial chemistry. Synthesis-Stuttgart, 1817-1821. #12152

  336. Gremlich, H.U. (1998) The use of optical spectroscopy in combinatorial chemistry. Biotechnol. Bioeng., 61, 179-187. #12972

  337. Gremlich, H.U. (1998) Infrared and Raman spectroscopy in combinatorial chemistry. Amer. Lab., 30, 33-39. #12275

  338. Griffey, R.H., An, H., Cummins, L.L., Gaus, H.J., Haly, B., Herrmann, R., & Cook, P.D. (1998) Rapid deconvolution of combinatorial libraries using HPLC fractionation. Tetrahedron, 54, 4067-4076. #10636

  339. Grippo, J.F., & Burn, P. (1998) Obesity genes: Molecular genetic approaches to drug target identification. Farmaco, 53, 262-265. #11070

  340. Groebke, K., Weber, L., & Mehlin, F. (1998) Synthesis of imidazo[1,2-A] Annulated pyridines, pyrazines and pyrimidines by a novel three-component condensation. Synlett, 661. #10912

  341. Guiles, J.W., Lanter, C.L., & Rivero, R.A. (1998) A visual tagging process for mix and sort combinatorial chemistry. Angew. Chem. Int. Ed., 37, 926-928. #10990

  342. Gung, B.W., Zhu, Z.H., Zou, D., Everingham, B., Oyeamalu, A., Crist, R.M., & Baudlier, J. (1998) Requirement for hydrogen-bonding cooperativity in small polyamides: A combined VT-NMR and VT-IR investigation. J. Org. Chem., 63, 5750-5761. #11850

  343. Gunzenhauser, S., Biala, E., & Strazewski, P. (1998) Tetraethylene glycol-derived spacer for oligonucleotides synthesis. Tetrahedron Lett., 29, 6277-6280. #11025

  344. Guo, J., McIntosh, R.S., Czarnocka, B., Weetman, A.P., Rapoport, B., & McLachlan, S.M. (1998) Relationship between autoantibody epitopic recognition and immunoglobulin gene usage. Clin. Exp. Immunol., 111, 408-414. #10716

  345. Gustafson, G.R., Baldino, C.M., O'Donnell, M.M.E., Sheldon, A., Tarsa, R.J., Verni, C.J., & Coffen, D.L. (1998) Incorporation of carbohydrates and peptides into large triazine-based screening libraries using automated parallel synthesis. Tetrahedron, 54, 4051-4065. #10635

  346. Haap, W.J., Kaiser, D., Walk, T.B., & Jung, G. (1998) Solid phase synthesis of diverse isoxazolidines via 1,3-dipolar cycloaddition. Tetrahedron, 54, 3705-3724. #10587

  347. Haap, W.J., Walk, T.B., & Jung, G. (1998) FT-IR mapping: A new tool for spatially resolved characterization of polymer-bound combinatorial compound libraries with IR microscopy. Angew. Chem. Int. Ed., 37, 3311-3314. #12153

  348. Habermann, J., Ley, S.V., & Scott, J.S. (1998) Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents. J. Chem. Soc. Perkin Trans. 1, 3127-3130. #13640

  349. Hall, B.J., & Sutherland, J.D. (1998) A practical method for the combinatorial synthesis of peptide aldehydes. Tetrahedron Lett., 39, 6593-6596. #11232

  350. Hall, S.E. (1998) Parallel organic synthesis in array format. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 291-306). John Wiley & Sons, New York. #11721

  351. Hamilton, D.G., Feeder, N., Teat, S.J., & Sanders, J.K.M. (1998) Reversible synthesis of pi-associated [2]catenanes by ring-closing metathesis: Towards dynamic combinatorial libraries of catenanes. New J. Chem., 22, 1019-1021. #12365

  352. Hammond, D.J. (1998) Identification of affinity ligands from peptide libraries and their applications. Chromatographia, 47, 475-476. #10987

  353. Hamper, B.C., Kolodziej, S.A., Scates, A.M., Smith, R.G., & Cortez, E. (1998) Solid phase synthesis of b-peptoids: N-Substituted b-aminopropionic acid oligomers. J. Org. Chem., 63, 708-718. #10569

  354. Hamper, B.C., Kolodziej, S.A., & Scates, A.M. (1998) Knoevenagel condensation of unsymmetrical malonamic esters and malonates on a solid support. Tetrahedron Lett., 39, 2047-2050. #10597

  355. Hanessian, S., & Xie, F. (1998) Polymer-bound p-alkoxybenzyl trichloracetimidates: Reagents for the protection of alcohols as benzyl ethers on solid-phase. Tetrahedron Lett., 39, 733-736. #10047

  356. Hanessian, S., & Xie, F. (1998) Exploring functional and molecular diversity with polymer-bound p-alkoxybenzyl ethers: Scope and applications of preparatively useful organic reactions. Tetrahedron Lett., 39, 737-740. #10048

  357. Harrison, J.G., & Balasubramanian, S. (1998) Synthesis and hybridization analysis of a small library of peptide-oligonucleotide conjugates. Nucl. Acid. Res., 26, 3136-3145. #11292

  358. Harrison, W. (1998) Changes in scale in automated pharmaceutical research. Drug Disc. Today, 3, 343-349. #11293

  359. Harvey, A.L. (1998) Advances in Drug Discovery Techniques. John Wiley & Sons, New York. ISBN 0471975095 #11591

  360. Harvey, A.L., & Waterman, P.G. (1998) The continuing contribution of biodiversity to drug discovery. Curr. Opin. Drug. Disc. Develop., 1, 71-76. #11389

  361. Haunert, F., Bolli, M.H., Hinzen, B., & Ley, S.V. (1998) Clean three-step synthesis of 4,5-dihydro-1H-pyrazoles starting from alcohols using polymer supported reagents. J. Chem. Soc. Perkin Trans. 1, 2235-2237. #13440

  362. Havez, S., Begtrup, M., Vedso, P., Andersen, K., & Ruhland, T. (1998) Directed ortho-lithiation on solid phase. J. Org. Chem., 63, 7418-7420. #12115

  363. Hawlisch, H., Frank, R., Hennecke, M., Baensch, M., Sohns, B., Arseniev, L., Bautsch, W., Kola, A., Klos, A., & Kohl, J. (1998) Site-directed C3a receptor antibodies from phage display libraries. Journal of Immunology, 160, 2947-2958. #10575

  364. Hayashi, Y., Katada, J., Harada, T., Tachiki, A., Iijima, K., Takiguchi, Y., Muramatsu, M., Miyazaki, H., Asari, T., Okazaki, T., Sato, Y., Yasuda, E., Yano, M., Uno, I., & Ojima, I. (1998) GPIIb/IIIa Integrin antagonists with the new conformational restriction unit, trisubstituted beta-amino acid derivatives, and a substituted benzamidine structure. J. Med. Chem., 41, 2345-2360. #11064

  365. He, X.H., Liu, S.J., & Perry, K.L. (1998) Identification of epitopes in cucumber mosaic virus using a phage-displayed random peptide library. J. Gen. Virol., 79, 3145-3153. #12154

  366. Heerding, D.A., Takata, D.T., Kwon, C., Huffman, W.F., & Samanen, J. (1998) Combinatorial chemistry. Use of an intramolecular ruthenium catalyzed olefin/alkyne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to construct functionalized hexahydroisoindoles. Tetrahedron Lett., 39, 6815-6818. #11226

  367. Heizmann, G., Hildebrandt, P., Tanner, H., Ketterer, S., Beglinger, C. & Eberle, A.N. (1998) Peptoid and hybrid peptoid-peptide ligands for the MSH and the GRP-preferring bombesin receptor developed from a combinatorial peptoid library. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 161-164). Mayflower Scientific Ltd., Kingswinford. #11498

  368. Helm, B.A., Sayers, I., Padlan, E.A., Mckendrick, J.E., & Spivey, A.C. (1998) Structure/function studies on Ige as a basis for the development of rational Ige antagonists. Allergy: European Journal of Allergy and Clinical Immunology, 53, 45-82. #11853

  369. Hemmer, B., Pinilla, C., Appel, J., Pascal, J., Houghten, R., & Martin, R. (1998) The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells. J. Pept. Res., 52, 338-345. #12368

  370. Hemmer, B., Vergelli, M., Pinilla, C., Houghten, R., & Martin, R. (1998) Probing degeneracy in T-cell recognition using peptide combinatorial libraries. Immunol. Today, 19, 163-168. #11151

  371. Henkel, B., & Bayer, E. (1998) 9-Hydroxy-9-(4-carboxyphenyl)fluorene: A new linker for solid phase synthesis. Tetrahedron Lett., 39, 9401-9402. #12024

  372. Hermann, T., & Westhof, E. (1998) RNA as a drug target: Chemical, modelling, and evolutionary tools. Curr. Opin. Biotechnol., 9, 66-73. #10714

  373. Hiemstra, H.S., Van Veelen, P.A., Schloot, N.C., Geluk, A., Van Meijgaarden, K.E., Willemen, S.J.M., Leunissen, J.A.M., Benckhuijsen, W.E., Amons, R., de Vries, R.R.P., Roep, B.O., Ottenhoff, T.H.M., & Drijfhout, J.W. (1998) Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries. Journal of Immunology, 161, 4078-4082. #11854

  374. Hiemstra, H.S., Benckhuijsen, W.E., Amons, R., Rapp, W., & Drijfhout, J.W. (1998) A new hybrid resin for stepwise screening of peptide libraries combined with single bead Edman sequencing. J. Peptide Sci., 4, 282-288. #10879

  375. Hiemstra, H.S., Duinkerken, G., Benckhuijsen, W.E., Amons, R., Roep, B.O. & Drijfhout, J.W. (1998) The use of incomplete synthetic peptide libraries for the identification of T(h) cell epitopes. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 477-478). Mayflower Scientific Ltd., Kingswinford. #11514

  376. Hilderman, R.H., Liu, G., & Zimmerman, J.K. (1998) A peptide isolated from a random phage peptide library is a structural mimic to the P1, P4-diadenosine 5'-tetraphosphate binding site on its receptor. Eur. J. Biochem., 258, 396-401. #12155

  377. Hilger, C.S., Willis, M.C., Wolters, M., & Pieken, W.A. (1998) Synthesis of Tc-99m-labeled, modified RNA. Tetrahedron Lett., 39, 9403-9406. #12025

  378. Hill, D.C., Wrigley, S.K., & Nisbet, L.J. (1998) Novel screen methodologies for identification of new microbial metabolites with pharmacological activity. Adv. Biochem. Eng. /Biotechnol., 59, 73-121. #11412

  379. Hill, D.C. (1998) Trends in development of high-throughput screening technologies for rapid discovery of novel drugs. Curr. Opin. Drug. Disc. Develop., 1, 92-97. #11392

  380. Hioki, H., & Still, W.C. (1998) Chemical evolution: A model system that selects and amplifies a receptor for the tripeptide (D)Pro(L)Val(D)Val. J. Org. Chem., 63, 904-905. #11419

  381. Hirschmann, R. (1998) Peptide related research: A means to further biological and chemical understanding. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 3-17). Mayflower Scientific Ltd., Kingswinford. #11476

  382. Ho, S.P., Bao, Y., Lesher, T., Malhotra, R., Ma, L.Y., Fluharty, S.J., & Sakai, R.R. (1998) Mapping of RNA accesible sites for antisense experiments with oligonucleotide libraries. Nat. Biotech., 16, 59-63. #10866

  383. Hoekstra, W.J., & Poulter, B.L. (1998) Combinatorial chemistry techniques applied to nonpeptide integrin antagonists. Curr. Med. Chem., 5, 195-204. #11073

  384. Hoess, R.H. (1998) Protein scaffolds for peptide libraries. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 389-399). John Wiley & Sons, New York. #11725

  385. Hoffmuller, U., & Schneider-Mergener, J. (1998) In vitro evolution and selection of proteins: Ribosome display for larger libraries. Angew. Chem. Int. Ed., 37, 3241-3243. #12156

  386. Holtzapple, C.K., & Stanker, L.H. (1998) Affinity selection of compounds in a fluoroquinolone chemical library by on-line immunoaffinity deletion coupled to column HPLC. Anal. Chem., 70, 4817-4821. #12157

  387. Holzwarth, A., Schmidt, P.W., & Maier, W.E. (1998) Detection of catalytic activity in combinatorial libraries of heterogeneous catalysts by IR thermography. Angew. Chem. Int. Ed., 37, 2644-2647. #12158

  388. Hone, N.D., Davies, S.G., Devereux, N.J., Taylor, S.L., & Baxter, A.D. (1998) A highly acid labile silicon linker for solid phase synthesis. Tetrahedron Lett., 39, 897-900. #10053

  389. Hong, S.Y., Oh, J.E., Kwon, M.Y., Choi, M.J., Lee, J.H., Lee, B.L., Moon, H.M., & Lee, K.H. (1998) Identification and characterization of novel antimicrobial decapeptides generated by combinatorial chemistry. Antimicrob. Agents Chemother., 42, 2534-2541. #11856

  390. Hori, M., & Janda, K.D. (1998) A soluble polymer approach to the "fishing out" principle: Synthesis and purification of beta-amino alcohols. J. Org. Chem., 63, 889-894. #12128

  391. Hori, M., Gravert, D.J., Wentworth, P.Jr., & Janda, K.D. (1998) Investigating highly crosslinked macroporous resins for solid-phase synthesis. Bioorg. Med. Chem. Lett., 8, 2363-2368. #11208

  392. Horvath, I.T. (1998) Fluorous biphase chemistry. Account. Chem. Res., 31, 641-650. #11802

  393. Horwell, D., Pritchard, M., Raphy, J. & Ratcliffe, G. (1998) Design and biological properties of non-peptide agonists and antagonists starting from the chemical structures of neuropeptides: Illustrations by courtesy of cholecystokinin and tachykinins. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 97-100). Mayflower Scientific Ltd., Kingswinford. #11478

  394. Hoveyda, A.H. (1998) Catalyst discovery through combinatorial chemistry. Chem. Biol., 5, R187-R191. #11296

  395. Hsieh, F., Keshishian, H., & Muir, C. (1998) Automated high throughput multiple target screening of molecular libraries by microfluidic MALDI-TOF MS. J. Biomol. Screen., 3, 189-198. #11857

  396. Hsieh, H.P., Wu, Y.T., Chen, S.T., & Wang, K.T. (1998) Dihydropyran-2-carboxylic acid, a novel bifunctional linker for the solid-phase synthesis of peptides containing a C-terminal alcohol. Chem. Commun., 649-650. #11030

  397. Hu, Y., & Porco, J.A.Jr. (1998) Alcoholysis and carbonyl hydrosilylation reactions using a polymer-supported trialkylsilane. Tetrahedron Lett., 39, 2711-2714. #10744

  398. Huang, C.Y., Uno, T., Murphy, J.E., Lee, S., Hamer, J.D., Escobedo, J.A., Cohen, F.E., Radhakrishnan, R., Dwarki, V., & Zuckermann, R.N. (1998) Lipitoids: Novel cationic lipids for cellular delivery of plasmid DNA in vitro. Chem. Biol., 5, 345-354. #11061

  399. Huang, W.Z., Petrosino, J., & Palzkill, T. (1998) Display of functional beta-lactamase inhibitory protein on the surface of M13 bacteriophage. Antimicrob. Agents Chemother., 42, 2893-2897. #12372

  400. Hughes, I. (1998) Design of self-coded combinatorial libraries to facilitate direct analysis of ligands by mass spectrometry. J. Med. Chem., 41, 3804-3811. #11858

  401. Hulme, C., Peng, J., Louridas, B., Menard, P., Krolikowski, P., & Kumar, N.V. (1998) Application of N-Boc-diamines for the solution phase synthesis of ketopiperazine libraries utilizing a Ugi/De-Boc/cyclization (UDC) strategy. Tetrahedron Lett., 39, 8047-8050. #11949

  402. Hulme, C., Peng, J., Morton, G., Salvino, J.M., Herpin, T., & Labaudiniere, R. (1998) Novel safety-catch linker and its application with a Ugi/De-Boc/cyclization (UDC). Strategy to access carboxylic acids, 1,4-benzodiazepines, diketopiperazines, ketopiperazines and dihydroquinoxalinones. Tetrahedron Lett., 39, 7227-7230. #11568

  403. Hulme, C., Peng, J., Tang, S.Y., Burns, C.J., Morize, I., & Labaudiniere, R. (1998) Improved procedure for the solution phase preparation of 1,4-benzodiazepine-2,5-dione libraries via Armstrong's convertible isonitrile and the Ugi reaction. J. Org. Chem., 63, 8021-8023. #13441

  404. Hulme, C., Morrissette, M.M., Volz, F.A., & Burns, C.J. (1998) The solution phase synthesis of diketopiperazine libraries via the Ugi reaction: Novel application of Armstrong's convertible isonitrile. Tetrahedron Lett., 39, 1113-1116. #10500

  405. Huyer, G., Kelly, J., Moffat, J., Zamboni, R., Jia, Z.C., Gresser, M.J., & Ramachandran, C. (1998) Affinity selection from peptide libraries to determine substrate specificity of protein tyrosine phosphatases. Anal. Biochem., 258, 19-30. #11156

  406. Illig, C., Eisennagel, S., Bone, R., Radzicka, A., Murphy, L., Randle, T., Spurlino, J., Salemme, F.R., & Soll, R.M. (1998) Expanding the envelope of structure-based drug design using chemical libraries: Application to small-molecule inhibitors of thrombin. Med. Chem. Res., 8, 244-260. #12374

  407. Ingallinella, P., Altamura, S., Bianchi, E., Taliani, M., Ingenito, R., Cortese, R., De Francesco, R., Steinkuhler, C., & Pessi, A. (1998) Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products. Biochemistry, 37, 8906-8914. #11059

  408. Iniguez, P., Zientara, S., Marault, M., Machin, I.B., Hannant, D., & Cruciere, C. (1998) Screening of horse polyclonal antibodies with a random peptide library displayed on phage - identification of ligands used as antigens in an elisa test to detect the presence of antibodies to equine arteritis virus. J. Virol. Meth., 73, 175-183. #11859

  409. Isaacs, E.D., Marcus, M., Aeppli, G., Xiang, X.D., Sun, X.D., Schultz, P., Kao, H.K., Cargill, G.S., & Haushalter, R. (1998) Synchrotron X-ray microbeam diagnostics of combinatorial synthesis. Appl. Phys. Lett., 73, 1820-1822. #11860

  410. Ishikawa, D., Kikkawa, H., Ogino, K., Hirabayashi, Y., Oku, N., & Taki, T. (1998) GD1a-replica peptides functionally mimic GD1a, an adhesion molecule of metastatic tumor cells, and suppress the tumor metastasis. FEBS Lett., 441, 20-24. #12161

  411. Ito, Y., & Manabe, S. (1998) Solid-phase oligosaccharide synthesis and related technologies. Curr. Opin. Chem. Biol., 2, 701-708. #12376

  412. Iverson, G.M., Jones, D.S., Marquis, D., Linnik, M.D., & Victoria, E.J. (1998) A chemically defined, toleragen-based approach for targeting anti-beta(2)-glycoprotein I antibodies. Lupus, 7, -S169. #12378

  413. Izumi, M., & Ichikawa, Y. (1998) Combinatorial synthesis of oligosaccharide library of 2,6-dideoxysugars. Tetrahedron Lett., 39, 2079-2082. #10600

  414. Jacobs, J.W. & Ni, Z.J. (1998) Encoded combinatorial chemistry. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 271-290). John Wiley & Sons, New York. #11720

  415. Jacobs, J.W., Patel, D.V., Yuan, Z., Holmes, C.P., Schullek, J., Antonenko, V.V., Grove, J.R., Kulikov, N., Maclean, D., Navre, M., Nguyen, C., Shi, L., Sundaram, A. & Sundberg, S.A. (1998) Light-directed chemical synthesis of positionally encoded peptide arrays. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 111-131). John Wiley & Sons, New York. #11710

  416. Jadhav, V.R., & Ganesh, K.N. (1998) Design of a combinatorial oligonucleotide library containing all possible hexamer palindromes: PCR synthesis and application for identifying restriction cleavage sites. Biochem. Biophys. Res. Commun., 242, 297-302. #10227

  417. James, K.D., & Ellington, A.D. (1998) The use of aluminum chloride for removal of Boc groups on 5'-amino-2',5'-dideoxyoligonucleotides during solid-phase synthesis. Tetrahedron Lett., 39, 175-178. #9866

  418. Jaspars, M., & Lawton, L.A. (1998) Cyanobacteria: A novel source of pharmaceuticals. Curr. Opin. Drug. Disc. Develop., 1, 77-84. #11390

  419. Jefferies, D. (1998) Selection of novel ligands from phage display libraries: An alternative approach to drug and vaccine discovery. Parasitol. Today, 14, 202-206. #11137

  420. Jenison, R.D., Jennings, S.D., Walker, D.W., Bargatze, R.F., & Parma, D. (1998) Oligonucleotide inhibitors of p-selectin-dependent neutrophil-platelet adhesion. Antisense Nucl. Acid Drug Devel., 8, 265-279. #11861

  421. Jensen, K.J., Alsina, J., Songster, M.F., Vagner, J., Albericio, F., & Barany, G. (1998) Backbone amide linker (BAL) strategy for solid-phase synthesis of C-terminal-modified and cyclic peptides. J. Amer. Chem. Soc., 120, 5441-5452. #10931

  422. Jensen, P.R., & Hammer, K. (1998) The sequence of spacers between the consensus sequences modulates the strength of prokaryotic promoters. Appl. Environ. Microbiol., 64, 82-87. #10752

  423. Jhaveri, S., Olwin, B., & Ellington, A.D. (1998) In vitro selection of phosphorothiolated aptamers. Bioorg. Med. Chem. Lett., 8, 2285-2290. #11195

  424. Johnson, C.R., Zhang, B., Fantauzzi, P., Hocker, M., & Yager, K.M. (1998) Libraries of N-alkylaminoheterocycles from nucleophilic aromatic substitution with purification by solid supported liquid extraction. Tetrahedron, 54, 4097-4106. #10639

  425. Johnson, M., Arles, C., & Boons, G.J. (1998) Vinyl glycosides in oligosaccharide synthesis (Part 5): A latent-active glycosylation strategy for the preparation of branched trisaccharide libraries. Tetrahedron Lett., 39, 9801-9804. #12058

  426. Johnston, H. (1998) An intelligent approach to combinatorial chemistry. Scientific Computing World, 18-19. #14731

  427. Jones, D.S., Gamino, C.A., & Randow, M.E. (1998) Synthesis of a cyclic-thioether peptide which binds anti-cardiolipin antibodies. Tetrahedron Lett., 39, 6107-6110. #11023

  428. Josey, J.A., Tarlton, C.A., & Payne, C.E. (1998) Novel linker for the solid-phase synthesis of guanidines. Tetrahedron Lett., 39, 5899-5902. #10981

  429. Jung, C., Kalbus, M., Fleckenstein, B., Melms, A., Jung, G., & Wiesmuller, K.H. (1998) New ligands for HLA DRB1 * 0301 by random selection of favourable amino acids ranked by competition studies with undecapeptide amide sublibraries. J. Immunol. Method, 219, 139-149. #12162

  430. Kagan, H.B. (1998) New screening methodologies or combinatorial chemistry applied to asymmetric catalysts. J. Organomet. Chem., 567, 3-6. #11863

  431. Kaldor, S.W. & Siegel, M.G. (1998) Synthetic organic chemistry on solid support. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 307-335). John Wiley & Sons, New York. #11722

  432. Kaljuste, K., & Tam, J.P. (1998) A novel on-resin synthesis of C-terminally amidated peptides. Tetrahedron Lett., 39, 9327-9330. #12022

  433. Kang, S.K., Kim, J.S., Yoon, S.K., Lim, K.H., & Yoon, S.S. (1998) Copper-catalyzed coupling of polymer bound iodide with organostannanes. Tetrahedron Lett., 39, 3011-3012. #10741

  434. Kapoor, T.M., Andreotti, A.H., & Schreiber, S.L. (1998) Exploring the specificity pockets of two homologous SH3 domains using structure-based, split-pool synthesis and affinity-based selection. J. Amer. Chem. Soc., 120, 23-29. #10234

  435. Karet, G. (1998) Software adapts to changes in combichem. R&D Mag., 40, 46-49. #12063

  436. Karet, G. (1998) Abbott accelerates its combichem efforts. R&D Mag., 40, 26-30. #12060

  437. Karlsson, K.F., Walse, B., Drakenberg, T., Roy, S., Bergquist, K.E., Pinkner, J.S., Hultgren, S.J., & Kihlberg, J. (1998) Binding of peptides in solution by the Escherichia coli chaperone PapD as revealed using an inhibition ELISA and NMR spectroscopy. Bioorg. Med. Chem., 6, 2085-2101. #12381

  438. Katakura, Y., Lim, E.T., Tsujii, S., Omasa, T., & Suga, K. (1998) The importance of ionic strength as a parameter in screening peptide ligands from a phage display library. Journal of Fermentation and Bioengineering, 85, 447-450. #11072

  439. Kates, S.A., McGuinness, B.F., Blackburn, C., Griffin, G.W., Sole, N.A., Barany, G., & Albericio, F. (1998) "High-load" polyethylene glycol-polystyrene (PEG-PS) graft supports for solid-phase synthesis. Biopolymers (Pept. Sci. ), 47, 365-380. #12263

  440. Katritzky, A.R., Belyakov, S.A., Fang, Y., & Kiely, J.S. (1998) Polymer-supported preparation of substituted phenols: A new example of simultaneous cyclization-cleavage reaction on solid-phase. Tetrahedron Lett., 39, 8051-8054. #11950

  441. Kauvar, L.M., Villar, H.O., Sportsman, J.R., Higgins, D.L., & Schmidt, D.E. (1998) Protein affinity map of chemical space. Journal of Chromatography B, 715, 93-102. #11865

  442. Kauvar, L.M., & Laborde, E. (1998) The diversity challenge in combinatorial chemistry. Curr. Opin. Drug. Disc. Develop., 1, 66-70. #11388

  443. Kauvar, L.M., & Villar, H.O. (1998) Deciphering cryptic similarities in protein binding sites. Curr. Opin. Biotechnol., 9, 390-394. #11301

  444. Kauvar, L.M. (1998) Approaches to new drug discovery. In G. Kruh & K.D. Tew (Eds.), Atlas of Clinical Oncology. (pp. in press. Current Medicine, Philadelphia. #11404

  445. Kay, B.K., Kurakin, A.V., & Hydederuyscher, R. (1998) From peptides to drugs via phage display. Drug Disc. Today, 3, 370-378. #11302

  446. Kearney, P.C., Fernandez, M., & Flygare, J.A. (1998) Solid-phase synthesis of 2-aminothiazoles. J. Org. Chem., 63, 196-200. #10238

  447. Kearney, P.C., Fernandez, M., & Flygare, J.A. (1998) Solid-phase synthesis of disubstituted guanidines. Tetrahedron Lett., 39, 2663-2666. #10742

  448. Keifer, P.A. (1998) New methods for obtaining high-resolution NMR spectra of solid-phase synthesis resins, natural products, and solution-state combinatorial chemistry libraries. Drugs Future, 23, 301-317. #10835

  449. Kempe, M., Keifer, P.A. & Barany, G. (1998) CLEAR supports for solid-phase synthesis. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 533-534). Mayflower Scientific Ltd., Kingswinford. #11515

  450. Kerwin, J.F.J. (1998) Combinatorial technologies: Prospects and future issues. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 475-481). John Wiley & Sons, New York. #11731

  451. Khosla, C. (1998) Combinatorial biosynthesis of "unnatural" natural products. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 401-417). John Wiley & Sons, New York. #11726

  452. Kiely, J.S., & Pei, Y. (1998) Heterocyclic mixture-based combinatorial libraries: Synthesis and analysis of composition (3,4-dihydro-2-(1H)-quinolinones). Trends in Drug Research, 29, 147-156. #12119

  453. Kim, D.E., Gu, H., & Baker, D. (1998) The sequences of small proteins are not extensively optimized for rapid folding by natural selection. Proc. Natl. Acad. Sci. USA, 95, 4982-4986. #11112

  454. Kim, S.H. (1998) Structure-based inhibitor design for CDK2, a cell cycle controlling protein kinase. Pure Appl. Chem., 70, 555-565. #11303

  455. Kim, S.J., Zheng, J., Hiremath, S.T., & Podila, G.K. (1998) Cloning and characterization of a symbiosis-related gene from an ectomycorrhizal fungus Laccaria bicolor. Gene, 222, 203-212. #12247

  456. Kim, S.W., Shin, Y.S., & Ro, S. (1998) Solution an solid phase combinatorial synthesis of peptidomimetic library containing diversified alpha-methylated amino acids. Bioorg. Med. Chem. Lett., 8, 1665-1668. #11117

  457. Kim, S.W., Koh, J.S., Lee, E.J., & Ro, S. (1998) Solid phase synthesis of benzamidine and butylamine-derived hydantoin libraries. Mol. Diversity, 3, 129-132. #10649

  458. Kim, S.W., Hong, C.Y., Lee, K., Lee, E.J., & Koh, J.S. (1998) Solid phase synthesis of benzylamine-derived sulfonamide library. Bioorg. Med. Chem. Lett., 8, 735-738. #11152

  459. Kim, S.W., Bauer, S.M., & Armstrong, R.W. (1998) Multicomponent solution phase synthesis of dehydroamino acid derivatives based on the Passerini reaction. Tetrahedron Lett., 39, 7031-7034. #11221

  460. Kim, S.W., Hong, C.Y., Koh, J.S., Lee, E.J., & Lee, K. (1998) Solid phase synthesis of benzamidine-derived sulfonamide libraries. Mol. Diversity, 3, 133-136. #10650

  461. Kim, S.W., Bauer, S.M., & Armstrong, R.W. (1998) Construction of combinatorial chemical libraries using a rapid and efficient solid phase synthesis based on a multicomponent condensation reaction. Tetrahedron Lett., 39, 6993-6996. #11219

  462. Kim, Y., & Zimmerman, S.C. (1998) Applications of dendrimers in bio-organic chemistry. Curr. Opin. Chem. Biol., 2, 733-742. #15509

  463. Kimura, T., Kaburaki, H., Tsujino, T., Watanabe, Y., & Kato, H. (1998) Signal transduction by the peptide which mimics the activity of thrombopoietin. Biochem. Mol. Biol. Int., 44, 1203-1209. #11093

  464. Kirshenbaum, K., Barron, A.E., Goldsmith, R.A., Armand, P., Bradley, E.K., Truong, K.T.V., Dill, K.A., Cohen, F.E., & Zuckermann, R.N. (1998) Sequence-specific polypeptoids: A diverse family of heteropolymers with stable secondary structure. Proc. Natl. Acad. Sci. USA, 95, 4303-4308. #11599

  465. Kiselyov, A.S., Eisenberg, S., & Luo, Y. (1998) Solid support synthesis of 14-membered macrocycles containing the thioether bridge via SNAr methodology. Tetrahedron, 54, 10635-10640. #12225

  466. Kiselyov, A.S., Smith, L.Jr., Virgilio, A., & Armstrong, R.W. (1998) Immobilized aldehydes and olefins in the solid support synthesis of tetrahydroquinolines via a three component condensation. Tetrahedron, 54, 7987-7996. #10919

  467. Kiselyov, A.S., Smith, L.Jr., & Armstrong, R.W. (1998) Solid support synthesis of polysubstituted tetrahydroquinolines via three-component condensation catalyzed by Yb(OTf)3. Tetrahedron, 54, 5089-5096. #12206

  468. Klimkait, T., Felder, E.R., Albrecht, G., & Hamy, F. (1998) Rational optimization of a HIV-1 Tat inhibitor: Rapid progress on combinatorial lead structures. Biotechnol. Bioeng., 61, 155-168. #12988

  469. Kniss, R. (1998) Revolution of the drug discovery process using laboratory-on-a-chip technology. Amer. Lab., 30, 40-42. #12276

  470. Ko, D.H., Kim, D.J., Lyu, C.S., Min, I.K., & Moon, H.S. (1998) New cleavage approaches to combinatorial synthesis of homoserine lactones. Tetrahedron Lett., 39, 297-300. #9875

  471. Kobayashi, S., Komiyama, S., & Ishitani, H. (1998) A convenient method for library construction: Parallel synthesis of beta-amino ester and quinoline derivatives in liquid phase using Ln(OTf)3-catalyzed three-component reactions. Biotech. Bioeng. (Comb. Chem. ), 61, 23-31. #12085

  472. Kobayashi, S., & Akiyama, R. (1998) Lanthanide triflate-catalyzed 1,3-dipolar cycloaddition reactions of polymer-supported nitrones with alkenes for the preparation of diverse 2-isoxazoline derivatives. Tetrahedron Lett., 39, 9211-9214. #12018

  473. Kobayashi, S., Wakabayashi, T., & Yasuda, M. (1998) Efficient synthesis of diverse monosaccharide derivatives in the solid phase. J. Org. Chem., 63, 4868-4869. #12122

  474. Koblizkova, A., Dolezel, J., & Macas, J. (1998) Subtraction with 3' modified oligonucleotides eliminates amplification artifacts in DNA libraries enriched for microsatellites. BioTechniques, 25, 32-38. #10872

  475. Koide, A., Bailey, C.W., Huang, X.L., & Koide, S. (1998) The fibronectin type III domain as a scaffold for novel binding proteins. J. Mol. Biol., 284, 1141-1151. #12386

  476. Koike, T., Ichikawa, K., Kasahara, H., Atsumi, T., Tsutsumi, A., & Matsuura, E. (1998) Epitopes on beta 2-GPI recognized by anticardiolipin antibodies. Lupus, 7, -S17. #12387

  477. Koinuma, H. (1998) Quantum functional oxides and combinatorial chemistry. Solid State Ionics, 108, 1-7. #10961

  478. Kolb, A.J. (1998) Assay miniaturisation in drug discovery. Innovations in Pharmaceutical Technology, 1, 69-73. #12090

  479. Kondo, Y., Shinkai, H., & Tanji, K. (1998) Solid phase synthesis of heterocyclic compounds [japanese]. J. Syn. Org. Chem. Jpn., 56, 18-26. #10688

  480. Kondo, Y., Shinkai, H., & Tanji, K. (1998) Solid phase synthesis of heterocyclic compounds. Yuki Gosei Kagaku Kyokaishi, 56, 2-10. #10566

  481. Koscielska, K., Kiczak, L., Kasztura, M., Wesolowska, O., & Otlewski, J. (1998) Phage display of proteins. Acta Biochim. Polon., 45, 705-720. #11870

  482. Kouskoff, V., Famiglietti, S., Lacaud, G., Lang, P., Rider, J.E., Kay, B.K., Cambier, J.C., & Nemazee, D. (1998) Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses. J. Exp. Med., 188, 1453-1464. #12388

  483. Kramer, A., & Schneider-Mergener, J. (1998) Synthesis and screening of peptide libraries on continuous cellulose membrane supports. Methods Mol. Biol., 87, 25-39. #11531

  484. Kramer, A., Stigler, R.D., Knaute, T., Hoffmann, B., & Schneider-Mergener, J. (1998) Stepwise transformation of a cholera toxin and a p24 (HIV-1) epitope into D-peptide analogs. Protein Eng., 11, 941-948. #12390

  485. Kramer, P.J. (1998) Genetic toxicology. J. Pharm. Pharmacol., 50, 395-405. #12768

  486. Kricka, L.J. (1998) Miniaturization of analytical systems. Clin. Chem., 44, 2008-2014. #11871

  487. Krook, M., Lindbladh, C., Eriksen, J.A., & Mosbach, K. (1998) Selection of a cyclic nonapeptide inhibitor to alpha-chymotrypsin using a phage display peptide library. Mol. Diversity, 3, 149-159. #10882

  488. Krook, M., Mosbach, K., & Ramstrom, O. (1998) Novel peptides binding to the Fc-portion of immunoglobulins obtained from a combinatorial phage display peptide library. J. Immunol. Method, 221, 151-157. #12167

  489. Kubinyi, H. (1998) Combinatorial and computational approaches in structure-based drug design. Curr. Opin. Drug. Disc. Develop., 1, 16-27. #11235

  490. Kubinyi, H., Folkers, G., & Martin, Y.C. (1998) 3D QSAR in Drug Design. Volume 2. Ligand-Protein Interactions and Molecular Similarity. Kluwer Academic Publishers, Dordrecht. #11239

  491. Kubinyi, H. (1998) Similarity and dissimilarity: A medicinal chemist's view. In H. Kubinyi, G. Folkers & Y.C. Martin (Eds.), 3D QSAR in Drug Design. Volume 2. Ligand-Protein Interactions and Molecular Similarity. (pp. 225-252). Kluwer Academic Publishers, Dordrecht. #11238

  492. Kubinyi, H. (1998) Structure-based design of enzyme inhibitors and receptor ligands. Curr. Opin. Drug. Disc. Develop., 1, 4-15. #11234

  493. Kulkarni, B.A., & Ganesan, A. (1998) Solid-phase synthesis of tetramic acids. Tetrahedron Lett., 39, 4369-4372. #10860

  494. Kulkarni, B.A., & Ganesan, A. (1998) Solution-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones. Chem. Commun., 785-786. #12208

  495. Kundu, B., Bauser, M., Betschinger, J., Kraas, W., & Jung, G. (1998) Identification of a potent analogue of nazumamide a through iteration of combinatorial tetrapeptide libraries. Bioorg. Med. Chem. Lett., 8, 1669-1672. #11183

  496. Kung, P.P., Bharadwaj, R., Fraser, A.S., Cook, D.R., Kawasaki, A.M., & Cook, P.D. (1998) Solution-phase synthesis of novel linear oxyamine combinatorial libraries with antibacterial activity. J. Org. Chem., 63, 1846-1852. #11032

  497. Kung, P.P., & Cook, P.D. (1998) Solution-phase simultaneous addition of functionalities (SPSAF) and chemical transformation to prepare N,N'-disubstituted piperazine libraries. Biotech. Bioeng. (Comb. Chem. ), 61, 119-125. #11306

  498. Kupke, T., Kempter, C., Jung, G. & Gotz, F. (1998) A new post-translational modification reaction oxidative decarboxylation of peptides catalyzed by flavoprotein EpiD. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 33-36). Mayflower Scientific Ltd., Kingswinford. #11477

  499. Kurakin, A., Hoffman, N.G., & Kay, B.K. (1998) Molecular recognition properties of the C-terminal Sh(3) domain of the Cbl associated protein, Cap. J. Pept. Res., 52, 331-337. #12392

  500. Kuroki, G. (1998) Automating organic synthesis. R&D Mag., 40, 61-63. #12064

  501. Kuster, G.J., & Scheeren, H.W. (1998) High pressure promoted tandem [4+2]/[3+2] cycloadditions on the solid phase. Tetrahedron Lett., 39, 3613-3616. #10811

  502. Kyranos, J.N., & Hogan, J.C.Jr. (1998) High-throughput characterization of combinatorial libraries generated by parallel synthesis. Anal. Chem., 70, 389A-395A. #10946

  503. Labadie, J.W. (1998) Polymeric supports for solid phase synthesis. Curr. Opin. Chem. Biol., 2, 346-352. #12072

  504. Labaudiniere, R.F. (1998) RPR' approach to high-speed parallel synthesis for lead generation. Drug Disc. Today, 3, 511-515. #15507

  505. Lachance, N., & Gallant, M. (1998) New method for the preparation of functionalized aryldiphenylsilanes (ArPh2SiH). Tetrahedron Lett., 39, 171-174. #9865

  506. Lago, M.A., Nguyen, T.T., & Bhatnagar, P. (1998) Solid phase synthesis of a 1,3,5-trisubstituted pyridinium salt library. Tetrahedron Lett., 39, 3885-3888. #10836

  507. Laird-Offringa, I.A., & Belasco, J.G. (1998) RNA-binding proteins tamed. Nat. Struc. Biol., 5, 665-668. #11307

  508. Lam, K.S., Sroka, T., Chen, M.L., Zhao, Y., Lou, Q., Wu, J.Z., & Zhao, Z.G. (1998) Application of one-bead one-compound combinatorial library methods in signal transduction research. Life Sci., 62, 1577-1583. #11160

  509. Lam, K.S. (1998) Determination of peptide substrate motifs for protein kinases using a "one-bead one-compound" combinatorial library approach. Methods Mol. Biol., 87, 83-86. #11535

  510. Lam, K.S., & Lebl, M. (1998) Synthesis of a one-bead one-compound combinatorial peptide library. Methods Mol. Biol., 87, 1-6. #11470

  511. Lametschwandtner, G., Brocard, C., Fransen, M., Van Veldhoven, P., Berger, J., & Hartig, A. (1998) The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it. Journal of Biological Chemistry, 273, 33635-33643. #12393

  512. Lampe, T.F.J., Weitz-Schmidt, G., & Wong, C.H. (1998) Parallel synthesis of sialyl Lewis X mimetics on a solid phase: Access to a library of fucopeptides. Angew. Chem. Int. Ed., 37, 1707-1711. #11308

  513. Langer, T., & Hoffmann, R.D. (1998) New principal components derived parameters describing molecular diversity of heteroaromatic residues. Quant. Struct. -Act. Relat., 17, 211-223. #11056

  514. Lawrence, D.S., & Niu, J.K. (1998) Protein kinase inhibitors: The tyrosine-specific protein kinases. Pharmacol. Ther., 77, 81-114. #10712

  515. Lebl, M. (1998) Solid-phase synthesis on planar supports. Biopolymers (Pept. Sci. ), 47, 397-404. #12265

  516. Lebl, M. (1998) A new approach to automated solid phase synthesis based on centrifugation of tilted plates. J. Assoc. Lab. Autom., 3, 59-61. #11029

  517. Lee, C.E., Kick, E.K., & Ellman, J.A. (1998) General solid-phase synthesis approach to prepare mechanism-based aspartyl protease inhibitor libraries: Identification of potent cathepsin d inhibitors. J. Amer. Chem. Soc., 120, 9735-9747. #11874

  518. Lee, J., Gauthier, D., & Rivero, R.A. (1998) Solid phase synthesis of 1-alkyl-2-alkylthio-5-carbamoylbenzimidazoles. Tetrahedron Lett., 39, 201-204. #9868

  519. Lee, S.H., Chung, S.H., & Lee, Y.S. (1998) Preparation of resin-bound ketimines via transimination and its application in the synthesis of hydantoin libraries. Tetrahedron Lett., 39, 9469-9472. #12026

  520. Leger, R., Yen, R., She, M.W., Lee, V.J., & Hecker, S.J. (1998) N-Linked solid phase peptide synthesis. Tetrahedron Lett., 39, 4171-4174. #10853

  521. Leipert, D., Nopper, D., Bauser, M., Gauglitz, G., & Jung, G. (1998) Investigation of the molecular recognition of amino acids by cyclopeptides with reflectometric interference spectroscopy. Angew. Chem. Int. Ed., 37, 3308-3311. #12168

  522. Leitner, A., Vogel, M., Radauer, C., Breiteneder, H., Stadler, B.M., Scheiner, O., Kraft, D., & Jensen-Jarolim, E. (1998) A mimotope defined by phage display inhibits IgE binding to the plant panallergen profilin. Eur. J. Immunol., 28, 2921-2927. #11875

  523. Lemmo, A.V., Rose, D.J., & Tisone, T.C. (1998) Inkjet dispensing technology: Applications in drug discovery. Curr. Opin. Biotechnol., 9, 615-617. #12396

  524. Leon, S., Quarrell, R., & Lowe, G. (1998) Evaluation of resins for on-bead screening: A study of papain and chymotrypsin specificity using PEGA-bound combinatorial peptide library. Bioorg. Med. Chem. Lett., 8, 2997-3002. #11952

  525. Lescrinier, T., Hendrix, C., Kerremans, L., Rozenski, J., Link, A., Samyn, P., Vanaerschot, A., Lescrinier, E., Eritja, R., Vanbeeumen, J., & Herdewijn, P. (1998) DNA-binding ligands from peptide libraries containing unnatural amino acids. Chem. Eur. J., 4, 425-433. #11019

  526. Levitan, B. (1998) Stochastic modeling and optimization of phage display. J. Mol. Biol., 277, 893-916. #11124

  527. Lewandowski, K., Murer, P., Svec, F., & Frechet, J.M.J. (1998) Highly selective chiral recognition on polymer supports: Preparation of a combinatorial library of dihydropyrimidines and its screening for novel chiral HPLC ligands. Chem. Commun., 2237-2238. #12397

  528. Lewell, X.Q., Judd, D.B., Watson, S.P., & Hann, M.M. (1998) RECAP - Retrosynthetic combinatorial analysis procedure: A powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistry. Journal of Chemical Information and Computer Sciences, 38, 511-522. #10963

  529. Lewis, K.C., Fitch, W.L., & Maclean, D. (1998) Characterization of a split-pool combinatorial library. LC GC-Mag. Separation Sci., 16, 644-649. #11312

  530. Ley, S.V., Bolli, M.H., Hinzen, B., Gervois, A.G., & Hall, B.J. (1998) Use of polymer supported reagents for clean multistep organic synthesis: Preparation of amines and amine derivatives from alcohols for use in compound library generation. J. Chem. Soc. Perkin Trans. 1, 2239-2241. #13442

  531. Li, J., Murray, C.W., Waszkowycz, B., & Young, S.C. (1998) Targeted molecular diversity in drug discovery: Integration of structure-based design and combinatorial chemistry. Drug Disc. Today, 3, 105-112. #10704

  532. Li, K., Vig, S., & Uckun, F.M. (1998) Stereocontrolled synthesis of the tetrahydrofuran unit of annonaceous acetogenins. Tetrahedron Lett., 39, 2063-2066. #10598

  533. Li, R., Xiao, X.Y., & Czarnik, A.W. (1998) Merrifield microtube(TM) reactors for solid phase synthesis. Tetrahedron Lett., 39, 8581-8584. #11959

  534. Li, W., & Yan, B. (1998) Effects of polymer supports on the kinetics of solid-phase organic reactions: A comparison of polystyrene- and Tentagel-based resins. J. Org. Chem., 63, 4092-4097. #11956

  535. Li, W.R., & Peng, S.Z. (1998) Rational design and synthesis of unsaturated 2,5-dioxopiperazine derivatives as potential protein tyrosine kinase inhibitors. Tetrahedron Lett., 39, 7373-7376. #11573

  536. Li, Z.G., Yeo, S.L., Pallen, C.J., & Ganesan, A. (1998) Solid-phase synthesis of potential protein tyrosine phosphatase inhibitors via the UGI four-component condensation. Bioorg. Med. Chem. Lett., 8, 2443-2446. #12169

  537. Liang, L., Chi, C., Wright, M., Timby, D., & Unger, S. (1998) Use of the N-in-1 approach for rapid pharmacokinetic screening of drug candidates using LC-MS-MS. Amer. Lab., 30, 11-14. #12272

  538. Lin, P., & Ganesan, A. (1998) Solid-phase synthesis of N-acyl-N'-carbamoylguanidines. Tetrahedron Lett., 39, 9789-9792. #12057

  539. Lin, P., & Ganesan, A. (1998) Solid-phase synthesis of peptidomimetic oligomers with a phosphodiester backbone. Bioorg. Med. Chem. Lett., 8, 511-514. #10693

  540. Link, A., van Calenbergh, S., & Herdewijn, P. (1998) Practical method for the parallel synthesis of 2'-amido-2'-deoxyadenosines. Tetrahedron Lett., 39, 5175-5176. #10894

  541. Linusson, A., Wold, S., & Norden, B. (1998) Fuzzy clustering of 627 alcohols, guided by a strategy for cluster analysis of chemical compounds for combinatorial chemistry. Chemometr. Intell. Lab. Syst., 44, 213-227. #12398

  542. Liras, P., Rodriguez-Garcia, A., & Martin, J.F. (1998) Evolution of the clusters of genes for beta-lactam antibiotics: A model for evolutive combinatorial assembly of new beta-lactams. Int. Microbiol., 1, 271-278. #15510

  543. Liu, D.X., Jiang, H.L., Chen, K.X., & Ji, R.Y. (1998) A new approach to design virtual combinatorial library with genetic algorithm based on 3D grid property. Journal of Chemical Information and Computer Sciences, 38, 233-242. #11039

  544. Liu, Y., Li, B., Zhang, S., Li, T.Y., Zhou, H., Li, W., Smith, R., & Dejersey, J. (1998) A novel method for selection of chymotrypsin inhibitors from a phage peptide library. Biochem. Mol. Biol. Int., 45, 155-161. #11082

  545. Lloyd, A.W. (1998) Combinatorial chemistry: Gene expression inhibitor. Drug Disc. Today, 3, 425. #11314

  546. Lloyd, A.W. (1998) Combinatorial chemistry. Drug Disc. Today, 3, 296. #11081

  547. Lombardi, S.J., Truong, A., Spence, P., Rhodes, K.J., & Jones, P.G. (1998) Structure-activity relationships of the K-v beta 1 inactivation domain and its putative receptor probed using peptide analogs of voltage-gated potassium channel alpha- and beta-subunits. Journal of Biological Chemistry, 273, 30092-30096. #12399

  548. Long, D.D., Frederiksen, S.M., Marquess, D.G., Lane, A.L., Watkin, D.J., Winkler, D.A., & Fleet, G.W.J. (1998) Potential intermediates for incorporation of polyhydroxylated prolines into combinatorial libraries. Tetrahedron Lett., 39, 6091-6094. #10999

  549. Long, D.D., Smith, M.D., Marquess, D.G., Claridge, T.D.W., & Fleet, G.W.J. (1998) A solid phase approach to oligomers of carbohydrate amino-acids: Secondary structure in a trimeric furanose carbopeptoid. Tetrahedron Lett., 39, 9293-9296. #12021

  550. Lorsbach, B.A., Bagdanoff, J.T., Miller, R.B., & Kurth, M.J. (1998) Isoxazolinoisoquinoline heterocycles via solid-phase Reissert and Suzuki reactions. J. Org. Chem., 63, 2244-2250. #11002

  551. Loughlin, W.A. (1998) Combinatorial synthesis: A heterocyclic chemist's perspective. Aust. J. Chem., 51, 875-893. #11958

  552. Lowary, T., Meldal, M., Helmboldt, A., Vasella, A., & Bock, K. (1998) Novel type of rigid C-linked glycosylacetylene-phenylalanine building blocks for combinatorial synthesis of C-linked glycopeptides. J. Org. Chem., 63, 9657-9668. #12171

  553. Lowik, D.W.P.M., Weingarten, M.D., Broekema, M., Brouwer, A.J., Still, W.C., & Liskamp, R.M.J. (1998) Tweezers with different bite: Increasing the affinity of synthetic receptors by varying the hinge part. Angew. Chem. Int. Ed., 37, 1846-1850. #11316

  554. Lowman, H.B., Chen, Y.M., Skelton, N.J., Mortensen, D.L., Tomlinson, E.E., Sadick, M.D., Robinson, I.C.A.F., & Clark, R.G. (1998) Molecular mimics of insulin-like growth factor 1 (IGF-1) for inhibiting IGF-1: IGF-binding protein interactions. Biochemistry, 37, 8870-8878. #11058

  555. Luo, Y., Ouyang, X.H., Armstrong, R.W., & Murphy, M.M. (1998) A case study of employing spectroscopic tools for monitoring reactions in the developmental stage of a combinatorial chemistry library. J. Org. Chem., 63, 8719-8722. #12172

  556. Lyngso, L.O., & Nielsen, J. (1998) Solid-phase synthesis of 3-amino-2-pyrazolines. Tetrahedron Lett., 39, 5845-5848. #10967

  557. Lyubarskaya, Y.V., Carr, S.A., Dunnington, D., Prichett, W.P., Fisher, S.M., Appelbaum, E.R., Jones, C.S., & Karger, B.L. (1998) Screening for high-affinity ligands to the Src SH2 domain using capillary isoelectric focusing-electrospray ionization ion trap mass spectrometry. Anal. Chem., 70, 4761-4770. #12402

  558. Maddalena, D.J. (1998) Applications of soft computing in drug design. Exp. Opin. Ther. Patents, 8, 249-258. #11166

  559. Maduskuie, T.P.Jr., McNamara, K.J., Ru, Y., Knabb, R.M., & Stouten, P.F.W. (1998) Rational design and synthesis of novel, potent bis-phenylamidine carboxylate factor Xa inhibitors. J. Med. Chem., 41, 53-62. #11244

  560. Malik, P., Terry, T.D., Bellintani, F., & Perham, R.N. (1998) Factors limiting display of foreign peptides on the major coat protein of filamentous bacteriophage capsids and a potential role for leader peptidase. FEBS Lett., 436, 263-266. #11877

  561. Maltais, R., & Poirier, D. (1998) A solution-phase combinatorial parallel synthesis of 3beta-amido-3alpha-hydroxy-5alpha-androstane-17ones. Tetrahedron Lett., 39, 4151-4154. #10851

  562. Marder, M., Viola, H., Bacigaluppo, J.A., Colombo, M.I., Wasowski, C., Wolfman, C., Medina, J.H., Ruveda, E.A., & Paladini, A.C. (1998) Detection of benzodiazepine receptor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistry. Biochem. Biophys. Res. Commun., 249, 481-485. #11319

  563. Markiewicz, W.T., Godzina, P., Markiewicz, M., & Astriab, A. (1998) Synthesis of a polyaminooligonucleotide combinatorial library. Nucleosides Nucleotides, 17, 1871-1880. #12404

  564. Marmillon, C., Jerosch, H., Bompart, J., Calas, M., Bonnet, P.A., & Escale, R. (1998) Lipophilic propanediamines: New building blocks for combinatorial chemistry. Tetrahedron Lett., 39, 6179-6180. #11024

  565. Marshall, A., & Hodgson, J. (1998) DNA chips: An array of possibilities. Nat. Biotech., 16, 27-31. #12132

  566. Martin, A., Butters, T.D., & Fleet, G.W.J. (1998) A highly cytotoxic L-rhamnose analogue of the antitumour agent spicamycin. Chem. Commun., 2119-2120. #11878

  567. Martin, Y.C., Brown, R.D. & Bures, M.G. (1998) Quantifying diversity. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 369-385). John Wiley & Sons, New York. #11724

  568. Marzinzik, A.L., & Felder, E.R. (1998) Key intermediates in combinatorial chemistry: Access to various heterocycles from a,b-unsaturated ketones on the solid phase. J. Org. Chem., 63, 723-727. #10568

  569. Masaki, Y., Tanaka, N., & Miura, T. (1998) Unprecedented polymer-supported pi-acid: Synthesis and its application as a promoter to the monothioacetalization of acetals. Tetrahedron Lett., 39, 5799-5802. #10966

  570. Masquelin, T., Delgado, Y., & Baumle, V. (1998) A facile preparation of a combinatorial library of 2,6-disubstituted triazines. Tetrahedron Lett., 39, 5725-5726. #10964

  571. Masquelin, T., Meunier, N., Gerber, F., & Rosse, G. (1998) Solution- and solid-phase synthesis of combinatorial libraries of trisubstituted 1,3,5-triazines. Heterocycles, 48, 2489-2505. #12405

  572. Matter, H. (1998) A validation study of molecular descriptors for the rational design of peptide libraries. J. Pept. Res., 52, 305-314. #12175

  573. Matthews, J., & Rivero, R.A. (1998) Solid-phase synthesis of substituted tetramic acids. J. Org. Chem., 63, 4808-4810. #11320

  574. Maxwell, I.E. (1998) Connecting with catalysis. Nature, 394, 325-326. #11179

  575. Mayer, J.P., Lewis, G.S., McGee, C., & Bankaitis-Davis, D. (1998) Solid-phase synthesis of benzimidazoles. Tetrahedron Lett., 39, 6655-6658. #11229

  576. McBride, J.D., Brauer, A.B.E., Nievo, M., & Leatherbarrow, R.J. (1998) The role of threonine in the P-2 position of bowman-birk proteinase inhibitors: Studies on P-2 variation in cyclic peptides encompassing the reactive site loop. J. Mol. Biol., 282, 447-457. #11881

  577. McIntosh, R., Watson, P., & Weetman, A. (1998) Somatic hypermutation in autoimmune thyroid disease. Immunol. Rev., 162, 219-231. #11123

  578. Mckendrick, J.E., Frormann, S., Luo, C., Semchuck, P., Vederas, J.C., & Malcolm, B.A. (1998) Rapid mass spectrometric determination of preferred irreversible proteinase inhibitors in combinatorial libraries. Int. J. Mass Spectrom., 176, 113-124. #11323

  579. McMinn, D.L., Hirsch, R., & Greenberg, M.M. (1998) An orthogonal solid phase support for the synthesis of oligonucleotides containing 3'-phosphates and its application in the preparation of photolabile hybridization probes. Tetrahedron Lett., 39, 4155-4158. #10852

  580. McNally, J.J., Youngman, M.A., & Dax, S.L. (1998) Mannich reactions of resin-bound substrates. 2.A versatile three-component solid-phase organic synthesis methodology. Tetrahedron Lett., 39, 967-970. #10489

  581. Medou, M., Bouygues, M., Rocheblave, L., Chermann, J.C., & Kraus, J.L. (1998) Synthesis and anti-HIV activities of symmetrical N-1,N-3-dibenzyl-2-hydroxy-propane derivatives. Bioorg. Med. Chem. Lett., 8, 1861-1866. #11324

  582. Mei, H.Y. & Czarnik, A.W. (1998) Oligonucleotide libraries as a source of molecular diversity. In E.M. Gordon & J.F.J. Kerwin (Eds.), Combinatorial Chemistry and Molecular Diversity in Drug Discovery. (pp. 165-178). John Wiley & Sons, New York. #11713

  583. Meldal, M. (1998) Introduction to combinatorial solid-phase assays for enzyme activity and inhibition. Methods Mol. Biol., 87, 51-57. #11532

  584. Meldal, M., Meinjohanns, E., Frische, K., Jensen, T., Hansen, P., Werdelin, O., Galli-Stampino, L., Mouritsen, S. & Bock, K. (1998) Libraries of synthetic glycopeptides in the characterization of the T-cell response to tumor associated mucin antigens. In Anonymous, Proceedings of the 2nd Chinese Peptide Symposium. (pp. 59-62). #11529

  585. Meldal, M., Svendsen, I., Juliano, L., Juliano, M.A., Del Nery, E., & Scharfstein, J. (1998) Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library assay. D-Amino acid inhibitors for cruzipain, cathepsin B and cathepsin L. J. Peptide Sci., 4, 83-91. #10627

  586. Meldal, M., Renil, M., Juliano, M.A., Jansson, A.M., Meinjohanns, E., Buchardt, J. & Schleyer, A. (1998) Novel PEG-based resins and synthetic methods: Azido acids in SPPS and direct solid phase peptide glycosylations. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 141-152). Mayflower Scientific Ltd., Kingswinford. #11496

  587. Mendonca, A.J. (1998) Drug discovery using the directed sorting technique. Amer. Lab., 30, 46-47. #10875

  588. Merritt, A.T. (1998) Uptake of new technology in lead optimization for drug discovery. Drug Disc. Today, 3, 505-510. #12408

  589. Merritt, A.T. (1998) Solution phase combinatorial chemistry. Comb. Chem. High Throughput Screening, 1, 57-72. #11006

  590. Metcalf, C.A.I., Vu, C.B., Sundaramoorthi, R., Jacobsen, V.A., Laborde, E.A., Green, J., Green, Y., Macek, K.J., Merry, T.J., Pradeepan, S.G., Uesugi, M., Varkhedkar, V.M., & Holt, D.A. (1998) Novel phosphate ester-linked resins: The solid-phase generation of phenyl phosphate containing compounds for SH2 inhibition. Tetrahedron Lett., 39, 3435-3438. #10807

  591. Metz, W.A., Jones, W.D., Ciske, F.L., & Peet, N.P. (1998) A simple method for coupling aldehydes to solid support. Bioorg. Med. Chem. Lett., 8, 2399-2402. #11215

  592. Meyer, J.P., Nefzi, A., Dorner, B., Ostresh, J.M., Hannah, A.L. & Houghten, R.A. (1998) Design and solid phase synthesis of linear and heterocyclic combinatorial libraries using peptide libraries as starting materials. In R. Ramage & R. Epton (Eds.), Peptides 1996: Proceedings of the Twenty-Fourth European Peptide Symposium. (pp. 643-644). Mayflower Scientific Ltd., Kingswinford. #11519

  593. Michael, K.L., Taylor, L.C., Schultz, S.L., & Walt, D.R. (1998) Randomly ordered addressable high-density optical sensor arrays. Anal. Chem., 70, 1242-1248. #11018

  594. Michels, P.C., Khmelnitsky, Y.L., Dordick, J.S., & Clark, D.S. (1998) Combinatorial biocatalysis: A natural approach to drug discovery. Trends Biotech., 16, 210-205. #11546

  595. Miller, M.W., Vice, S.F., & McCombie, S.W. (1998) Mild N-dealkylation of tertiary, benzylic amines with acid chlorides: Application to solid-phase chemistry. Tetrahedron Lett., 39, 3429-3432. #10806

  596. Millington, C.R., Quarrell, R., & Lowe, G. (1998) Aryl hydrazides as linkers for solid phase synthesis which are cleavable under mild oxidative conditions. Tetrahedron Lett., 39, 7201-7204. #11223

  597. Mink, D., Mecozzi, S., & Rebek, J.Jr. (1998) Natural products analogs as scaffolds for supramolecular and combinatorial chemistry. Tetrahedron Lett., 39, 5709-5712. #10958

  598. Misetic, A., & Boyd, M.K. (1998) The pixyl (Px) group: A novel photocleavable protecting group for primary alcohols. Tetrahedron Lett., 39, 1653-1656. #10603

  599. Mohamed, N., Bhatt, U., & Just, G. (1998) Efficient synthesis of substituted oxopiperazines from amino acids. Tetrahedron Lett., 39, 8213-8216. #12010

  600. Mohan, R., Yun, W., Buckman, B.O., Liang, A., Trinh, L., & Morrissey, M.M. (1998) Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor Xa inhibitors. Bioorg. Med. Chem. Lett., 8, 1877-1882. #11157

  601. Molteni, V., Annunziata, R., Cinquini, M., Cozzi, F., & Banaglia, M. (1998) Soluble polymer-supported synthesis of imines and beta-lactams. Tetrahedron Lett., 39, 1257-1260. #10507

  602. Mondorf, K., Kaufman, D.B., & Carbonell, R.G. (1998) Screening of combinatorial peptide libraries: Identification of ligands for affinity purification of proteins using a radiological approach. J. Pept. Res., 52, 526-536. #12176

  603. Moore, M., & Norris, P. (1998) Di