PAPERS PUBLISHED IN 1996

This list is arranged by the name of the first author. Please, note the change in numbering of the references. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (michal@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M., Leblova Z.: Dynamic database of references in molecular diversity. Internet http://www.5z.com.

Recently added entries are marked in bold

1. Abelson, J.N. (1996) Combinatorial Chemistry. Academic Press, San Diego. ISBN 0121821684 #4648

2. Acevedo, O.L., & Andrews, R.S. (1996) Synthesis of propane-2,3-diol combinatorial monomers. Tetrahedron Lett., 37, 3931-3934. #4601

3. Adey, N.B., & Kay, B.K. (1996) Identification of calmodulin-binding peptide consensus sequences from a phage-displayed random peptide library. Gene, 169, 133-134. #4149

4. Adey, N.B., Guo, R., Hanson, H.L., Rider, J.E., Sparks, A.B., & Kay, B.K. (1996) Construction and screening of M13 phage-displayed random peptide libraries. Methods Mol. Cell. Biol., 6, 3-14. #9835

5. Adey, N.B., Sparks, A.B., Beasley, J. & Kay, B.K. (1996) Construction of random peptide libraries in bacteriophage M13. In Anonymous, Phage Display of Peptides and Proteins. (pp. 67-78). #8448

6. Aita, T., & Husimi, Y. (1996) Fitness spectrum among random mutants on Mt Fuji-type fitness landscape. J. Theor. Biol., 182, 469-485. #5591

7. Allee, C. (1996) Data management for automated drug discovery laboratories. Lab. Robotics Automation, 8, 307-310. #9978

8. Allin, S.M., & Shuttleworth, S.J. (1996) The preparation and first application of a polymer-supported "Evans" oxazolidines. Tetrahedron Lett., 37, 8023-8026. #5753

9. Ambos, M., & Richon, A.B. (1996) The combinatorial chemistry and mass screening Yellow Pages. Net. Sci., 2, #10034 (Available on Internet)

10. An, H., & Cook, P.D. (1996) Solution phase combinatorial chemistry.I.Synthesis of polyazacyclophane scaffolds and tertiary amine libraries. Tetrahedron Lett., 37, 7233-7236. #5532

11. Andersen, P.S., Orum, H., & Engberg, J. (1996) One-step cloning of murine Fab gene fragments independent of IgH isotype for phage display libraries. BioTechniques, 20, 340-342. #4142

12. Appel, J.R., Buencamino, J., Houghten, R.A. & Pinilla, C. (1996) Mapping the specificity of an antibody against an oncogenic sequence using peptide combinatorial libraries and substitution analogs: Implications for breast cancer detection. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 794-795). Mayflower Scientific Ltd., Kingswinford. #5053

13. Appel, J.R., Buencamino, J., Houghten, R.A., & Pinilla, C. (1996) Exploring antibody polyspecificity using synthetic combinatorial libraries. Mol. Diversity, 2, 29-34. #4835 (Available on Internet)

14. Appel, J.R., Muller, S., Benkirane, N., Houghten, R.A., & Pinilla, C. (1996) Highly specific, cross-reactive sequences recognized by an anti- HBsAg antibody identified from a positional scanning synthetic combinatorial library. Peptide Res., 9, 174-182. #5587

15. Appell, K.C., Chung, T.D.Y., Ohlmeyer, M.H.J., Sigal, N.H., Baldwin, J.J., & Chelsky, D. (1996) Biological screening of a large combinatorial library. J. Biomol. Screen., 1, 27-31. #10039

16. Armstrong, N., Adey, N.B., McConnell, S.J. & Kay, B.K. (1996) Vectors for phage display. In Anonymous, Phage Display of Peptides and Proteins. (pp. 35-53). #8447

17. Armstrong, R.W., Tempest, P.A., & Cargill, J.F. (1996) Microchip encoded combinatorial libraries. Generation of a spatially encoded library from a pool synthesis. Chimia, 50, 258-260. #5857

18. Armstrong, R.W., Combs, A.P., Tempest, P.A., Brown, S.D., & Keating, T.A. (1996) Multiple-component condensation strategies for combinatorial library synthesis. Account. Chem. Res., 29, 123-131. #3992

19. Arnold, G.F., Resnick, D.A., Smith, A.D., Geisler, S.C., Holmes, A.K., & Arnold, E. (1996) Chimeric rhinoviruses as tools for vaccine development and characterization of protein epitopes. Intervirology, 39, 72-78. #8184

20. Ashton, M.J., Jaye, M.C., & Mason, J.S. (1996) New perspectives in lead generation II: Evaluating molecular diversity. Drug Disc. Today, 1, 71-78. #5701

21. Athanassopoulos, P., Barlos, K., Hatzi, O., Gatos, D. & Tzavara, C. (1996) Phase change during peptide synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 243-246). Mayflower Scientific Limited, Birmingham. #8930

22. Atuegbu, A., Maclean, D., Nguyen, C., Gordon, E.M., & Jacobs, J.W. (1996) Combinatorial modification of natural products: Preparation of unencoded and encoded libraries of Rauwolfia alkaloids. Bioorg. Med. Chem., 4, 1097-1106. #4896

23. Backes, B.J., Virgilio, A.A., & Ellman, J.A. (1996) Activation method to prepare a highly reactive acylsulfonamide "safety-catch" linker for solid-phase synthesis. J. Amer. Chem. Soc., 118, 3055-3056. #4137

24. Baek, S.H., Seo, J.K., Chae, C.B., Suh, P.G., & Ryu, S.H. (1996) Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries. Journal of Biological Chemistry, 271, 8170-8175. #4412

25. Bailey, N., Dean, A.W., Judd, D.B., Middlemiss, D., Storer, R., & Watson, S.P. (1996) A convenient procedure for the solution phase preparation of 2- aminothiazole combinatorial libraries. Bioorg. Med. Chem. Lett., 6, 1409-1414. #4922

26. Baker, B.E., Kline, N.J., Treado, P.J., & Natan, M.J. (1996) Solution-based assembly of metal surfaces by combinatorial methods. J. Amer. Chem. Soc., 118, 8721-8722. #5314

27. Balass, M., Morag, E., Bayer, E.A., Fuchs, S., Wilchek, M., & Katchalski-Katzir, E. (1996) Recovery of high-affinity phage from a nitrostreptavidin matrix in phage-display technology. Anal. Biochem., 243, 264-269. #8253

28. Baldwin, J.J. (1996) Design,synthesis and use of binary encoded synthetic chemical libraries. Mol. Diversity, 2, 81-88. #5328 (Available on Internet)

29. Baldwin, J.J. (1996) Solid phase chemistry in combinatorial library construction. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-158. American Chemical Society,Washington,D, #5894

30. Baldwin, J.J., & Henderson, I. (1996) Recent advances in the generation of small-molecule combinatorial libraries: Encoded split synthesis and solid-phase synthetic methodology. Med. Res. Rev., 16, 391-405. #5281

31. Baldwin, J.J., Kirk, G.L., Dillard, L.W., & Connelly, J.A. (1996) Design, synthesis, and preparation of an encoded small-molecule library for a wide variety of 96-well based bioassays. Methods Mol. Cell. Biol., 6, 74-88. #9838 3847

32. Balkenhohl, F., von dem Bussche-Hunnefeld, C., Lansky, A., & Zechel, C. (1996) Combinatorial synthesis of small organic molecules. Angew. Chem. Int. Ed., 35, 2289-2337. #5694

33. Bannwarth, W., Huebscher, J., & Barner, R. (1996) A new linker for primary amines applicable to combinatorial approaches. Bioorg. Med. Chem. Lett., 6, 1525-1528. #4949

34. Barbas, C.F.I., & Burton, D.R. (1996) Selection and evolution of high-affinity human antiviral antibodies. Trends Biotech., 14, 230-234. #5129

35. Barbato, G., Cicero, D.O., Bianchi, E., Pessi, A., & Bazzo, R. (1996) High-resolution solution structure of two members of a conformationally homogeneous combinatorial peptide library based on the classical zinc-finger motif. J. Biomol. NMR, 8, 36-48. #5339

36. Barn, D.R., Morphy, J.R., & Rees, D.C. (1996) Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters. Tetrahedron Lett., 37, 3213-3216. #4746

37. Barry, M.A., Dower, W.J., & Johnston, S.A. (1996) Toward cell-targeting gene therapy vectors: Selection of cell- binding peptides from random peptide-presenting phage libraries. Nat. Med., 2, 299-305. #4144

38. Bauer, B.E. (1996) Automation issues at the interface between combinatorial chemistry and high-throughput screening. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 233-245). American Chemical Society, Washington,DC. #5115

39. Baum, R. (1996) Combinatorial chemistry. C&EN, 74, 28-28. #4610

40. Beck-Sickinger, A.G. & Jung, G. (1996) From multiple peptide synthesis to peptide libraries. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 79-109). VCH, Weinheim. #8170

41. Begent, R.H.J., Verhaar, M.J., Chester, K.A., Casey, J.L., Green, A.J., Napier, M.P., Hope-Stone, L.D., Cushen, N., Keep, P.A., Johnson, C.J., Hawkins, R.E., Hilson, A.J.W., & Robson, L. (1996) Clinical evidence of efficient tumor targeting based on single- chain Fv antibody selected from a combinatorial library. Nat. Med., 2, 979-984. #5340

42. Bi, Y., & Schultz, P.G. (1996) Building blocks for peptide and carbamate libraries. Bioorg. Med. Chem. Lett., 6, 2299-2300. #5545

43. Bianchi, E., Barbato, G., Wallace, A., Cortese, R., Felici, F., Bazzo, R. & Pessi, A. (1996) The zinc finger motif as a conformation-inducting template for selection-driven design of peptidomimetics. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 159-162). Mayflower Scientific Limited, Birmingham. #8917

44. Bianchi, E., Folgori, A., Wallace, A., Nicotra, M., Barbato, G., Bazzo, R., Cortese, R., Felici, F. & Pessi, A. (1996) Design and structural validation of a conformationally- homogenous peptide combinatorial library. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 284-286). Mayflower Scientific Ltd., Kingswinford. #5041

45. Bicknell, A.J., & Hird, N.W. (1996) Synthesis of a highly functionalized rigid template by solid-phase azomethine ylide cycloadditon. Bioorg. Med. Chem. Lett., 6, 2441-2444. #5750

46. Binley, J.M., Ditzel, H.J., Barbas, C.F.I., Sullivan, N., Sodroski, J., Parren, P.W.H.I., & Burton, D.R. (1996) Human antibody responses to HIV type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen binding. AIDS Res. Hum. Retroviruses, 12, 911-924. #4923

47. Blaha, I., Flegel, M., Cerna, V., Pavlik, M., Pokorny, V., Mudra, P., Lepsa, L. & Zenisek, K. (1996) Automatic peptide synthesizer useful for multiple peptide synthesis and peptide libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 319-320). Mayflower Scientific Limited, Birmingham. #3235

48. Blake, J., Johnston, J.V., Hellstrom, K.E., Marquardt, H., & Chen, L. (1996) Use of combinatorial peptide libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes. J. Exp. Med., 184, 121-130. #4971

49. Blondel, A., Nageotte, R., & Bedouelle, H. (1996) Destabilizing interactions between the partners of a bifunctional fusion protein. Protein Eng., 9, 231-238. #4567

50. Blondelle, S.E., Houghten, R.A., & Perez-Paya, E. (1996) All D-amino acid hexapeptide inhibitors of melittin's cytolytic activity derived from synthetic combinatorial libraries. J. Mol. Recog., 9, 168. #8687

51. Blondelle, S.E., Forood, B., Houghten, R.A. & Perez-Paya, E. (1996) Design of conformationally defined combinatorial libraries based upon "protein-like" structural motifs. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 293-294). Mayflower Scientific Ltd., Kingswinford. #3132

52. Blondelle, S.E., Houghten, R.A., & Perez-Paya, E. (1996) Identification of inhibitors of melittin using nonsupport-bound combinatorial libraries. Journal of Biological Chemistry, 271, 4093-4099. #4154

53. Blondelle, S.E., & Houghten, R.A. (1996) Use of nonsupport-bound synthetic combinatorial libraries in cell-based bioassay systems. Methods Mol. Cell. Biol., 6, 26-34. #8688

54. Blondelle, S.E., Takahashi, E., Houghten, R.A., & Perez-Paya, E. (1996) Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial libraries. Biochem. J., 313, 141-147. #3741

55. Blondelle, S.E., Perez-Paya, E., & Houghten, R.A. (1996) Synthetic combinatorial libraries: Novel discovery strategy for identification of antimicrobial agents. Antimicrob. Agents Chemother., 40, 1067-1071. #4694

56. Blondelle, S.E., & Houghten, R.A. (1996) Novel antimicrobial compounds identified using synthetic combinatorial library technology. Trends Biotech., 14, 60-66. #4138

57. Blundell, T.L. (1996) Structure-based drug design. Nature, 384, 23-26. #10865

58. Bluthner, M., Bautz, E.K.F., & Bautz, F.A. (1996) Mapping of epitopes recognized by PM/Scl autoantibodies with gene-fragment phage display libraries. J. Immunol. Method, 198, 187-198. #8140

59. Boden, P., Eden, J.M., Hodgson, J., Horwell, D.C., Howson, W., Meecham, K., Suman-Chauhan, N., Pritchard, M.C. & Raphy, J. (1996) The development of non-peptide NK(3) receptor antagonists.The application of a dipeptide chemical library to drug design. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 639-640). Mayflower Scientific Ltd., Kingswinford. #2743

60. Boden, P., Eden, J.M., Hodgson, J., Horwell, D.C., Hughes, J., McKnight, A.T., Lewthwaite, R.A., Pritchard, M.C., Raphy, J., Meecham, K., Ratcliffe, G.S., Suman-Chauhan, N., & Woodruff, G.N. (1996) Use of dipeptide chemical library in the development of non- peptide tachykinin NK3 receptor selective antagonists. J. Med. Chem., 39, 1664-1675. #4581

61. Boehm, T.L. & Showalter, H.D.H. (1996) Development of a silicon-based traceless linker for solid-phase organic synthesis. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. BIOT-121. American Chemical Society,Washington,D, #6004

62. Boger, D.L., Tarby, C.M., Myers, P.L., & Caporale, L.H. (1996) Generalized dipeptidomimetic template: Solution phase parallel synthesis of combinatorial libraries. J. Amer. Chem. Soc., 118, 2109-2110. #4005

63. Bohm, H.J., & Klebe, G. (1996) What can we learn from molecular recognition in protein-ligand complexes for the design of new drugs? Angew. Chem. Int. Ed., 35, 2589-2614. #11381

64. Bondy, S., Cheng, S., Saunders, J., Tarby, C., & Wheeler, K. (1996) Molecular diversity and solid-phase synthesis. Drug Disc. Today, 1, 132-133. #6010

65. Bonnycastle, L.L.C., Mehroke, J.S., Rashed, M., Gong, X., & Scott, J.K. (1996) Probing the basis of antibody reactivity with a panel of constrained peptide libraries displayed by filamentous phage. J. Mol. Biol., 258, 747-762. #4693

66. Boons, G.J., Heskamp, B., & Hout, F. (1996) Vinyl glycosides in oligosaccharide synthesis: A strategy for the preparation of trisaccharide libraries based on latent-active glycosylation. Angew. Chem. Int. Ed., 35, 2845-2847. #8239

67. Borman, S. (1996) Combinatorial chemistry. C&EN, 76, 47-67. #10561

68. Borman, S. (1996) Combinatorial chemists focus on small molecules, molecular recognition, and automation. C&EN, 74, 29-54. #4611

69. Borman, S. (1996) Combinatorial catalysts. C&EN, 37-39. #12282

70. Borman, S. (1996) Unnatural peptide synthesis automated. C&EN, 32-32. #4928

71. Bottger, V., Bottger, A., Howard, S.F., Picksley, S.M., Chene, P., Garcia-Echeverria, C., Hochkeppel, H.K., & Lane, D.P. (1996) Identification of novel mdm2 binding peptides by phage display. Oncogene, 13, 2141-2147. #8135

72. Botti, P., Pallin, T.D., & Tam, J.P. (1996) Cyclic peptides from linear unprotected peptide precursors through thiazolidine formation. J. Amer. Chem. Soc., 118, 10018-10024. #5547

73. Boutin, J.A., & Fauchere, A.L. (1996) Combinatorial peptide synthesis: Statistical evaluation of peptide ditribution. Trends Pharmacol. Sci., 17, 8-12. #4321

74. Boutin, J.A., Hennig, P., Lambert, P.H., Bertin, S., Petit, L., Mahieu, J.P., Serkiz, B., Volland, J.P., & Fauchere, J.L. (1996) Combinatorial peptide libraries: Robotic synthesis and analysis by nuclear magnetic resonance, mass spectrometry, tandem mass spectrometry, and high-performance capillary electrophoresis techniques. Anal. Biochem., 234, 126-141. #4131

75. Boutin, J.A. & Fauchere, J.L. (1996) Second-generation robotic synthesizer for peptide, pseudopeptide and non-peptide libraries. In J.N. Little, C. O'Neil & J.R. Strimaitis (Eds.), Proceedings of the International Symposium on Laboratory Automation and Robotics 1995. (pp. 197-210). Zymark Corporation, Hopkinton. #8223

76. Bowditch, R.D., Tani, P., Fong, K.C., & McMillan, R. (1996) Characterization of autoantigenic epitopes on platelet glycoprotein IIb/IIIa using random peptide libraries. Blood, 88, 4579-4584. #8261

77. Brandstetter, T.W., de la Fuente, C., Kim, Y., Cooper, R.I., Watkin, D.J., Oikonomakos, N.G., Johnson, L.N., & Fleet, G.W.J. (1996) alpha-Azidoesters as divergent intermediates for combinatorial generation of glucofuranose libraries of novel N-linked glycopeptides. Tetrahedron, 52, 10711-10720. #6039 4172

78. Bray, A.M. (1996) The transformed group library method: A new library design and mixture decode strategy. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 290-292). Mayflower Scientific Ltd., Kingswinford. #5043

79. Brown, K.S. (1996) Drug, biotech firms beginning to embrace combinatorial chemistry. Scientist, 10, 1-5. #4690

80. Brown, R.D., & Martin, Y.C. (1996) Use of structure-activity data to compare structure-based clustering methods and descriptors for use in compound selection. Journal of Chemical Information and Computer Sciences, 36, 572-584. #5345

81. Brown, S.D., & Armstrong, R.W. (1996) Synthesis of tetrasubstituted ethylenes on solid support via resin capture. J. Amer. Chem. Soc., 118, 6331-6332. #4830

82. Brummel, C.L., Vickerman, J.C., Carr, S.A., Hemling, M.E., Roberts, G.D., Johnson, W., Weinstock, J., Gaitanopoulos, D., Benkovic, S.J., & Winograd, N. (1996) Evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries. Anal. Chem., 68, 237-242. #3927

83. Brunjes, J., Metzger, J.W. & Jung, G. (1996) QMass: A computer program for the analysis of mass spectra of peptide libraries. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 511-520). VCH, Weinheim. #8180

84. Buckman, B.O., & Mohan, R. (1996) Solid-phase synthesis of 1,3-dialkyl quinazoline-2,4-diones. Tetrahedron Lett., 37, 4439-4442. #4798

85. Buettner, J.A., Dadd, C.A., Baumbach, G.A., Masecar, B.L., & Hammond, D.J. (1996) Chemically derived peptide libraries: A new resin and methodology for lead identification. Int. J. Peptide Prot. Res., 47, 70-83. #3987

86. Bunin, B.A., Plunkett, M.J., & Ellman, J.A. (1996) Synthesis and evaluation of 1,4-benzodiazepine libraries. Methods Enzymol., 267, 448-466. #3671

87. Bunin, B.A., Plunkett, M.J. & Ellman, J.A. (1996) Synthesis and evaluation of three 1,4-benzodiazepine libraries. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 405-424). VCH, Weinheim. #2160

88. Burgess, K., Godbout, C., Li, W., & Payza, K. (1996) A small library of peptidomimetics to systematically vary and test the effects of X(1) constraints. Bioorg. Med. Chem. Lett., 6, 2761-2764. #5738

89. Burgess, K., Li, W. & Lim, D. (1996) Solid phase syntheses of peptidomimetics. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-157. American Chemical Society,Washington,D, #6079

90. Burgess, K., Moye-Sherman, D. & Porte, A.M. (1996) Libraries of transition-metal catalysts. High throughput screening of catalysts for synthetic organic methodology. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 128-136). American Chemical Society, Washington,DC. #3607

91. Burgess, K., Shin, H. & Totani, R. (1996) Methodology for syntheses of ureas libraries. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. ORGN-279. American Chemical Society,Washington,D, #6080

92. Burlingame, A.L., Boyd, R.K., & Gaskell, S.J. (1996) Mass spectrometry. Anal. Chem., 68, 599R-651R. #4772

93. Burritt, J.B., Bond, C.W., Doss, K.W., & Jesaitis, A.J. (1996) Filamentous phage display of oligopeptide libraries. Anal. Biochem., 238, 1-13. #4920

94. Caflisch, A. (1996) Computational combinatorial ligand design: Application to human alpha-thrombin. J. Comput. Aid. Molec. Design, 10, 372-396. #5764

95. Caflisch, A., & Karplus, M. (1996) Computational combinatorial chemistry for de novo ligand design: Review and assessment. Perspect. Drug Disc. Design, 3, 51-84. #5214

96. Caldwell, E.E.O., Nadkarni, V.D., Fromm, J.R., Linhardt, R.J., & Weiler, J.M. (1996) Importance of specific amino acids in protein binding sites for heparin and heparan sulfate. Int. J. Biochem. Cell Biol., 28, 203-216. #4703

97. Cao, X., & Mjalli, A.M.M. (1996) Combinatorial method for the synthesis of a-hydroxy phosphonates on Wang resin. Tetrahedron Lett., 37, 6073-6076. #5227

98. Caparon, M., DeCiechi, P., Devine, C.S., Olins, P., & Lee, S.C. (1996) Analysis of novel streptavidin-binding peptides, identified using a phage display library, shows that amino acids external to a perfectly conserved consensus sequence and to the presented peptides contribute to binding. Mol. Diversity, 1, 241-246. #5334 (Available on Internet)

99. Caporale, C., Caruso, C., & Buonocore, V. (1996) Determination of primary structure of homologous proteins by sequence analysis of peptide mixture. J. Protein Chem., 15, 405-405. #5510

100. Carbonell, X., & Villaverde, A. (1996) Peptide display on functional tailspike protein of bacteriophage P22. Gene, 176, 225-229. #8151

101. Cardno, M., & Bradley, M. (1996) A simple multiple release system for combinatorial library and peptide analysis. Tetrahedron Lett., 37, 135-138. #3459

102. Cargill, J.F., & Maiefski, R.R. (1996) Automated combinatorial chemistry on solid phase. Lab. Robotics Automation, 8, 139-148. #5344

103. Carter, J.M., Mansfield, K., Zizza, R. & Lee-Own, V. (1996) Development of a synthetic peptide based immunoassay for hepatitis B surface antigen. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 309-310). Mayflower Scientific Ltd., Kingswinford. #2741

104. Case-Green, S.C., Mir, K.U., Milner, N. & Southern, E.M. (1996) Synthesis and applications of spatially addressable oligonucleotide arrays. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 57-60). Mayflower Scientific Limited, Birmingham. #8898

105. Cesareni, G., Minenkova, O., Dente, L., Iannolo, G., Zucconi, A., Citterich, M.H., Lanfrancotti, A., Castagnoli, L. & Vetriani, C. (1996) Structural and functional constraints in the display of peptides on filamentous phage capsids. In R. Cortese (Ed.), Combinatorial Libraries: Synthesis, Screening and Application Potential. (pp. 113-126). Walter de Gruyter, Berlin. #4343

106. Chabala, J.C., Baldwin, J.J., Burbaum, J.J., Chelsky, D., Dillard, L.W., Henderson, I., Li, G., Ohlmeyer, H.J., Randle, T.L., Reader, J.C., Rokosz, L. & Sigal, N.H. (1996) Drug discovery and optimization using binary-encoded small molecule combinatorial libraries. In M.J. Browne & P.L. Thurlby (Eds.), Genomes, Molecular Biology and Drug Discovery. (pp. 131-150). Academic Press, Inc., London, San Diego. #3773

107. Chabala, J.C., Baldwin, J.J., Burbaum, J.J., Chelsky, D., Dillard, L.W., Henderson, I., Li, G., Ohlmeyer, M.H.J., Randle, T.L., Reader, J.C., Rokosz, L. & Sigal, N.H. (1996) Synthesis of binary encoded small molecule libraries and their application to drug discovery and optimization. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 101-106). Mayflower Scientific Limited, Birmingham. #8905

108. Chaiken, I.M., & Janda, K.D. (1996) Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. Americal Chemical Society, Washington,DC. ISBN 0841234507 #5093

109. Chakravarty, S., Mavunkel, B.J., Goehring, R.R., & Kyle, D.J. (1996) Novel bradykinin receptor antagonists from a structurally directed non-peptide combinatorial library. Immunopharmacology, 33, 61-67. #5235

110. Chakravarty, S., Mavunkel, B.J., Andy, R. & Kyle, D.J. (1996) Nonpeptidic bradykinin antagonists from a structurally directed non-peptide combinatorial library. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 717-718). Mayflower Scientific Ltd., Kingswinford. #5049

111. Chakravarty, S., Mavunkel, B.J., Andy, R. & Kyle, D.J. (1996) Synthesis and characterization of a combinatorial library: Application to the discovery of a bradykinin B(2) receptor antagonist. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 339-340). Mayflower Scientific Limited, Birmingham. #8945

112. Chan, P.M., Keller, P.R., Connors, R.W., Leopold, W.R., & Miller, W.T. (1996) Amino-terminal sequence determinants for substrate recognition by platelet-derived growth factor receptor tyrosine kinase. FEBS Lett., 394, 121-125. #5596

113. Chan, T.Y., Chen, A., Allanson, N., Chen, R., Liu, D., & Sofia, M.J. (1996) Solid phase synthesis of peptidoglycan monomers for the generation of a combinatorial library. Tetrahedron Lett., 37, 8097-8100. #5747

114. Chan, T.Y., Chen, A., Allanson, N., Chen, R., Liu, D. & Sofia, M.J. (1996) Solid supported glycopeptide synthesis for the construction of a glycopeptide combinatorial library. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. MEDI-198. American Chemical Society,Washington,D, #6143

115. Chapman, D. (1996) The measurement of molecular diversity: A three-dimensional approach. J. Comput. Aid. Molec. Design, 10, 501-512. #8249

116. Chen, C., Dagnino, R.Jr., De Souza, E.B., Grigoriadis, D.E., Huang, C.Q., Kim, K.I., Liu, Z., Moran, T., Webb, T.R., Whitten, J.P., Xie, Y.F., & McCarthy, J.R. (1996) Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor 1 receptor anatagonists. J. Med. Chem., 39, 4358-4360. #12093

117. Chen, C.L., Strop, P., Lebl, M., & Lam, K.S. (1996) One bead-one compound combinatorial peptide library: Different types of screening. Methods Enzymol., 267, 211-219. #4785

118. Chen, J.J., Teesch, L.M., & Spatola, A.F. (1996) Using cyclic peptide mixtures as probes for metal ion host-guest interactions. Lett. Peptide Sci., 3, 17-24. #5263

119. Chen, W.P., Cheng, C.M., Wang, A.H.J., & Kuo, T.T. (1996) Single-stranded DNA binding protein from bacteriophage cf: Characterization, gene localization and protein-ssDNA complex. BBA-Gene Struct. Expression, 1309, 147-155. #8143

120. Chen, Y.C.J., Delbrook, K., Dealwis, C., Mimms, L., Mushahwar, I.K., & Mandecki, W. (1996) Discontinuous epitopes of hepatitis B surface antigen derived from a filamentous phage peptide library. Proc. Natl. Acad. Sci. USA, 93, 1997-2001. #4145

121. Cheng, S., Comer, D.D., Williams, J.P., Myers, P.L., & Boger, D.L. (1996) Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules. J. Amer. Chem. Soc., 118, 2567-2573. #4425

122. Cheng, S., Tarby, C.M., Comer, D.D., Williams, J.P., Caporale, L.H., Myers, P.L., & Boger, D.L. (1996) A solution-phase strategy for the synthesis of chemical libraries containig small organic molecules: A universal and dipeptide mimetics template. Bioorg. Med. Chem., 4, 727-737. #4631

123. Cheng, X., Kay, B.K., & Juliano, R.L. (1996) Identification of a biologically significant DNA-binding peptide motif by use of a random phage display library. Gene, 171, 1-8. #4847

124. Cheng, Y., Suenaga, T., & Still, W.C. (1996) Sequence-selective peptide binding with a peptido-A,B-trans- steroidal receptor selected from an encoded combinatorial receptor library. J. Amer. Chem. Soc., 118, 1813-1814. #4126

125. Choong, I.C., & Ellman, J.A. (1996) Solid-phase synthesis: Applications to combinatorial libraries. Annu. Rep. Med. Chem., 31, 309-318. #8134

126. Chu, Y.H., Dunayevskiy, Y.M., Kirby, D.P., Vouros, P., & Karger, B.L. (1996) Affinity capillary electrophoresis-mass spectrometry for screening combinatorial libraries. J. Amer. Chem. Soc., 118, 7827-7835. #5231

127. Chucholowski, A., Masquelin, T., Obrecht, D., Stadlwieser, J., & Villalgordo, J.M. (1996) Novel solution- and solid-phase strategies for the parallel and combinatorial synthesis of small-molecular-weight compound libraries. Chimia, 50, 525-530. #8188

128. Ciesiolka, J., Illangasekare, M., Majerfeld, I., Nickles, T., Welch, M., Yarus, M., & Zinnen, S. (1996) Affinity selection-amplification from randomized ribioligonucleotide pools. Methods Enzymol., 267, 315-335. #4791

129. Colas, P., Cohen, B., Jessen, T., Grishina, I., McCoy, J., & Brent, R. (1996) Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2. Nature, 380, 548-550. #4415

130. Cole, B.M., Shimizu, K.D., Krueger, C.A., Harrity, J.P.A., Snapper, M.L., & Hoveyda, A.H. (1996) Discovery of chiral catalysts through ligand diversity: Ti-catalyzed enantioselective addition of TMSCN to meso epoxides. Angew. Chem. Int. Ed., 35, 1668-1671. #5273

131. Collins, M.A. (1996) Computer-aided screening: Myth, magic, or reality. J. Biomol. Screen., 1, 81-84. #10044

132. Combs, A.P., Kapoor, T.M., Feng, S., Chen, J.K., Daude-Snow, L.F., & Schreiber, S.L. (1996) Protein structure-based combinatorial chemistry: Discovery of non-peptide binding elements to Src SH3 domain. J. Amer. Chem. Soc., 118, 287-288. #3860

133. Conrad, R.C., Giver, L., Tian, Y., & Ellington, A.D. (1996) In vitro selection of nucleic acid aptamers that bind proteins. Methods Enzymol., 267, 336-366. #4792

134. Cook, A.F. & Fathi, R. (1996) Phosphorus as a scaffold: Combinatorial libraries of non- nucleotide phosphoramidates. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 30-39). American Chemical Society, Washington,DC. #5097

135. Cook, P.D., Kiely, J.S., & Sprankle, K. (1996) C.C.U. ISIS Pharmaceuticals Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis. US Patent. 5,539,083. 200,742, #12296

136. Cortese, R. (1996) Combinatorial Libraries: Synthesis, Screening and Application Potential. Walter de Gruyter, New York. ISBN 311014395X #8472

137. Cramer, R.D., Clark, R.D., Patterson, D.E., & Ferguson, A.M. (1996) Bioisosterism as a molecular diversity descriptor: Steric fields of single "topomeric" conformers. J. Med. Chem., 39, 3060-3069. #5071

138. Crews, C.M. (1996) Deciphering isozyme function: Exploring cell biology with chemistry in the post-genomic era. Chem. Biol., 3, 961-965. #8241

139. Cummins, D.J., Andrews, C.W., Bentley, J.A., & Cory, M. (1996) Molecular diversity in chemical databases: Comparison of medicinal chemistry knowledge bases and databases of commercially available compounds. Journal of Chemical Information and Computer Sciences, 36, 750-763. #11400

140. Curran, D.P., & Hadida, S. (1996) Tris(2-(perfluorohexyl)ethyl)tin hydride: A new fluorous reagent for use in traditional organic synthesis and liquid phase combinatorial synthesis. J. Amer. Chem. Soc., 118, 2531-2532. #4426

141. Curran, D.P., & Hoshino, M. (1996) Stille couplings with fluorous tin reactants: Attractive features for preparative organic synthesis and liquid-phase combinatorial synthesis. J. Org. Chem., 61, 6480-6481. #5391

142. Curran, D.P. (1996) Combinatorial organic synthesis and phase separation: Back to the future. Chemtracts:Org. Chem., 9, 75-87. #4862

143. Cyvin, S.J., Lloyd, E.K., Cyvin, B.N., & Brunvoll, J. (1996) Chemical relevance of a pure combinatorial problem: Isomers of conjugated polyenes. Struct. Chem., 7, 183-186. #4859

144. Czarnik, A.W., & DeWitt, S.H. (1996) Small molecule combinatorial libraries via Parke-Davis' DIVERSOMER method. Chem. Brit., #2420

145. Czarnik, A.W., & DeWitt, S.H. (1996) Automating synthesis. Chem. Brit., 43-45. #8208

146. Czarnik, A.W. (1996) Guest editorial. Account. Chem. Res., 29, 112-113. #3990

147. Czarnik, A.W., & Nova, M.P. (1996) No static at all. Chem. Brit., 39-41. #9971

148. Dang, C., & Jayasena, S.D. (1996) Oligonucleotide inhibitors of Taq DNA polymerase facilitate detection of low copy number targets by PCR. J. Mol. Biol., 264, 268-278. #5776

149. Dankwardt, S.M., Phan, T.M., & Krstenansky, J.L. (1996) Combinatorial synthesis of small-molecule libraries using 3- amino-5-hydroxybenzoic acid. Mol. Diversity, 1, 113-120. #2825 (Available on Internet)

150. Davenport, M.P., Quinn, C.L., Valsasnini, P., Sinigaglia, F., Hill, A.V.S., & Bell, J.I. (1996) Analysis of peptide-binding motifs for two disease associated HLA-DR13 alleles using an M13 phage display library. Immunology, 88, 482-486. #5124

151. Davies, K., & Briant, C. (1996) Combinatorial chemistry library design using pharmacophore diversity. Net. Sci., 1, #5503 (Available on Internet)

152. Davies, K. (1996) Using pharmacophore diversity to select molecules to test from commercial catalogues. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 309-316). American Chemical Society, Washington,DC. #5121

153. Davis, J.P., Janjic, N., Javornik, B.E., & Zichi, D.A. (1996) Identifying consensus patterns an secondary structure in SELEX sequence sets. Methods Enzymol., 267, 302-314. #4790

154. Davis, P.W., & Ecker, D.J. (1996) Synthesis methods for iterative synthesis/screening strategies. Methods Mol. Cell. Biol., 6, 56-66. #9836 3847

155. de Bont, D.B.A., Moree, W.J., & Liskamp, R.M.J. (1996) Molecular diversity of peptidomimetics: Approaches to the solid- phase synthesis of peptidosulfonamides. Bioorg. Med. Chem., 4, 667-672. #4623

156. de Bont, D.B.A., Dijkstra, G.D.H., den Hartog, J.A.J., & Liskamp, R.M.J. (1996) Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin. Bioorg. Med. Chem. Lett., 6, 3035-3040. #8259

157. de Groot, A., Krijger, J.J., Filloux, A., & Tommassen, J. (1996) Characterization of type II protein secretion (xcp) genes in the plant growth-stimulating Pseudomonas putida, strain WCS358. Mol. Gen. Genet., 250, 491-504. #4428

158. de Kruif, J., & Logtenberg, T. (1996) Leucine zipper dimerized bivalent and bispecific scFv antibodies from a semi-synthetic antibody phage display library. Journal of Biological Chemistry, 271, 7630-7634. #4417

159. de Wildt, R.M.T., Finnern, R., Ouwehand, W.H., Griffiths, A.D., van Venrooij, W.J., & Hoet, R.M.A. (1996) Characterization of human variable domain antibody fragments against the U1 RNA-associated A protein, selected from a synthetic and a patient-derived combinatorial V gene library. Eur. J. Immunol., 26, 629-639. #4695

160. DeCiechi, P.A., Devine, C.S., Lee, S.C., Howard, S.C., Olins, P.O., & Caparon, M.H. (1996) Utilization of multiple phage display libraries for the identification of dissimilar peptide motifs that bind to a B7-1 monoclonalantibody. Mol. Diversity, 1, 79-86. #4116 (Available on Internet)

161. Delaney, J.S. (1996) Assessing the ability of chemical similarity measures to discriminate between active and inactive compounds. Mol. Diversity, 1, 217-222. #5333 (Available on Internet)

162. Demangel, C., Lafaye, P., & Mazie, J.C. (1996) Reproducing the immune response against the Plasmodium vivax merozoite surface protein 1 with mimotopes selected from a phage-displayed peptide library. Mol. Immunol., 33, 909-916. #8160

163. Deutscher, S.L., Crider, M.E., Ringbauer, J.A., Komissarov, A.A., & Quinn, T.P. (1996) Stability studies of nucleic acid-binding Fab isolated from combinatorial bacteriophage display libraries. Arch. Biochem. Biophys., 333, 207-213. #5479

164. Devlin, J.P. (1996) The impact of high throughput organic synthesis on R&D in bio-based industries. Net. Sci., #4316 (Available on Internet) http://www.awod.com/netsci/Issues/Mar96/feature3.html

165. Devraj, R., & Cushman, M. (1996) A versatile solid phase synthesis of lavendustin A and certain biologically active analogs. J. Org. Chem., 61, 9368-9373. #8250

166. DeWitt, S.H., Bear, B.R., Brussolo, J.S., Duffield, M.J., Hogan, E.M., Kibbey, C.E., MacDonald, A.A., Nickell, D.G., Rhoton, R.L. & Robertson, G.A. (1996) A modular system for combinatorial and automated synthesis. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 207-218). American Chemical Society, Washington,DC. #5113

167. DeWitt, S.H., & Czarnik, A.W. (1996) Combinatorial organic synthesis using Parke-Davis's DIVERSOMER method. Account. Chem. Res., 29, 114-122. #3991

168. Dhalluin, C., Pop, I., Deprez, B., Melnyk, P., Tartar, A. & Lippens, G. (1996) Magic-angle spinning NMR spectroscopy of polystyrene-bound organic molecules: Monitoring a three-step solid-phase synthesis involving a Heck reaction. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 255-272). American Chemical Society, Washington,DC. #5117

169. DiCesare, J.C., McComas, C.B., Thomas, J. & Carroll, F.I. (1996) Modification of the titanium isopropoxide catalyzed reductive amination reaction and its application to solid phase synthesis. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. ORGN-91. American Chemical Society,Washington,D, #6296

170. Ding, Y., Labbe, J., Kanie, O., & Hindsgaul, O. (1996) Towards oligosaccharide libraries: A study of the random galactosylation of unprotected N-acetylglucosamine. Bioorg. Med. Chem., 4, 683-692. #4626

171. Dinh, Q., Weng, N.P., Kiso, M., Ishida, H., Hasegawa, A., & Marcus, D.M. (1996) High affinity antibodies against Le(x) and sialyl Le(x) from a phage display library. Journal of Immunology, 157, 732-738. #4876

172. Diouri, M., Girouard, G.S., Allen, C.M., Sircar, S., Vanlier, J.E., & Weber, J.M. (1996) New stimulation ligand of the adenovirus 2 protease. Virology, 224, 510-516. #8141

173. Ditzel, H.J., Itoh, K., & Burton, D.R. (1996) Determinants of polyreactivity in a large panel of recombinant human antibodies from HIV-1 infection. Journal of Immunology, 157, 739-749. #4924

174. Doleckova, L., Pavlik, M., Voburka, Z., Rinnova, M., Suttnar, J. & Dyr, J.E. (1996) Characterization of binding sites of fibrin specific monoclonal antibodies using cotton-bound combinatorial peptide libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 347-350). Mayflower Scientific Limited, Birmingham. #8948

175. Dooley, C.T., Bower, A.N. & Houghten, R.A. (1996) Identification of mu-selective tetrapeptides using a positional scanning combinatorial library containing L-,D- and unnatural amino acids. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 623-624). Mayflower Scientific Ltd., Kingswinford. #2828

176. Dorey, E. (1996) Nobel discovery in combinatorial chemistry. Nat. Biotech., 14, 1643-1643. #8161

177. Dorner, B., Husar, G.M., Ostresh, J.M., & Houghten, R.A. (1996) The synthesis of peptidomimetic combinatorial libraries through succesive amide alkylations. Bioorg. Med. Chem., 4, 709-715. #4629

178. Dorner, B., Blondelle, S.E., Pinilla, C., Appel, J., Dooley, C.T., Eichler, J., Ostresh, J.M., Perez-Paya, E. & Houghten, R.A. (1996) Soluble synthetic combinatorial libraries: The use of molecular diversities for drug discovery. In R. Cortese (Ed.), Combinatorial Libraries: Synthesis, Screening and Application Potential. (pp. 1-25). Walter de Gruyter, Berlin. #4339

179. Dorner, B., Ostresh, J.M., Husar, G.M., & Houghten, R.A. (1996) Generation of peralkylated peptidomimetic combinatorial libraries. Methods Mol. Cell. Biol., 6, 35-40. #8689

180. Dorner, B., Eichler, J., Husar, G.M., Ostresh, J.M. & Houghten, R.A. (1996) N-Alkylated peptidomimetic combinatorial libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 351-352). Mayflower Scientific Limited, Birmingham. #8949

181. Dottavio, D. (1996) Phagemid-displayed peptide libraries. In Anonymous, Phage Display of Peptides and Proteins. (pp. 113-125). #8449

182. Dottavio, D. (1996) Epitope mapping using phage-displayed peptide libraries. Methods Mol. Biol., 66, 181-193. #5595

183. Doyle, M.V., Doyle, L.V., Fong, S., Goodson, R.J., Panganiban, L., Drummond, R., Winter, J. & Rosenberg, S. (1996) The utilization of platelets and whole cells for the selection of peptides ligands from phage display libraries. In R. Cortese (Ed.), Combinatorial Libraries: Synthesis, Screening and Application Potential. (pp. 158-174). Walter de Gruyter, Berlin. #4346

184. Dressman, B.A., Spangle, L.A., & Kaldor, S.W. (1996) Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization/cleavage step. Tetrahedron Lett., 37, 937-940. #3885

185. du Plessis, D.H. & Jordaan, P. (1996) Phage libraries displaying random peptides derived from a target sequence. In Anonymous, Phage Display of Peptides and Proteins. (pp. 141-150). #8451

186. Duenas, M., Chin, L.T., Malmborg, A.C., Casalvilla, R., Ohlin, M., & Borrebaeck, C.A.K. (1996) In vitro immunization of naive human B cells yields high affinity immunoglobulin G antibodies as illustrated by phage library. Immunology, 89, 1-7. #5341

187. Dunayevskiy, Y.M., Vouros, P., Wintner, E.A., Shipps, G.W., Carell, T., & Rebek, J.Jr. (1996) Application of capillary electrophoresis-electrospray ionization mass spectrometry in the determination of molecular diversity. Proc. Natl. Acad. Sci. USA, 93, 6152-6157. #4646

188. Edwards, K.J., Barker, J.H.A., Daly, A., Jones, C., & Karp, A. (1996) Microsatelite libraries enriched for several microsatellite sequences in plants. BioTechniques, 20, 758-760. #4645

189. Eggena, M., Targan, S.R., Iwanczyk, L., Vidrich, A., Gordon, L.K., & Braun, J. (1996) Phage display cloning and characterization of an immunogenetic marker (perinuclear anti-neutrophil cytoplasmic antibody) in ulcerative colitis. Journal of Immunology, 156, 4005-4011. #4685

190. Eggenweiler, H.M. & Bayer, E. (1996) Gel-phase (13)C-NMR monitoring of solid phase glycoside synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 363-366). Mayflower Scientific Limited, Birmingham. #8952

191. Egner, B.J., Cardno, M., & Bradley, M. (1996) Linkers for combinatorial chemistry and reaction analysis using solid phase in situ mass spectrometry. J. Chem. Soc. Chem. Commun., 2163-2164. #4130

192. Eichler, J., Lucka, A.W., Pinilla, C., & Houghten, R.A. (1996) Novel a-glucosidase inhibitors identified using multiple cyclic peptide combinatorial libraries. Mol. Diversity, 1, 233-240. #4843 (Available on Internet)

193. Eichler, J., Lucka, A.W. & Houghten, R.A. (1996) Positional scanning combinatorial libraries built around mono- and bicyclic peptide templates. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 201-204). Mayflower Scientific Limited, Birmingham. #8922

194. Ellman, J.A. (1996) Design, synthesis, and evaluation of small-molecule libraries. Account. Chem. Res., 29, 132-143. #3993

195. Estaquier, J., Boutillon, C., Georges, B., Ameisen, J.C., Tartar, A., & Auriault, C. (1996) A combinatorial peptide library around of the human immunodeficiency virus (HIV-1) V3 domain leads to distinct T helper cell responses. J. Peptide Sci., 2, 165-175. #8582

196. Estevez, J.C., Saunders, J., Besra, G.S., Brennan, P.J., Nash, R.J., & Fleet, G.W.J. (1996) Mimics of L-rhamnose: Synthesis of C-glycosides of L- rhamnofuranose and an a-azidoester as divergent intermediates for combinatorial generation of rhamnofuranose libraries. Tetrahedron:Asymmetry, 7, 383-386. #4156

197. Evans, D.M., Williams, K.P., McGuinness, B., Tarr, G., Regnier, F., Afeyan, N., & Jindal, S. (1996) Affinity-based screening of combinatorial libraries using automated, serial-column chromatography. Nat. Biotech., 14, 504-507. #4692

198. Fakhfakh, F., Ayadi, H., Bahloul, Z., Jarraya, A., Sioud, M., & Zouali, M. (1996) Antibody epitopes probed by immunoselected phage-display library peptides in members of a family with various rheumatic manifestations. Clin. Exp. Rheumatol., 14, 607-611. #8262

199. Fang, R., Qi, J., Lu, Z.B., Zhou, H., Li, W., & Shen, J.C. (1996) Selection of trypsin inhibitors in phage peptide library. Biochem. Biophys. Res. Commun., 220, 53-56. #4423

200. Fathi, R., Rudolph, M.J., Gentles, R.G., Patel, R., MacMillan, E.W., Reitman, M.S., Pelham, D., & Cook, A.F. (1996) Synthesis and properties of combinatorial libraries of phosphoramidates. J. Org. Chem., 61, 5600-5609. #5091

201. Felder, E.R., Heizmann, G., Matthews, I.T., Rink, H., & Spieser, E. (1996) A new combination of protecting groups and links for encoded synthetic libraries suited for consecutive tests on the solid phase and in solution. Mol. Diversity, 1, 109-112. #4119 (Available on Internet)

202. Felici, F., Galfre, G., Luzzago, A., Monaci, P., Nicosia, A., & Cortese, R. (1996) Phage-displayed peptides as tools for characterization of human sera. Methods Enzymol., 267, 116-128. #4780

203. Fell, J.B., Chin, J.A., Shapiro, M.J. & Wareing, J.R. (1996) Analytical techniques in combinatorial chemistry: HPLC NMR of a mixture of positional isomers. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. ANYL-29. American Chemical Society,Washington,D, #6383

204. Feng, S.B., Kapoor, T.M., Shirai, F., Combs, A.P., & Schreiber, S.L. (1996) Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Chem. Biol., 3, 661-670. #5472

205. Fenniri, H. (1996) Recent advances at the interface of medicinal and combinatorial chemistry. Views on methodologies for the generation and evaluation of diversity and application to molecular recognition and catalysis. Curr. Med. Chem., 3, 343-378. #8194

206. Ferguson, A.M., Patterson, D.E., Garr, C.D., & Underiner, T.L. (1996) Designing chemical libraries for lead discovery. J. Biomol. Screen., 1, 65-73. #5342

207. Figliozzi, G.M., Goldsmith, R., Ng, S.C., Banville, S.C., & Zuckermann, R.N. (1996) Synthesis of N-substituted glycine peptoid libraries. Methods Enzymol., 267, 437-447. #4797

208. Finn, P.W., & Mason, J.S. (1996) Computer-based screening of compound databases for the identification of new leads. Drug Disc. Today, 1, 363-370. #8519

209. Fisch, I., Kontermann, R.E., Finnern, R., Hartley, O., Soler-Gonzales, A.S., Griffiths, A.D., & Winter, G. (1996) A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage. Proc. Natl. Acad. Sci. USA, 93, 7761-7766. #5130

210. Fitzgerald, K., Chiswell, D., Earnshaw, J., Smith, R., Kenten, J., Williams, R. & McCafferty, J. (1996) Isolating high affinity human antibodies from phage repertoires. In R. Cortese (Ed.), Combinatorial Libraries: Synthesis, Screening and Application Potential. (pp. 188-204). Walter de Gruyter, Berlin. #4348

211. Fitzgerald, M.C., Harris, K., Shevlin, C.G., & Siuzdak, G. (1996) Direct characterization of solid phase resin-bound molecules by mass spectrometry. Bioorg. Med. Chem. Lett., 6, 979-982. #5755

212. Fitzwater, T., & Polisky, B. (1996) A SELEX primer. Methods Enzymol., 267, 275-301. #4789

213. Fleckenstein, B., Kalbacher, H., Muller, C.P., Stoll, D., Halder, T., Jung, G., & Wiesmuller, K.H. (1996) New ligands binding to the human leukocyte antigen class II molecule DRB1(*)0101 based on the activity pattern of an undecapeptide library. Eur. J. Biochem., 240, 71-77. #5278

214. Floyd, C.D., Lewis, C.N., Patel, S.R., & Whittaker, M. (1996) A method for the synthesis of hydroxamic acids on solid phase. Tetrahedron Lett., 37, 8045-8048. #5756

215. Foley, M.A., Hassman, A.S., Drewry, D.H., Greer, D.G., Wagner, C.D., Feldman, P.L., Berman, J., Bickett, D.M., McGeehan, G.M., Lambert, M.H., & Green, M. (1996) Rapid synthesis of novel dipeptide inhibitors of human collagenase and gelatinase using solid phase chemistry. Bioorg. Med. Chem. Lett., 6, 1905-1910. #5226

216. Francis, M.B., Finney, N.S., & Jacobsen, E.N. (1996) Combinatorial approach to the discovery of novel coordination complexes. J. Amer. Chem. Soc., 118, 8983-8984. #5386

217. Frank, R., Hoffmann, S., Kiess, M., Lahmann, H., Tegge, W., Behn, C. & Gausepohl, H. (1996) Combinatorial synthesis on membrane supports by the SPOT technique: Imaging peptide sequence and shape space. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 363-386). VCH, Weinheim. #8179

218. Freidinger, R.M. (1996) Nonpeptide ligands for peptide receptors. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 896-898). Mayflower Scientific Ltd., Kingswinford. #5059

219. Freier, S.M., Konings, D.A.M., Wyatt, J.R., & Ecker, D.J. (1996) 'Mutational SURF': A strategy for improving lead compounds identified from combinatorial libraries. Bioorg. Med. Chem., 4, 717-725. #4630

220. Frische, K., Meldal, M., Werdelin, O., Mouritsen, S., Jensen, T., Galli-Stampino, L., & Bock, K. (1996) Multiple column synthesis of a library of T-cell stimulating T(n)-antigenic glycopeptide analogues for the molecular characterization of T-cell-glycan specificity. J. Peptide Sci., 2, 212-222. #8573

221. Fruchtel, J.S., & Jung, G. (1996) Organic chemistry on solid supports. Angew. Chem. Int. Ed., 35, 17-42. #3975

222. Fruchtel, J.S. & Jung, G. (1996) Polymer supported organic synthesis: A review. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 19-78). VCH, Weinheim. #9664

223. Fu, H., & Khosla, C. (1996) Antibiotic activity of polyketide products derived from combinatorial biosynthesis: Implications for directed evolution. Mol. Diversity, 1, 121-124. #4121 (Available on Internet)

224. Fujisao, S., Matsushita, S., Nishi, T., & Nishimura, Y. (1996) Identification of HLA-DR9 (DRB1*0901)-binding peptide motifs using a phage fUSE5 random peptide library. Hum. Immunol., 45, 131-136. #4419

225. Fujita, S. (1996) Pseudo-point groups and chronality in enumeration of reaction pairs. Theor. Chim. Acta, 94, 105-124. #5484

226. Fujita, S. (1996) The sphericity concept for an orbit of bonds. Formulation of chirogenic sites in a homospheric orbit and of bond- differentiating chiral reactions with applications to C-60-adducts. Journal of Chemical Information and Computer Sciences, 36, 270-285. #4432

227. Fukase, K., Leger, R., & Still, W.C. (1996) Highly selective binding of L-Val-D-Gln(Trt) sequence with a synthetic receptor Elucidation with an encoded combinatorial library. Peptide Chem., 33, 285-288. #6462

228. Furka, A., Campian, E., Peterson, M.L. & Saneii, H.H. (1996) Applicability of peptide omission libraries in screening. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 317-318). Mayflower Scientific Ltd., Kingswinford. #3030

229. Furka, A. (1996) Chemical synthesis of peptide libraries. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 111-137). VCH, Weinheim. #8172

230. Furka, A., Campian, E., Peterson, M., Saneii, H.H. & Chou, J. (1996) Combinatorial chemistry: Past and present developments. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 151-158). Mayflower Scientific Limited, Birmingham. #8916

231. Galfre, G., Monaci, P., Nicosia, A., Luzzago, A., Felici, F., & Cortese, R. (1996) Immunization with phage-displayed mimotopes. Methods Enzymol., 267, 109-115. #4779

232. Gallop, M.A. (1996) Hot papers. Combinatorial chemistry. Applications of combinatorial technologies to drug discovery. Scientist, 10, 14-14. #5141

233. Gao, B., & Esnouf, M.P. (1996) Elucidation of the core residues of an epitope using membrane-based combinatorial peptide libraries. Journal of Biological Chemistry, 271, 24634-24638. #5598

234. Gao, J., Cheng, X., Chen, R., Sigal, G.B., Bruce, J.E., Schwartz, B.L., Hofstadler, S.A., Anderson, G.A., Smith, R.D., & Whitesides, G.M. (1996) Screening derivatized peptide libraries for tight binding inhibitors to carbonic anhydrase II by electrospray ionization mass spectrometry. J. Med. Chem., 39, 1949-1955. #4696

235. Garcia, M.E., Gavin, J.A., Deng, N., Andrievsky, A.A., & Mallouk, T.E. (1996) Combinatorial synthesis of modular chiral cyclophanes. Tetrahedron Lett., 37, 8313-8316. #5740

236. Garigipati, R.S., Adams, B., Adams, J.L., & Sarkar, S.K. (1996) Use of spin echo magic angle spinning H-1 NMR in reaction monitoring in combinatorial organic synthesis. J. Org. Chem., 61, 2911-2914. #4570

237. Garr, C.D., Peterson, J.R., Schultz, L., Oliver, A.R., Undenner, T.L., Cramer, R.D., Ferguson, A.M., Lawless, M.S., & Patterson, D.E. (1996) Solution-phase synthesis of chemical libraries for lead discovery. J. Biomol. Screen., 1, 179-186. #8757

238. Gates, C.M., Stemmer, W.P.C., Kaptein, R., & Schatz, P.J. (1996) Affinity selective isolation of ligands from peptide libraries through display on a lac repressor "headpiece dimer". J. Mol. Biol., 255, 373-386. #4719

239. Gayo, L.M., & Suto, M.J. (1996) Use of pentafluorophenyl esters for one-pot protectional/activation of amino and thiol carboxylic acids. Tetrahedron Lett., 37, 4915-4918. #5761

240. Gazerro, L., Pinori, M. & Mascagni, P. (1996) Preparation of synthetic peptide libraries using a multi column parallel-flow MPS device. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 369-372). Mayflower Scientific Limited, Birmingham. #3447

241. Gething, M.J. (1996) Molecular chaperones: Clasping the price. Curr. Biol., 6, 1573-1576. #8156

242. Geysen, H.M., Wagner, C.D., Bodnar, W.M., Markworth, C.J., Parke, G.J., Schoenen, F.J., Wagner, D.S., & Kinder, D.S. (1996) Isotope or mass encoding of combinatorial libraries. Chem. Biol., 3, 679-688. #5398

243. Gibbons, J.A., Hancock, A.A., Vitt, C.R., Knepper, S., Buckner, S.A., Brune, M.E., Milicic, I., Kerwin, J.F.J., Richter, L.S., Taylor, E.W., Spear, K.L., Zuckermann, R.N., Spellmeyer, D.C., Braeckman, R.A., & Moos, W.H. (1996) Pharmacologic characterization of CHIR 2279, an N-subtituted glycine peptoid with high-affinity binding for alpha 1- adrenoceptors. J. Pharmacol. Exp. Ther., 277, 885-899. #5008

244. Gibson, S., McGuire, R., & Rees, D.C. (1996) Principal components describing biological activities and molecular diversity of heterocyclic aromatic ring fragments. J. Med. Chem., 39, 4065-4072. #5470

245. Gilbertson, S.R., & Wang, X. (1996) The combinatorial synthesis of chiral phosphine ligands. Tetrahedron Lett., 37, 6475-6478. #5251

246. Gilon, C., Bitan, G., Zeltser, I. & Muller, D. (1996) Simultaneous multiple synthesis of backbone-cyclic peptide libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 205-208). Mayflower Scientific Limited, Birmingham. #8923

247. Gingrich, J.C., Boehrer, D.M., & Basu, S.B. (1996) Partial CviJI digestion as an alternative approach to generate cosmid sublibraries for large-scale sequencing projects. BioTechniques, 21, 99-104. #4827

248. Goff, D.A., & Zuckermann, R.N. (1996) The synthesis of 2-oxopiperazines by intramolecular Michael addition on solid support. Tetrahedron Lett., 37, 6247-6250. #5252

249. Gong, B., Chen, X., Cheng, M., Li, R., Kenyon, G.L. & Cohen, F.E. (1996) Structure-based design and solid phase synthesis of cysteine protease inhibitors for parasitic diseases. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. MEDI-39. American Chemical Society,Washington,D, #6534 4335

250. Goodfellow, V.S., Laudeman, C.P., Gerrity, J.I., Burkhard, M., Strobel, E. & McLeod, D.A. (1996) Rationally designed diverse non-peptides: Variously substituted piperazine and piperazinedione libraries targeted for the discovery of bradykinin and other G-protein coupled receptor antagonists. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 381-384). Mayflower Scientific Limited, Birmingham. #3242

251. Goodfellow, V.S., Laudeman, C.P., Gerrity, J.I., Burkard, M., Strobel, E., Zuzack, J.S., & McLeod, D.A. (1996) Rationally designed non-peptides: Variously substituted piperazine libraries for the discovery of bradykinin antagonists and other g-protein-coupled receptor ligands. Mol. Diversity, 2, 97-102. #4838 (Available on Internet)

252. Gooding, O., Hoeprich, P.D.Jr., Labadie, J.W., Porco, J.A.Jr., van Eikeren, P. & Wright, P. (1996) Boosting the productivity of medicinal chemistry through automation tools: Novel technological developments enable a wide range of automated synthetic procedures. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 199-206). American Chemical Society, Washington,DC. #5112

253. Gordeev, M.F., Patel, D.V., Wu, J., & Gordon, E.M. (1996) Approaches to combinatorial synthesis of heterocycles: Solid phase synthesis of pyridines and pyrido[2,3-d]pyrimidines. Tetrahedron Lett., 37, 4643-4646. #4856

254. Gordeev, M.F., Patel, D.V., & Gordon, E.M. (1996) Approaches to combinatorial synthesis of heterocycles: A solid- phase synthesis of 1,4-dihydropyridines. J. Org. Chem., 61, 924-928. #3758

255. Gordon, E.M., Gallop, M.A., & Patel, D.V. (1996) Strategy and tactics in combinatorial organic synthesis. Applications to drug discovery. Account. Chem. Res., 29, 144-154. #3593

256. Gosselin, F., Direnzo, M., Ellis, T.H., & Lubell, W.D. (1996) Photoacoustic FTIR spectroscopy, a nondestructive method for sensitive analysis of solid-phase organic chemistry. J. Org. Chem., 61, 7980-7981. #5767

257. Gras-Masse, H., Rollin, C., Grzych, J.M., Rommens, C., Auriault, C. & Tartar, A. (1996) Use of combinatorial peptides, or "mixotopes", for more efficient detection of antibodies to a non-variable antigen. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 804-805). Mayflower Scientific Ltd., Kingswinford. #5054

258. Gravert, D.J. & Janda, K.D. (1996) Liquid-phase combinatorial synthesis. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 118-127). American Chemical Society, Washington,DC. #5102

259. Gravert, D.J., & Janda, K.D. (1996) Developing small-molecule libraries for drug discovery. Trends Biotech., 14, 110-112. #4771

260. Graybill, T.L., Agrafiotis, D.K., Bone, R., Illig, C.R., Jaeger, E.P., Locke, K.T., Lu, T., Salvino, J.M., Soll, R.M., Spurlino, J.C., Subasinghe, N., Tomczuk, B.E. & Salemme, F.R. (1996) Enhancing the drug discovery process by integration of high-throughput chemistry and structure-based drug design. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 16-29). American Chemical Society, Washington,DC. #5096

261. Gremlich, H.U., & Berets, S.L. (1996) Use of FT-IR internal reflection spectroscopy in combinatorial chemistry. Appl. Spectrosc., 50, 532-536. #4590

262. Griffin, L.C. & Leung, L.L.K. (1996) Discovery and characterization of a thrombin aptamer selected from a combinatorial ssDNA library. In R. Cortese (Ed.), Combinatorial Libraries: Synthesis, Screening and Application Potential. (pp. 87-112). Walter de Gruyter, Berlin. #4342

263. Griffith, M.C., Dooley, C.T., Houghten, R.A. & Kiely, J.S. (1996) Solid-phase synthesis, characterization, and screening of a 43, 000-compound tetrahydroisoquinoline combinatorial library. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 50-57). American Chemical Society, Washington,DC. #5098

264. Gude, M., Piarulli, U., Potenza, D., Salom, B., & Gennari, C. (1996) A new method for the solution and solid phase synthesis of chiral b -sulfonopeptides under mild conditions. Tetrahedron Lett., 37, 8589-8592. #5736

265. Gui, J., Moyana, T., Malcolm, B., & Xiang, J. (1996) Identification of a decapeptide with the binding reactivity for tumor-associated TAG72 antigen froma phage displayed library. Protein-Struct. Funct. Genet., 24, 352-358. #4418

266. Guiles, J.W., Johnson, S.G., & Murray, W.V. (1996) Solid-phase Suzuki coupling for C-C bond formation. J. Org. Chem., 61, 5169-5171. #5143

267. Guiles, J.W., Johnson, S.G. & Murray, W.V. (1996) Solid phase Suzuki for C-C bond formation. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. ORGN-126. American Chemical Society,Washington,D, #6569

268. Gundlach, B.R., Wiesmuller, K.H., Junt, T., Kienle, S., Jung, G., & Walden, P. (1996) Specificity and degeneracy of minor histocompatibility antigen-specific MHC-restricted CTL. Journal of Immunology, 156, 3645-3651. #5010

269. Gundlach, B.R., Wiesmuller, K.H., Junt, T., Kienle, S., Jung, G., & Walden, P. (1996) Determination of T cell epitopes with random peptide libraries. J. Immunol. Method, 192, 149-155. #4926

270. Hamilton, S.D. (1996) Special issue on automation in drug discovery. Editorial notes. Lab. Robotics Automation, 8, 259-259. #9972

271. Hamilton, S.D., Armstrong, J.W., Gerren, R.A., Janssen, A.M., Peterson, J.V., & Stanton, R.A. (1996) An overview of automated biotechnology screening. Lab. Robotics Automation, 8, 287-294. #9976

272. Hamm, J. (1996) Characterisation of antibody-binding RNAs selected from structurally constrained libraries. Nucl. Acid. Res., 24, 2220-2227. #6592

273. Hammer, J. & Sinigaglia, F. (1996) Identification of MHC binding motifs with synthetic and phage displayed peptide libraries. In R. Cortese (Ed.), Combinatorial Libraries: Synthesis, Screening and Application Potential. (pp. 175-187). Walter de Gruyter, Berlin. #4347

274. Hamper, B.C., Dukesherer, D.R., & South, M.S. (1996) Solid-phase synthesis of proline analogs via a three component 1, 3-dipolar cycloaddition. Tetrahedron Lett., 37, 3671-3674. #4935

275. Han, H., & Janda, K.D. (1996) Soluble polymer-bound ligand-accelerated catalysis: Asymmetric dihydroxylation. J. Amer. Chem. Soc., 118, 7632-7633. #5166

276. Han, H., & Janda, K.D. (1996) Azatides: Solution and liquid phase syntheses of a new peptidomimetics. J. Amer. Chem. Soc., 118, 2539-2544. #3636

277. Han, Y., Walker, S.D., & Young, R.N. (1996) Silicon directed ipso-subtitution of polymer bound arylsilanes: Preparation of biaryls via the Suzuki cross-coupling reaction. Tetrahedron Lett., 37, 2703-2706. #4742

278. Hanessian, S., & Devasthale, P.V. (1996) Generation of functional diversity via nitroaldol condensations of a-aminoacid aldehydes. A new and stereocontrolled route to acyclic 1,3-diamino-2-alcohols. Tetrahedron Lett., 37, 987-990. #3886

279. Hanessian, S., & Yang, R.Y. (1996) Solution and solid phase synthesis of 5-alkoxyhydantoin libraries with a three-fold functional diversity. Tetrahedron Lett., 37, 5835-5838. #5232

280. Hanke, J., Sanches, D.O., Henriksson, J., Aslund, L., Pettersson, U., Frasch, A.C.C., & Hoheisel, J.D. (1996) Mapping the Trypanosoma cruzi genome: Analyses of representative cosmid libraries. BioTechniques, 21, 686-693. #5468

281. Harada, K., Martin, S.S., & Frankel, A.D. (1996) Selection of RNA-binding peptides in vivo. Nature, 380, 175-179. #4653

282. Hardin, J.H., & Smietana, F.R. (1996) Automating combinatorial chemistry: A primer on benchtop robotic systems. Mol. Diversity, 1, 270-274. #4842 (Available on Internet)

283. Harness, J.R. (1996) Automation of high-throughput synthesis: Automated laboratory workstations designed to perform and support combinatorial chemistry. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 188-198). American Chemical Society, Washington,DC. #5107

284. Harris, A.L. & Toyonaga, B.E. (1996) Application of polymer-supported chemistry to the discovery and optimization of lead drug candidates. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 298-308). American Chemical Society, Washington,DC. #5120

285. Harrison, J.L., Williams, S.C., Winter, G., & Nissim, A. (1996) Screening of phage antibody libraries. Methods Enzymol., 267, 83-108. #4778

286. Hassan, M., Hagler, A.T. & Struthers, R.S. (1996) Generation of consensus pharmacophore models from a library of constrained peptides. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 295-296). Mayflower Scientific Ltd., Kingswinford. #5044

287. Hassan, M., Bielawski, J.P., Hempel, J.C., & Waldman, M. (1996) Optimization and visualization of molecular diversity of combinatorial libraries. Mol. Diversity, 2, 64-74. #4840 (Available on Internet)

288. Healy, J.M., Haruki, M., & Kikuchi, M. (1996) Preferred motif for integrin binding identified using a library of randomized RGD peptides displayed on phage. Protein Peptide Lett., 3, 23-30. #5347

289. Hebert, N. (1996) Convergent solid-phase synthesis of phosphoramidate combinatorial libraries. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 40-49). American Chemical Society, Washington,DC. #3651

290. Hegy, G., Gorlach, E., Richmond, R., & Bitsch, F. (1996) High throughput electrospray mass spectrometry of combinatorial chemistry racks with automated contamination surveillance and results reporting. Rapid Commun. Mass Spectrom., 10, 1894-1900. #8756

291. Heizmann, G., Tanner, H. & Eberle, A.N. (1996) New ligands for the human melanoma MSH receptor identified by a peptoid library (oligo N-substituted glycines). In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 391-394). Mayflower Scientific Limited, Birmingham. #3185 Poster at 4th International Symposium Solid Phase Synthesis and Combinatorial Chemical Libraries, Edinburgh, Scotland, UK, September 12-16, 1995

292. Hendrickson, T.L., Spencer, J.R., Kato, M., & Imperiali, B. (1996) Design and evaluation of potent inhibitors of asparagine-linked protein glycosylation. J. Amer. Chem. Soc., 118, 7636-7637. #5236

293. Hirabayashi, Y., Fukuda, H., Kimura, J., Miyamoto, M., & Yasui, K. (1996) Identification of peptides mimicking the antigenicity and immunogenicity of conformational epitopes on Japanese encephalitis virus protein using synthetic peptide libraries. J. Virol. Meth., 61, 23-36. #5493

294. Hirschmann, R., Yao, W., Cascieri, M.A., Strader, C.D., Maechler, L., Cichy-Knight, M.A., Hynes, J.Jr., van Rijn, R.D., Sprengeler, P.A., & Smith, A.B.I. (1996) Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic. J. Med. Chem., 39, 2441-2448. #11680

295. Hoeger, C.A., Jiang, G.C., Koerber, S.C., Reisine, T., Liapakis, G. & Rivier, J.E. (1996) Betide based strategy for the design of GnRH and receptor selective somatostatin analogs. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 635-636). Mayflower Scientific Ltd., Kingswinford. #5065

296. Hoekstra, W.J., Maryanoff, B.E., Andrade-Gordon, P., Cohen, J.H., Costanzo, M.J., Damiano, B.P., Haertlein, B.J., Harris, B.D., Kauffman, J.A., Keane, P.M., McComsey, D.F., Villani, F.J., & Yabut, S.C. (1996) Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ- 50042. Bioorg. Med. Chem. Lett., 6, 2371-2376. #6665

297. Hoeprich, P.D.Jr. (1996) Automated solid phase synthesis of small organic molecules. Nat. Biotech., 14, 1311-1313. #6667

298. Hoffman, N.G., Sparks, A.B., Carter, J.M., & Kay, B.K. (1996) Binding properties of SH3 peptide ligands identified from phage-displayed random peptide libraries. Mol. Diversity, 2, 5-12. #4834 (Available on Internet)

299. Hoffmann, S. & Frank, R. (1996) New safety-catch linkages for the direct release of peptide amides into aqueous buffers. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 407-410). Mayflower Scientific Limited, Birmingham. #8960

300. Hogan, J.C.Jr. (1996) Directed combinatorial chemistry. Nature, 384, 17-19. #5772

301. Hollinshead, S.P. (1996) Synthesis and reactions of heterocyclic libraries on a solid support. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-156. American Chemical Society,Washington,D, #6671

302. Hollinshead, S.P. (1996) Stereoselective synthesis of highly functionalized pyrrolidines via 1,3-dipolar cycloaddition reactions on a solid support. Tetrahedron Lett., 37, 9157-9160. #8167

303. Holmes, C.P., Jones, D.G., Frederick, B.T. & Dong, L.C. (1996) Development of a new ortho-nitrobenzyl photolabile linker for solid phase synthesis. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 44-45). Mayflower Scientific Ltd., Kingswinford. #2745

304. Horwell, D., Pritchard, M., Raphy, J., & Ratcliffe, G. (1996) "Targeted" molecular diversity: Design and development of non-peptide antagonists for cholecystokinin and tachykinin receptors. Immunopharmacology, 33, 68-72. #5515

305. Horwell, D.C., Pritchard, M., Raphy, J., & Ratcliffe, G.S. (1996) Targeted molecular diversity: Design and development of non-peptide anatagonists for cholecystokinin and tachykinin receptors. Immunopharmacology, 33, 68-72. #12094

306. Houghten, R.A., Blondelle, S.E., Dooley, C.T., Dorner, B., Eichler, J., & Ostresh, J.M. (1996) Libraries from libraries: Generation and comparison of screening profiles. Mol. Diversity, 2, 41-45. #4837 (Available on Internet)

307. Houghten, R.A., Dooley, C.T. & Ostresh, J.M. (1996) The use of soluble polyamine combinatorial libraries for the identification of potent opioid receptor active compounds. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 278-280). Mayflower Scientific Ltd., Kingswinford. #5039

308. Houston, M.E.Jr., Wallace, A., Bianchi, E., Pessi, A., & Hodges, R.S. (1996) Use of a conformationally restricted secondary structural element to display peptide libraries: A two-stranded alpha- helical coiled-coil stabilized by lactam bridges. J. Mol. Biol., 262, 270-282. #5494

309. Howard, S.P., Meiklejohn, H.G., Shivak, D., & Jahagirdar, R. (1996) A tonB-like protein and a novel membrane protein containing an ATP-binding cassette function together in exotoxin secretion. Mol. Microbiol., 22, 595-604. #8142

310. Hruby, V.J. (1996) Synthesis of peptide libraries for lead structure screening. In C.A. Wermuth (Ed.), The Practice of Medicinal Chemistry. (pp. 135-151). Academic Press Limited, New York. #4613

311. Hruby, V.J., Shenderovich, M., Lam, K.S., & Lebl, M. (1996) Design considerations and computer modeling related to the development of molecular scaffolds and peptide mimetics for combinatorial chemistry. Mol. Diversity, 2, 46-56. #5324 (Available on Internet)

312. Hsieh-Wilson, L.C., Xiang, X.D., & Schultz, P.G. (1996) Lessons from the immune system: From catalysis to material science. Account. Chem. Res., 29, 164-170. #3995

313. Hsieh, K.H., Demaine, M.M., & Gurusidaiah, S. (1996) Side reactions in solid-phase peptide synthesis and their applications. Int. J. Peptide Prot. Res., 48, 292-298. #5497

314. Hua, T.D., Lamaty, F., Souriau, C., Rolland-Fulcrand, V., Lazaro, R., Viallefont, P., Lefranc, M.P., & Weill, M. (1996) Specific recognition of a tetrahedral phosphonamidate transition state analogue group by a recombinant antibody Fab fragment. Amino Acids, 10, 167-172. #4572

315. Huang, P.Y., Baumbach, G.A., Dadd, C.A., Buettner, J.A., Masecar, B.L., Hentsch, M., Hammond, D.J., & Carbonell, R.G. (1996) Affinity purification of von Willebrand factor using ligands derived from peptide libraries. Bioorg. Med. Chem., 4, 699-708. #4628

316. Hudlicky, T., Abboud, K.A., Entwistle, D.A., Fan, R.L., Maurya, R., Thorpe, A.J., Bolonick, J., & Myers, B. (1996) Toluene-dioxygenase-mediated cis-dihydroxylation of aromatics in enantioselective synthesis. Iterative glycoconjugate coupling strategy and combinatorial design for the synthesis of oligomers of nor-saccharides, inositols and pseudosugars with interesting molecular properties. Synthesis-Stuttgart, 897-911. #6696 4154

317. Hutchins, S.M., & Chapman, K.T. (1996) Fischer indole synthesis on a solid support. Tetrahedron Lett., 37, 4869-4872. #4901

318. Hutchins, S.M., & Chapman, K.T. (1996) Solid phase synthesis of tetrahydroisoquinolines & tetrahydroimidazopyridines. Tetrahedron Lett., 37, 4865-4868. #4900

319. Iorio, E.J., & Still, W.C. (1996) Macrocyclic triamines as linkers in two-armed receptors for peptides. Bioorg. Med. Chem. Lett., 6, 2673-2676. #5739

320. Ivanetich, K.M., & Santi, D.V. (1996) Preparation of equimolar mixtures of peptides by adjustment of activated amino acid concentrations. Methods Enzymol., 267, 247-260. #4787

321. Jacobsson, K., & Frykberg, L. (1996) Phage display shot-gun cloning of ligand-binding domains of prokaryotic receptors approaches 100% correct clones. BioTechniques, 20, 1070-1081. #4604

322. James, I. (1996) Solid Phase Chemistry Publications. Chiron Mimotopes, Clayton Victoria. #5563

323. Janda, K.D., & Han, H. (1996) Combinatorial chemistry: A liquid-phase approach. Methods Enzymol., 267, 234-246. #3635

324. Janzen, B., & Domanico, P. (1996) The 384-well plate: Pros and cons. J. Biomol. Screen., 1, 63-64. #10043

325. Janzen, W.P. (1996) High throughput screening as a discovery tool in the pharmaceutical industry. Lab. Robotics Automation, 8, 261-265. #9973

326. Jaume, J.C., Portolano, S., Rapoport, B., & McLachlan, S.M. (1996) Influence of the light chain repertoire on immunoglobulin genes encoding thyroid autoantibody Fab from combinatorial libraries. Autoimmunity, 24, 11-23. #5593

327. Jette, D.C., Kreutz, F.T., Malcolm, B.A., Wishart, D.S., Noujaim, A.A., & Suresh, M.R. (1996) Epitope-mapping of prostate-specific antigen with monoclonal antibodies. Clin. Chem., 42, 1961-1969. #8155

328. Jin, H., Li, B., Cunningham, B., Tom, J., Yang, R., Sehl, P., Thomas, G.R., Ko, A., Oare, D., & Lowe, D.G. (1996) Novel analog of atrial natriuretic peptide selective for receptor-A produces increased diuresis and natriuresis in rats. J. Clin. Invest., 98, 969-976. #5476

329. Jindal, S. (1996) Automated target-based screening of soluble libraries. In K. Emory & J. Schlegel (Eds.), Cost-Effective Strategies for Automated and Accelerated High- Throughput Screening. Biomedical Library Series, Southborough. #5138

330. Jiracek, J., Yiotakis, A., Vincent, B., Checler, F., & Dive, V. (1996) Development of the first potent and selective inhibitor of the zinc endopeptidase neurolysin using a systematic approach based on combinatorial chemistry of phosphinic peptides. Journal of Biological Chemistry, 271, 19606-19611. #5087

331. Johnson, C.R. & Zhang, B. (1996) Horner-Wadsworth-Emmons alkene synthesis on solid phase monitoring by (31)P gel phase NMR. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 429-430). Mayflower Scientific Limited, Birmingham. #8965

332. Johnson, C.R. & Zhang, B. (1996) Macrocycle synthesis on solid supports using the Horner-Wadsworth-Emmons reaction. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. ORGN-125. American Chemical Society,Washington,D, #6775

333. Jolley, M.E. (1996) Fluorescence polarization assays for the detection of proteases and their inhibitors. J. Biomol. Screen., 1, 33-38. #10040

334. Jongsma, M.A., Stiekema, W.J., & Bosch, D. (1996) Combatting inhibitor-insensitive proteases if insect pests. Trends Biotech., 14, 331-333. #5477

335. Jung, G., Niedermann, G., Eichmann, K., Uebel, S., Tampe, R., Walden, P., Ihlenfeldt, H.G., Kraas, W., Kienle, S. & Wiesmuller, K.H. (1996) Processing, transport and MHC restricted presentation of antigens studied by peptide libraries. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 761-763). Mayflower Scientific Ltd., Kingswinford. #5050

336. Jung, G., Hofstetter, H., Feiertag, S., Stoll, D., Hofstetter, O., Wiesmuller, K.H., & Schurig, V. (1996) Cyclopeptide libraries as new chiral selectors in capillary electrophoresis. Angew. Chem. Int. Ed., 35, 2148-2150. #5552

337. Jung, G. (1996) Combinatorial Peptide and Nonpeptide Libraries: A Handbook. VCH, Weinheim;New York. ISBN 3527293809 #8474

338. Jung, G. (1996) Natural peptide libraries of microbial and mammalian origin. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 1-18). VCH, Weinheim. #8169

339. Jung, K.W., Zhao, X.Y., & Janda, K.D. (1996) A linker that allows efficient formation of aliphatic C-H bonds on polymeric supports. Tetrahedron Lett., 37, 6491-6494. #5250

340. Kaldor, S.W., Siegel, M.G., Fritz, J.E., Dressman, B.A., & Hahn, P.J. (1996) Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries. Tetrahedron Lett., 37, 7193-7196. #5531

341. Kaldor, S.W., Fritz, J.E., Tang, J., & McKinney, E.R. (1996) Discovery of antirhinoviral leads by screening a combinatorial library of ureas prepared using covalent scavengers. Bioorg. Med. Chem. Lett., 6, 3041-3044. #8260

342. Kar, S., Ghosh, R.K., Ghosh, A.N., & Ghosh, A. (1996) Integration of the DNA of a novel filamentous bacteriophage VSK from Vibrio cholerae 0139 into the host chromosomal DNA. FEMS Microbiol. Lett., 145, 17-22. #8149

343. Kaspari, A., Schierhorn, A., & Schutkowski, M. (1996) Solid-phase synthesis of peptide-4-nitroanilides. Int. J. Peptide Prot. Res., 48, 486-494. #8183

344. Kast, P., & Hilvert, D. (1996) Genetic selection strategies for generating and characterizing catalysts. Pure Appl. Chem., 68, 2017-2024. #8136

345. Kast, P., Asif-Ullah, M., Jiang, N., & Hilvert, D. (1996) Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: The importance of electrostatic catalysis. Proc. Natl. Acad. Sci. USA, 93, 5043-5048. #4532

346. Kates, S.A., Triolo, S.A., Griffin, G.W., Herman, L.W., Tarr, G., Sole, N.A., Diekmann, E., El-Faham, A., Ionescu, D., Albericio, F. & Carpino, L.A. (1996) Advances in the use of onium-based coupling reagents: Application for solid phase peptide synthesis and combinatorial libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 41-50). Mayflower Scientific Limited, Birmingham. #8896

347. Katz, B.A., Liu, B., & Cass, R. (1996) Structure-based design tools: Structural and thermodynamic comparison with biotin of a small molecule that binds to streptavidin with micromolar affinity. J. Amer. Chem. Soc., 118, 7914-7920. #5482

348. Kay, B. (1996) Screening phage-displayed random peptide libraries for peptide antagonists. In K. Emory & J. Schlegel (Eds.), Cost-Effective Strategies for Automated and Accelerated High- Throughput Screening. Biomedical Library Series, Southborough. #5139

349. Kay, B.K., & Paul, J.I. (1996) High-throughput screening strategies to identify inhibitors of protein protein interactions. Mol. Diversity, 1, 139-140. #3864 (Available on Internet)

350. Kay, B.K. & Hoess, R.H. (1996) Principles and applications of phage display. In Anonymous, Phage Display of Peptides and Proteins. (pp. 21-34). #8446

351. Kayushin, A.L., Korosteleva, M.D., Miroshnikov, A.I., Kosch, W., Zubov, D., & Piel, N. (1996) A convenient approach to the synthesis of trinucleotide phosphoramidites. Synthons for the generation of oligonucleotide/peptide libraries. Nucl. Acid. Res., 24, 3748-3755. #5599

352. Keating, T.A., & Armstrong, R.W. (1996) Postcondensation modifications of Ugi four-component condensation products: 1-Isocyanocyclohexene as a convertible isocyanide. Mechanism of conversion, synthesis of diverse structures, and demonstration of resin capture. J. Amer. Chem. Soc., 118, 2574-2583. #5561

353. Keating, T.A., & Armstrong, R.W. (1996) A remarkable two-step synthesis of diverse 1,4-benzodiazepine-2,5-diones using the Ugi four-component condensation. J. Org. Chem., 61, 8935-8939. #10063

354. Keene, J.D. (1996) The first combinatorial library. Scientist, 10, 13-13. #5279

355. Keene, J.D. (1996) Randomization and selection of RNA to identify targets from RRM RNA-binding proteins and antibodies. Methods Enzymol., 267, 367-383. #4793

356. Keifer, P.A., Baltusis, L., Rice, D.M., Tymiak, A.A., & Shoolery, J.N. (1996) A comparison of NMR spectra obtained for solid-phase-synthesis resins using conventional high-resolution, magic-angle-spinning, and high-resolution magic-angle-spinning probes. J. Magn. Resonance, 119, 65-75. #6835 4340

357. Keifer, P.A. (1996) Influence of resin structure, tether length, and solvent upon the high-resolution (1)H NMR spectra of solid-phase-synthesis resins. J. Org. Chem., 61, 1558-1559. #4128

358. Keilholz, W., Stevanovic, S., Arnold, D. & Rammensee, H.G. (1996) C-Terminal sequence analysis of peptides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 441-444). Mayflower Scientific Limited, Birmingham. #9025

359. Keilholz, W. & Stevanovic, S. (1996) Multiple sequence analysis of natural and synthetic peptide libraries. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 287-301). VCH, Weinheim. #8175

360. Kelly, M.A., Liang, H., Sytwu, I.I., Vlattas, I., Lyons, N.L., Bowen, B.R., & Wennogle, L.P. (1996) Characterization of SH2. Ligand interactions via library affinity selection with mass spectrometric detection. Biochemistry, 35, 11747-11755. #5396

361. Kempe, M. & Barany, G. (1996) Novel highly cross-linked supports for solid-phase applications. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 191-194). Mayflower Scientific Limited, Birmingham. #8921

362. Keough, T., Shaffer, J.D., Lacey, M.P., Riley, T.A., Marvin, W.B., Scurria, M.A., Hasselfield, J.A., & Hesselberth, E.P. (1996) Detailed characterization of antisense DNA oligonucleotides. Anal. Chem., 68, 3405-3412. #5546

363. Khmelnitsky, Y.L., Michels, P.C., Dordick, J.S. & Clark, D.S. (1996) Generation of solution-phase libraries of organic molecules by combinatorial biocatalysis. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 144-157). American Chemical Society, Washington,DC. #5104

364. Khosla, C., & Zawada, R.J.X. (1996) Generation of polyketide libraries via combinatorial biosynthesis. Trends Biotech., 14, 335-341. #5478

365. Kibbey, C.E. (1996) Quantitation of combinatorial libraries of small organic molecules by normal-phase HPLC with evaporative light-scattering detection. Mol. Diversity, 1, 247-258. #5335 (Available on Internet)

366. Kim, J.M., Bi, Y., Paikoff, S.J., & Schultz, P.G. (1996) The solid phase synthesis of oligoureas. Tetrahedron Lett., 37, 5305-5308. #5083

367. Kim, J.M., Wilson, T.E., Norman, T.C., & Schulz, P.G. (1996) Synthesis of a cyclic urea as a nonnatural biopolymer scaffold. Tetrahedron Lett., 37, 5309-5312. #5084

368. Kim, R.M., Manna, M., Hutchins, S.M., Griffin, P.R., Yates, N.A., Bernick, A.M., & Chapman, K.T. (1996) Dendrimer-supported combinatorial chemistry. Proc. Natl. Acad. Sci. USA, 93, 10012-10017. #5395

369. Kim, S.U., & Lee, E.J. (1996) What is combinatorial chemistry. Hwahak Sekye, 36, 35-44. #6860

370. Klussmann, S., Nolte, A., Bald, R., Erdmann, V.A., & Furste, J.P. (1996) Mirror-image RNA that binds D-adenosine. Nat. Biotech., 14, 1112-1115. #5399

371. Knill, E., Schliep, A., & Torney, D.C. (1996) Interpretation of pooling experiments using the Markov chain Monte Carlo method. J. Comput. Biol., 3, 395-406. #8147

372. Kobayashi, S., Hachiya, I., Suzuki, S., & Moriwaki, M. (1996) Polymer-supported silyl enol ethers. Synthesis and reactions with imines for the preparation of an amino alcohol library. Tetrahedron Lett., 37, 2809-2812. #4607

373. Kobayashi, S., Nagayama, S., & Busujima, T. (1996) Polymer scandium-catalyzed three-component reactions leading to diverse amino ketone, amino ester, and amino nitrile derivatives. Tetrahedron Lett., 37, 9221-9224. #8168

374. Kobayashi, S., & Nagayama, S. (1996) A new methodology for combinatorial synthesis. Preparation of diverse quinoline derivatives using a novel polymer-supported scandium catalyst. J. Amer. Chem. Soc., 118, 8977-8978. #5584

375. Kobayashi, S., Hachiya, I., & Yasuda, M. (1996) Aldol reactions on solid phase. Sc(OTf)3-Catalyzed Aldol reactions of polymer-supported silyl enol ethers with aldehydes providing convenient methods for the preparation of 1,3-diol, b-hydroxy carboxylic acid, and b-hydroxy aldehyde libraries. Tetrahedron Lett., 37, 5569-5572. #5079

376. Kobayashi, S., Moriwaki, M., Akiyama, R., Suzuki, S., & Hachiya, I. (1996) Parallel synthesis using Mannich-type three-component reactions and "Field Synthesis" for the construction of an amino alcohol library. Tetrahedron Lett., 37, 7783-7786. #5752

377. Koh, J.S., & Ellman, J.A. (1996) Palladium-mediated three-component coupling strategy for the solid-phase synthesis og tropane derivatives. J. Org. Chem., 61, 4494-4495. #4885

378. Konings, D.A.M., Wyatt, J.R., Ecker, D.J., & Freier, S.M. (1996) Deconvolution of combinatorial libraries for drug discovery: Theoretical comparison of pooling strategies. J. Med. Chem., 39, 2710-2719. #4852

379. Kooyman, D.L., McClellan, S.B., Parker, W., Avissar, P.L., Velardo, M.A., Platt, J.L., & Logan, J.S. (1996) Identification and characterization of a galactosyl peptide mimetic: Implications for use in removing xenoreactive anti-A Gal antibodies. Transplantation, 61, 851-855. #4589

380. Kooyman, D.L., McClellan, S.B., Parker, W.R., Avissar, P.L., Velardo, M.A., Nielsen, D.H., Platt, J.L., & Logan, J.S. (1996) Identification and characterization of a peptide mimeotope of galactose a 1,3 galactose. Transplant. Proc., 28, 554-554. #4571

381. Kowalski, J., & Lipton, M.A. (1996) Solid phase synthesis of a diketopiperazine catalyst contatining the unnatural amino acid (S)-norarginine. Tetrahedron Lett., 37, 5839-5840. #5233

382. Kozal, M.J., Shah, N., Shen, N., Yang, R., Fucini, R., Merigan, T.C., & et al. (1996) Extensive polymorphism observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nat. Med., 2, 753-759. #11100

383. Krchnak, V., Weichsel, A.S., Issakova, O., Lam, K.S., & Lebl, M. (1996) Bifunctional scaffolds as templates for synthetic combinatorial libraries. Mol. Diversity, 1, 177-182. #4803 (Available on Internet)

384. Krchnak, V., & Lebl, M. (1996) Synthetic library techniques: Subjective (biased and generic) thoughts and views. Mol. Diversity, 1, 193-216. #4806 (Available on Internet)

385. Krchnak, V., Weichsel, A.S., Cabel, D., Flegelova, Z., & Lebl, M. (1996) Structurally homogenous and heterogenous synthetic combinatorial libraries. Mol. Diversity, 1, 149-164. #4801 (Available on Internet)

386. Krchnak, V., Sepetov, N.F., Kocis, P., Patek, M., Lam, K.S. & Lebl, M. (1996) Combinatorial libraries of synthetic structures: Synthesis, screening, and structure determination. In R. Cortese (Ed.), Combinatorial Libraries: Synthesis, Screening and Application Potential. (pp. 27-52). Walter de Gruyter, Berlin. #2430

387. Krchnak, V., Weichsel, A.S., Cabel, D. & Lebl, M. (1996) Structurally homogenous and heterogenous libraries: Scaffold- based libraries and libraries built using bifunctional building blocks. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 99-117). American Chemical Society, Washington,DC. #5101

388. Krchnak, V. & Lebl, M. (1996) MARS: Multiple automatic robot synthesizer featuring a novel timing procedure and random access to reagents and reaction vessels. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 93-96). Mayflower Scientific Limited, Birmingham. #6934 3656

389. Krchnak, V., Vagner, J., Flegelova, Z., Weichsel, A.S., Barany, G. & Lebl, M. (1996) Use of solid-phase Mitsunobu and Wittig reactions for contruction of peptide and non-peptide libraries. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 307-308). Mayflower Scientific Ltd., Kingswinford. #3640

390. Krebber, A., Burmester, J., & Pluckthun, A. (1996) Inclusion of an upstream transcriptional terminator in phage display vectors abolishes background expression of toxic fusions with coat protein g3p. Gene, 178, 71-74. #8152

391. Kreissig, S., Schuddekopf, K., Dear, N., & Boehm, T. (1996) Expression of peptides encoded by exons in cloned mammalian DNA. Nucl. Acid. Res., 24, 4358-4359. #8145

392. Krieger, J.H. (1996) New software kicks in. Web technology and drugs discovery power fast-moving development efforts in computational chemistry software. C&EN, 30-37. #5257

393. Kuebler, P.J., & Nixon, D.F. (1996) Cytotoxic T cell induction with ratchet peptide libraries. Vaccine, 14, 1664-1670. #8238

394. Kumar, P.K.R., Nishikawa, S., & Nakamura, Y. (1996) Evolutionary molecular engineering in Japan. Mol. Diversity, 1, 135-138. #4123 (Available on Internet)

395. Kurth, M.J. (1996) Solid-phase chemistry: A C-C bond focus. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-153. American Chemical Society,Washington,D, #6968

396. Kurth, M.J., Randall, L.A.A., & Takenouchi, K. (1996) Solid-phase combinatorial synthesis of polyisoxazolines: A two-reaction iterative protocol. J. Org. Chem., 61, 8755-8761. #8538

397. Labadie, J.W., Deegan, T.L., Gooding, O.W., Heisler, K., Newcomb, W.S., Porco, J.A.Jr., Tran, T.H. & van Eikeren, P. (1996) New poly(styrene-oxyethylene) graft copolymers as supports for solid-phase organic synthesis. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. PMSE-250. American Chemical Society,Washington,D, #6973

398. Laisney, I.L., Benjamin, H., Gefter, M., & Strosberg, A.D. (1996) Permissive residues within the minimal epitopes of neutralizing monoclonal antibodies to the V3 loop of HIV-1. Eur. J. Immunol., 26, 1634-1640. #5136

399. Lam, K.S., Lou, Q., Wu, J., Salmon, S.E. & Phan, H. (1996) Identification and characterization of a novel peptide substrate for P60(c-src) protein tyrosine kinase using a one-bead one-bead combinatorial peptide library method. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 287-289). Mayflower Scientific Ltd., Kingswinford. #5042

400. Lam, K.S. (1996) International conference on combinatorial library methods for basic research and drug discovery. Mol. Diversity, 2, 1-1. #8159

401. Lam, K.S., & Lebl, M. (1996) Synthesis and screening of a "one-bead-one-compound" combinatorial peptide library. Methods Mol. Cell. Biol., 6, 15-25. #8598

402. Lam, K.S., Lou, Q., Zhao, Z.G., Chen, M.L., Salmon, S.E., Wade, S. & Lebl, M. (1996) Identification and applications of idiotype-specific peptides for two murine B-cell lymphoma cell lines. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 806-807). Mayflower Scientific Ltd., Kingswinford. #5066

403. Lam, K.S., Lake, D., Salmon, S.E., Smith, J., Chen, M.L., Wade, S., Abdul-Latif, F., Leblova, Z., Ferguson, R.D., Krchnak, V., Sepetov, N.F., & Lebl, M. (1996) A one-bead one-peptide combinatorial library method for B-cell epitope mapping. Methods: A Companion to Methods in Enzymology, 9, 482-493. #5576

404. Lam, K.S. (1996) Application of the "one-bead one-compound" combinatorial library method in basic research and drug discovery. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. I&EC-10. American Chemical Society,Washington,D, #6979

405. Lam, K.S. & Lebl, M. (1996) Combinatorial library based on the one-bead-one-compound concept. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 173-201). VCH, Weinheim. #2428

406. Lang, I.M., Chuang, T.L., Barbas, C.F., & Schleef, R.R. (1996) Purification of storage granule protein-23. A novel protein identified by phage display technology and interaction with type 1 plasminogen activator inhibitor. Journal of Biological Chemistry, 271, 30126-30135. #8139

407. Larhed, M., Lindeberg, G., & Hallberg, A. (1996) Rapid microwave-assisted Suzuki coupling on solid-phase. Tetrahedron Lett., 37, 8219-8222. #5744

408. Lato, S.M., & Ellington, A.D. (1996) Screening chemical libraries for nucleic-acid-binding drugs by in vitro selection: A test case with lividomycin. Mol. Diversity, 2, 103-110. #5329 (Available on Internet)

409. Lavoie, A., Cantin, A.M. & Escher, E. (1996) Development of b-lactam peptides for elastase inhibition in cystic fibrosis. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 297-298). Mayflower Scientific Ltd., Kingswinford. #2748

410. Lebl, M., Krchnak, V., Strop, P. & Lam, K.S. (1996) Construction and screening of peptide and nonpeptide libraries based on one-bead-one-compound principle. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 890-892). Mayflower Scientific Ltd., Kingswinford. #5057

411. Lebl, M., Krchnak, V., Patek, M., & Lam, K.S. (1996) Synthetic combinatorial libraries of scaffolded and unordered structures. Methods Mol. Cell. Biol., 6, 41-55. #7005 3847

412. LeCocq, J. (1996) Gryphon sciences: Combinatorial chemistry play with a twist. Bioventure View, 1-7. #4995

413. Lehmann, J., & et al. (1996) Redesigning drug discovery. Nature, 384, 1-5. #10864

414. Leon, S. (1996) Playing the chemical lottery. Chem. Ind. -London, 463-464. #7018

415. Lescrinier, T., Busson, R., Rozenski, J., Janssen, G., van Aerschot, A., & Herdewijn, P. (1996) Incorporation of 5-hydroxytryptophan in oligopeptides. Tetrahedron, 52, 6965-6972. #4608

416. Letulle, M.M., Collins, N., Davis, P., Knapp, R., Lee, K., Yamamura, H., Porreca, F. & Hruby, V.J. (1996) Solid phase synthesis of a directed small organic library: Discovery of a new class of delta opioid drug lead. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 281-284). Mayflower Scientific Limited, Birmingham. #8935

417. Leung, P.S.C., Cha, S., Joplin, R.E., Galperin, C., VandeWater, J., Ansari, A.A., Coppel, R.L., Schatz, P.J., Cwirla, S., Fabris, L.E., Neuberger, J.M., & Gershwin, M.E. (1996) Inhibition of PDC-E2 human combinatorial autoantibodies by peptide mimotopes. J. Autoimmun., 9, 785-793. #8248

418. Ley, A.C., Markland, W., & Ladner, R.C. (1996) Obtaining a family of high-affinity, high-specificity protein inhibitors of plasmin and plasma kallikrein. Mol. Diversity, 2, 119-124. #5332 (Available on Internet)

419. Li, J. (1996) CAMD in modern drug discovery. Drug Disc. Today, 1, 311-312. #5280

420. Liang, R., Yan, L., Loebach, J., Ge, M., Uozumi, Y., Sekanina, K., Horan, N., Gildersleeve, J., Thompson, C., Smith, A., Biswas, K., Still, W.C., & Kahne, D. (1996) Parallel synthesis and screening of a solid phase carbohydrate library. Science, 274, 1520-1522. #8666

421. Liang, R., Yan, L., Loebach, J., Uozumi, Y., Ge, M., Horan, N., Gildersleeve, J., Thompson, C. & Smith, A. (1996) Polymer-supported carbohydrate libraries. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-4. American Chemical Society,Washington,D, #7041

422. Licitra, E.J., & Liu, J.O. (1996) A three-hybrid system for detecting small ligand-protein receptor interactions. Proc. Natl. Acad. Sci. USA, 93, 12817-12821. #8153

423. Light, J., Maki, R., & Assamunt, N. (1996) Expression cloning of cDNA by phage display selection. Nucl. Acid. Res., 24, 4367-4368. #5779

424. Lin, M., & Shapiro, M.J. (1996) Mixture analysis in combinatorial chemistry. Application of diffusion-resolved NMR spectroscopy. J. Org. Chem., 61, 7617-7619. #5554

425. Lin, N.T., & Tseng, Y.H. (1996) The ori of filamentous phage phi Lf is located within the gene encoding the replication initiation protein. Biochem. Biophys. Res. Commun., 228, 246-251. #8144

426. Lin, S.K. (1996) Molecular diversity assessment: Logarithmic relations of information and species diversity and logarithmic relations of entropy and indistinguishability after rejection of Gibbs paradox of entropy of mixing. Molecules, 1, 57-67. #5581

427. Linderoth, N.A., Model, P., & Russel, M. (1996) Essential role of a sodium dodecyl sulfate-resistant protein IV multimer in assembly-export of filamentous phage. J. Bacteriol., 178, 1962-1970. #4414

428. Linnen, J., Wages, J.Jr., Zhang-Keck, Z.Y., Fry, K.E., Krawczynski, K.Z., Alter, H., Koonin, E., Gallagher, M., Alter, M., Hadziyannis, S., Karayiannis, P., Fung, K., Nakatsuji, Y., Shih, J.W.K., Young, L., Piatak, M.Jr., Hoover, C., Fernandez, J., Chen, S., Zou, J.C., Morris, T., Hyams, K.C., Ismay, S., Lifson, J.D., Hess, G., Foung, S.K.H., Thomas, H., Bradley, D., Margolis, H., & Kim, J.P. (1996) Molecular cloning and disease association of hepatitis G virus: A transfusion-transmissible agent. Science, 271, 505-508. #7058

429. Lipkowitz, K.B., & Boyd, D.B. (1996) Reviews in Computational Chemistry. VCH Publishers,Inc., New York. ISBN 0471186481 #11589

430. Liu, G., Bryant, R.T., & Hilderman, R.H. (1996) Isolation of a tripeptide from a random phage peptide library that inhibits P(1),P(4)-diadenosine 5'-tetraphosphate binding to its receptor. Biochemistry, 35, 197-201. #4718

431. Lloyd, A.W. (1996) Solid-phase synthesis in the development of small-molecule libraries. Drug Disc. Today, 1, 42-43. #7062 4378

432. Lloyd, J., Schmidt, J.B., Hunt, J.T., Barrish, J.C., Little, D.K., & Tymiak, A.A. (1996) Solid phase synthesis of phosphinic acid endothelin converting enzyme inhibitors. Bioorg. Med. Chem. Lett., 6, 1323-1326. #7063 4363

433. Lockhart, D.J., Dong, H., Byrne, M.C., Follettie, M.T., Gallo, M.V., Chee, M.S., Mittmann, M., Wang, C., Kobayashi, M., Horton, H., & Brown, E.L. (1996) Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat. Biotech., 14, 1675-1680. #8162

434. Lombardi, A., Bryson, J.W., & DeGrado, W.F. (1996) De novo design of heterotrimeric coiled coils. Biopolymers, 40, 495-504. #8367

435. Lomonossoff, G.P., & Johnson, J.E. (1996) Use of macromolecular assemblies as expression systems for peptides and synthetic vaccines. Curr. Opin. Struct. Biol., 6, 176-182. #4582

436. Loo, J.A., & DeJohn, D.E. (1996) Application of mass spectrometry for characterizing and identifying ligands from combinatorial libraries. Annu. Rep. Med. Chem., 31, 319-325. #11401

437. Look, G.C., Schullek, J.R., Holmes, C.P., Chinn, J.P., Gordon, E.M., & Gallop, M.A. (1996) The identification of cyclooxygenase-1 inhibitors from 4- thiazolidinone combinatorial libraries. Bioorg. Med. Chem. Lett., 6, 707-712. #4133

438. Lorimer, I.A.J., Keppler-Hafkemeyer, A., Beers, R.A., Pegram, C.N., Bigner, D.D., & Pastan, I. (1996) Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: Targeting with a single chain antibody variable domain isolated by phage display. Proc. Natl. Acad. Sci. USA, 93, 14815-14820. #8164

439. Lorsch, J.R. & Szostak, J.W. (1996) In vitro selection of nucleic acid sequences that bind small molecules. In R. Cortese (Ed.), Combinatorial Libraries: Synthesis, Screening and Application Potential. (pp. 69-86). Walter de Gruyter, Berlin. #4341

440. Lou, Q., Wu, J., Salmon, S.E., & Lam, K.S. (1996) Structure-activity relationship of a novel peptide substrate for p60c-src protein tyrosine kinase. Lett. Peptide Sci., 2, 289-296. #7073

441. Lou, Q., Leftwich, M.E., & Lam, K.S. (1996) Identification of GIYWHHY as a novel peptide substrate for human p60(c-src) protein tyrosine kinase. Bioorg. Med. Chem., 4, 677-682. #4625

442. Lowe, G. & Quarrell, R. (1996) Determining S(n)' specificities of serine proteinases using combinatorial peptide libraries, and evidence that enzymes can penetrate tentagel resin beads. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 291-294). Mayflower Scientific Limited, Birmingham. #8936

443. Lowik, D.W.P.M., Mulders, S.J.E., Cheng, Y., Shao, Y., & Liskamp, R.M.J. (1996) Synthetic receptors based on peptidosulfonamide peptidomimetics. Tetrahedron Lett., 37, 8253-8256. #5737

444. Lundin, K., Samuelsson, A., Jansson, M., Hinkula, J., Wahren, B., & Persson, M.A.A. (1996) Peptides isolated from random peptide libraries on phage elicit a neutralizing anti-HIV-1 response: Analysis of immunological mimicry. Immunology, 89, 579-586. #12491

445. Luo, Z.W., Wang, R.X., & Lai, L.H. (1996) RASSE: A new method for structure based drug design. Journal of Chemical Information and Computer Sciences, 36, 1187-1194. #8132

446. Lutz, J., Rudolph-Bohner, S., Moroder, L., Kolbeck, W., Osapay, G. & Goodman, M. (1996) A novel route to benzodiazepine diversomers. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 61-62). Mayflower Scientific Ltd., Kingswinford. #3031

447. Luu, T., Pham, S., & Deshpande, S. (1996) Automated multiple peptide synthesis: Improvements in obtaining quality peptides. Int. J. Peptide Prot. Res., 47, 91-97. #3988

448. MacDonald, A.A., DeWitt, S.H., Hogan, E.M., & Ramage, R. (1996) A solid phase approach to quinolones using the DIVERSOMER technology. Tetrahedron Lett., 37, 4815-4818. #4855

449. MacDonald, A.A., DeWitt, S.H., Hogan, E. & Ramage, R. (1996) Synthesis of quinolone antibiotics by DIVERSOMER(TM) technology. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 115-116). Mayflower Scientific Limited, Birmingham. #8908

450. MacDonald, A.A., Nickell, D.G., & DeWitt, S.H. (1996) Combinatorial chemistry: Quality vs. quantity. Pharmaceut. News, 3, 19-22. #8276

451. MacDonald, A.A., DeWitt, S.H., Ghosh, S., Hogan, E.M., Kieras, L., Czarnik, A.W., & Ramage, R. (1996) The impact of polystyrene resins in solid-phase organic synthesis. Mol. Diversity, 1, 183-186. #4804 (Available on Internet)

452. Maletic, M., Wennemers, H., McDonald, D.Q., Breslow, R., & Still, W.C. (1996) Selective binding of the dipeptides L-Phe-D-Pro and D-Phe-L-Pro to b-cyclodextrin. Angew. Chem. Int. Ed., 35, 1490-1492. #5180

453. Malik, P., Terry, T.D., Gowda, L.R., Langara, A., Petukhov, S.A., Symmons, M.F., Welsh, L.C., Marvin, D.A., & Perham, R.N. (1996) Role of capsid structure and membrane protein processing in determining the size and copy number of peptides displayed on the major coat protein of filamentous bacteriophage. J. Mol. Biol., 260, 9-21. #4927

454. Malik, P., & Perham, R.N. (1996) New vectors for peptide display on the surface of filamentous bacteriophage. Gene, 171, 49-51. #4849

455. Malik, P., Terry, T.D. & Perham, R.N. (1996) Multiple display of foreign peptide epitopes on filamentous bacteriophage virions. In Anonymous, Phage Display of Peptides and Proteins. (pp. 127-139). #8450

456. Marchand-Brynaert, J., Bouchet, M., Touillaux, R., Beauve, C., & Fastrez, J. (1996) Design and synthesis of a bifunctional label for selection of beta-lactamase displayed on filamentous bacteriophage by catalytic activity. Tetrahedron, 52, 5591-5606. #4588

457. Markiewicz, M., Astriab, A., & Markiewicz, W.T. (1996) Application of a synthetic oligonucleotide combinatorial library in triplex DNA studies. Collect. Czech. Chem. Commun., 61, S120-S121. #5261

458. Markiewicz, W.T., Markiewicz, M., Astriab, A., & Godzina, P. (1996) Studies on the synthesis and applications of synthetic oligonucleotide combinatorial libraries. Collect. Czech. Chem. Commun., 61, S315-S318. #5259

459. Markland, W., Roberts, B.L., & Ladner, R.C. (1996) Selection for protease inhibitors using bacteriophage display. Methods Enzymol., 267, 28-51. #4775

460. Marsh, I., Smith, H., Leblanc, C. & Bradley, M. (1996) Solid phase polyamine linkers: Synthesis and combinatorial utility. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 111-114). Mayflower Scientific Limited, Birmingham. #8907

461. Marsh, I.R., Smith, H., & Bradley, M. (1996) Solid phase polyamine linkers. Their utility in synthesis and the preparation of directed libraries against trypanothione reductase. J. Chem. Soc. Chem. Commun., 941-942. #7121

462. Martin, E.L., Rens-Domiano, S., Schatz, P.J., & Hamm, H.E. (1996) Potent peptide analogues of a G protein receptor-binding region obtained with a combinatorial library. Journal of Biological Chemistry, 271, 361-366. #3728

463. Martin, Y.C. (1996) Opportunities for computational chemists afforded by the new strategies in drug discovery: An opinion. Net. Sci., 2, #10031 (Available on Internet)

464. Marzinzik, A.L., & Felder, E.R. (1996) Solid support synthesis of highly functionalized pyrazoles and isoxazoles; scaffolds for molecular diversity. Tetrahedron Lett., 37, 1003-1006. #3881

465. Matsushita, S., Nishi, T., Oiso, M., Yamaoka, K., Yone, K., Kanai, T., & Nishimura, Y. (1996) HLA-DQ-binding peptide motifs.1. Comparative binding analysis of type II colagen-derived peptides to DR and DQ molecules of rheumatoid arthritis-susceptible and non-susceptible haplotypes. Int. Immunol., 8, 757-764. #4973

466. Mattheakis, L.C., Dias, J.M., & Dower, W.J. (1996) Cell-free synthesis of peptide libraries displayed on polysomes. Methods Enzymol., 267, 195-210. #4784

467. Maulik, S., & Patel, S.D. (1996) Molecular Biotechnology: Therapeutic applications and strategies. Liss Publication, New York. ISBN 0471116815 #11590

468. Mayer, J.P., Bankaitis-Davis, D., Zhang, J., Beaton, G., Bjergarde, K., Andersen, C.M., Goodman, B.A., & Herrera, C.J. (1996) Application of the Pictet-Spengler reaction in combinatorial chemistry. Tetrahedron Lett., 37, 5633-5636. #5132

469. Mayer, J.P., Zhang, J., Bjergarde, K., Lenz, D.M., & Gaudino, J.J. (1996) Solid phase synthesis of 1,4-benzodiazepine-2,5-diones. Tetrahedron Lett., 37, 8081-8084. #7140 4510

470. McBride, J.D., Harbeck, B., & Leatherbarrow, R.J. (1996) Resin-coupled cyclic peptides as proteinase inhibitors. Protein Peptide Lett., 3, 193-198. #5343

471. McBride, J.D., Freeman, N., Domingo, G.J., & Leatherbarrow, R.J. (1996) Selection of chymotrypsin inhibitors from a conformationally-constrained combinatorial peptide library. J. Mol. Biol., 259, 819-827. #4846

472. McBride, J.D., Freeman, N., Domingo, G.J. & Leatherbarrow, R.J. (1996) Selection of proteinase inhibitors from a conformationally-constrained combinatorial peptide library. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 465-468). Mayflower Scientific Limited, Birmingham. #8970

473. McCafferty, J. (1996) Phage display: Factors affecting panning efficiency. In Anonymous, Phage Display of Peptides and Proteins. (pp. 261-276). #8455

474. McCarty, J.S., Rudiger, S., Schonfeld, H.J., Schneider-Mergener, J., Nakahigashi, K., Yura, T., & Bukau, B. (1996) Regulatory region C of the E. coli heat shock transcription factor, sigma32, constitutes a DnaK binding site and is conserved among eubacteria. J. Mol. Biol., 256, 829-837. #4724

475. McConnell, S.J., Uveges, A.J., Fowlkes, D.M., & Spinella, D.G. (1996) Construction and screening of M13 phage libraries displaying long random peptides. Mol. Diversity, 1, 165-176. #4802 (Available on Internet)

476. McDewitt, J.P., & Lansbury, P.T.J. (1996) Glycosamino acids: New building blocks for combinatorial synthesis. J. Amer. Chem. Soc., 118, 3818-3828. #4569

477. McGuinness, B.T., Walter, G., Fitzgerald, K., Schuler, P., Mahohey, W., Duncan, A.R., & Hoogenboom, H.R. (1996) Phage diabody repertoires for selection of large numbers of bispecific antibody fragments. Nat. Biotech., 14, 1149-1154. #5474

478. McNamee, D. (1996) Industry benefits as chemical libraries grow. Lancet, 347, 890-890. #7158

479. Mecchia, M., Casato, M., Tafi, R., Filocamo, G., Bonomo, L., Fiorilli, M., Cortese, R., Migliaccio, G., & Nicosia, A. (1996) Nonrheumatoid IgM in human hepatitis C virus-associated type II cryoglobulinemia recognize mimotopes of the CD4-like LAG-3 protein. Journal of Immunology, 157, 3727-3736. #5594

480. Mennuni, C., Santini, C., Dotta, F., Farilla, L., Dimario, U., Fierabracci, A., Bottazzo, G., Cortese, R., & Luzzago, A. (1996) Selection of phage-displayed peptides mimicking type 1 diabetes- specific epitopes. J. Autoimmun., 9, 431-436. #4894

481. Metzger, J.W., Wiesmuller, K.H., Kienle, S., Brunjes, J. & Jung, G. (1996) Mass spectrometric analysis of peptide libraries. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 247-285). VCH, Weinheim. #8174

482. Meyers, H.V., Dilley, G.J., Powers, T.S., Winssinger, N.A., & Pavia, M.R. (1996) Versatile method for parallel synthesis. Methods Mol. Cell. Biol., 6, 67-73. #9837 3847

483. Miceli, R.M., Myszka, D.G., Peishoff, C.E. & Chaiken, I.M. (1996) Phage expression of a de novo designed coiled coil stem loop miniprotein scaffold for constrained peptide library display. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 172-187). American Chemical Society, Washington,DC. #5106

484. Mikawa, Y.G., Maruyama, I.N., & Brenner, S. (1996) Surface display of proteins on bacteriophage lambda heads. J. Mol. Biol., 262, 21-30. #5499

485. Miller, J.L., & Lyle, V.A. (1996) Mimotope anti-mimotope probing of structural relationships in platelet glycoprotein Ib alpha. Proc. Natl. Acad. Sci. USA, 93, 3565-3569. #4583

486. Mjalli, A.M.M. & Toyonaga, B.E. (1996) Polymer-supported chemistry: Synthesis of small ring heterocycles. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 70-80). American Chemical Society, Washington,DC. #3648

487. Mjalli, A.M.M., & Harris, A.L. (1996) Lead generation using combinatorial chemistry in drug discovery. J. Biomol. Screen., 1, 17-18. #10036

488. Mjalli, A.M.M., Sarshar, S., & Baiga, T.J. (1996) Solid phase synthesis of pyrroles derived from a four component condensation. Tetrahedron Lett., 37, 2943-2946. #4750

489. Mjalli, A.M.M. & Toyonaga, B.E. (1996) Application of solid phase synthesized small molecule libraries in drug discovery. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. BIOT-119. American Chemical Society,Washington,D, #7211

490. Moates, F.C., Somani, M., Annamalai, J., Richardson, J.T., Luss, D., & Willson, R.C. (1996) Infrared thermographic screening of combinatorial libraries of heterogenous catalysts. Ind. Eng. Chem. Res., 35, 4801. #11218

491. Mohan, R., Chou, Y.L., & Morrissey, M.M. (1996) Pictet-Spengler reaction on solid support: Synthesis of 1,2,3,4-tetrahydro-b-carboline libraries. Tetrahedron Lett., 37, 3963-3966. #4600

492. Molineaux, C.J., Goodwin, W., Chai, L., Zhang, X. & Israel, D.I. (1996) A high-throughput functional assay for G-protein-coupled receptors: Method for screening combinatorial libraries. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 273-283). American Chemical Society, Washington,DC. #5118

493. Mollah, A.K., Aleman, M.A., Albright, R.A., & Mossing, M.C. (1996) Core packing defects in an engineered Cro monomer corrected by combinatorial mutagenesis. Biochemistry, 35, 743-748. #4616

494. Moore, M. (1996) Attack as the best form of defense: Natural products in the forefront of contemporary drug research. J. Biomol. Screen., 1, 19-21. #10037

495. Moos, W.H. (1996) Combinatorial chemistry: A "molecular diversity space" Odyssey approaches 2001. Pharmaceut. News, 3, 23-26. #8277

496. Moos, W.H., & Okajima, N. (1996) Molecular diversity. Kagaku, 51, 472. #8212

497. Moroder, L., Lutz, J., Grams, F., Rudolph-Bohner, S., Osapay, G., Goodman, M., & Kolbeck, W. (1996) A new efficient method for the synthesis of 1,4-benzodiazepine-2, 5-dione diversomers. Biopolymers, 38, 295-295. #5560

498. Muir, T.W., Dawson, P.E., Fitzgerald, M.C., & Kent, S.B.H. (1996) Probing the chemical basis of binding activity in an SH3 domain by protein signature analysis. Chem. Biol., 3, 817-825. #8148

499. Muller, K., Gombert, F.O., Manning, U., Grossmuller, F., Graff, P., Zaegel, H., Zuber, J.F., Freuler, F., Tschopp, C., & Baumann, G. (1996) Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting. Journal of Biological Chemistry, 271, 16500-16505. #4969

500. Murphy, M.M., Schullek, J.R., Gordon, E.M., & Gallop, M.A. (1996) Combinatorial organic synthesis of highly functionalized pyrrolidines: Identification of a potent angiotensin converting enzyme inhibitor from a mercaptoacyl proline library. J. Amer. Chem. Soc., 118, 714-714. #4320

501. Musser, J.H., Fugedi, P., Anderson, M.B., Rao, N., Peto, C., Tyrrell, D., Holme, K., & Tressler, R. (1996) Carbohydrates as a source of molecular diversity for drug discovery. Drug News Perspect., 9, 133-141. #4531

502. Myers, P. (1996) Combinatorial chemistry: The road to Hitsville? Pharmaceut. News, 3, 16-18. #8275

503. Myers, P. L. A totally integrated approach to combinatorial chemistry. In: Anonymous. (Eds.) Zymark Corporation, Hopkinton, MA Proceedingds of the International Symposium of Laboratory Robotics and Automation 1995. #8301

504. Nagesha, H.S., Yu, M., & Wang, L.F. (1996) Application of linker-ligation-PCR for construction of phage display epitope libraries. J. Virol. Meth., 60, 147-154. #5217

505. Narita, S., Tanaka, R., Ito, T., Okada, K., Taketani, S., & Inokuchi, H. (1996) Molecular cloning and characterization of a cDNA that encodes protoporphyrinogen oxidase of Arabidopsis thaliana. Gene, 182, 169-175. #12493

506. Natarajan, A.T., & et al. (1996) Frequencies of X-ray induced pericentric inversions and centric rings in human blood lymphocytes detected by FISH using chromosome arm specific DNA libraries. Mutat. Res., 372, 1-7. #9355

507. Nawrocki, J.P., Wigger, M., Watson, C.H., Hayes, T.W., Senko, M.W., Benner, S.A., & Eyler, J.R. (1996) Analysis of combinatorial libraries using electrospray Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun. Mass Spectrom., 10, 1860-1864. #8190

508. Nedved, M.L., Habibi-Goudarzi, S., Ganem, B., & Henion, J.D. (1996) Characterization of benzodiazepine "combinatorial" chemical libraries by on-line immunoaffinity extraction, coupled column HPLC-ion spray mass spectrometry-tandem mass spectrometry. Anal. Chem., 68, 4228-4236. #8133

509. Nemoto, H., Miyata, J., & Fukumoto, K. (1996) A novel and general route to diverse A-ring aromatic trichothecanes via cyclobutanes. Tetrahedron, 52, 10363-10374. #5014

510. Neophytou, P.I., Roep, B.O., Arden, S.D., Muir, E.M., Duinkerken, G., Kallan, A., de Vries, R.R.P., & Hutton, J.C. (1996) T-cell epitope analysis using subtracted expression libraries (TEASEL): Application to a 38-kDa autoantigen recognized by T cells from an insulin-dependent diabetic patient. Proc. Natl. Acad. Sci. USA, 93, 2014-2018. #4146

511. Nestler, H.P., Wennemers, H., Sherlock, R., & Dong, D.L.Y. (1996) Microautoradiographic identification of receptor-ligand interactions in bead-supported combinatorial libraries. Bioorg. Med. Chem. Lett., 6, 1327-1330. #4921

512. Nestler, H.P. (1996) Sequence-selective nonmacrocyclic two-armed receptors for peptides. Mol. Diversity, 2, 35-40. #4841 (Available on Internet)

513. Network Science. (1996) Combinatorial chemistry: A strategy for the future. Net. Sci., #8589 (Available on Internet)

514. Newton, C.G. (1996) Patenting combinatorial libraries and associated technologies. Exp. Opin. Ther. Patents, 6, 827-835. #5495

515. Ni, Z.J., Maclean, D., Holmes, C.P., & Gallop, M.A. (1996) Encoded combinatorial chemistry: Binary coding using chemically robust secondary amine tags. Methods Enzymol., 267, 261-274. #4788

516. Ni, Z.J., Maclean, D., Holmes, C.P., Murphy, M.M., Ruhland, B., Jacobs, J.W., Gordon, E.M., & Gallop, M.A. (1996) Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags. J. Med. Chem., 39, 1601-1608. #4573

517. Nicosia, A., Monaci, P., Luzzago, A., Galfre, G., Felici, F., Prezzi, C., Mennuni, C., Meola, A., Mecchia, M. & Cortese, R. (1996) Discovery of disease-specific mimotopes by screening phage libraries with human serum samples. In R. Cortese (Ed.), Combinatorial Libraries: Synthesis, Screening and Application Potential. (pp. 144-157). Walter de Gruyter, Berlin. #4345

518. Nielsen, J., & Rasmussen, P.H. (1996) Implementation of combinatorial cleavage and deprotection scheme.1.Synthesis of phthalhydrazide libraries. Tetrahedron Lett., 37, 3351-3354. #4609

519. Nielsen, J., & Lyngso, L.O. (1996) Combinatorial solid-phase synthesis of balanol analogues. Tetrahedron Lett., 37, 8439-8442. #5746

520. Nielsen, J. (1996) Combinatorial chemistry and automation. Drug Disc. Today, 1, 458-460. #5768

521. Nielsen, P.E. (1996) Peptide nucleic acids: A new dimension to peptide libraries and aptamers. Methods Enzymol., 267, 426-436. #4796

522. Nishi, T., Budde, R.J.A., McMurray, J.S., Obeyesekere, N.U., Safdar, N., Levin, V.A., & Saya, H. (1996) Tight-binding inhibitory sequences against pp60(c-src) identified using a random 15-amino-acid peptide library. FEBS Lett., 399, 237-240. #12494

523. Norman, T.C., Gray, N.S., Koh, J.T., & Schultz, P.G. (1996) A structure-based library approach to kinase inhibitors. J. Amer. Chem. Soc., 118, 7430-7431. #5123

524. O'Donnell, M.J., Zhou, C., & Scott, W.L. (1996) Solid-phase unnatural peptide synthesis (UPS). J. Amer. Chem. Soc., 118, 6070-6071. #4828

525. Ohlin, M., Owman, H., Mach, M., & Borrebaeck, C.A.K. (1996) Light chain shuffling of a high affinity antibody results in a drift in epitope recognition. Mol. Immunol., 33, 47-56. #4431

526. Oldenburg, K.R., Vo, K.T., Ruhland, B., Schatz, P.J., & Yuan, Z. (1996) A dual culture assay for detection of antimicrobial activity. J. Biomol. Screen., 1, 123-130. #10045

527. Ostresh, J.M., Blondelle, S.E., Dorner, B., & Houghten, R.A. (1996) Generation and use of nonsupport-bound peptide and peptidomimetics combinatorial libraries. Methods Enzymol., 267, 220-233. #4786

528. Owen, J.A., Muirhead, K., Jensen, C., & Jonak, Z.L. (1996) Successful in vitro antigen-dependent activation of 24-hour-old peripheral blood lymphocytes. J. Immunol. Method, 190, 39-49. #4677

529. Pacchioni, B., Trevisan, S., Gomirato, S., Toppo, S., Valle, G., & Lanfranchi, G. (1996) Semi-multiplex PCR technique for screening of abundant transcripts during systematic sequencing of cDNA libraries. BioTechniques, 21, 644-649. #5469

530. Pan, Z., & Still, W.C. (1996) Macrocyclic oligomers of isophthalic acid and trans-1,2- diaminocyclohexane-building blocks for synthetic peptide receptors. Tetrahedron Lett., 37, 8699-8702. #5748

531. Panchal, R.G., Cusack, E., Cheley, S., & Bayley, H. (1996) Tumor protease-activated, pore-forming toxins from a combinatorial library. Nat. Biotech., 14, 852-856. #4966

532. Pandit, S.D., Donis-Keller, H., Iwamoto, T., Tomich, J.M., & Pike, L.J. (1996) The multiple endocrine neoplasia type 2B point mutation alters long-term regulation and enhances the transforming capacity of the epidermal growth factor receptor. Journal of Biological Chemistry, 271, 5850-5858. #5003

533. Panek, J.S., & Zhu, B. (1996) Synthesis of aromatic 1,2-diazines by inverse electron demand Diels-Alder reaction of polymer-supported 1,2,4,5-tetrazines. Tetrahedron Lett., 37, 8151-8154. #5741

534. Park, W.K.C., Auer, M., Jaksche, H., & Wong, C.H. (1996) Rapid combinatorial synthesis of aminoglycoside antibiotic mimetics: Use of a polyethylene glycol-linked amine and a neamine-derived aldehyde in multiple component condensation as a strategy for the discovery of new inhibitors of the HIV RNA Rev responsive elements. J. Amer. Chem. Soc., 118, 10150-10155. #5548

535. Parlow, J.J. (1996) The use of anion exchange resins for the synthesis of combinatorial libraries containing aryl and heteroaryl ethers. Tetrahedron Lett., 37, 5257-5260. #5081

536. Parlow, J.J., & Normansell, J.E. (1996) Discovery of herbicidal lead using polymer-bound activated esters in generating a combinatorial library of amides and esters. Mol. Divers