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PAPERS PUBLISHED IN 2003

This list is arranged by the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (m@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M.: Dynamic database of references in molecular diversity. Internet http://www.5z.com/divinfo.


Recently added entries are marked in bold

  1. Abreu,P.M., & Branco,P.S. (2003) Natural product-like combinatorial libraries. J. Braz. Chem. Soc., 14, 675-712. #18732

  2. Adamatzky,A. (2003) On dynamically non-trivial three-valued logics: oscillatory and bifurcatory species. Chaos, Solitons & Fractals, 18, 917-936. #18856

  3. Adrian,J.C., Jr., & Snapper,M.L. (2003) Multiple Component Reactions: An Efficient Nickel-Catalyzed Reformatskii-Type Reaction and Its Application in the Parallel Synthesis of .beta.-Amino Carbonyl Libraries. J. Org. Chem., 68, 2143-2150. #18962

  4. Agrafiotis,D.K., & Xu,H. (2003) A Geodesic Framework for Analyzing Molecular Similarities. Journal of Chemical Information and Computer Sciences, 43, 475-484. #18972

  5. Akporiaye,D., Wendelbo,R., Vistad,O., Karlsson,A., Plassen,M., Lillerud,K.P., & McCoy,J. (2003) Combinatorial hydrothermal synthesis. Zeoraito, 20, 18-24. #18685

  6. Al Obeidi,F., Austin,R.E., Okonya,J.F., & Bond,D.R.S. (2003) Microwave-assisted solid-phase synthesis (MASS): Parallel and combinatorial chemical library synthesis. Mini-Reviews in Medicinal Chemistry, 3, 449-460. #18808

  7. Alberti,S., & Parodi,S. (2003) Signaling protein networks as targets of new antineoplastic drugs. International Journal of Biological Markers, 18, 57-61. #18795

  8. Alcazar,J., Alonso,J.M., Bartolome,J.M., Iturrino,L., & Matesanz,E. (2003) Synthesis of novel 3-substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines as potential new scaffolds for drug discovery: selective introduction of substituents on the pyridine ring. Tetrahedron Lett., 44, 8983-8986. #18726

  9. Alluri,P.G., Reddy,M.M., Bachhawat-Sikder,K., Olivos,H.J., & Kodadek,T. (2003) Isolation of Protein Ligands from Large Peptoid Libraries. J. Amer. Chem. Soc., 125, 13995-14004. #18735

  10. Anon. (2003) Recent patents in combinatorial chemistry. Nat. Biotech., 21, 1103. #18772

  11. Anon. (2003) 8th international symposium on solid phase synthesis and combinatorial libraries. Asian Journal of Chemistry, 15, 1120. #19914

  12. Anon. (2003) 2nd International conference on multi component reactions, combinatorial and related chemistry. Asian Journal of Chemistry, 15, 190. #18995

  13. Anon. (2003) Combinatorial chemistry. QSAR & Combinatorial Science, 22, 788-790. #18724

  14. Appeldoorn,C.C.M., Molenaar,T.J.M., Bonnefoy,A., Van Leeuwen,S.H., Vandervoort,P.A.H., Hoylaerts,M.F., Van Berkel,T.J.C., & Biessen,E.A.L. (2003) Rational Optimization of a Short Human P-selectin-binding Peptide Leads to Nanomolar Affinity Antagonists. Journal of Biological Chemistry, 278, 10201-10207. #18935

  15. Aptula,A.O., Kuehne,R., Ebert,R.U., Cronin,M.T.D., Netzeva,T.I., & Schueuermann,G. (2003) Modeling discrimination between antibacterial and non-antibacterial activity based on 3D molecular descriptors. QSAR & Combinatorial Science, 22, 113-128. #18846

  16. Bagley,M.C., Dale,J.W., Ohnesorge,M., Xiong,X., & Bower,J. (2003) A Facile Solution Phase Combinatorial Synthesis of Tetrasubstituted Pyridines Using the Bohlmann-Rahtz Heteroannulation Reaction. Journal of Combinatorial Chemistry, 5, 41-44. #19002

  17. Barker,E.J., Gardiner,E.J., Gillet,V.J., Kitts,P., & Morris,J. (2003) Further Development of Reduced Graphs for Identifying Bioactive Compounds. Journal of Chemical Information and Computer Sciences, 43, 346-356. #18959

  18. Barnes-Seeman,D., Park,S.B., Koehler,A.N., & Schreiber,S.L. (2003) Expanding the functional group compatibility of small-molecule microarrays: Discovery of novel calmodulin ligands. Angewandte Chemie, International Edition, 42, 2376-2379. #18848

  19. Barron,D.M., Chatterjee,S.K., Ravindra,R., Roof,R., Baloglu,E., Kingston,D.G.I., & Bane,S. (2003) A fluorescence-based high-throughput assay for antimicrotubule drugs. Anal. Biochem., 315, 49-56. #18913

  20. Barry,C.E.I. (2003) Modern drug development. Issues in Infectious Diseases, 2, 137-150. #18720

  21. Bashford,K.E., Burton,M.B., Cameron,S., Cooper,A.L., Hogg,R.D., Kane,P.D., MacManus,D.A., Matrunola,C.A., Moody,C.J., Robertson,A.A.B., & Warne,M.R. (2003) The Bohlmann-Rahtz route to functionalized pyridine scaffolds and their use in library synthesis. Tetrahedron Lett., 44, 1627-1629. #18965

  22. Basso,A., & Bradley,M. (2003) Site-site interactions within high-loading PAMAM dendrimer resin beads. Tetrahedron Lett., 44, 2699-2702. #18940

  23. Beers,K.L., Douglas,J.F., Amis,E.J., & Karim,A. (2003) Combinatorial Measurements of Crystallization Growth Rate and Morphology in Thin Films of Isotactic Polystyrene. Langmuir, 19, 3935-3940. #18925

  24. Belder,D. (2003) From DNA sequencer to a system for organic synthesis. Nachrichten aus der Chemie, 51, 757-759. #18647

  25. Belosludov, Rodion V., Takami, Seiichi, Kubo, Momoji, and Miyamoto, Akira Combinatorial computational chemistry approach in the design of new catalysts and functional materials. In: Anonymous. (Eds.) Combinational Materials Synthesis. #18637NEW

  26. Berkessel,A. (2003) The discovery of catalytically active peptides through combinatorial chemistry. Curr. Opin. Chem. Biol., 7, 409-419. #18837

  27. Berst,F., Holmes,A.B., & Ladlow,M. (2003) The development and preparation of the 2,4-dimethoxybenzyl arylhydrazine (DMBAH) \"latent\" safety-catch linker: solid phase synthesis of ketopiperazines. Organic & Biomolecular Chemistry, 1, 1711-1719. #18834

  28. Bertini,V., Pocci,M., Lucchesini,F., Alfei,S., & De Munno,A. (2003) Polystyrene resins containing 1,3-propanedithiol functions for solid-phase organic syntheses. Synlett, 864-866. #18877

  29. Bertini,V., Lucchesini,F., Pocci,M., Alfei,S., & De Munno,A. (2003) Reductive cleavage of 1,3-dithiane systems anchored on polymers useful for supported organic syntheses. Synlett, 1201-1203. #18826

  30. Bertozzi,F., Gundersen,B.V., Gustafsson,M., & Olsson,R. (2003) A Combinatorial Scaffold Approach Based upon a Multicomponent Reaction. Organic Letters, 5, 1551-1554. #18911

  31. Bhalla,U.S. (2003) Understanding complex signaling networks through models and metaphors. Progress in Biophysics & Molecular Biology, 81, 45-65. #18721

  32. Blackwell,H.E. (2003) Out of the oil bath and into the oven-microwave-assisted combinatorial chemistry heats up. Organic & Biomolecular Chemistry, 1, 1251-1255. #18671

  33. Blass,B.E., Coburn,K.R., Faulkner,A.L., Seibel,W.L., & Srivastava,A. (2003) Applications of solid supported azide anion. A one-pot, two-step preparation of functionalized 1,2,3-triazoles. Tetrahedron Lett., 44, 2153-2155. #18951

  34. Blom,K.F., Sparks,R., Doughty,J., Everlof,J.G., Haque,T., & Combs,A.P. (2003) Optimizing Preparative LC/MS Configurations and Methods for Parallel Synthesis Purification. Journal of Combinatorial Chemistry, 5, 670-683. #18797

  35. Boelens,H.F.M., Iron,D., Westerhuis,J.A., & Rothenberg,G. (2003) Tracking chemical kinetics in high-throughput systems. Chemistry--A European Journal, 9, 3876-3881. #18770

  36. Boger,D.L., Desharnais,J., & Capps,K. (2003) Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions. Angewandte Chemie, International Edition, 42, 4138-4176. #19350

  37. Bolla,M.L., Azevedo,E.V., Smith,J.M., Taylor,R.E., Ranjit,D.K., Segall,A.M., & McAlpine,S.R. (2003) Novel Antibiotics: Macrocyclic Peptides Designed to Trap Holliday Junctions. Organic Letters, 5, 109-112. #18987

  38. Bork,J.T., Lee,J.W., Khersonsky,S.M., Moon,H.S., & Chang,Y.T. (2003) Novel Orthogonal Strategy toward Solid-Phase Synthesis of 1,3,5-Substituted Triazines. Organic Letters, 5, 117-120. #18986

  39. Boulon,G. (2003) Yb3+-doped oxide crystals for diode-pumped solid state lasers: crystal growth, optical spectroscopy, new criteria of evaluation and combinatorial approach. Optical Materials (Amsterdam, Netherlands), 22, 85-87. #18703

  40. Boulon,G., Laversenne,L., Goutaudier,C., Guyot,Y., & Cohen-Adad,M.T. (2003) Radiative and non-radiative energy transfers in Yb3+-doped sesquioxide and garnet laser crystals from a combinatorial approach based on gradient concentration fibers. Journal of Luminescence, 102-103, 417-425. #18926

  41. Box,K., Elliott,S., & Cimpan,G. (2003) High throughput pKa and logD7.4 measurements. PharmaChem, 2, 55-59. #18767

  42. Braeckmans,K., De Smedt,S.C., Roelant,C., Leblans,M., Pauwels,R., & Demeester,J. (2003) Encoding microcarriers by spatial selective photobleaching. Nature Materials, 2, 169-173. #18949

  43. Braeckmans,K., De Smedt,S.C., Leblans,M., Roelant,C., Pauwels,R., & Demeester,J. (2003) Encoded microcarrier beads signal the way to better combinatorial libraries and biological assays. Mod. Drug Dis., 6, 28-30, 32. #18702

  44. Briem,H. (2003) De novo design methods. Ernst Schering Research Foundation Workshop, 42, 153-166. #18687

  45. Brodbeck,B., Pullmann,B., Schmitt,S., & Nettekoven,M. (2003) Parallel iterative solution-phase synthesis of 5-amino-1-aryl-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acid amide derivatives. Tetrahedron Lett., 44, 1675-1678. #18964

  46. Byun,J.W., Lee,D.H., & Lee,Y.S. (2003) Preparation of polymer-bound pyrazolone active esters for combinatorial chemistry. Tetrahedron Lett., 44, 8063-8067. #18746

  47. Caporossi,G., Gutman,I., Hansen,P., & Pavlovic,L. (2003) Graphs with maximum connectivity index. Computational Biology and Chemistry, 27, 85-90. #18854

  48. Carvalho,I., Pupo,M.T., Borges,A.D.L., & Bernardes,L.S.C. (2003) Introduction to molecular modeling of drugs in the medicinal chemistry experimental course. Quim. Nova, 26, 428-438. #18855

  49. Cavalli,G., Shooter,A.G., Pears,D.A., & Steinke,J.H.G. (2003) Non-PEG-Derived Polyethers as Solid Supports. 1. Synthesis, Swelling Studies, and Functionalization. Journal of Combinatorial Chemistry, 5, 637-644. #18801

  50. Cawse,J.N., Olson,D., Chisholm,B.J., Brennan,M., Sun,T., Flanagan,W., Akhave,J., Mehrabi,A., & Saunders,D. (2003) Combinatorial chemistry methods for coating development. V: Generating a combinatorial array of uniform coatings samples. Progress in Organic Coatings, 47, 128-135. #18774

  51. Chaltin,P., Borgions,F., Rozenski,J., Van Aerschot,A., & Herdewijn,P. (2003) New dsDNA-binding hybrid molecules combining an unnatural peptide and an intercalating moiety. Helv. Chim. Acta, 86, 533-547. #18904

  52. Chamorro,C., & Liskamp,R.M.J. (2003) Approaches to the Solid Phase of a Cyclotriveratrylene Scaffold-Based Tripodal Library as Potential Artificial Receptors. Journal of Combinatorial Chemistry, 5, 794-801. #18777

  53. Charmot,D. (2003) Material discovery and formulation optimization using high throughput methods. Actualite Chimique, 11-16. #18676

  54. Chen,C.H.-T., & Zhang,W. (2003) FluoMar, a Fluorous Version of the Marshall Resin for Solution-Phase Library Synthesis. Organic Letters, 5, 1015-1017. #18947

  55. Chen,P. (2003) Electrospray ionization tandem mass spectrometry in high-throughput screening of homogeneous catalysts. Angewandte Chemie, International Edition, 42, 2832-2847. #18653

  56. Chen,Y., Lam,Y., & Lai,Y.H. (2003) Solid-Phase Synthesis of Pyrazolines and Isoxazolines with Sodium Benzenesulfinate as a Traceless Linker. Organic Letters, 5, 1067-1069. #18941

  57. Cheng,Z., Li,W., & Yun,L. (2003) Application of the combinatorial chemistry to research of natural products. Huaxue Jinzhan, 15, 194-203. #18828

  58. Chibale,K., & Musonda,C.C. (2003) The synthesis of parasitic cysteine protease and trypanothione reductase inhibitors. Curr. Med. Chem., 10, 1863-1889. #18779

  59. Chisholm,B., Potyrailo,R., Shaffer,R., Cawse,J., Brennan,M., & Molaison,C. (2003) Combinatorial chemistry methods for coating development. III. Development of a high throughput screening method for abrasion resistance: correlation with conventional methods and the effects of abrasion mechanism. Progress in Organic Coatings, 47, 112-119. #18776

  60. Chisholm,B.J., Potyrailo,R.A., Cawse,J.N., Shaffer,R.E., Brennan,M., & Molaison,C.A. (2003) Combinatorial chemistry methods for coating development. IV. The importance of understanding process capability. Progress in Organic Coatings, 47, 120-127. #18775

  61. Chu,Y.H., Shul,Y.G., Choi,W.C., Woo,S.I., & Han,H.S. (2003) Evaluation of the Nafion effect on the activity of Pt-Ru electrocatalysts for the electro-oxidation of methanol. Journal of Power Sources, 118, 334-341. #18874

  62. Ciobanu,L.C., & Poirier,D. (2003) Solid-Phase Parallel Synthesis of 17.alpha.-Substituted Estradiol Sulfamate and Phenol Libraries Using the Multidetachable Sulfamate Linker. Journal of Combinatorial Chemistry, 5, 429-440. #19590

  63. Clark,R.D., Kar,J., Akella,L., & Soltanshahi,F. (2003) OptDesign: Extending Optimizable k-Dissimilarity Selection to Combinatorial Library Design. Journal of Chemical Information and Computer Sciences, 43, 829-836. #18900

  64. Clough,J., Chen,S., Gordon,E.M., Hackbarth,C., Lam,S., Trias,J., White,R.J., Candiani,G., Donadio,S., Romano,G., Ciabatti,R., & Jacobs,J.W. (2003) Combinatorial modification of natural products: synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications. Bioorganic & Medicinal Chemistry Letters, 13, 3409-3414. #18752

  65. Coats,S.J., Link,J.S., & Hlasta,D.J. (2003) Alternative Solvents for Elevated-Temperature Solid-Phase Parallel Synthesis. Application to Thionation of Amides. Organic Letters, 5, 721-724. #18958

  66. Collart,F.R., & Huberman,E. (2003) Identification of specific inhibitors of IMP dehydrogenase. ACS Symposium Series, 839, 282-293. #18691

  67. Collinsova,M., Castro,C., Garrow,T.A., Yiotakis,A., Dive,V., & Jiracek,J. (2003) Combining Combinatorial Chemistry and Affinity Chromatography. Highly Selective Inhibitors of Human Betaine: Homocysteine S-Methyltransferase. Chemistry & Biology, 10, 113-122. #18944

  68. Comer,J., & Box,K. (2003) High-throughput measurement of drug pKa values for ADME screening. JALA, 8, 55-59. #18905

  69. Cora,F., Catlow,C.R., Civalleri,B., & Orlando,R. (2003) Acid Strength of Low-Valence Dopant Ions in Microporous Zeolites and AlPOs. J. Phys. Chem. B, 107, 11866-11870. #18749

  70. Corcoran,O., & Spraul,M. (2003) LC-NMR-MS in drug discovery. Drug Disc. Today, 8, 624-631. #18813

  71. Corma,A., Serra,J.M., & Chica,A. (2003) Discovery of new paraffin isomerization catalysts based on SO42-/ZrO2 and WOx/ZrO2 applying combinatorial techniques. Catalysis Today, 81, 495-506. #18809

  72. Dahlgren,A., Kvarnstrom,I., Vrang,L., Hamelink,E., Hallberg,A., Rosenquist,A., & Samuelsson,B. (2003) Solid-phase library synthesis of reversed-statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II. Bioorganic & Medicinal Chemistry, 11, 827-841. #19959

  73. Dai,W.M., Guo,D.S., Sun,L.P., & Huang,X.H. (2003) Microwave-Assisted Solid-Phase Organic Synthesis (MASPOS) as a Key Step for an Indole Library Construction. Organic Letters, 5, 2919-2922. #19451

  74. Dallinger,D., Gorobets,N.Y., & Kappe,C.O. (2003) High-Throughput Synthesis of N3-Acylated Dihydropyrimidines Combining Microwave-Assisted Synthesis and Scavenging Techniques. Organic Letters, 5, 1205-1208. #18922

  75. Dargaville,T.R., George,G.A., Hill,D.J.T., & Whittaker,A.K. (2003) High energy radiation grafting of fluoropolymers. Progress in Polymer Science, 28, 1355-1376. #18782

  76. Das,R.N., Lew,C., Zergioti,I., Thompson,M.O., & Giannelis,E.P. (2003) Combinatorial laser processing of dielectric/ferroelectric thin and thick films. Materials Research Society Symposium Proceedings, 748, 153-157. #18863

  77. De Luca,L., Giacomelli,G., Porcheddu,A., Salaris,M., & Taddei,M. (2003) Cellulose Beads: a New Versatile Solid Support for Microwave-Assisted Synthesis. Preparation of Pyrazole and Isoxazole Libraries. Journal of Combinatorial Chemistry, 5, 465-471. #18864

  78. De Luca,S., Ulhaq,S., Dixon,M.J., Essex,J., & Bradley,M. (2003) Solid-phase synthesis of a focused library of trypanothione reductase inhibitors. Tetrahedron Lett., 44, 3195-3197. #19625

  79. de Vries,J.G., & de Vries,A.H.M. (2003) The power of high-throughput experimentation in homogeneous catalysis research for fine chemicals. Eur. J. Org. Chem., 799-811. #18694

  80. Dearden,J.C. (2003) In silico prediction of drug toxicity. J. Comput. Aid. Molec. Design, 17, 119-127. #18781

  81. Delpiccolo,C.M.L., Fraga,M.A., & Mata,E.G. (2003) An Efficient, Stereoselective Solid-Phase Synthesis of .beta.-Lactams Using Mukaiyama's Salt for the Staudinger Reaction. Journal of Combinatorial Chemistry, 5, 208-210. #18919

  82. Dessole,G., Marchetti,M., & Taddei,M. (2003) Hydroformylation of Terminal Alkenes Supported on Solid Phase: Synthetic Tool for Combinatorial Chemistry. Journal of Combinatorial Chemistry, 5, 198-200. #18914

  83. Di,L., Kerns,E.H., Fan,K., McConnell,O.J., & Carter,G.T. (2003) High throughput artificial membrane permeability assay for blood-brain barrier. Eur. J. Med. Chem., 38, 223-232. #18921

  84. Di,L., Kerns,E.H., Hong,Y., Kleintop,T.A., McConnell,O.J., & Huryn,D.M. (2003) Optimization of a higher throughput microsomal stability screening assay for profiling drug discovery candidates. J. Biomol. Screen., 8, 453-462. #18754

  85. Ding,Y., Habib,Q., Shaw,S.Z., Li,D.Y., Abt,J.W., Hong,Z., & An,H. (2003) Synthesis of New 3'-, 5-, and N4-Modified 2'-O-Methylcytidine Libraries on Solid Support. Journal of Combinatorial Chemistry, 5, 851-859. #19346

  86. Doi,T., Nagamiya,H., & Takahashi,T. (2003) A library synthesis of cyclic depsipeptides aurilide and its derivatives on solid-support. Peptide Science, 39th, 45-46. #19523

  87. Dombi,K.L., Steiner,U.E., & Richert,C. (2003) Rapidly Measuring Reactivities of Carboxylic Acids to Generate Equireactive Building Block Mixtures: A Spectrometric Assay. Journal of Combinatorial Chemistry, 5, 45-60. #18981

  88. Downes,M., Verdecia,M.A., Roecker,A.J., Hughes,R., Hogenesch,J.B., Kast-Woelbern,H.R., Bowman,M.E., Ferrer,J.L., Anisfeld,A.M., Edwards,P.A., Rosenfeld,J.M., Alvarez,J.G.A., Noel,J.P., Nicolaou,K.C., & Evans,R.M. (2003) A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Molecular Cell, 11, 1079-1092. #18878

  89. Eames, Jason and Watkinson, Michael Polymeric scavenger reagents in organic synthesis. In: Anonymous. (Eds.) Organic Synthesis Highlights V. #18646NEW

  90. Ede,N.J., & Wu,Z. (2003) Beyond Rf tagging. Curr. Opin. Chem. Biol., 7, 374-379. #18839

  91. Edwards,P.J. (2003) Purification strategies for combinatorial and parallel chemistry. Comb. Chem. High Throughput Screening, 6, 11-27. #18707

  92. Eglin,M., Rossi,A., & Spencer,N.D. (2003) X-ray Photoelectron Spectroscopy Analysis of Tribostressed Samples in the Presence of ZnDTP: A Combinatorial Approach. Tribology Letters, 15, 199-209. #18799

  93. Enjalbal,C., Lamaty,F., Sanchez,P., Suberchicot,E., Ribiere,P., Varray,S., Lazaro,R., Yadav-Bhatnagar,N., Martinez,J., & Aubagnac,J.L. (2003) Characterization of Soluble Polymer Supported Organic Compounds by LC/Electrospray Ionization MS Toward a Complete Automation of the Liquid-Phase Process in Combinatorial Chemistry. Anal. Chem., 75, 175-184. #19000

  94. Enjalbal,C., Maux,D., Combarieu,R., Martinez,J., & Aubagnac,J.L. (2003) Imaging Combinatorial Libraries by Mass Spectrometry: from Peptide to Organic-Supported Syntheses. Journal of Combinatorial Chemistry, 5, 102-109. #19720

  95. Epple,R., Kudirka,R., & Greenberg,W.A. (2003) Solid-Phase Synthesis of Nucleoside Analogs. Journal of Combinatorial Chemistry, 5, 292-310. #18943

  96. Ercole,F., FitzGerald,M., Perera,S., Ede,N., Riley,P., & Campbell,R. (2003) A combinatorial approach in designing hydrophilic surfaces for solid-phase peptide synthesis. J. Appl. Polym. Sci., 89, 3371-3378. #18792

  97. Erlanson,D.A., Lam,J.W., Wiesmann,C., Luong,T.N., Simmons,R.L., DeLano,W.L., Choong,I.C., Burdett,M.T., Flanagan,W.M., Lee,D., Gordon,E.M., & O'Brien,T. (2003) In situ assembly of enzyme inhibitors using extended tethering. Nat. Biotech., 21, 308-314. #18950

  98. Espada,A., & Rivera-Sagredo,A. (2003) Ammonium hydrogencarbonate, an excellent buffer for the analysis of basic drugs by liquid chromatography-mass spectrometry at high pH. Journal of Chromatography, A, 987, 211-220. #18961

  99. Falco,J.L., Matallana,J.L., Barberena,J., Teixido,J., & Borrell,J.I. (2003) Solid-phase synthesis of 2-substituted 4-amino-7-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidines: An example of cyclization-assisted cleavage. Mol. Diversity, 6, 3-11. #18805

  100. Far,A.R. (2003) Ketenes in polymer-assisted synthesis. Angewandte Chemie, International Edition, 42, 2340-2348. #18665

  101. Fassina,G., & Miertus,S. (2003) Combinatorial technologies in biotechnology. Chimica Oggi, 21, 28-31. #18650

  102. Feher,M., & Schmidt,J.M. (2003) Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry. Journal of Chemical Information and Computer Sciences, 43, 218-227. #18996

  103. Felder,E.R., Martina,K., Scarpella,S., & Tato,M. (2003) Versatile monitoring tools in parallel solid-phase synthesis. Chimia, 57, 229-236. #18660

  104. Feliu,L., Subra,G., Martinez,J., & Amblard,M. (2003) Spiroimidazolidinone Library Derivatives on SynPhase Lanterns. Journal of Combinatorial Chemistry, 5, 356-361. #19591

  105. Feng,Y. (2003) A marriage of chemistry and biology. Chin. Sci. Bull., 48, 949-951. #18823

  106. Fernandez,J.L., & Bard,A.J. (2003) Scanning Electrochemical Microscopy. 47. Imaging Electrocatalytic Activity for Oxygen Reduction in an Acidic Medium by the Tip Generation-Substrate Collection Mode. Anal. Chem., 75, 2967-2974. #18876

  107. Fischer,P.M. (2003) Diketopiperazines in peptide and combinatorial chemistry. J. Peptide Sci., 9, 9-35. #18708

  108. Fujimori,T., Wirsching,P., & Janda,K.D. (2003) Preparation of a Kroehnke Pyridine Combinatorial Library Suitable for Solution-Phase Biological Screening. Journal of Combinatorial Chemistry, 5, 625-631. #18850

  109. Fung,E.N., Chu,I., Li,C., Liu,T., Soares,A., Morrison,R., & Nomeir,A.A. (2003) Higher-throughput screening for caco-2 permeability utilizing a multiple sprayer liquid chromatography/tandem mass spectrometry system. Rapid Commun. Mass Spectrom., 17, 2147-2152. #18753

  110. Gabarda,A.E., & Curran,D.P. (2003) Solution-Phase Parallel Synthesis of 115 Homosilatecan Analogues. Journal of Combinatorial Chemistry, 5, 617-624. #18844

  111. Geistlinger,T.R., & Guy,R.K. (2003) Novel Selective Inhibitors of the Interaction of Individual Nuclear Hormone Receptors with a Mutually Shared Steroid Receptor Coactivator 2. J. Amer. Chem. Soc., 125, 6852-6853. #18879

  112. Gelens,E., Koot,W.J., Menge,W.M.P.B., Ottenheijm,H.C.J., & Timmerman,H. (2003) Solid-phase synthesis of heterocyclic aromates: Applicability towards combinatorial chemistry; a review. Comb. Chem. High Throughput Screening, 6, 79-99. #18706

  113. Gentry,E.J., Telikepalli,H., Srinivas,P., & Mitscher,L.A. (2003) Tetraacyldiborates: Selective and efficient acylation reagents suitable for multiple parallel synthetic applications. Comb. Chem. High Throughput Screening, 6, 139-145. #18907

  114. Genzer,J., Fischer,D.A., & Efimenko,K. (2003) Combinatorial near-edge x-ray absorption fine structure: Simultaneous determination of molecular orientation and bond concentration on chemically heterogeneous surfaces. Appl. Phys. Lett., 82, 266-268. #18982

  115. Gerritz,S.W., Norman,M.H., Barger,L.A., Berman,J., Bigham,E.C., Bishop,M.J., Drewry,D.H., Garrison,D.T., Heyer,D., Hodson,S.J., Kakel,J.A., Linn,J.A., Marron,B.E., Nanthakumar,S.S., & Navas,F.J., III. (2003) High-Throughput Manual Parallel Synthesis Using SynPhase Crowns and Lanterns. Journal of Combinatorial Chemistry, 5, 110-117. #18976

  116. Ghosh,A. (2003) Guest section Computational bioinorganic chemistry. Part III. The tools of the trade: from high-level ab initio calculations to structural bioinformatics. Curr. Opin. Chem. Biol., 7, 110-112. #18977

  117. Gibbs,P.R., Uehara,C.S., Nguyen,P.T., & Willson,R.C. (2003) Imaging polarimetry for high throughput chiral screening. Biotechnol. Progr., 19, 1329-1334. #18875

  118. Gitsov,I., & Zhu,C. (2003) Novel Functionally Grafted Pseudo-Semi-interpenetrating Networks Constructed by Reactive Linear-Dendritic Copolymers. J. Amer. Chem. Soc., 125, 11228-11234. #18778

  119. Gladfelter,W.L., Xia,B., Chen,F., Campbell,S.A., & Roberts,J.T. (2003) Balancing reactor fluid dynamics and deposition kinetics to achieve compositional variation in combinatorial chemical vapor depositions of ZrO2, HfO2 and SnO2. Proceedings - Electrochemical Society, 2003-8, 829-838. #18768

  120. Gobbi,A., & Lee,M.L. (2003) DISE: Directed Sphere Exclusion. Journal of Chemical Information and Computer Sciences, 43, 317-323. #19001

  121. Gong,Y.D., Seo,J.S., Chon,Y.S., Hwang,J.Y., Park,J.Y., & Yoo,S.E. (2003) Construction of 6-Amino-2,2-Dimethyl-3,4,6-Trisubstituted-2H-1-Benzopyran Library by Solid Phase Synthesis. Journal of Combinatorial Chemistry, 5, 577-589. #19434

  122. Goody,R.S., Alexandrov,K., & Engelhard,M. (2003) Manufacture of modified proteins by combined synthesis and biosynthesis. BIOspektrum, 9, 42-45. #18680

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  128. Guo,T., & Hobbs,D.W. (2003) Privileged structure-based combinatorial libraries targeting G protein-coupled receptors. Assay and Drug Development Technologies, 1, 579-592. #18764

  129. Gupta,P., Singh,S.K., Srinivasan,T., & Kundu,B. (2003) Identification of antifungal agents using combinatorial approach: An overview. Current Medicinal Chemistry: Anti-Infective Agents, 2, 113-133. #18674

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  131. Haase,B. (2003) Affymetrix GeneChip microarrays: Technology and applications. BIOspektrum, 9, 99-100. #18898

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  135. Hatanaka,Y. (2003) Development of rapid photoaffinity labeling with probe-integrated solid matrix. Yakugaku Kenkyu no Shinpo, 19, 81-89. #18883

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  138. Hill,C.M., Li,W.S., Thoden,J.B., Holden,H.M., & Raushel,F.M. (2003) Enhanced Degradation of Chemical Warfare Agents through Molecular Engineering of the Phosphotriesterase Active Site. J. Amer. Chem. Soc., 125, 8990-8991. #18821

  139. Hisamoto,H., Kikutani,Y., & Kitamori,T. (2003) Microchip-based organic synthesis. Shokubai, 45, 252-256. #18677

  140. Hochguertel,M., Biesinger,R., Kroth,H., Piecha,D., Hofmann,M.W., Krause,S., Schaaf,O., Nicolau,C., & Eliseev,A.V. (2003) Ketones as Building Blocks for Dynamic Combinatorial Libraries: Highly Active Neuraminidase Inhibitors Generated via Selection Pressure of the Biological Target. J. Med. Chem., 46, 356-358. #18984

  141. Hochlowski,J., Cheng,X., Sauer,D., & Djuric,S. (2003) Studies of the Relative Stability of TFA Adducts vs Non-TFA Analogues for Combinatorial Chemistry Library Members in DMSO in a Repository Compound Collection. Journal of Combinatorial Chemistry, 5, 345-349. #18831

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  144. Hughes,D. (2003) Microbial genetics: Exploiting genomics, genetics and chemistry to combat antibiotic resistance. Nature Reviews Genetics, 4, 432-441. #18672

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  146. Humet,M., Carbonell,T., Masip,I., Sanchez-Baeza,F., Mora,P., Canton,E., Gobernado,M., Abad,C., Perez-Paya,E., & Messeguer,A. (2003) A positional scanning combinatorial library of peptoids as a source of biological active molecules: identification of antimicrobials. Journal of Combinatorial Chemistry, 5, 597-605. #19511

  147. Huo,Q., & Leblanc,R.M. (2003) Combinatorial surface chemistry: a novel concept for Langmuir and Langmuir-Blodgett films research. Surfactant Science Series, 109, 619-634. #18997

  148. Husemoen,G., Olsson,R., Andersson,C.M., Harvey,S.C., & Hansen,H.C. (2003) Solution-Phase Parallel Wittig Olefination: Synthesis of Substituted 1,2-Diarylethanes. Journal of Combinatorial Chemistry, 5, 606-609. #18860

  149. Iden,R., Schrof,W., Hadeler,J., & Lehmann,S. (2003) Combinatorial materials research in the polymer industry: Speed versus flexibility. Macromolecular Rapid Communications, 24, 63-72. #18697

  150. Ivachtchenko,A.V., Kovalenko,S.M., & Drushlyak,O.G. (2003) Synthesis of Substituted 4-Oxo-2-thioxo-1,2,3,4-tetrahydroquinazolines and 4-Oxo-3,4-dihydroquinazoline-2-thiols. Journal of Combinatorial Chemistry, 5, 775-788. #18785

  151. Ivachtchenko,A.V., Kobak,V.V., Ilyin,A.P., Trifilenkov,A.S., & Busel,A.A. (2003) New Scaffolds for Combinatorial Synthesis. II. 6-Sulfamoylquinolinecarboxylic Acids. Journal of Combinatorial Chemistry, 5, 645-652. #18815

  152. Ivanciuc,O. (2003) Design of topological indices. Part 27. Szeged matrix for vertex- and edge-weighted molecular graphs as a source of structural descriptors for QSAR models. Revue Roumaine de Chimie, 47, 479-492. #18862

  153. Jackson,R.W., Tabone,J.C., & Howbert,J.J. (2003) Identification of TNF-.alpha. inhibitors from a split-pool library based on a tyrosine-proline peptidomimetic scaffold. Bioorganic & Medicinal Chemistry Letters, 13, 205-208. #19737

  154. Jain,R., Kamau,M., Wang,C., Ippolito,R., Wang,H., Dulina,R., Anderson,J., Gange,D., & Sofia,M.J. (2003) 3-Azido-3-deoxy-glycopyranoside derivatives as scaffolds for the synthesis of carbohydrate-Based universal pharmacophore mapping libraries. Bioorganic & Medicinal Chemistry Letters, 13, 2185-2189. #19530

  155. Jamois,E.A., Lin,C.T., & Waldman,M. (2003) Design of focused and restrained subsets from extremely large virtual libraries. Journal of Molecular Graphics & Modelling, 22, 141-149. #18783

  156. Jensen,K.J., & Nielsen,J. (2003) Bioorganic and combinatorial chemistry. Part 1. Dansk Kemi, 84, 21-24. #18693

  157. Jimenez,J.C., Chavarria,B., Lopez-Macia,A., Royo,M., Giralt,E., & Albericio,F. (2003) Tentoxin as a Scaffold for Drug Discovery. Total Solid-Phase Synthesis of Tentoxin and a Library of Analogues. Organic Letters, 5, 2115-2118. #19563

  158. Jones,R.M., Boatman,P.D., Semple,G., Shin,Y.J., & Tamura,S.Y. (2003) Clinically validated peptides as templates for de novo peptidomimetic drug design at G-protein-coupled receptors. Current Opinion in Pharmacology, 3, 530-543. #18743

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  160. Kaltenboeck,A., Hibert,M., & Langer,T. (2003) Putative Dynamics of Vasopressin in its V1a Receptor Binding Site. Recept. Channel., 9, 93-106. #18916

  161. Karki,R.G., Gokhale,V.M., Kharkar,P.S., & Kulkarni,V.M. (2003) Azole compounds designed by molecular modelling show antifungal activity as predicted. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 42B, 372-381. #18948

  162. Kazmierczak,K., Zablotna,E., Jaskiewicz,A., Miecznikowska,H., & Rolka,K. (2003) Selection of low-molecular-mass trypsin and chymotrypsin inhibitors based on the binding loop of CMTI-III using combinatorial chemistry methods. Biochem. Biophys. Res. Commun., 310, 811-815. #18747

  163. Keifer,P.A. (2003) Flow injection analysis NMR (FIA-NMR): A novel flow NMR technique that complements LC-NMR and direct injection NMR (DI-NMR). Magn. Reson. Chem., 41, 509-516. #18829

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  166. Khandekar,S.S., Daines,R.A., & Lonsdale,J.T. (2003) Bacterial .beta.-ketoacyl-acyl carrier protein synthases as targets for antibacterial agents. Current Protein and Peptide Science, 4, 21-29. #18716

  167. Khersonsky,S.M., Jung,D.W., Kang,T.W., Walsh,D.P., Moon,H.S., Jo,H., Jacobson,E.M., Shetty,V., Neubert,T.A., & Chang,Y.T. (2003) Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening. J. Amer. Chem. Soc., 125, 11804-11805. #18756

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  170. Kiryushko,D., Kofoed,T., Skladchikova,G., Holm,A., Berezin,V., & Bock,E. (2003) A Synthetic Peptide Ligand of Neural Cell Adhesion Molecule (NCAM), C3d, Promotes Neuritogenesis and Synaptogenesis and Modulates Presynaptic Function in Primary Cultures of Rat Hippocampal Neurons. Journal of Biological Chemistry, 278, 12325-12334. #18915

  171. Kiyonaka,S., Shinkai,S., & Hamachi,I. (2003) Combinatorial library of low molecular-weight organo- and hydrogelators based on glycosylated amino acid derivatives by solid-phase synthesis. Chemistry--A European Journal, 9, 976-983. #19643

  172. Kiyonaka,S., Zhou,S.l., & Hamachi,I. (2003) Preparation of nano-biomaterials from various compound group. Mirai Zairyo, 3, 36-45. #18688

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  175. Knight,V., Sanglier,J.J., DiTullio,D., Braccili,S., Bonner,P., Waters,J., Hughes,D., & Zhang,L. (2003) Diversifying microbial natural products for drug discovery. Applied Microbiology and Biotechnology, 62, 446-458. #18731

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  178. Koberstein,R., Aissaoui,H., Bur,D., Clozel,M., Fischli,W., Jenck,F., Mueller,C., Nayler,O., Sifferlen,T., Treiber,A., & Weller,T. (2003) Tetrahydroisoquinolines as orexin receptor antagonists: strategies for lead optimization by solution-phase chemistry. Chimia, 57, 270-275. #18658

  179. Konishi,T., Hondo,T., Araki,T., Nishio,K., Tsuchiya,T., Matsumoto,T., Suehara,S., Todoroki,S.i., & Inoue,S. (2003) Glass formation and reddish coloring properties in zinc phosphotellurite glass. Materials Research Society Symposium Proceedings, 754, 465-470. #18789

  180. Konishi,T., Hondo,T., Araki,T., Nishio,K., Tsuchiya,T., Matsumoto,T., Suehara,S., Todoroki,S.i., & Satoru,I. (2003) Investigation of glass formation and color properties in the P2O5-TeO2-ZnO system. Journal of Non-Crystalline Solids, 324, 58-66. #18796

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  183. Krattiger,P., McCarthy,C., Pfaltz,A., & Wennemers,H. (2003) Catalyst-substrate coimmobilization: A strategy for catalysts discovery in split-and-mix libraries. Angewandte Chemie, International Edition, 42, 1722-1724. #18881

  184. Krupicka,A., Johansson,M., Hult,A., & Favaro,G. (2003) Mechanical surface characterization: A promising procedure to screen organic coatings. Journal of Coatings Technology, 75, 19-27. #18894

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  187. Kubo,M., Kubota,T., Jung,C., Seki,K., Takami,S., Koizumi,N., Omata,K., Yamada,M., & Miyamoto,A. (2003) Combinatorial Computational Chemistry Approach to the High-Throughput Screening of Metal Sulfide Catalysts for CO Hydrogenation Process. Energy & Fuels, 17, 857-861. #18804

  188. Lam,K.S., Liu,R., Miyamoto,S., Lehman,A.L., & Tuscano,J.M. (2003) Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research. Account. Chem. Res., 36, 370-377. #18681

  189. Lam,P.Y.S., Adams,J.J., Clark,C.G., Calhoun,W.J., Luettgen,J.M., Knabb,R.M., & Wexler,R.R. (2003) Discovery of 3-Amino-4-Chlorophenyl P1 as a novel and potent benzamidine mimic via solid-phase synthesis of an isoxazoline library. Bioorganic & Medicinal Chemistry Letters, 13, 1795-1799. #19581

  190. Lan,P., Porco,J.A., Jr., South,M.S., & Parlow,J.J. (2003) The Development of a Chromatography-Free Mitsunobu Reaction: Synthesis and Applications of an Anthracene-Tagged Phosphine Reagent. Journal of Combinatorial Chemistry, 5, 660-669. #18800

  191. Landon,L.A., & Deutscher,S.L. (2003) Combinatorial discovery of tumor targeting peptides using phage display. J. Cell. Biochem., 90, 509-517. #18727

  192. Langer,T., & Krovat,E.M. (2003) Chemical feature-based pharmacophores and virtual library screening for discovery of new leads. Current Opinion in Drug Discovery & Development, 6, 370-376. #18664

  193. Langer,T., & Wolber,G. (2003) Feature-based pharmacophores: virtual screening for lead identification. G. I. T. Laboratory Journal, Europe, 7, 208-210. #18786

  194. Laursen,J.B., Petersen,L., Jensen,K.J., & Nielsen,J. (2003) Efficient synthesis of glycosylated phenazine natural products and analogs with DISAL (methyl 3,5-dinitrosalicylate) glycosyl donors. Organic & Biomolecular Chemistry, 1, 3147-3153. #18765

  195. Lazo,J.S., & Wipf,P. (2003) Small molecule regulation of phosphatase-dependent cell signaling pathways. Oncology Research, 13, 347-352. #18645

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  198. Lee,J.W., Louie,Y.Q., Walsh,D.P., & Chang,Y.T. (2003) Nitrophenol Resins for Facile Amide and Sulfonamide Library Synthesis. Journal of Combinatorial Chemistry, 5, 330-335. #19713

  199. Lee,R.E., Protopopova,M., Crooks,E., Slayden,R.A., Terrot,M., & Barry,C.E.I. (2003) Combinatorial Lead Optimization of [1,2]-Diamines Based on Ethambutol as Potential Antituberculosis Preclinical Candidates. Journal of Combinatorial Chemistry, 5, 172-187. #18978

  200. Lee,S.H., Clapham,B., Koch,G., Zimmermann,J., & Janda,K.D. (2003) Solid-Phase Rhodium Carbenoid N-H Insertion Reactions: the Synthesis of a Diverse Array of Indoles. Journal of Combinatorial Chemistry, 5, 188-196. #18973

  201. Leitheiser,C.J., Smith,K.L., Rishel,M.J., Hashimoto,S., Konishi,K., Thomas,C.J., Li,C., McCormick,M.M., & Hecht,S.M. (2003) Solid-Phase Synthesis of Bleomycin Group Antibiotics. Construction of a 108-Member Deglycobleomycin Library. J. Amer. Chem. Soc., 125, 8218-8227. #19509

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  203. Lesik,R.B., Zimenkovs'kii,B.S., Yarmolyuk,S.N., & Subtel'na,I.Y. (2003) Synthesis of potential biologically active compounds on the base of 5-carboxymethylidene-2-4-thiazolidinedione. Farmatsevtichnii Zhurnal (Kiev), 51-56. #18906

  204. Lesyk,R.B., Zimenkovsky,B.S., Subtel'na,I.Y., Soronovych,I.I., Semenciv,G.M., & Roman,O.M. (2003) Effective approach to obtaining of combinatorial library of heterocycles with thioisocoumarin template. Farmatsevtichnii Zhurnal (Kiev), 56-60. #18773

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  212. Liao,Y., Fathi,R., & Yang,Z. (2003) Convergent Solid-Phase Synthesis of Symmetrical Benzo[b]furan's Dimerizer. Journal of Combinatorial Chemistry, 5, 79-81. #18990

  213. Lin,C., Zhang,Z., & Zhu,X. (2003) Application of scavenger resin in combinatorial chemistry. Huaxue Tongbao, 66, 536-543. #18641

  214. Lindquist,C., Tedebark,U., Ersoy,O., & Somfai,P. (2003) Microwave-assisted coupling of carboxylic acids to a polymer bound hydrazine linker. Syn. Commun., 33, 2257-2262. #18807

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  217. Luo,J., & Huang,W. (2003) A new strategy for solid phase synthesis of a secondary amide library using sulfonamide linker via radical traceless cleavage. Mol. Diversity, 6, 33-41. #19824

  218. Maier,W.F. (2003) Combinatorial chemistry in catalysis and materials research. Chemie Ingenieur Technik, 75, 1048. #18750

  219. Makino,S., Nakanishi,E., & Tsuji,T. (2003) Efficient solid-phase synthesis of 2,1,3-benzothiadiazin-4-one 2-oxides with SynPhase lanterns. Bull. Kor. Chem. Soc., 24, 389-392. #18902

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  221. Manku,S., Wang,F., & Hall,D.G. (2003) Synthesis and High Performance Liquid Chromatography/Electrospray Mass Spectrometry Single-Bead Decoding of Split-Pool Structural Libraries of Polyamines Supported on Polystyrene and Polystyrene/Ethylene Glycol Resins. Journal of Combinatorial Chemistry, 5, 379-391. #18918

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  223. Mari,F., & Fields,G.B. (2003) Conopeptides: unique pharmacological agents that challenge current peptide methodologies. Chimica Oggi, 21, 43-48. #18642

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  226. Meier,M.A.R., Hoogenboom,R., Fijten,M.W.M., Schneider,M., & Schubert,U.S. (2003) Automated MALDI-TOF-MS Sample Preparation in Combinatorial Polymer Research. Journal of Combinatorial Chemistry, 5, 369-374. #18884

  227. Meier,M.A.R., & Schubert,U.S. (2003) A multiple-layer-spotting approach for MALDI-TOF-MS: New possibilities for an implementation into combinatorial polymer research. Polymeric Materials Science and Engineering, 88, 72-73. #18927

  228. Meisenbach,M., Allmendinger,T., & Mak,C.P. (2003) Scale-Up of the Synthesis of a Pyrimidine Derivative Directly on Solid Support. Organic Process Research & Development, 7, 553-558. #18871

  229. Merlot,C., Domine,D., Cleva,C., & Church,D.J. (2003) Chemical substructures in drug discovery. Drug Disc. Today, 8, 594-602. #18820

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  232. Migihashi,C., & Sato,F. (2003) Solid-phase synthesis of a novel series of 2,3,4,5-tetrahydro-1,4-benzodiazepin-2,5-dione libraries. J. Heterocycl. Chem., 40, 143-147. #18938

  233. Miller,J.L., Bradley,E.K., & Teig,S.L. (2003) Luddite: An Information-Theoretic Library Design Tool. Journal of Chemical Information and Computer Sciences, 43, 47-54. #18983

  234. Mineno,T., & Avery,M.A. (2003) Giardiasis: Recent progress in chemotherapy and drug development. Current Pharmaceutical Design, 9, 841-855. #18692

  235. Mironov,M.A., Mokrushin,V.S., & Maltsev,S.S. (2003) New method for the combinatorial search of multi component reactions. Synlett, 943-946. #18852

  236. Mordkovich,V.Z., Hayashi,H., Haemori,M., Fukumura,T., & Kawasaki,M. (2003) Discovery and optimization of new ZnO-based phosphors using a combinatorial method. Advanced Functional Materials, 13, 519-524. #18802

  237. Morita,T. (2003) Development of high throughput genotoxicity screening assays using bacteria. Kankyo Hen'igen Kenkyu, 25, 23-31. #18806

  238. Muller,R.P., Philipp,D.M., & Goddard,W.A., III. (2003) Quantum Mechanical-Rapid Prototyping Applied to Methane Activation. Topics in Catalysis, 23, 81-98. #18803

  239. Murahashi,S.I. (2003) Transition-metal-based Lewis acid, base, and ambiphilic catalysts: Development of non-salt alternative processes. J. Syn. Org. Chem. Jpn., 61, 425-435. #18673

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  243. Nakatsuka,T. (2003) The role of parallel solution. Phase organic synthesis for drug discovery. Kagaku to Kogyo (Osaka, Japan), 77, 42-47. #18713

  244. Nara,S., Tanaka,R., Eishima,J., Hara,M., Takahashi,Y., Otaki,S., Foglesong,R.J., Hughes,P.F., Turkington,S., & Kanda,Y. (2003) Discovery and Structure-Activity Relationships of Novel Piperidine Inhibitors of Farnesyltransferase. J. Med. Chem., 46, 2467-2473. #18886

  245. Nefzi,A., Ostresh,J.M., & Houghten,R.A. (2003) Combinatorial chemistry: mixture-based combinatorial libraries of acyclic and heterocyclic compounds from amino acids and short peptides. EXS, 93, 109-123. #18695

  246. New,D.C., Miller-Martini,D.M., & Wong,Y.H. (2003) Reporter gene assays and their applications to bioassays of natural products. Phytotherapy Research, 17, 439-448. #18668

  247. Ng,H.T., Chen,B., Koehne,J.E., Cassell,A.M., Li,J., Han,J., & Meyyappan,M. (2003) Growth of Carbon Nanotubes: A Combinatorial Method To Study the Effects of Catalysts and Underlayers. J. Phys. Chem. B, 107, 8484-8489. #18818

  248. Nguyen,R., & Huc,I. (2003) Optimizing the reversibility of hydrazone formation for dynamic combinatorial chemistry. Chemical Communications (Cambridge, United Kingdom), 942-943. #18912

  249. Nicolaou,K.C., Roecker,A.J., Hughes,R., van Summeren,R., Pfefferkorn,J.A., & Winssinger,N. (2003) Novel strategies for the solid phase synthesis of substituted indolines and indoles. Bioorganic & Medicinal Chemistry, 11, 465-476. #18985

  250. Nicolaou,K.C., Evans,R.M., Roecker,A.J., Hughes,R., Downes,M., & Pfefferkorn,J.A. (2003) Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Organic & Biomolecular Chemistry, 1, 908-920. #19562

  251. Niculescu,S.P. (2003) Artificial neural networks and genetic algorithms in QSAR. THEOCHEM, 622, 71-83. #18704

  252. Ning,M., Li,Z., & Zhao,W. (2003) Progress in Ugi reaction. Huaxue Jinzhan, 15, 186-193. #18661

  253. Okuzumi,T., Nakanishi,E., Tsuji,T., & Makino,S. (2003) Efficient solid-phase synthesis of diverse 1,2,3-benzotriazin-4-ones using tert-butyl nitrite. Tetrahedron Lett., 44, 5539-5542. #18841

  254. Olk,C.H., Tibbetts,G.G., Simon,D., & Moleski,J.J. (2003) Combinatorial preparation and infrared screening of hydrogen sorbing metal alloys. Journal of Applied Physics, 94, 720-725. #18845

  255. Omata,K., Watanabe,Y., Umegaki,T., Hashimoto,M., & Yamada,M. (2003) Catalyst development for methanol synthesis using parallel reactors for high-throughput screening based on a 96 well microplate system. Journal of the Japan Petroleum Institute, 46, 328-334. #18763

  256. Opatz,T., Kallus,C., Wunberg,T., Schmidt,W., Henke,S., & Kunz,H. (2003) D-glucose as a pentavalent chiral scaffold. Eur. J. Org. Chem., 1527-1536. #18891

  257. Orain,D., Koch,G., & Giger,R. (2003) From solution-phase studies to solid-phase synthesis: a new indole based scaffold for combinatorial chemistry. Chimia, 57, 255-261. #18659

  258. Organ,M.G., & Mayer,S. (2003) Synthesis of 4-(5-Iodo-3-Methylpyrazolyl) Phenylsulfonamide and Its Elaboration To a COX II Inhibitor Library by Solution-Phase Suzuki Coupling Using Pd/C as a Solid-Supported Catalyst. Journal of Combinatorial Chemistry, 5, 118-124. #19730

  259. Ortholand,J.Y. (2003) Combinatorial chemistry in the discovery of new medicines: 10 years of progress. Actualite Chimique, 103-107. #18816

  260. Otto,S., & Kubik,S. (2003) Dynamic Combinatorial Optimization of a Neutral Receptor That Binds Inorganic Anions in Aqueous Solution. J. Amer. Chem. Soc., 125, 7804-7805. #18832

  261. Otto,S. (2003) Dynamic combinatorial chemistry: A new method for selection and preparation of synthetic receptors. Current Opinion in Drug Discovery & Development, 6, 509-520. #18759

  262. Owa,T. (2003) Chemical genetics. Farumashia, 39, 22-26. #18714

  263. Park,J.K., Park,S.M., Kim,C.H., Park,H.D., & Choi,S.Y. (2003) Synthesis of Gd2O3:Eu, Li Phosphor by Modified Combinatorial Chemistry and Its Photoluminescence Behavior. Journal of the Electrochemical Society, 150, H27-H31. #18989

  264. Parsons,A. (2003) New tricks for stacking bricks. Chemistry Review (Deddington, United Kingdom), 12, 2-5. #18955

  265. Pascual,R., Mateu,M., Gasteiger,J., Borrell,J.I., & Teixido,J. (2003) Design and Analysis of a Combinatorial Library of HEPT Analogues: Comparison of Selection Methodologies and Inspection of the Actually Covered Chemical Space. Journal of Chemical Information and Computer Sciences, 43, 199-207. #19003

  266. Pastor,J.J., Lingard,I., Bhalay,G., & Bradley,M. (2003) Ion-Extraction Ladder Sequencing from Bead-Based Libraries. Journal of Combinatorial Chemistry, 5, 85-90. #18975

  267. Patra,A., Roy,A.K., Joshi,B.S., Roy,R., Batra,S., & Bhaduri,A.P. (2003) The Baylis-Hillman chemistry in aqueous media: elucidation of mechanism for synthesis of ether side-product leads to an efficient approach to C-O bond formation. Tetrahedron, 59, 663-670. #18979

  268. Pena,D., Minnaard,A.J., Boogers,J.A.F., de Vries,A.H.M., de Vries,J.G., & Feringa,B.L. (2003) Improving conversion and enantioselectivity in hydrogenation by combining different monodentate phosphoramidites; a new combinatorial approach in asymmetric catalysis. Organic & Biomolecular Chemistry, 1, 1087-1089. #18870

  269. Peri,F., Nicotra,F., Leslie,C.P., Micheli,F., Seneci,P., & Marchioro,C. (2003) D-glucose as a regioselectively addressable scaffold for combinatorial chemistry on solid phase. J. Carbohyd. Chem., 22, 57-71. #18917

  270. Pescarmona,P.P., van der Waal,J.C., & Maschmeyer,T. (2003) Application of combinatorial chemistry and high-speed experimentation concepts to the study of titanium-silsesquioxane catalysts. Catalysis Today, 81, 347-357. #18811

  271. Pinilla,C., Appel,J.R., Borras,E., & Houghten,R.A. (2003) Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries. Nature Medicine (New York, NY, United States), 9, 118-122. #18719

  272. Pintore,M., van de Waterbeemd,H., Piclin,N., & Chretien,J.R. (2003) Prediction of oral bioavailability by adaptive fuzzy partitioning. Eur. J. Med. Chem., 38, 427-431. #18880

  273. Pirrung,M.C., & Liu,H. (2003) Modular, Parallel Synthesis of an Illudinoid Combinatorial Library. Organic Letters, 5, 1983-1985. #19595

  274. Pittman,C.U., Jr. (2003) Polymer supports in synthesis. Polymer News, 28, 183-184. #18787

  275. Portlock,D.E., Naskar,D., West,L., Ostaszewski,R., & Chen,J.J. (2003) Solid-phase synthesis of five-dimensional libraries via a tandem Petasis-Ugi multi-component condensation reaction. Tetrahedron Lett., 44, 5121-5124. #19503

  276. Potyrailo,R.A., Wroczynski,R.J., Pickett,J.E., & Rubinsztajn,M. (2003) High-throughput fabrication, performance testing, and characterization of one-dimensional libraries of polymeric compositions. Macromolecular Rapid Communications, 24, 123-130. #18946

  277. Potyrailo,R.A., Wroczynski,R.J., Lemmon,J.P., Flanagan,W.P., & Siclovan,O.P. (2003) Fluorescence Spectroscopy and Multivariate Spectral Descriptor Analysis for High-Throughput Multiparameter Optimization of Polymerization Conditions of Combinatorial 96-Microreactor Arrays. Journal of Combinatorial Chemistry, 5, 8-17. #18994

  278. Potyrailo,R.A. (2003) Analytical spectroscopic tools for high-throughput screening of combinatorial materials libraries. TrAC, Trends in Analytical Chemistry, 22, 374-384. #18667

  279. Potyrailo,R.A., Chisholm,B.J., Morris,W.G., Cawse,J.N., Flanagan,W.P., Hassib,L., Molaison,C.A., Ezbiansky,K., Medford,G., & Reitz,H. (2003) Development of Combinatorial Chemistry Methods for Coatings: High-Throughput Adhesion Evaluation and Scale-Up of Combinatorial Leads. Journal of Combinatorial Chemistry, 5, 472-478. #18849

  280. Pringle,A.K., Morrison,B., Bradley,M., Iannotti,F., & Sundstrom,L.E. (2003) Characterisation of a novel class of polyamine-based neuroprotective compounds. Naunyn-Schmiedeberg's Archives of Pharmacology, 368, 216-224. #18751

  281. Prior,D.V., Connor,A.L., & Wilding,I.R. (2003) The Enterion capsule. Drugs and the Pharmaceutical Sciences, 126, 273-288. #18722

  282. Raith,K. (2003) Hyphenation of affinity capillary electrophoresis with mass spectrometry. Drugs and the Pharmaceutical Sciences, 128, 329-349. #18655

  283. Rao,R.D., Uhm,J.H., Krishnan,S., & James,C.D. (2003) Genetic and signaling pathway alterations in glioblastoma: relevance to novel targeted therapies. Frontiers in Bioscience, 8, E270-E280. #18675

  284. Redman,J.E., Wilcoxen,K.M., & Ghadiri,M.R. (2003) Automated Mass Spectrometric Sequence Determination of Cyclic Peptide Library Members. Journal of Combinatorial Chemistry, 5, 33-40. #18992

  285. Remsing,L.L., Bahadori,H.R., Carbone,G.M., McGuffie,E.M., Catapano,C.V., & Rohr,J. (2003) Inhibition of c-src Transcription by Mithramycin: Structure-Activity Relationships of Biosynthetically Produced Mithramycin Analogues Using the c-src Promoter as Target. Biochemistry, 42, 8313-8324. #18851

  286. Roberts,S.L., Furlan,R.L.E., Otto,S., & Sanders,J.K.M. (2003) Metal-ion induced amplification of three receptors from dynamic combinatorial libraries of peptide-hydrazones. Organic & Biomolecular Chemistry, 1, 1625-1633. #18835

  287. Robillard,M.S., Bacac,M., van den Elst,H., Flamigni,A., van der Marel,G.A., van Boom,J.H., & Reedijk,J. (2003) Automated Parallel Solid-Phase Synthesis and Anticancer Screening of a Library of Peptide-Tethered Platinum(II) Complexes. Journal of Combinatorial Chemistry, 5, 821-825. #19347

  288. Roda,A., Guardigli,M., Pasini,P., & Mirasoli,M. (2003) Bioluminescence and chemiluminescence in drug screening. Analytical and Bioanalytical Chemistry, 377, 826-833. #18737

  289. Rosania,G.R. (2003) Supertargeted chemistry: Identifying relationships between molecular structures and their sub-cellular distribution. Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates), 3, 659-685. #18710

  290. Roy,I., & Gupta,M.N. (2003) Selectivity in affinity chromatography. Biotechnology and Bioprocessing, 27, 57-94. #18643

  291. Saito,K., Jin,D.H., Ogawa,T., Muramoto,K., Hatakeyama,E., Yasuhara,T., & Nokihara,K. (2003) Antioxidative properties of tripeptide libraries prepared by the combinatorial chemistry. J. Agric. Food Chem., 51, 3668-3674. #18882

  292. Salemme,F.R. (2003) Chemical genomics as an emerging paradigm for postgenomic drug discovery. Pharmacogenomics, 4, 257-267. #18678

  293. Sales,S., Adamson,V., & Allison,K. (2003) Automated screening systems; technology integration for high throughput drug discovery. PharmaChem, 2, 73-77. #18817

  294. Salo,P.K., Pertovaara,A.M., Salo,V.M., Salomies,H.E.M., & Kostiainen,R.K. (2003) High-performance thin-layer chromatography method for assessment of the quality of combinatorial libraries, and comparison with liquid chromatography-ultraviolet-mass spectrometry. Journal of Combinatorial Chemistry, 5, 223-232. #18923

  295. Salvino,J.M., Gerard,B., Ye,H.F., Sauvagnat,B., & Dolle,R.E. (2003) The Solid-Phase Synthesis and Use of N-Monosubstituted Piperazines in Chemical Library Synthesis. Journal of Combinatorial Chemistry, 5, 260-266. #18954

  296. Sampson,T. (2003) Aptamers and SELEX: the technology. World Patent Information, 25, 123-129. #18669

  297. Sanchez-Perez,A.M., Montoliu,C., & Felipo,V. (2003) Trialkylglycines: a new family of compounds with in vivo neuroprotective activity. CNS Drug Reviews, 9, 263-274. #18725

  298. Sato,T., & Yamagata,T. (2003) Construction of saccharide library by cells. Tanpakushitsu Kakusan Koso, 48, 1213-1219. #18670

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  300. Sauer,W.H.B., & Schwarz,M.K. (2003) Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity. Journal of Chemical Information and Computer Sciences, 43, 987-1003. #18936

  301. Scheidtmann,J., Saalfrank,J.W., & Maier,W.F. (2003) Plattenbau-automated synthesis of catalysts and materials libraries. Studies in Surface Science and Catalysis, 145, 13-20. #18648

  302. Scheuermann,J., Volonterio,A., Zerbe,O., Zanda,M., & Neri,D. (2003) Discovery and investigation of lead compounds as binders to the extra-domain B of the angiogenesis marker, fibronectin. Drug Development Research, 58, 268-282. #18873

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  309. Schwardt,O., Kolb,H., & Ernst,B. (2003) Drug discovery today. Current Topics in Medicinal Chemistry (Hilversum, Netherlands), 3, 1-9. #18717

  310. Secundo,F., Carrea,G., De Amici,M., Di Ventimiglia,S.J., & Dordick,J.S. (2003) A combinatorial biocatalysis approach to an array of cholic acid derivatives. Biotechnol. Bioeng., 81, 391-396. #18970

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  312. Sem,D., Villar,H., & Kelly,M. (2003) Technological innovations are creating a powerful tool for target identification and chemical proteomics. Mod. Drug Dis., 6, 26-28,30. #18766

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  314. Shi,B., Scobie,M., & Boyle,R.W. (2003) Parallel synthesis of unsymmetrically substituted tetraphenyl porphyrins on Wang resin. Tetrahedron Lett., 44, 5083-5086. #18857

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  316. Smith,A.P., Sehgal,A., Douglas,J.F., Karim,A., & Amis,E.J. (2003) Combinatorial mapping of surface energy effects on diblock copolymer thin film ordering. Macromolecular Rapid Communications, 24, 131-135. #18945

  317. Smith,R.C., Hoilien,N., Chien,J., Campbell,S.A., Roberts,J.T., & Gladfelter,W.L. (2003) Combinatorial Chemical Vapor Deposition. Achieving Compositional Spreads of Titanium, Tin, and Hafnium Oxides by Balancing Reactor Fluid Dynamics and Deposition Kinetics. Chemistry of Materials, 15, 292-298. #18998

  318. Smith,S. (2003) Combinatorial chemistry in the development of new crop protection products. Pesticide Outlook, 14, 21-26. #18709

  319. Sohn,K.S., Lee,J.M., Jeon,I.W., & Park,H.D. (2003) Combinatorial Searching for Tb3+-Activated Phosphors of High Efficiency at Vacuum UV Excitation. Journal of the Electrochemical Society, 150, H182-H186. #18822

  320. Song,A., Zhang,J., Lebrilla,C.B., & Lam,K.S. (2003) A Novel and Rapid Encoding Method Based on Mass Spectrometry for \"One-Bead-One-Compound\" Small Molecule Combinatorial Libraries. J. Amer. Chem. Soc., 125, 6180-6188. #18893

  321. Sopkova-de Oliveira Santos,J., Lancelot,J.C., Bouillon,A., & Rault,S. (2003) 2-(6-Bromopyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane and (6-bromopyridin-3-yl)boronic acid, new bifunctional building blocks for combinatorial chemistry. Acta Crystallographica, Section C: Crystal Structure Communications, C59, o111-o113. #18895

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  327. Stieber,F., Grether,U., & Waldmann,H. (2003) Development of the traceless phenylhydrazide linker for solid-phase synthesis. Chemistry--A European Journal, 9, 3270-3281. #18791

  328. Stieber,F., Grether,U., Mazitschek,R., Soric,N., Giannis,A., & Waldmann,H. (2003) Multistep solid-phase synthesis of an antibiotic and receptor tyrosine kinase inhibitors using the traceless phenylhydrazide linker. Chemistry--A European Journal, 9, 3282-3291. #18790

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  330. Stoll,V., Stewart,K.D., Maring,C.J., Muchmore,S., Giranda,V., Gu,Y.g., Wang,G., Chen,Y., Sun,M., Zhao,C., Kennedy,A.L., Madigan,D.L., Xu,Y., Saldivar,A., Kati,W., Laver,G., Sowin,T., Sham,H.L., Greer,J., & Kempf,D. (2003) Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series. Biochemistry, 42, 718-727. #18988

  331. Strausberg,R.L., & Schreiber,S.L. (2003) From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes. Science (Washington, DC, United States), 300, 294-295. #18684

  332. Svedberg,E.B., van de Veerdonk,R.J.M., Howard,K.J., & Madsen,L.D. (2003) Quantifiable combinatorial materials science approach applied to perpendicular magnetic recording media. Journal of Applied Physics, 93, 5519-5526. #18896

  333. Svejgaard,L., Fuglsang,H., Jensen,P.B., Kelly,N.M., Pedersen,H., Andersen,K., Ruhland,T., & Jensen,K.J. (2003) Synthesis of two D-glucosamine derived 3,4-epoxides as potential scaffolds for combinatorial chemistry. J. Carbohyd. Chem., 22, 179-184. #18858

  334. Swamy,K.M.K., Yeh,W.B., Lin,M.J., & Sun,C.M. (2003) Microwave-assisted polymer-supported combinatorial synthesis. Curr. Med. Chem., 10, 2403-2423. #18740

  335. Swords,W.E., Jones,P.A., & Apicella,M.A. (2003) The lipo-oligosaccharides of Haemophilus influenzae: An interesting array of characters. Journal of Endotoxin Research, 9, 131-144. #18654

  336. Tai,C.C., Chang,T., Roller,B., & Jessop,P.G. (2003) High-Pressure Combinatorial Screening of Homogeneous Catalysts: Hydrogenation of Carbon Dioxide. Inorg. Chem., 42, 7340-7341. #18734

  337. Takahashi,T., Nagamiya,H., Doi,T., Griffiths,P.G., & Bray,A.M. (2003) Solid Phase Library Synthesis of Cyclic Depsipeptides: Aurilide and Aurilide Analogues. Journal of Combinatorial Chemistry, 5, 414-428. #18899

  338. Tamamura,H., Kato,T., Hori,T., Otaka,A., & Fujii,N. (2003) Stereoselective synthesis of peptidomimetics with hydroxyethylamine dipeptide isosteres utilizing aza-Payne rearrangement and O,N-acyl transfer reactions. Peptide Science, 39th, 143-146. #18861

  339. Tanaka,H., Ohno,H., Kawamura,K., Ohtake,A., Nagase,H., & Takahashi,T. (2003) Solid-phase synthesis of naltrindole derivatives using Fischer indole synthesis based on one-pot release and cyclization methodology. Organic Letters, 5, 1159-1162. #18931

  340. Teixido,M., Altamura,M., Quartara,L., Giolitti,A., Maggi,C.A., Giralt,E., & Albericio,F. (2003) Bicyclic Homodetic Peptide Libraries: Comparison of Synthetic Strategies for Their Solid-Phase Synthesis. Journal of Combinatorial Chemistry, 5, 760-768. #19447

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