PAPERS PUBLISHED IN 2000

This list is arranged by the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (michal@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M., Leblova Z.: Dynamic database of references in molecular diversity. Internet http://www.5z.com.

Recently added entries are marked in bold

1. Anonymous. (2000) Combinatorial chemistry. Small-molecule-RNA interactions. Drug Disc. Today, 5, 167. #14908

2. Anonymous. (2000) Combinatorial chemistry on the WWW. TRAC-Trend. Anal. Chem., 19, VII. #14909

3. Anonymous. (2000) Combinatorial chemistry. Optimization of growth hormone secretagogues. Drug Disc. Today, 5, 303. #14906

4. Anonymous. (2000) Combinatorial chemistry. Antiviral prostanoid libraries. Drug Disc. Today, 5, 211. #14907

5. Adamczyk, M., & Grote, J. (2000) Synthesis of novel spirolactams by reaction of fluorescein methyl ester with amines. Tetrahedron Lett., 41, 807-809. #14259

6. Adlington, R.M., Baldwin, J.E., Pritchard, G.J., & Spencer, K.C. (2000) Synthesis of novel C-nucleosides with potential applications in combinatorial and parallel synthesis. Tetrahedron Lett., 41, 575-578. #13889

7. Aita, T., Urata, S., & Husimi, Y. (2000) From amino acid landscape to protein landscape: Analysis of genetic codes in terms of fitness landscape. Journal of Molecular Evolution, 50, 313-323. #14911

8. Alam, M.R., Maeda, M., & Sasaki, S. (2000) DNA-binding peptides searched from the solid-phase combinatorial library with the use of the magnetic beads attaching the target duplex DNA. Bioorg. Med. Chem., 8, 465-473. #14913

9. Albericio, F., Garcia, J., Michelotti, E.L., Nicolas, E., & Tice, C.M. (2000) Solid phase synthesis of sulfahydantoins. Tetrahedron Lett., 41, 3161-3163. #14552

10. Albrecht, M. (2000) From molecular diversity to template-directed self-assembly: New trends in metallo-supramolecular chemistry. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 36, 127-151. #14914

11. Alonso, C., Nantz, M.H., & Kurth, M.J. (2000) b-Dimethylphenylsilylethyl esters: A linker for solid-phase chemistry. Tetrahedron Lett., 41, 5617-5622. #15416

12. Alvarez-Gutierrez, J.M., Nefzi, A., & Houghten, R.A. (2000) Solid phase synthesis of 1-substituted pyroglutamates. Tetrahedron Lett., 41, 851-854. #14261

13. Alvarez-Gutierrez, J.M., Nefzi, A., & Houghten, R.A. (2000) Solid phase synthesis of 1,3-disubstituted succinimides. Tetrahedron Lett., 41, 609-612. #13902

14. Amatschek, K., Necina, R., Hahn, R., Schallaun, E., Schwinn, H., Josic, D., & Jungbauer, A. (2000) Affinity chromatography of human blood coagulation factor VIII on monoliths with peptides from a combinatorial library. HRC-J. High Res. Chromatogr., 23, 47-58. #14917

15. An, H., & Cook, P.D. (2000) Methodologies for generating solution-phase combinatorial libraries. Chem. Rev., 100, 3311-3340. #15609

16. Andre, A., Puca, A., Sansone, F., Brandi, A., Antico, G., & Calogero, R.A. (2000) Reinitiation of protein synthesis in Escherichia coli can be induced by mRNA cis-elements unrelated to canonical translation initiation signals. FEBS Lett., 468, 73-78. #14919

17. Andrews, K. (2000) Argonaut Technologies AG. Reaping the benefits of parallel synthesis: Meeting challenges from discovery to development. Chimia, 54, 155-157. #14920

18. Angelaud, R., Matsumoto, Y., Korenaga, T., Kudo, K., Senda, M., & Mikami, K. (2000) Optical rotation per refractive index unit, or enantiomeric (e) factor, for screening enantioselective catalysts through asymmetric activation or carbohydrates. Chirality, 12, 544-547. #14921

19. Armstrong, G.D. (2000) Carbohydrate receptor mimicry as a basis for anti-infective therapy. Curr. Opin. Drug. Disc. Develop., 3, 191-202. #14359

20. Aronov, A.M., Munagala, N.R., Ortiz De Montellano, P.R., Kuntz, I.D., & Wang, C.C. (2000) Rational design of selective submicromolar inhibitors of tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase. Biochemistry, 39, 4684-4691. #14699

21. Arya, P., Kutterer, K.M.K., & Barkley, A. (2000) Glycomimetics: A programmed approach toward neoglycopeptide libraries. Journal of Combinatorial Chemistry, 2, 120-126. #14371

22. Attardi, M.E., Porcu, G., & Taddei, M. (2000) Malachite green, a valuable reagent to monitor the presence of free COOH on the solid-phase. Tetrahedron Lett., 41, 7391-7394. #15632

23. Attardi, M.E., Falchi, A., & Taddei, M. (2000) A sensitive visual test for detection of OH groups on resin. Tetrahedron Lett., 41, 7395-7399. #15633

24. Aznar, F., Valdes, C., & Cabal, M.P. (2000) Enamines in solid-phase: Synthesis and reactivity towards electrophiles. Tetrahedron Lett., 41, 5683-5687. #15419

25. Backes, B.J., Harris, J.L., Leonetti, F., Craik, C.S., & Ellman, J.A. (2000) Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin. Nat. Biotech., 18, 187-193. #14924

26. Bae, D.G., Gho, Y.S., Yoon, W.H., & Chae, C.B. (2000) Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis. Journal of Biological Chemistry, 275, 13588-13596. #14925

27. Bakhtiar, R., & Nelson, R.W. (2000) Electrospray ionization and matrix-assisted laser desorption ionization mass spectrometry. Emerging technologies in biomedical sciences. Biochem. Pharmacol., 59, 891-905. #14626

28. Baldino, C.M. (2000) Perspective articles on the utility and application of solution-phase combinatorial chemistry. Journal of Combinatorial Chemistry, 2, 89-103. #14366

29. Ball, W.J., Jr., Wang, Z.M., Malik, B., Kasturi, R., Dey, P., Short, M.K., & Margolies, M.N. (2000) Selection of peptidic mimics of digoxin from phage-displayed peptide libraries by anti-digoxin antibodies. J. Mol. Biol., 301, 101-115. #15760

30. Banfi, L., Guanti, G., & Riva, R. (2000) Passerini multicomponent reaction of protected a-aminoaldehydes as a tool for combinatorial synthesis of enzyme inhibitors. Chem. Commun., 985-986. #15761

31. Banks, P., Gosselin, M., & Prystay, L. (2000) Fluorescence polarization assays for high throughput screening of G protein-coupled receptors. J. Biomol. Screen., 5, 159-167. #15438

32. Barban, V., Fraysse-Corgier, S., Paranhos-Baccala, G., Petit, M., Manin, C., Berard, Y., Prince, A.M., Mandrand, B., & Meulien, P. (2000) Identification of a human epitope in hepatitis C virus (HCV) core protein using a molecularly cloned antibody repertoire from a non-symptomatic, anti-HCV-positive patient. J. Gen. Virol., 81, 461-469. #13911

33. Barchi, J.J. (2000) Emerging roles of carbohydrates and glycomimetics in anticancer drug design. Current Pharmaceutical Design, 6, 485-501. #14927

34. Barco, A., Benetti, S., De Risi, C., Marchetti, P., Pollini, G.P., & Zanirato, V. (2000) Solid-phase synthesis of indolizidine and quinolizidine derivatives. Journal of Combinatorial Chemistry, 2, 337-340. #14685

35. Bark, S.J., Schmid, S., & Hahn, K.M. (2000) A highly efficient method for site-specific modification of unprotected peptides after chemical synthesis. J. Amer. Chem. Soc., 122, 3567-3573. #14928

36. Barlos, K., Gatos, D., Mourtas, S., Nikoletou, A., Karavoltsos, M., Bali, D. & Shoina, V. (2000) Solid-phase synthesis of thiol and thioether functions containing peptides and complex organic molecules. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 198-199). Kluwer Academic Publisher, Dordrecht. #15729

37. Barnes, C., & Balasubramanian, S. (2000) Recent developments in the encoding and deconvolution of combinatorial libraries. Curr. Opin. Chem. Biol., 4, 346-350. #14929

38. Barry, C.E.I., Slayden, R.A., Sampson, A.E., & Lee, R.E. (2000) Use of genomics and combinatorial chemistry in the development of new antimycobacterial drugs. Biochem. Pharmacol., 59, 221-231. #13913

39. Barthe, P., Rochette, S., Vita, C., & Roumestand, C. (2000) Synthesis and NMR solution structure of an alpha-helical hairpin stapled with two disulfide bridges. Protein Sci., 9, 942-955. #14931

40. Bartsevich, V.V., & Juliano, R.L. (2000) Regulation of the MDR1 gene by transcriptional repressors selected using peptide combinatorial libraries. Mol. Pharmacol., 58, 1-10. #14932

41. Basso, A., Evans, B., Pegg, N., & Bradley, M. (2000) Solid-phase synthesis of aryl ethers on high loading dendrimer resin. Tetrahedron Lett., 41, 3763-3767. #14559

42. Batra, S., Rastogi, S.K., Kundu, B., Patra, A., & Bhaduri, A.P. (2000) A novel isoxazole-based scaffold for combinatorial chemistry. Tetrahedron Lett., 41, 5971-5974. #15426

43. Battersby, B.J., Bryant, D., Meutermans, W., Matthews, D., Smythe, M.L., & Trau, M. (2000) Toward larger chemical libraries: Encoding with fluorescent colloids in combinatorial chemistry. J. Amer. Chem. Soc., 122, 2138-2139. #14627

44. Bauer, U., Egner, B.J., Nilsson, I., & Berghult, M. (2000) Parallel solution phase synthesis of N-substituted 2-pyrazoline libraries. Tetrahedron Lett., 41, 2713-2717. #14542

45. Baumann, M., Dietrich, U., Koenigs, C. & Griesinger, C. (2000) Combinatorial peptide synthesis, NMR-aided screening and testing of low molecular weight RNA-ligands. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 170-171). Kluwer Academic Publisher, Dordrecht. #15717

46. Baxter, A.D., Boyd, E.A., Cox, P.B., Loh, V.Jr., Monteils, C., & Proud, A. (2000) 4,6-Dichloro-5-nitropyrimidine: A versatile building block for the solid phase synthesis of dihydropteridinones. Tetrahedron Lett., 41, 8177-8181. #15627

47. Becattini, B., Capozzi, G., Falciani, C., Menichetti, S., Nativi, C., & Salvini, A. (2000) Carbohydrate-based peptido mimetics. Synthesis of two new scaffolds for combinatorial libraries. J. Carbohyd. Chem., 19, 653-657. #14934

48. Bedford, M.T., Sarbassova, D., Xu, J., Leder, P., & Yaffe, M.B. (2000) A novel Pro-Arg motif recognized by WW domains. Journal of Biological Chemistry, 275, 10359-10369. #14936

49. Beeley, L.J., Duckworth, D.M., & Southan, C. (2000) The impact of genomics on drug discovery. Prog. Med. Chem., 37, 1-43. #14752

50. Beeley, N., & Berger, A. (2000) A revolution in drug discovery. Combinatorial chemistry still needs logic to drive science forward. Editorial. BMJ, 321, 581-582. #15581

51. Beeley, N.R.A. (2000) Can peptides be mimicked? Drug Disc. Today, 5, 354-363. #15467

52. Belogi, G., Zhu, T., & Boons, G.J. (2000) Polystyrylboronic acid as a reusable polymeric support for oligosaccharide synthesis. Tetrahedron Lett., 41, 6965-6968. #15546

53. Belu, A.M., Brocchini, S., Kohn, J., & Ratner, B.D. (2000) Characterization of combinatorially designed polyarylates by time-of-flight secondary ion mass spectrometry. Rapid Commun. Mass Spectrom., 14, 564-571. #14732

54. Bennett, W.M. (2000) Organic reactions on solid support. An overwiew. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 139-262). Oxford University Press, Oxford. #15670

55. Bentley, L., Fehrsen, J., Jordaan, F., Huismans, H., & du, P.D. (2000) Identification of antigenic regions on VP2 of African horsesickness virus serotype 3 by using phage-displayed epitope libraries. J. Gen. Virol., 81, 993-1000. #14939

56. Berger, T.A., & Wilson, W.H. (2000) High-speed screening of combinatorial libraries by gradient packed-column supercritical fluid chromatography. J. Biochem. Biophys. Meth., 43, 77-85. #14940

57. Berger, T.A., Fogleman, K., Staats, T., Bente, P., Crocket, I., Farrell, W., & Osonubi, M. (2000) The development of a semi-preparatory scale supercritical-fluid chromatograph for high-throughput purification of 'combi-chem' libraries. J. Biochem. Biophys. Meth., 43, 87-111. #15575

58. Berkessel, A., & Riedl, R. (2000) Combinatorial de novo synthesis of catalysts: How much of a hit-structure is needed for activity? Journal of Combinatorial Chemistry, 2, 215-219. #14446

59. Beroza, P., & Suto, M.J. (2000) Designing chiral libraries for drug discovery. Drug Disc. Today, 5, 364-372. #15466

60. Berst, F., Holmes, A.B., Ladlow, M., & Murray, P.J. (2000) A latent aryl hydrazine 'safety-catch' linker compatible with N-alkylation. Tetrahedron Lett., 41, 6649-6653. #15528

61. Bevan, C.D., & Lloyd, R.S. (2000) A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates. Anal. Chem., 72, 1781-1787. #14944

62. Bhattacharyya, S., Fan, L., Vo, L., & Labadie, J. (2000) Titanium(IV) isopropoxide mediated solution phase reductive amination on an automated platform: Application in the generation of urea and amide libraries. Comb. Chem. High Throughput Screening, 3, 117-124. #14588

63. Bhattacharyya, S. (2000) Polymer-supported reagents and catalysts: Recent advances in synthetic applications. Comb. Chem. High Throughput Screening, 3, 65-92. #14585

64. Bi, X.N., Haque, T.S., Zhou, J., Skillman, A.G., Lin, B., Lee, C.E., Kuntz, I.D., Ellman, J.A., & Lynch, G. (2000) Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus. J. Neurochem., 74, 1469-1477. #14945

65. Birch-Machin, I., Ryder, S., Taylor, L., Iniguez, P., Marault, M., Cegile, L., Zientara, S., Cruciere, C., Cancellotii, F., Koptopoulos, G., Mumford, J., Binns, M., Davis-Poynter, N., & Hannant, D. (2000) Utilisation of bacteriophage display libraries to identify peptide sequences recognised by Equine herpesvirus type 1 specific equine sera. J. Virol. Meth., 88, 89-104. #741

66. Blackburn, C., & Guan, B. (2000) A novel dealkylation affording 3-aminoimidazo[1,2-a]pyridines: Access to new substitution patterns by solid-phase synthesis. Tetrahedron Lett., 41, 1495-1500. #14332

67. Blair, W.S., Lin, P.F., Meanwell, N.A., & Wallace, O.B. (2000) HIV-1 entry: An expanding portal for drug discovery. Drug Disc. Today, 5, 183-194. #15477

68. Blanco, L., Bloch, R., Bugnet, E., & Deloisy, S. (2000) Solid phase Diels-Alder/retro Diels-Alder reactions. A new method for traceless linker strategy. Tetrahedron Lett., 41, 7875-7878. #15636

69. Blaney, P., Grigg, R., Rankovic, Z., & Thoroughgood, M. (2000) Application of Grignard reagents to the synthesis of tertiary methylamines via resin-bound oxyiminium ions. Tetrahedron Lett., 41, 6639-6642. #15527

70. Blaney, P., Grigg, R., Rankovic, Z., & Thoroughgood, M. (2000) Solid-phase synthesis of tertiary methylamines via reductive alkylation-fragmenation using a hydroxylamine linker. Tetrahedron Lett., 41, 6635-6638. #15526

71. Blaskovich, M.A., Boatman, P.D., Cao, B., Eguchi, M., Kim, H.O., Lee, M., Little, T., Mathew, F., McCann, I., Mehlin, C., Nakanishi, H., Nelson, S., Nguyen, M., Ogbu, C., Qabar, M.N., Ruan, F., Shea, J.P., Stasiak, M., Urban, J. & Kahn, M. (2000) Highly efficient and versatile construction of secondary structure peptide mimetic libraries: Application to biology and drug development. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 191-193). Kluwer Academic Publisher, Dordrecht. #15726

72. Blass, B.E., Burt, T.M., Liu, S., Portlock, D.E., & Swing, E.M. (2000) A facile KF/Al2O3 mediated, selective alkylation of benzodiazepin-2,5-diones. Tetrahedron Lett., 41, 2063-2066. #14342 OLDOLD

73. Blondelle, S.E., & Lohner, K. (2000) Combinatorial libraries: A tool to design antimicrobial and antifungal peptide analogues having lytic specificities for structure-activity relationship studies. Biopolymers (Pept. Sci. ), 55, 74-87. #15553

74. Blondelle, S.E., Crooks, E., Aligue, R., Agell, N., Bachs, O., Esteve, V., Tejero, R., Celda, B., Pastor, M.T., & Perez-Paya, E. (2000) Novel, potent calmodulin antagonists derived from an all-D hexapeptide combinatorial library that inhibit in vivo cell proliferation: Activity and structural characterization. J. Pept. Res., 55, 148-162. #14266

75. Boger, D.L., Lee, J.K., Goldberg, J., & Jin, Q. (2000) Two comparisons of the performance of positional scanning and deletion synthesis for the identification of active constituents in mixture combinatorial libraries. J. Org. Chem., 65, 1467-1474. #14948

76. Boger, D.L., Fink, B.E., & Hedrick, M.P. (2000) A new class of highly cytotoxic diketopiperazines. Bioorg. Med. Chem. Lett., 10, 1019-1020. #15579

77. Boger, D.L. & Goldberg, J. (2000) Multi-step solution phase combinatorial synthesis. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 303-326). Oxford University Press, Oxford. #14367

78. Bohm, H.J., & Stahl, M. (2000) Structure-based library design: Molecular modelling merges with combinatorial chemistry. Curr. Opin. Chem. Biol., 4, 283-286. #14949

79. Bohm, V.P.W., Weskamp, T., Gstottmayr, C.W.K., & Herrmann, W.A. (2000) Nickel-catalyzed cross-coupling of aryl chlorides with aryl Grignard reagents. Angew. Chem. Int. Ed., 39, 1602-1604. #14629

80. Bolin, D.R., Swain, A.L., Sarabu, R., Berthel, S.J., Gillespie, P., Huby, N.J.S., Makofske, R., Orzechowski, L., Perrotta, A., Toth, K., Cooper, J.P., Jiang, N., Falcioni, F., Campbell, R., Cox, D., Gaizband, D., Belunis, C.J., Vidovic, D., Ito, K., Crowther, R., Kammlott, U., Zhang, X.L., Palermo, R., Weber, D., & Guenot, J. (2000) Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures. J. Med. Chem., 43, 2135-2148. #14950

81. Borman, S. (2000) Combinatorial synthesis hits the spot. C&EN, 78, 25-27. #14678

82. Borman, S. (2000) Combinatorial encoding technique: A lucky charm. C&EN, 78, 40-41. #14805

83. Borman, S. (2000) Combinatorial chemistry: Redefining the scientific method. C&EN, 78, 53-65. #15441

84. Borrebaeck, C.A.K. (2000) Antibodies in diagnostics: From immunoassays to protein chips. Immunol. Today, 21, 379-382. #15463

85. Bourne, G.T., McGeary, R.P., Golding, S.W., Meutermans, W.D.F., Alewood, P.F. & Smythe, M.L. (2000) An evaluation of a novel safety catch linker for development of cyclic peptide libraries. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 98-99). Kluwer Academic Publisher, Dordrecht. #15705

86. Boutin, J.A., Lahaye, C., Pegurier, C., Nicolas, J.P., Fauchere, J.L., Langlois, M., Renard, P., Delagrange, P., & Canet, E. (2000) Screening of ligand binding on melatonin receptor using non-peptide combinatorial libraries. Journal of Receptor and Signal Transduction Research, 20, 105-118. #14957

87. Bowen, R.L., Farahani, M., Dickens, S.H., & Guttman, C.M. (2000) MALDI-TOF MS analysis of a library of polymerizable cyclodextrin derivatives. J. Dent. Res., 79, 905-911. #14630

88. Bradley, E.K., Beroza, P., Penzotti, J.E., Grootenhuis, P.D.J., Spellmeyer, D.C., & Miller, J.L. (2000) A rapid computational method for lead evolution: Description and application to alpha(1)-adrenergic antagonists. J. Med. Chem., 43, 2770-2774. #14961

89. Bradley, M., & Weber, L. (2000) Combinatorial chemistry. Evolution of design and design of evolution. Editorial overview. Curr. Opin. Chem. Biol., 4, 255-256. #14962

90. Brannetti, B., Via, A., Cestra, G., Cesareni, G., & Citterich, M.H. (2000) SH3-SPOT: An algorithm to predict preferred ligands to different members of the SH3 gene family. J. Mol. Biol., 298, 313-328. #14963

91. Brase, S. (2000) New linkers for solid phase organic chemistry. Multidirectional (multifunctional), backbone amide, and traceless linker. Chim. Oggi, 18, 14-19. #15680

92. Breitenbucher, J.G., & Figliozzi, G. (2000) Solid-phase synthesis of 4-aryl-1,4-dihydropyridines via the Hantzsch three component condensation. Tetrahedron Lett., 41, 4311-4315. #14598

93. Brennan, M.B. (2000) Drug discovery filtering out failures early in the game. C&EN, 78, 63-73. #14535

94. Briehn, C.A., Kirschbaum, T., & Bauerle, P. (2000) Polymer-supported synthesis of regioregular head-to-tail-coupled oligo(3-arylthiophene)s utilizing a traceless silyl linker. J. Org. Chem., 65, 352-359. #13923

95. Brinker, A., Weber, E., Stoll, D., Voigt, J., M ller, A., Sewald, N., Jung, G., Wiesmuller, K.H., & Bohley, P. (2000) Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections. Eur. J. Biochem., 267, 5085-5092. #15762

96. Broome, B.M., & Hecht, M.H. (2000) Nature disfavors sequences of alternating polar and non-polar amino acids: Implications for amyloidogenesis. J. Mol. Biol., 296, 961-968. #14965

97. Brouwer, A.J., Van der Linden, H.J., & Liskamp, R.M.J. (2000) Combinatorial chemistry for ligand development in catalysis: Synthesis and catalysis screening of peptidosulfonamide tweezers on the solid phase. J. Org. Chem., 65, 1750-1757. #14631

98. Brown, K.C. (2000) New approaches for cell-specific targeting: Identification of cell-selective peptides from combinatorial libraries. Curr. Opin. Chem. Biol., 4, 16-21. #14967

99. Brown, R.C.D., Castro, J.L., & Moriggi, J.D. (2000) Solid-phase synthesis of cyclic sulfonamides employing a ring-closing metathesis-cleavage strategy. Tetrahedron Lett., 41, 3681-3685. #14558

100. Bryan, W.M., Huffman, W.F., & Bhatnagar, P.K. (2000) Combinatorial chemistry. Preparation of phenoxypropanolamines. Tetrahedron Lett., 41, 6997-7000. #15550

101. Buchardt, J., Schiodt, C.B., Ferreras, M., Foged, N.T., Delaisse, J.M. & Meldal, M. (2000) Combinatorial library of phosphinic peptides for discovery of MMP inhibitors on solid-phase. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 443-444). Kluwer Academic Publisher, Dordrecht. #15737

102. Buolamwini, J.K. (2000) Cell cycle molecular targets in novel anticancer drug discovery. Current Pharmaceutical Design, 6, 379-392. #14969

103. Burger, K., Spengler, J., Hennig, L., Herzschuh, R., & Essawy, S.A. (2000) Synthesis of derivatives of omega-isocyanato-alpha-methylamino, omega-ureido-alpha-methylamino, and N-alpha-methyl-alpha,omega-diamino acids. Monatshefte fur Chemie, 131, 463-473. #14970

104. Burgess, K., & Cook, D. (2000) Syntheses of nucleoside triphosphates. Chem. Rev., 100, 2047-2059. #14570

105. Burkett, B.A., & Chai, C.L.L. (2000) N-Fmoc-dehydroalanine: A versatile molecular scaffold for the rapid solid-phase synthesis of cycloaliphatic amino acids. Tetrahedron Lett., 41, 6661-6664. #15529

106. Buvoli, A., Buvoli, M., & Leinwand, L.A. (2000) Enhanced detection of tRNA isoacceptors by combinatorial oligonucleotide hybridization. RNA, 6, 912-918. #14697

107. Calama, M.C., Timmerman, P., & Reinhoudt, D.N. (2000) Guest-templated selection and amplification of a receptor by noncovalent combinatorial synthesis. Angew. Chem. Int. Ed., 39, 755-758. #14313

108. Caldarelli, M., Baxendale, I.R., & Ley, S.V. (2000) Clean and efficient synthesis of azo dyes using polymer-supported reagents. Green Chemistry, 2, 43-45. #14971

109. Cameron, A., Fortenberry, Y., & Lindberg, I. (2000) The SAAS granin exhibits structural and functional homology to 7B2 and contains a highly potent hexapeptide inhibitor of PC1. FEBS Lett., 473, 135-138. #14973

110. Cannarsa, M.J. (2000) CombiCat 1999. A brief summary of papers presented. Chim. Oggi, 6, 22-25. #14707

111. Cardullo, F., Calama, M.C., Snellink-Ruel, B.H.M., Weidmann, J.L., Bielejewska, A., Fokkens, R., Nibbering, N.M.M., Timmerman, P., & Reinhoudt, D.N. (2000) Covalent capture of dynamic hydrogen-bonded assemblies. Chem. Commun., 367-368. #14974

112. Carlson, C.B., & Beal, P.A. (2000) Solid-phase synthesis of acridine-peptide conjugates and their analysis by tandem mass spectrometry. Organic Letters, 2, 1465-1468. #14975

113. Cassell, G., Klemm, M., Pinilla, C., & Segall, A. (2000) Dissection of bacteriophage lambda site-specific recombination using synthetic peptide combinatorial libraries. J. Mol. Biol., 299, 1193-1202. #14976

114. Castelino, P., Lewis, D., Shimmin, D., Clough, G., & Harding, D. (2000) Automated sample storage for drug discovery. Chim. Oggi, 17, 32-35. #13891

115. Chakraborty, T.K., Jayaprakash, S., Srinivasu, P., Govardhana Chary, M., Diwan, P.V., Nagaraj, R., Ravi Sankar, A., & Kunwar, A.C. (2000) Synthesis and structural studies of oligomers of 6-amino-2,5-anhydro-6-deoxy-D-mannonic acid. Tetrahedron Lett., 41, 8167-8171. #15626

116. Chames, P., & Baty, D. (2000) Antibody engineering and its applications in tumor targeting and intracellular immunization. FEMS Microbiol. Lett., 189, 1-8. #15469

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163. Deadman, J. (2000) Proteinase inhibitors and activators strategic targets for therapeutic intervention. J. Peptide Sci., 6, 421-431. #15610

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209. Franzen, R.G. (2000) Recent advances in the preparation of heterocycles on solid support: A review of the literature. Journal of Combinatorial Chemistry, 2, 195-214. #14444

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514. Plater, M.J., Murdoch, A.M., Morphy, J.R., Rankovic, Z., & Rees, D.C. (2000) Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins. Journal of Combinatorial Chemistry, 2, 508-512. #15603

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516. Pons, J.F., Mishir, Q., Nouvet, A., & Brookfield, F. (2000) Thiazole formation via traceless cleavage of Rink resin. Tetrahedron Lett., 41, 4965-4968. #14614

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525. Rau, H.K., DeJonge, N. & Haehnel, W. (2000) Combinatorial synthesis of de novo metalloproteins with tuned redox potential. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 490-492). Kluwer Academic Publisher, Dordrecht. #15741

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527. Ravn, P., Arnau, J., Madsen, S.M., Vrang, A., & Israelsen, H. (2000) The development of TnNuc and its use for the isolation of novel secretion signals in Lactococcus lactis. Gene, 242, 347-356. #14324

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530. Reichmann, L., & Winter, G. (2000) Novel folded protein domains generated by combinatorial shuffling of polypeptide segments. Proc. Natl. Acad. Sci. USA, 97, 10068-10073. #15578

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534. Richmond, R. (2000) The analytical characterisation of sub-minute measurement duty cycles in flow injection analysis mass spectrometry by their carry-over. Anal. Chim. Acta, 403, 287-294. #14248

535. Rinnova, M., Novakova, M., Kasicka, V., & Jiracek, J. (2000) Side reactions during photochemical cleavage of an amethyl-6-nitroveratryl-based photolabile linker. J. Peptide Sci., 6, 355-365. #15449

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537. Ronn, L.C.B., Olsen, M., Ostergaard, S., Kiselyov, V., Berezin, V., Mortensen, M.T., Lerche, M.H., Jensen, P.H., Soroka, V., Saffell, J.L., Doherty, P., Poulsen, F.M., Bock, E., Holm, A., & Saffell, J. (2000) Identification of a neuritogenic ligand of the neural cell adhesion molecule using a combinatorial library of synthetic peptides (vol 18, pg 1000, 1999). Nat. Biotech., 18, 559. #15278

538. Rosse, G., Kueng, E., Page, M.G.P., Schauer-Vukasinovic, V., Giller, T., Lahm, H.W., Hunziker, P., & Schlatter, D. (2000) Rapid identification of substrates for novel proteases using a combinatorial peptide library. Journal of Combinatorial Chemistry, 2, 461-466. #15598

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543. Roy, S., & Hecht, M.H. (2000) Cooperative thermal denaturation of proteins designed by binary patterning of polar and nonpolar amino acids. Biochemistry, 39, 4603-4607. #14700

544. Rudolf, M.P., Zuercher, A.W., Nechansky, A., Ruf, C., Vogel, M., Miescher, S.M., Stadler, B.M., & Kricek, F. (2000) Molecular basis for nonanaphylactogenicity of a monoclonal anti-IgE antibody. Journal of Immunology, 165, 813-819. #15285

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549. Sanchez, R.M., Graybill, T.L., Moore, M.L. & Veber, D.F. (2000) The synthesis of matrix matalloprotease inhibitor libraries using a hybrid mix/split parallel approach. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 441-442). Kluwer Academic Publisher, Dordrecht. #15736

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563. Schroeder, F.C., Farmer, J.J., Smedley, S.R., Attygalle, A.B., Eisner, T., & Meinwald, J. (2000) A combinatorial library of macrocyclic polyamines produced by a ladybird beetle. J. Amer. Chem. Soc., 122, 3628-3634. #15301

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