Six new photolabile linkers for solid-phase synthesis. 1. Methods of preparation
Eva B. ┼kerblom, K. Hubert Agback, Alf S. Nygren
Medicinal Chemistry, Pharmacia & Upjohn AB, S-75182 Uppsala, Sweden
In the synthesis of combinatorial chemical libraries on solid phase, there is a need to cleave the compounds from the solid support before the library can be tested for biological activity. It is advantageous to use linkers which will release the libraries by mild photolytic cleavage. We have developed six new linkers of the photosensitive a-methyl 2-nitrobenzyl type containing amino, hydroxy, bromo and methylamino groups, and also 4-nitrophenoxycarbonyl activated OH and NH_2 groups.
combinatorial chemical library, linkers, photolysis, solid-phase synthesis