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Amino Acid Database, January 14, 1997.

We are pleased to release a new version of "Peptide Synthesis Database", which lists compounds (such as Boc- and Fmoc-amino acids) useful for peptide synthesis. The new features of this version 4.0 are:
1) FileMaker Pro run-time version (for Mac and PC) is attached so that the database may be downloaded with the software and be used locally.
2) The database lists 1429 residues from 24 suppliers compared to 1279 residues from 17 suppliers in the previous version.
3) Several non-commercial compounds are listed.
4) The layout of the price information is improved.

We strongly recommend you to use the database locally because of its quick and flexible search functions. You may access to our database through Internet.
Yasuo Konishi, Ph. D.
Head, Peptide Chemistry
National Research Council Canada
Biotechnology Research Institute
Tel. (514) 496-6339
Fax (514) 496-6232

UC Berkeley Course, January 14, 1997

Readers in the San Francisco area will be interested in the following UC Berkeley Extension course, which will include material on diversity and combinatorial chemistry:
Perspectives in Computer-Aided Molecular Design
X416.2 (2 semester units in EE and Computer Science)

Scientists who use computers to study and design new molecules are faced with a bewildering array of theories, techniques, and software packages. This course provides a framework to help chemists, molecular biologists, and genetic engineers understand and apply the latest techniques in computer-aided molecular design. The instructors use a case-study approach, balancing theory with applications. Lectures and discussions are combined with computing demonstrations of popular software packages for molecular design. Topics range from traditional statistical and molecular modeling studies to more recent macromolecular and 3D structural database applications. You learn about successful strategies for lead development and optimization and are encouraged to apply the techniques to problems in your own research. This course familiarizes you with the techniques and software packages in the field, so you are able to choose an appropriate method, get the most out of it, and more effectively plan for future applications in your research. Guest lecturers include Robert McDowell (Genentech), Steve Muskal (Glaxo/Wellcome- Affymax), and Phil Magee (BIOSAR).

Instructor: Douglas Henry, MDL Information Systems, Inc. (dough@mdli.com) 10 evenings, Feb. 13 thru Apr. 24: Thurs., 7-10 PM (no meeting Apr. 17) San Francisco extension center - Room 16 (near Moscone at Howard) Cost: $400 (EDP 036657)

For enrollment information, see p. 112 in the UC Extension Spring '97 catalog, call (510) 642-4111, or visit http://www.unex.berkeley.edu:4243.

New MDL Academic Package, September 16, 1996

Announcing New MDL Academic Package for North American Academic Institutions

We will issue a press release concerning this package; I wanted to give the members of these (diversity) lists an early notice. MDL is offering (available immediately) a new bundle of databases and programs intended to help researchers at academic institutions in their search for important chemical information and in their maintenance of their own research results. The bundle consists of databases and programs that are in wide use throughout the pharmaceutical and chemical industries, and that should be uniquely helpful in academic research. These products also will give students an important early look at software they are likely to encounter when then enter the workforce.

The databases in the package include two 3D molecule databases (a comprehensive list of compounds from over 200 chemical suppliers and a database of 78,000 drug candidates, complete with biological activity information), three reaction databases (containing 600,000 reactions covering novel syntheses and preparative methods in organic chemistry from 1946 onwards) and Metabolite, a database of metabolic transformation of xenobiotic compounds (as well as a registry system for storing your own metabolic transformation information.)

The programs in the package include ISIS (a client-server package that is used for structure, reaction and data storage, searching, retrieval and viewing), Chemscape (a package you can use to search and view 2D/3D molecule and reaction databases within the WWW environment), ISIS for Excel, and Project Library (a program designed to manage combinatorial "libraries"). Institutions that license the MDL Academic Package can distribute copies of the client software to their students and faculty members, and these individuals can then use that client software to access the databases provided (as well as create and access their own databases).

This package is initially available in North America only for $20,000 per year. Details about the MDL Academic Package can be found at: http://www.mdli.com/academic/academic.html.

A FAQ page is provided at http://www.mdli.com/academic/aca_faq.html.

If you have any questions, please feel free to contact me at:

David Hughes
Group Manager, Core Products, ISIS Business Unit
MDL Information Systems, Inc.
14600 Catalina Street
San Leandro, CA 94577
phone: (510) 895-1313, x.1432
fax: (510) 352-2870
email: davidh@mdli.com

New book from ACS, July 25, 1996

ACS has just published a 27-chapter volume, Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery. The volume is edited by Irwin Chaiken, University of Pennsylvania, and Kim Janda, The Scripps Research Institute. It can be ordered by calling 1-800 227 9919 and is avaibable for $109.95.

For more information call: Cheryl Shanks, ACS Books, tel.:(202) 872 4566

Journal MOLECULES, July 15, 1996

The journal MOLECULES published by Springer is also related to Molecular Diversity. Our organisation MDPI is called Molecular Diversity Preservation International.

Recently we decided to focus the journal MOLECULES on organic synthesis and natural products. The part regarding molecular diversity will be less emphasized and deleted. We preserve molecular diversity by publishing the first chemistry journal that encourages authors to submit compound samples to MDPI in Switzerland.

MOLECULES/MDPI also plan to organize The Electronic Conference on Synthetic Organic Chemistry, June 15-July 15, 1997.

For more information contact:
Dr. Shu-Kun Lin
Institute of Organic Chemistry
University of Basel
St. Johanns Ring 19
CH-4056 Basel, Switzerland
Tel.: +41 79 322 3379
FAX: +41 61 302 8918
E-Mail: LIN@ubaclu.unibas.ch
MDPI URL: http://www.unibas.ch/mdpi/
Molecules URL: http://science.springer.de/molec/molecule.htm