DO YOU WANT TO DISCOVER NEW DRUGS FASTER THAN GLAXO AND MERCK WITHOUT
SPENDING MILLIONS IN AUTOMATION?
IF YOU DO, THEN YOU NEED:
MULTIBLOCK -- Instrument for Multiple and Combinatorial Synthesis
MULTIBLOCK works in big pharma laboratories (Astra, Bristol Myers, Ciba,
Glaxo, E. Merck, Merck Frosst, Novo Nordisk, Organon, Rhone Poulenc, Sandoz,
Searle, Takeda, Wyeth Ayerst...), small biotech companies (Amylin, Medivir, Peptor,
QCB, Zymogenetics...), and academia (Universities of Louisville, Rhode Island,
Utrecht, Stanford...) all over the world (Canada, Colombia, Czech Republic,
Denmark, England, France, Germany, Israel, Italy, Japan, Korea, Netherlands,
Singapore, Sweden, Switzerland, U.S.A....).
48 REACTOR VERSION WITH REFORMATTING ATTACHMENT FOR DIRECT TRANSFER OF PRODUCTS INTO MICROTITERPLATES IS NOW AVAILABLE !
The synthesizer (Fig. 1 and Fig. 2) consists of four parts:
For more information about the use of MULTIBLOCK we recommend the reading
of the User's Manual.
teflon block that holds 48 (42 reactor version discontinued) reactors,
polypropylene syringes equipped with plastic frit;
Vagner J.; Peptide Res. 3, 182 (1990));
- A vacuum adaptor that connects each reactor to
vacuum line and serves for fast washing under continuous-flow
- Two teflon plates with 48 (42 reactor version
discontinued) stoppers to which the teflon block is attached during
deprotection or condensation reaction;
- Glass cover used in the randomization step. You can use
various coupling reagents, resins,protecting groups in the same run of
multistep synthesis. Reactions can be performed in the incubator under
elevated temperature, or even in ultrasonic bath (see e.g.Vagner, J.,
Kocna, P., Krchnak, V.: Peptide Res. 4, 284 (1991)).
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